scholarly journals Genetic Biomarkers in Association with Depressive Disorder in UAE Residents: A Pilot Case Study

2021 ◽  
Vol 36 (4) ◽  
pp. e293-e293
Author(s):  
Nailah Mahmood ◽  
Rukhsana Nawaz ◽  
Hidaya Abdul Kadir ◽  
Fadwa Al Mughairbi
Keyword(s):  
Depressive Disorder ◽  
Protective Factor ◽  
Depressive Disorders ◽  
Target Genes ◽  
Familial Aggregation ◽  
Large Body ◽  
Reference Level ◽  
P Value ◽  
Depressed Group ◽  
Significant Difference

Objectives: We sought to explore the expression of genes associated with depressive disorder in patients with depression compared to control patients. A large body of research in the area of genetics has shown familial aggregation for depressive disorders. The purpose of this study was to identify genetic risk factors in developing depression, particularly among the population residing in the UAE. Methods: We investigated five associated genes (PPARGC1A,CAMKMT,HSD11B1,SLC6A4,and MAOA) previously linked to depression and anxiety in other populations. The study was carried out in Al Ain, although participants were from different nationalities. Blood samples were collected over a period of seven months, and lab work was carried out over a period of two months from September 1, 2018 to May 30, 2019. We screened the prevalence of the PPARGC1A,CAMKMT,HSD11B1,SLC6A4, and MAOA in 29 patients with depressive disorder and 30 controls using the quantitative real-time polymerase chain reaction method. Results: The expression of the PPARGC1A gene, studied for the first time in the UAE population. The independent t-test was used to check the significance of difference between the expression levels of target genes where the control was set at a reference level of 1.0. PPARGC1A gene is lower among the depressed group which showed mean difference: 0.4 and p-value: 0.02, indicating a strong association with depression. No significant difference was found in the genes’ expression of CAMKMT with p-value 0.150, MAOA p-value 0.070, SLC6A4 p-value 0.750, and HSD11B1 p-value 0.100 in two groups in comparison with (p < 0.050). Conclusions: These results open several possibilities for further research to study the role of this gene as a protective factor against developing depression.

scholarly journals A double-blind randomized placebo-controlled study of low dose mirtazapine once daily in patients of major depressive disorders on escitalopram

2019 ◽  
Vol 8 (5) ◽  
pp. 1067
Author(s):  
Mallikarjuna Rao I. ◽  
Usha Kiran Prayaga ◽  
Dharma Rao Uppada ◽  
Ramachandra Rao E. ◽  
B. L. Kudagi
Keyword(s):  
Depressive Disorders ◽  
Low Dose ◽  
Rating Scale ◽  
Controlled Study ◽  
P Value ◽  
Chi Square ◽  
Double Blind ◽  
Increased Risk ◽  
Significant Difference ◽  
Chi Square Test

Background: The SSRIs being used as 1st line therapy in treatment of depression have delayed therapeutic effect which makes the patient vulnerable to an increased risk of suicide and decreased adherence to the treatment and will prematurely discontinue the therapy. The present study was conducted to evaluate if low dose mirtazapine-escitalopram combination therapy has any add on benefit over monotherapy with escitalopram.Methods: In a single-centered, comparative study involving patients with depression attending the out-patient after screening and exclusion, 60 eligible patients were randomly assigned to receive tablet mirtazapine 7.5 mg plus tablet escitalopram 10 mg intervention or tablet escitalopram 10 mg plus placebo intervention in a double-blind 6-week treatment phase. The primary outcome measure was the change in the 17-item Hamilton Depression Rating Scale (HDRS) and Montgomery-Asberg Depression Rating Scale (MADRS) score from baseline. Participants were evaluated at baseline, 1st, 2nd,4th and 6th week. Results were analyzed using Chi-Square test for adverse effects and independent t-test analysis for efficacy parameter.Results: In the analysis of results at 6th week the numbers of patients achieved remission in mirtazapine group are more with a p-value of 0.018 which is significant and the numbers of responders in mirtazapine group are also more which is statistically significant on chi-square test. There is no significant difference was observed between the two groups with reference to occurrence of adverse effect.Conclusions: Adding low dose mirtazapine has an added benefit in terms of efficacy and getting remission early with more number of responders in the treatment of major depression.

