scholarly journals Recurrent Trichosporon asahii Glossitis: A Case Report

2008 ◽  
Vol 9 (3) ◽  
pp. 114-120 ◽  
Author(s):  
Ban Tawfeek Shareef ◽  
Azian Harun ◽  
Yusof Roziawati ◽  
Ismail Shaiful Bahari ◽  
Zakuan Zainy Deris ◽  
...  
Keyword(s):  
Case Report ◽  
Wide Spectrum ◽  
Antifungal Susceptibility ◽  
Resistance Mechanism ◽  
Clinical Manifestations ◽  
Superficial Infection ◽  
Trichosporon Asahii ◽  
Clinical Presentations ◽  
Wide Range ◽  
Oral Environment

Abstract Aim This case report aims at describing an infection of the tongue as a manifestation of a Trichosporon asahii infection, its association with bronchial asthma and steroid administration, and to present a review of the literature pertaining to its antifungal susceptibility profile. Background Trichosporon asahii has been reported to be associated with a wide spectrum of clinical manifestations, ranging from superficial infection to severe disseminated diseases, particularly in immunocompromised patients. Case Report A 36-year-old male asthmatic patient with recurrent glossitis presented with a chief complaint of burning sensation and two red areas on the dorsum of the tongue of three months duration. The glossitis was associated with Trichosporon asahii, which had a reduced susceptibility to some azole antifungal agents. Summary Trichosporon asahii is an emerging fungal pathogen which may cause a wide range of clinical manifestations. More reports on its various clinical presentations in the oral environment need to be made available in the literature. To date there is a paucity of data on its prevalence, pathogenesis, and antifungal resistance mechanism. Citation Shareef BT, Harun A, Roziawati Y, Shaiful Bahari I, Deris ZZ, Ravichandran M. Recurrent Trichosporon asahii Glossitis: A Case Report. J Contemp Dent Pract 2008 March; (9)3:114-120.

scholarly journals Esophageal Variceal Bleeding as the First Manifestation of COVID-19 Infection: A Case Report

2022 ◽  
Vol 7 (01) ◽  
pp. 41-45
Author(s):  
Christos Sotiropoulos, MD, MSc ◽  
Eftichia Sakka, MD ◽  
Georgios Theocharis, MD, PhD ◽  
Konstantinos Thomopoulos, MD, PhD
Keyword(s):  
Liver Cirrhosis ◽  
Case Report ◽  
Variceal Bleeding ◽  
Clinical Manifestations ◽  
Polymerase Chain Reaction Test ◽  
Variceal Hemorrhage ◽  
Esophageal Variceal ◽  
Esophageal Variceal Bleeding ◽  
Wide Range ◽  
Upper Gastrointestinal

Liver cirrhosis is a defined liver disease with a wide range of clinical manifestations. Variceal bleeding is the main source of gastrointestinal hemorrhage among cirrhotic patients induced by several factors, such as alcohol consumption or infections. This is a report of a cirrhotic patient presenting with esophageal variceal bleeding in the context of COVID-19 infection. We report the case of a 53-year-old patient with liver cirrhosis and multifocal hepatocellular carcinoma presenting with upper gastrointestinal bleeding as the first manifestation of COVID-19 infection. Upon admission, the patient had no symptoms suggestive of a respiratory tract infection or any contact with positive SARS-CoV-2 individual and upper gastrointestinal endoscopy revealed variceal hemorrhage. After a few hours the patient manifested with fever, cough and dyspnea and a SARS-CoV-2 polymerase chain reaction test obtained was positive. The patient was initially treated with endoscopic band ligation and transferred in the COVID-19 infection clinic, where after a few days of hospitalization he passed away. The devastating pandemic of coronavirus disease 2019 had altered the pathophysiology and clinical presentation of several chronic diseases. This case report suggests that coronavirus disease as a potential triggering factor of variceal bleeding.

scholarly journals Host-Directed Therapies for Cutaneous Leishmaniasis

2021 ◽  
Vol 12 ◽  
Author(s):  
Fernanda O. Novais ◽  
Camila Farias Amorim ◽  
Phillip Scott
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Inflammatory Diseases ◽  
Wide Spectrum ◽  
Substantial Evidence ◽  
Novel Approach ◽  
Clinical Presentations ◽  
Wide Range ◽  
Parasite Replication ◽  
Inflammatory Drugs ◽  
Improve Clinical Outcome

