scholarly journals In vivo Evaluation of Zirconia Abutments in Implant supported Restorations in Partially Edentulous Patients

2017 ◽  
Vol 7 (1) ◽  
pp. 35-42
Author(s):  
Anita Kapri ◽  
Sudhir Joshi
Keyword(s):  
Social Sciences ◽  
Titanium Implants ◽  
P Value ◽  
In Vivo Evaluation ◽  
The Social ◽  
Scale Scores ◽  
Edentulous Patients ◽  
Biological Outcomes

ABSTRACT Dental implants have been a universally accepted option for prosthetic rehabilitation of partially edentulous patients. Titanium implants abutments exhibit a dull grayish hue and give an unnatural appearance. Abutments based on zirconia are one of the alternatives to titanium abutments. To date, few comparative studies have reported on esthetic and biological outcomes of implant-supported restorations with zirconia abutments. Purpose To clinically evaluate the esthetic performance of zirconia abutments in implant-supported restorations. Materials and methods A total of 24 anterior implant sites were chosen for the placement of implants. A delayed loading protocol was followed; 12 zirconia abutments were placed along with 12 titanium abutments in the contralateral sites. Biological and esthetic variables were recorded by a periodontist and prosthodontist. The patients were followed 2 weeks, 1, 3, and 6 months postinsertion. Results All the data for Copenhagen index score and visual analog scale scores were evaluated by the prosthodontist at follow-up appointments; the means were tabulated. The data were statistically analyzed using Statistical Package for the Social Sciences software utilizing paired t-test; p value was found to be significant for all parameters except distal papilla and symmetry, which showed p = 0.257 and p = 0.110 respectively. Conclusion According to the results of this study, esthetic performances of zirconia abutment in implant-supported restorations were determined to be higher than those values associated with titanium abutments. How to cite this article Kapri A, Gupta A, Joshi S. In vivo Evaluation of Zirconia Abutments in Implant supported Restorations in Partially Edentulous Patients. J Contemp Dent 2017;7(1):35-42.

Formation and In Vitro and In Vivo Evaluation of Surface Modified Implants by HAp, Carbonated-HAp and Titanium Oxide

2007 ◽  
Vol 539-543 ◽  
pp. 687-691 ◽  
Author(s):  
Masazumi Okido ◽  
Ryoichi Ichino ◽  
Kotaro Kuroda
Keyword(s):  
Titanium Oxide ◽  
Titanium Implant ◽  
Titanium Implants ◽  
Contact Ratio ◽  
In Vivo Evaluation ◽  
Ft Ir ◽  
Mouse Osteoblast ◽  
Surface Modified

Hydroxyapatite (Ca10(PO4)6(OH)2, HAp), carbonated HAp and titanium oxide are of interest for bone-interfacing implant applications, because of their demonstrated osteoconductive properties. They were coated on the titanium implants and investigated the in vitro and in vivo performance. HAp coatings were performed by the thermal substrate method in aqueous solutions. Titanium oxide film was also formed on the titanium implants by gaseous oxidation, or by anodizing in the acidic solution. All the specimens covered with HAp, carbonated HAp or TiO2 (rutile or anatase). were characterized by XRD, EDX, FT-IR and SEM. In the in vitro testing, the mouse osteoblast-like cells (MC3T3-E1) were cultured on the coated and non-coated specimens for up to 30 days. Moreover, the osseointegration was evaluated from the rod specimens implanted in rats femoral for up to 8 weeks. In in vivo evaluations two weeks postimplantation, new bone formed on the coated and non-coated titanium rods in the cancellous bone and cortical bone, respectively. Bone-implant contact ratio, in order to evaluate of new bone formation, was significantly depended on the compound formed on the titanium implant.

Alemtuzumab Reduces Chronic Graft Versus Host Disease (cGVHD) and Treatment Related Mortality (TRM) after Reduced Intensity Conditioning for AML and MDS.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 1076-1076 ◽  
Author(s):  
Koen van Besien ◽  
Marcos de Lima ◽  
Andrew Artz ◽  
Betul Oran ◽  
Wendy Stock ◽  
...  
Keyword(s):  
Chronic Gvhd ◽  
Progression Free Survival ◽  
Patient Characteristics ◽  
Cancer Center ◽  
P Value ◽  
Unrelated Donor ◽  
Post Transplant ◽  
Md Anderson

Abstract In vivo T-cell depletion with alemtuzumab has been used to reduce acute and chronic GVHD. In order to evaluate its overall effect on transplant outcomes in AML and MDS we compared 90 pts who received fludarabine/melphalan/alemtuzumab (FMA) conditioning and post-transplant tacrolimus at the University of Chicago, with 112 who received fludarabine/melphalan (FM) and post-transplant tacrolimus/methotrexate at MD Anderson Cancer Center. Pt and transplant characteristics were well balanced except for a higher proportion of MDS in the FM group. Median age, proportion unrelated donor tx and proportion high/intermediate and low risk by ASBMT criteria were balanced between the groups. With median follow up of 28 months in both groups, one year progression free survival and overall survival are identical. TRM is significantly higher after FM, but relapse is higher in FMA. 19/103 d 28 survivors after FM vs 7/84 after FMA developed gr III–IV acute GVHD (p=0.04). 46/77 d100 survivors after FM developed ext cGVHD vs 7/63 after FMA (p=0.0000). 43 patients remain alive after FM and 27 have ext cGVHD. 41 remain alive after FMA and 1 has ext cGVHD. Alemtuzumab results in a considerable reduction in acute and particularly chronic GVHD. TRM is reduced compared with standard GVHD prophylaxis. Low incidence of chronic GVHD and reduced TRM may be the major benefit of this strategy. Relapse rates are increased, because of reduced GVL effects or because of improved early survival of high risk patients. Other approaches are necessary for improving long term outcomes. Patient Characteristics and Outcome FMA FM P-value N 90 102 Age (range) 54 (22–74) 51 (17–77) 0.6 AML/MDS 13/77 29/83 0.04 MUD/related 42/48 59/63 0.5 High./Intermediate/LowRisk 48/13/28 76/10/26 0.12 Median Follow up mths (range) 28 (3–89) 28 (1–66) 0.07 TRM@ 100 days 13% + 7% 24% + 8% 0.04 TRM@ 1 year 30% + 12% 42% + 10% 0.04 Relapse @ 1 year 40% + 12% 26% + 10% 0.01 PFS @ 2 years 33% + 11% 37% + 9% 0.9 OS @ 2 year 42% + 11% 44% + 9% 0.5 AGVD gr III–IV 7/84 19/103 0.04 Ext cGVHD 7/63 46/77 0.0000 Ext cGVHD in survivors 1/41 27/43 0.0000