Sociodemographic and clinical characteristics of depressive disorder in Saada in Yemen

2011 ◽  
Vol 26 (S2) ◽  
pp. 2193-2193
Author(s):  
A.Y. Shuwail
Keyword(s):  
Depressive Disorder ◽  
Depressive Disorders ◽  
Statistical Significance ◽  
Depressive Illness ◽  
Common Symptom ◽  
International Studies ◽  
Significant Difference ◽  
Global Burden Of Diseases ◽  
Loss Of Appetite ◽  
Suicidal Ideas

BackgroundDepression has been recognized as a major public health evidenced by its ranking of fourth position among the global burden of diseases. Many believe it will occupy second position by the year 2020. This is the first study in Saada and Yemen.Aims of the studyTo determine the clinical and sociodemographic characteristic of depressive disorders in Saada country.MethodsPatients who attended the medical OPD in general hospital during six month and consented to participate in this were screened with Hospital Anxiety and Depressive Scale (HAD). Identified depressed patients were studied and results were analysis.Results714 patients attended, 20 refused to participate. 694 patients were screened by HAD Scale. 438(63%) were men. 21% were borderline and only 16% fulfilled the score for depression.72.3 suffer from loss of appetite, 50% from fatigue, 50% from loss of interest, 21% from suicidal ideas, 41% sleep disturbance and 12% of guilt feeling. 28% suffered from dizziness, 23% of gasterointestinal symptoms, and 16% from aches and pains. There was statistically significant difference between major depressive disorder and mixed anxiety and depressive disorder in that women were more. There was a trend towards statistical significance (P = 0.054) between delusions and qat chewing. There was no statistical significance with hallucination and qat chewing. Results were analysed and compared with other local and international studies.ConclusionMild depressive illness is more common in women, there was no impact of qat on depression, loss of appetite was the most common symptom. These finding are consistent with other local studies.

scholarly journals Crocus sativus L. versus Citalopram in the Treatment of Major Depressive Disorder with Anxious Distress: A Double-Blind, Controlled Clinical Trial

2016 ◽  
Vol 50 (04) ◽  
pp. 152-160 ◽  
Author(s):  
A. Ghajar ◽  
S. Neishabouri ◽  
N. Velayati ◽  
L. Jahangard ◽  
N. Matinnia ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Rating Scale ◽  
Crocus Sativus ◽  
Controlled Clinical Trial ◽  
P Value ◽  
Major Depressive ◽  
Significant Difference ◽  
Hamilton Rating Scale ◽  
Crocus Sativus L

Abstract Introduction: Saffron (Crocus sativus L.) has demonstrated antidepressant effects in clinical studies and extensive anxiolytic effects in experimental animal models. Methods: 66 patients with major depressive disorder accompanied by anxious distress were randomly assigned to receive either saffron (30 mg/day) or citalopram (40 mg/day) for 6 weeks. Hamilton Rating Scale for Depression (HAM-D) and Hamilton Rating Scale for Anxiety (HAM-A) were used to assess treatment effect during the trial. Results: 60 participants finished the study. Patients who received either saffron or citalopram showed significant improvement in scores of the Hamilton Rating Scale for Depression (P-value<0.001 in both groups) and Hamilton Rating Scale for Anxiety (P-value<0.001 in both groups). Comparison of score changes between the 2 trial arms showed no significant difference (P-value=0.984). Frequency of side effects was not significantly different between the 2 groups. Discussion: The present study indicates saffron as a potential efficacious and tolerable treatment for major depressive disorder with anxious distress.

scholarly journals Depressive disorders in patients with pharmaco-resistant mesial temporal lobe epilepsy

2017 ◽  
Vol 46 (2) ◽  
pp. 752-760 ◽  
Author(s):  
Eleonora Borges Gonçalves ◽  
Tania Aparecida Marchiori de Oliveira Cardoso ◽  
Clarissa Lin Yasuda ◽  
Fernando Cendes
Keyword(s):  
Depressive Disorder ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Depressive Disorders ◽  
Case Series ◽  
Mesial Temporal Lobe Epilepsy ◽  
Psychiatric Interview ◽  
Case Series Study ◽  
Significant Difference ◽  
Mesial Temporal Lobe

Objectives To assess depressive disorders in patients with mesial temporal lobe epilepsy (MTLE) refractory to medical treatment. Methods Adult patients with refractory MTLE completed two questionnaires (Mini International Neuropsychiatric Interview (MINI) and the Beck Depression Inventory (BDI) had a semi-structured psychiatric interview and a high resolution MRI scan. For complete neuropsychiatric diagnosis, as per International Classification of Diseases (ICD-10), the results were combined with clinical history and additional information from the patients’ family. Results Of the 40 patients identified for this case series study which took place from 2008–2012, 31 (77.5%) had a depressive disorder: 14 had dysthymia, 11 had recurrent depressive disorder and 6 had bipolar disorder. Of the nine patients without a firm diagnosis of mood disorder, seven had isolated symptoms of depression or anxiety and two presented with mixed depression/anxiety symptoms. Only 8/31 (25.8%) patients were receiving antidepressant treatment. There was no association between BDI scores and seizure frequency. No significant difference was found between patients with and without depression and the presence or laterality of HA. Conclusions Depressive disorders are common, underdiagnosed and undertreated in patients with refractory MTLE.