Cutaneous leishmaniasis exhibits a wide spectrum of clinical presentations from self-resolving infections to severe chronic disease. Anti-parasitic drugs are often ineffective in the most severe forms of the disease, and in some cases the magnitude of the disease can result from an uncontrolled inflammatory response rather than unrestrained parasite replication. In these patients, host-directed therapies offer a novel approach to improve clinical outcome. Importantly, there are many anti-inflammatory drugs with known safety and efficacy profiles that are currently used for other inflammatory diseases and are readily available to be used for leishmaniasis. However, since leishmaniasis consists of a wide range of clinical entities, mediated by a diverse group of leishmanial species, host-directed therapies will need to be tailored for specific types of leishmaniasis. There is now substantial evidence that host-directed therapies are likely to be beneficial beyond autoimmune diseases and cancer and thus should be an important component in the armamentarium to modulate the severity of cutaneous leishmaniasis.

scholarly journals Simultaneous involvement of optic and abducens nerves by Lyme disease: Case report with review of the literature

2019 ◽  
Vol 11 (3) ◽  
Author(s):  
Iman Dabiri ◽  
Ahmet Z. Burakgazi
Keyword(s):  
Case Report ◽  
Lyme Disease ◽  
False Negative ◽  
Diagnostic Process ◽  
Review Of The Literature ◽  
Ocular Manifestations ◽  
First Case ◽  
Clinical Presentations ◽  
Disease Case ◽  
Wide Range

Ocular manifestations of Lyme disease (LD) remain a rare feature of the disease, but it may present a wide range of clinical presentations with different combinations. LD related optic neuritis or cranial nerve (CN) six palsy have been reported in the literature. However, this is the first case report of simultaneous involvement of CN 2 and CN 6 in a patient with LD. The diagnosis of LD can be challenging and initial laboratory tests can be a false negative. It is paramount important to repeat the diagnostic test if clinical suspicious is ongoing. With this case, we aim to increase awareness of clinicians for possible ocular manifestations of LD and its complex diagnostic process.

scholarly journals Post-Translational Modifications of Proteins: Novel Insights in the Autoimmune Response in Rheumatoid Arthritis

Cells ◽  
2019 ◽  
Vol 8 (7) ◽  
pp. 657 ◽  
Author(s):  
Francesco Carubbi ◽  
Alessia Alunno ◽  
Roberto Gerli ◽  
Roberto Giacomelli
Keyword(s):  
Rheumatoid Arthritis ◽  
Wide Spectrum ◽  
Clinical Manifestations ◽  
Autoimmune Response ◽  
Response To Treatment ◽  
Post Translational Modifications ◽  
Wide Range ◽  
Specific Proteins ◽  
Modified Proteins ◽  
Immunogenic Properties

Post-translational modifications (PTM) are chemical changes mostly catalyzed by enzymes that recognize specific target sequences in specific proteins. These modifications play a key role in regulating the folding of proteins, their targeting to specific subcellular compartments, their interaction with ligands or other proteins, and eventually their immunogenic properties. Citrullination is the best characterized PTM in the field of rheumatology, with antibodies anticyclic citrullinated peptides being the gold standard for the diagnosis of rheumatoid arthritis (RA). In recent years, growing evidence supports not only that a wide range of proteins are subject to citrullination and can trigger an autoimmune response in RA, but also that several other PTMs such as carbamylation and acetylation occur in patients with this disease. This induces a wide spectrum of autoantibodies, as biomarkers, with different sensitivity and specificity for diagnosis, which may be linked to peculiar clinical manifestations and/or response to treatment. The purpose of this review article is to critically summarize the available literature on antibodies against post-translationally modified proteins, in particular antibodies against citrullinated proteins (ACPA) and antibodies against modified proteins (AMPA), and outline their diagnostic and prognostic role to be implemented in clinical practice for RA patients.

scholarly journals A case of urticaria multiforme with unusual presentation

2019 ◽  
Vol 6 (6) ◽  
pp. 1946
Author(s):  
Mohammad S. Alkhowailed
Keyword(s):  
Case Report ◽  
Physical Examination ◽  
Erythema Multiforme ◽  
Case History ◽  
Diagnostic Tests ◽  
Clinical Manifestations ◽  
Unusual Presentation ◽  
Effective Management ◽  
Urticarial Vasculitis ◽  
Wide Range