scholarly journals Quality of life, anxiety and depressive disorders in patients with extrasystolic arrhythmia

2020 ◽  
Author(s):  
Alexey Y. Mikhaylov ◽  
Alexei V. Yumashev ◽  
Eugeny Kolpak
Keyword(s):  
Depressive Disorder ◽  
Depressive Disorders ◽  
Depression Scale ◽  
Depression And Anxiety ◽  
Ventricular Extrasystole ◽  
Significant Difference ◽  
Different Types ◽  
Development Of Anxiety ◽  
Assessment Scales

IntroductionThe aim of this study was to perform a comparative and economic analysis of the degree of development of anxiety-depressive disorder in patients with different types of extrasystolic arrhythmia using different assessment scales.Material and methodsThe study was conducted in 2018–2019 at the premises of clinic No. 4, involving 450 patients (Moscow, Russia). Patients were divided into three groups: with coronary heart disease (CHD) (147 patients), with myocardiodystrophy (MCD) (113) and with cardiopsychoneurosis (CPN) (190). Everyone underwent round-the-clock electrocardiography (ECG) and echocardiography. If symptoms of depressive disorder are detected in a timely manner, the risk of adverse cardiovascular diseases may be reduced.ResultsDepression and anxiety indicators on all three scales differed significantly (p ≤ 0.05) in patients with supraventricular extrasystole (more than 40 points on the Zung scale, 14 points on the Montgomery-Asberg depression scale, more than 38 points on Zung and 3 points on Covi anxiety scales). For patients with ventricular extrasystole, a significant difference was established between groups 1 and 2 only in terms of the level of depression on the Zung scale. Factors of psychogenic origin determine the development of cardiac rhythm disturbances.ConclusionsThe study showed that for supraventricular extrasystoles, these factors determine the overall health of the patient. The differences between the three groups are significant on all scales of depression and anxiety (p ≤ 0.05). The most susceptible to depression and anxiety are patients with extrasystolic arrhythmias diagnosed with CHD, as well as MCD.

Prevalence of depressive disorders in shanghai children aged 8∼12 years

2011 ◽  
Vol 26 (S2) ◽  
pp. 623-623
Author(s):  
J. Fan ◽  
H.-L. Gu ◽  
H.-L. Yang ◽  
W.-Y. Wang ◽  
J. Yi ◽  
...  
Keyword(s):  
Depressive Disorder ◽  
Prevalence Rate ◽  
Primary Schools ◽  
Depressive Disorders ◽  
Depression Scale ◽  
Epidemiological Studies ◽  
Cluster Sampling ◽  
Significant Difference ◽  
Prevalence Of Depression ◽  
Dsm Iv

ObjectiveThe purpose of this study was to investigated the prevalence child depression in primary schools.Methods3685 students from Grade 3 to Grade 5 were selected from 7 primary schools of Pudong district in Shanghai by random and cluster sampling. The study design consisted of a screening stage in which the Center for Epidemiological Studies Depression Scale for Children(CES-DC) were used, and a clinical interview stage in which the K-SADS-present state version (K-SADS) and DSM-IV were used. The diagnoses of depressive disorder were made according the DSM-IV criteria.ResultsThe prevalence of children depression was 1.60% (95%CI = 1.19%∼2.00%). The prevalence rate of male(2.08%) was significant higher than that of female (1.09%)(X2=5.40, P = 0.02). The rate of depressive disorder increased with age from 0.57% (8 years old) to 2.47% (12 years old). The prevalence of depression was no significant difference between ages from 8 to 12 years old (X2 = 4.49, P = 0.34).ConclusionThe prevalence rate of children depression in Shanghai is low. The prevalence of depression among boys is much higher than that of girls.It shows the prevalence of depression is no significant difference between ages from 8 to 12 years old.

Abstract 469: Gene Expression Profiling Reveals Genes and Pathways Involved in the Cardiac Protection of Valosin-containing Protein in the Heart

2016 ◽  
Vol 119 (suppl_1) ◽  
Author(s):  
Shaunrick Stoll ◽  
Xin Chen ◽  
Charles Wang ◽  
Hongyu Qiu
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Target Genes ◽  
B Cell Lymphoma ◽  
P Value ◽  
Cardiac Protection ◽  
Microarray Gene Expression ◽  
Significant Difference

Aims: Valosin-containing protein (VCP) participates in signaling pathways essential for cell homeostasis in multiple tissues, yet its role in mammalian heart remains largely unknown. Our recent studies showed that overexpression of VCP protects cardiomyocytes from stress- induced cell death in both in vitro and in vivo , however, it is unknown which target genes and pathways are regulated by VCP through which the heart may be protected from stress-induced injury. Here we provided the first in vivo evidence of the VCP-regulated target genes by microarray gene expression profiling in a transgenic mouse model. Methods and results: We generated a transgenic (TG) mouse that over-expressed 3.5 fold VCP specifically in the heart. Total RNA extracted from the heart tissues from both adult VCP TG and their litter-matched wild type (WT) mice (N=4/group) was assayed by using Affymetrix Mouse Genome 430 2.0 Array, which interrogates over 39,000 transcripts. Differentially expressed genes (DEGs) were defined by p-value ≤ 0.05 and FC (fold change) ≥ 1.5, and totally 581 DEGs were identified between VCP TG and WT. Applying a more stringent criteria (FDR ≤ 0.05 and FC ≥ 1.5), we identified 21 upregulated and 28 downregulated genes in VCP TG mouse hearts compared to WT. Among the top DEGs, there is a significant up-regulation in the genes regulating the stress response and oxidation in VCP TG versus WT, such as a kinase interacting protein by 2.6 folds which is a key regulator of cardiac stress; glutathione peroxidase 1 by 2.2 folds which is an antioxidant enzyme and anti-apoptotic mediators: protein kinase C delta by 2.3 folds and B-cell lymphoma 2 by 2.7 folds. VCP TG mice also exhibits an upregulation in the genes involved in cellular structure and contractility, e.g., alpha 1 actin by 3.3 folds, myosin light chain 9 by 8.2 folds and Tropomyosin 2 by 4.5 folds which is a gene regulating the binding of myosin and actin. Other DEGs include the upregulated-genes regulating cellular amino acid metabolism such as pterin-4 alpha-carbinolamine dehydratase by 9.7folds, phosphatidic acid phosphatase 2c by 3.4 folds and sortilin 1 by 2.4 folds. Conclusion: Significant difference of gene regulation exists between VCP TG and WT in the heart, which may be the mechanism of VCP-mediated cardiac protection.

scholarly journals Plasma Total Thiols and Total Thiol/Albumin Ratio in Patients Suffering from Depression

2021 ◽  
Author(s):  
AS Meenakshi Sundaram ◽  
Krishnananda Prabhu
Keyword(s):  
Oxidative Stress ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Depressive Disorders ◽  
Control Group ◽  
P Value ◽  
Major Depressive ◽  
Albumin Ratio ◽  
Total Thiol ◽  
Plasma Thiols

Introduction: Increased oxidative stress has been reported in patients who suffer from depressive disorders. Albumin acts as a target for plasma protein oxidation during oxidative stress. The plasma thiols act as significant in vivo antioxidants. Major SH-groups are found on the surface of albumin molecules. Since depressive disorders are related to oxidative stress. Only a few studies have been done that correlate plasma total thiols with major depressive disorder. The authors intended to draw a relationship between oxidative stress, thiols and major depressive disorder by estimating total plasma thiols and calculating the ratio of thiol/albumin. The study may throw some light in understanding whether the use of anti-oxidant supplements to counter oxidative stress in depressed patients. Aim: The aims was to estimate plasma thiols, albumin and obtain a plasma thiol/albumin ratio in people suffering from depression and compare the levels with the control group. Materials and Methods: This case control study was conducted in Kasturba Medical College, Manipal. Plasma thiols were estimated using Ellman’s method. Plasma albumin levels were estimated using Bromo-cresol green dye binding method. Mann- Whitney U test was used for analysing the data for total thiols and thiol/albumin ratio. A p-value <0.05 was considered significant. Results: The study group was made up of 43 (22 males and 21 females) patients and the control group was made up of 40 (18 males and 22 females) healthy controls. Plasma thiol levels and the plasma total thiol/albumin ratio were significantly elevated (p-value=0.00036) in cases (depression) as compared to that of the controls. Conclusion: Plasma total thiols can be used as an early marker for understanding the risk for major depressive disorders and also be used as a prognostic indicator in the follow up of patients suffering from major depressive disorder who are under treatment.