Urticaria multiforme is a condition which manifests as acute, polycyclic, annular oedematous pink plaques with an ecchymosis hue that is associated with acral edema. The condition is often misdiagnosed as erythema multiforme, serum-sickness-like reactions, or urticarial vasculitis. Author present a case of acute annular urticaria in a 3-year-old girl who presented with unusual clinical manifestations of the condition. Through this case report, Author aim to emphasize the wide range of morphologic manifestations that can be seen in urticaria multiforme. This can assist pediatric physicians to differentiate urticaria multiforme from other clinical dermatologic conditions and prevent misdiagnosis. A detailed case history and physical examination, along with relevant diagnostic tests can enable prompt and effective management of the condition.

scholarly journals Smart Check - COVID-19 triage system: evaluation of the impact on the screening time and identification of clinical manifestations of SARS-CoV-2 infection in a public health service.

2021 ◽  
Author(s):  
Fernando Anschau ◽  
Paulo Worm ◽  
Luciane Kopittke ◽  
Luis Humberto de Mello Villwock ◽  
Marcos Luiggi Lemos Sartori ◽  
...  
Keyword(s):  
Wide Spectrum ◽  
Clinical Manifestations ◽  
Signs And Symptoms ◽  
Control Analysis ◽  
Evaluation Tool ◽  
Clinical Presentations ◽  
Before And After ◽  
Loss Of Appetite ◽  
The Impact ◽  
Triage Time

Introduction: Most patients with COVID-19 have mild or moderate manifestations, however, there is a wide spectrum of clinical presentations and even more severe repercussions that require high diagnostic suspicion. Vital sign acquisition and monitoring are crucial for detecting and responding to patients with COVID-19. Objective: Thus, we conducted this study to demonstrate the impact of using a tool called Smart Check on the triage time of patients with suspected COVID-19 and to identify the main initial clinical manifestations in these cases. Methodology: We assessed triage times before and after the use of Smart Check in 11,466 patients. In this group, we identified 211 patients for the identification of COVID-19 clinical manifestations in a case-control analysis. Results: Smart Check was able to decrease the triage time by 33 seconds on average, with 75% of the exams being performed within 5 minutes, whereas with the usual protocol these steps were performed within 6 minutes. A range of clinical presentations made up the COVID-19 initial manifestations. Those with the highest frequency were dry cough (46.8%), fever (41.3%), dyspnea (35.8%), and headache (32.1%). Loss of appetite, fever, and ageusia were the manifestations that had a statistically significant association with the SARS-CoV-2 presence. Conclusions: Smart Check, a simple clinical evaluation tool, along with the targeted use of rapid PCR testing, can optimize triage time for patients with and without COVID-19. In triage centers, a number of initial signs and symptoms should be cause for SARS-CoV-2 infection suspicion, in particular the association of respiratory, neurological, and gastrointestinal manifestations. Keywords: new coronavirus, COVID-19, triage, clinical manifestations

scholarly journals Duodenocecal Fistula Developing after Hairpin Ingestion: A Case Report

2017 ◽  
Vol 23 (2) ◽  
Author(s):  
Fatima Naumeri ◽  
Hafiz Mahmood Ahmad
Keyword(s):  
Case Report ◽  
Pediatric Population ◽  
Clinical Manifestations ◽  
Wide Range ◽  
One Year

AbstractForeign body ingestion is quite a common pheno-menon in pediatric population and presents with a wide range of clinical manifestations. This is a case report of hair pin ingestion which presented in pedia-tric surgery emergency one year post ingestion with duodenocecal fistula and was managed with removal of hair pin and repair of duodenal and cecal fistula rents primarily. 

scholarly journals Delirium Associated with Salicylate and Acetaminophen Overdose in a Patient with COVID-19: A Case Report

2020 ◽  
Vol 4 (4) ◽  
pp. 517-520
Author(s):  
Tyler Wen ◽  
Jason Chu ◽  
Danielle Allenspach ◽  
David Van
Keyword(s):  
Emergency Department ◽  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Mental Status ◽  
Clinical Manifestations ◽  
Altered Mental Status ◽  
Psychosocial Stressors ◽  
Acetaminophen Overdose ◽  
Wide Range

Introduction: The coronavirus disease 2019 (COVID-19) pandemic has created numerous clinical challenges for physicians, in part due to its wide range of clinical manifestations and associated complications. Case Report: Here we present the case of a 69-year-old man who was admitted to the emergency department with fever, dyspnea, and altered mental status. We believe the patient’s condition was precipitated by a COVID-19 infection-induced delirium, a setting in which he ingested aspirin and acetaminophen in overdose that required lifesaving interventions. Conclusion: This case illustrates the potential for neuropsychiatric effects in COVID-19 patients due to both direct viral central nervous system pathology and pandemic-related psychosocial stressors.