Prevalence of involuntary hospitalization in patients with depressive disorders

2016 ◽  
Vol 33 (S1) ◽  
pp. S419-S420
Author(s):  
Á. Palma Conesa ◽  
F.N. Dinamarca Cáceres ◽  
M. Grifell Guardia ◽  
L. Galingo Guarin ◽  
L. González Contreras ◽  
...  
Keyword(s):  
Depressive Disorder ◽  
Emergency Service ◽  
Depressive Disorders ◽  
Symptom Control ◽  
Cross Sectional Study ◽  
Involuntary Hospitalization ◽  
Cross Sectional ◽  
Significant Difference ◽  
Competing Interest ◽  
Harm Prevention

IntroductionDepression is a disabling disorder with a high socio-economic impact. It might require hospitalization for symptom control and/or harm prevention. Other depressive disorders might as well require hospitalization in benefit of the patient. Hospitalization may be involuntary. Hospitalization willfulness in depressive patients has not been systematically studied in recent years.ObjectiveThe aim of this study is to explore the necessity of involuntary hospitalization in patients presenting depressive symptoms at the emergency service that were later diagnosed with a depressive disorder.Materials and methodsFrom all patients visited in the psychiatric emergency service from 2012 to April 2015 those that were hospitalized in the acute mental health unit and diagnosed with a depressive disorder were studied. All those monopolar depression diagnoses were considered, excluding those within the bipolar spectrum. Diagnosis followed CIE-9 criteria. A descriptive cross-sectional study of the samples was then conducted. Statistical analysis was performed using SPSS software (SPSS Inc., Chicago, Ill.).ResultsFrom all 385 depressive disorders, 169 were involuntary admissions (43.9%), 196 were voluntary (50.9%) and 20 were scheduled (5.2%), difference was statistically significant (P < 0.05). Mean age, was 59.52 years for involuntary admissions, 61.7 for voluntary and 63.6 years for scheduled, with a statistically significant difference (P < 0.05). Gender differences were not significant.ConclusionsMost depressive disorders were hospitalized voluntarily. However, a relevant percentage of patients required involuntary hospitalization. Younger patients presented a higher ratio of involuntary hospitalization. Reasons for involuntary hospitalization needs should be further studied.Disclosure of interestThe authors have not supplied their declaration of competing interest. Liliana Galindo is a Rio Hortega fellowship (ISC-III; CM14/00111).

Operating room nurses’ perception of professional values

2018 ◽  
Vol 26 (6) ◽  
pp. 1765-1776
Author(s):  
Camellia Torabizadeh ◽  
Fatemeh Darari ◽  
Shahrzad Yektatalab
Keyword(s):  
Operating Room ◽  
Large Body ◽  
Nurse Anesthetists ◽  
Professional Values ◽  
P Value ◽  
University Hospitals ◽  
Cross Sectional ◽  
Significant Difference ◽  
Operating Room Nurses ◽  
Nursing Professional

Background and significance of research: Nurses’ awareness of professional values and how those values affect their behaviors is an integral part of nursing care. There is a large body of research on nursing professional values, however, a careful survey of the available literature did not yield any studies investigating the status of professional values in operating rooms. Objective: This study aims to investigate the perception of operating room nurses of university hospitals toward professional values. Research plan: In this cross-sectional study, data were collected using Schank and Weis’s Nurses Professional Values Scale–Revised. The collected data were analyzed in SPSS version 16. Participants and settings: The 513 participants of the study consisted of operating room nurses and nurse anesthetists from six university hospitals. Ethical considerations: This study has been approved by the ethics committee of the university. Findings: The mean total professional values score of the operating room staff was found to be 100.84 ± 15.685, which indicates that the participants had a positive perception toward observance of nursing professional values in practice. The results showed that the participants considered the domains of justice and activism as, respectively, the most and the least important. The operating room staff’s overall professional values scores were not found to correlate significantly with their ages, professional experience, university majors, or attendance at ethics workshops. However, a significant difference was found between the professional values scores of the female and male staff. The professional values scores of the operating room nurses and the nurse anesthetists were not significantly different (p value = 0.494). Conclusion: Operating room staff’s awareness of professional values is essential to providing care to patients based on professional principles. Accordingly, there is need for programs to raise operating room nurses’ awareness of their professional duties and improve their professional performance.

Sign in / Sign up

Export Citation Format

Share Document