Peritoneal Dialysis-Related Peritonitis due to Melioidosis: A Potentially Devastating Condition

2017 ◽  
Vol 37 (2) ◽  
pp. 183-190
Author(s):  
Talerngsak Kanjanabuch ◽  
Nuttha Lumlertgul ◽  
Lachlan J. Pearson ◽  
Tanittha Chatsuwan ◽  
Krit Pongpirul ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Inhibitory Concentration ◽  
Monsoon Season ◽  
Clinical Manifestations ◽  
Microbial Biofilms ◽  
Clinical Presentations ◽  
Wide Range ◽  
Laboratory Investigations ◽  
Baseline Characteristics ◽  
Culture Positive

BackgroundMelioidosis, an infectious disease caused by Burkholderia pseudomallei, is endemic in Southeast Asia and Northern Australia. Although a wide range of clinical manifestations from this organism are known, peritonitis associated with peritoneal dialysis (PD) has rarely been reported.Patients and MethodsPeritoneal dialysis patients from all regions in Thailand were eligible for the study if they had peritonitis and either peritoneal fluid or effluent culture positive for B. pseudomallei. Patient data obtained included baseline characteristics, laboratory investigations, treatments, and clinical outcomes. When possible, PD fluid and removed Tenckhoff (TK) catheters were submitted for analyses of minimal inhibitory concentration (MIC) and microbial biofilm, respectively.ResultsTwenty-six patients were identified who were positive for peritoneal B. pseudomallei infection. The recorded mean age was 50 ± 15 (24 – 75) years, and the majority (58%) were female. Most of the cases were farmers living in Northeastern and Northern Thailand. Almost half of the cases had diabetes. Infections were reported commonly during the monsoon season and winter. The clinical presentations of peritonitis were similar to the manifestations from other microorganisms. Nine patients (41%) died (7 from sepsis), 6 fully recovered, and 7 switched to permanent hemodialysis. The mortality was potentially associated with sepsis ( p = 0.007), infection during the monsoon season ( p = 0.017), high initial dialysate neutrophils ( p = 0.045), and high hematocrit ( p = 0.045). Although no antibiotic resistance to ceftazidime and carbapenems was detected, approximately 50% of patients died with this treatment. Microbial biofilms were identified on the luminal surface of 4 out of 5 TK catheters, but the removal of the catheter did not alter the outcomes.ConclusionPeritoneal dialysis-related peritonitis due to melioidosis is uncommon but highly fatal. Increased awareness, early diagnosis, and optimal management are mandatory.

scholarly journals Case Report: A Novel TNFAIP3 Mutation Causing Haploinsufficiency of A20 With a Lupus-Like Phenotype

2021 ◽  
Vol 12 ◽  
Author(s):  
Zachary R. Shaheen ◽  
Sarah J. A. Williams ◽  
Bryce A. Binstadt
Keyword(s):  
Case Report ◽  
Early Onset ◽  
Autoinflammatory Disease ◽  
Clinical Symptoms ◽  
Novel Mutation ◽  
Genetic Mutations ◽  
Loss Of Function ◽  
Gene Encoding ◽  
Clinical Presentations ◽  
Wide Range

Genetic mutations that result in loss-of-function of the protein A20 result in an early-onset autoinflammatory disease—haploinsufficiency of A20 (HA20). The reported clinical presentations of HA20 include a Behcet’s disease-like phenotype and a more lupus-like phenotype. We have identified a novel mutation in the gene encoding A20 in a pediatric patient with chronic lymphadenopathy, lupus-like symptoms, and progressive hypogammaglobulinemia. This case illustrates the wide range of clinical symptoms, including immunodeficiency, that can occur in patients with HA20.

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