Survival in patients with locally advanced breast cancer after neoadjuvant docetaxel (T), carboplatin (C), and trastuzumab (H)

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e11573-e11573
Author(s):  
H. R. Chang ◽  
R. Prati ◽  
J. A. Gornbein ◽  
D. Chung ◽  
J. A. Glaspy
Keyword(s):  
Breast Cancer ◽  
Tumor Size ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Pathologic Complete Response ◽  
Tumor Stage ◽  
Bivariate Analysis ◽  
In Vivo Evaluation

e11573 Background: Neoadjuvant chemotherapy (NAC) has been widely used in patients with LABC. Although survival rates after neoadjuvant and adjuvant therapy are similar, NAC was shown to increase lumpectomy surgery and allow in vivo evaluation of treatment response. It is thought that pathologic complete response (pCR) after NAC by itself or together with other factors could predict overall survival (OS) and/or relapse free survival (RFS). Methods: Seventy-one of the 74 enrolled patients (mean tumor size=7.7cm) were analyzed. All patients received 4 cycles of T (75mg/m2) and C (AUC=6) before and after surgery. HER2+ patients were randomized to receive either TCH or TC preoperatively; both received 1 year of H. Tumor size and nodal status were estimated clinically at baseline and pathologically after surgery. Bi & multivariate analyses were performed on pCR, clinical and pathologic characteristics to predict OS and RFS. Hazard ratios (HR) are reported. Results: The median follow up was 2.0 years with 8 deaths and 9 recurrences. Nineteen (26.8%) had pCR. Kaplan-Meier RFS was 82.0% & 54.2% and OS was 88.9% vs 70.6% at 3 years follow up for pCR & non-pCR respectively. In the bivariate analysis, pCR (HR=0.32, p=0.114), lower tumor stage (p=0.097) and negative LN (p=0.0695) trended a favorable RFS. Lower tumor stage (p=0.032), negative LN (p=0.029) and lumpectomy surgery (p=0.023) were associated with better OS. In multivariate analysis, inflammatory breast cancer (p=0.041) and triple negative breast cancer-TNBC (p=0.044) predicted poor OS. Conclusions: With few deaths/recurrences we were unable to conclusively identify predictors for OS or RFS. Inflammatory and TNBC remain poor prognosticators for OS and RFS. pCR was a suggestive predictor (HR<1) but not statistically significant probably due to low sample size and high number of pCR cases that were TNBC. [Table: see text]

In vivo evaluation of copper release and acute local tissue reactions after implantation of copper-coated titanium implants in rats

2013 ◽  
Vol 8 (3) ◽  
pp. 035009 ◽  
Author(s):  
Andreas Hoene ◽  
Cornelia Prinz ◽  
Uwe Walschus ◽  
Silke Lucke ◽  
Maciej Patrzyk ◽  
...  
Keyword(s):  
Titanium Implants ◽  
In Vivo Evaluation ◽  
Local Tissue ◽  
Copper Release ◽  
Tissue Reactions

scholarly journals Imaging of microglial activation in MS using PET: Research use and potential future clinical application

2016 ◽  
Vol 23 (4) ◽  
pp. 496-504 ◽  
Author(s):  
Laura Airas ◽  
Eero Rissanen ◽  
Juha Rinne
Keyword(s):  
Complex Disease ◽  
Treatment Options ◽  
Quantitative Information ◽  
Imaging Biomarkers ◽  
In Vivo Evaluation ◽  
Non Invasive ◽  
Positron Emission ◽  
Magnetic Resonance Imaging Mri

Multiple sclerosis (MS) is a complex disease, where several processes can be selected as a target for positron emission topography (PET) imaging. Unlike magnetic resonance imaging (MRI), PET provides specific and quantitative information, and unlike neuropathology, it can be non-invasively applied to living patients, which enables longitudinal follow-up of the MS pathology. In the study of MS, PET can be useful for in vivo evaluation of specific pathological characteristics at various stages of the disease. Increased understanding of the progressive MS pathology will enhance the treatment options of this undertreated condition. The ultimate goal of developing and expanding PET in the study of MS is to have clinical non-invasive in vivo imaging biomarkers of neuroinflammation that will help to establish prognosis and accurately measure response to therapeutics. This topical review provides an overview of the promises and challenges of the use of PET in MS.

scholarly journals Prevalence of familial hypercholesterolemia in Attica region, Greece

2021 ◽  
Vol 7 (1) ◽  
pp. 26
Author(s):  
Niki Pavlatou ◽  
Nikoletta Rovina ◽  
Georgia Toylia ◽  
Olga Kadda ◽  
Christina Marvaki ◽  
...  
Keyword(s):  
Social Sciences ◽  
Familial Hypercholesterolemia ◽  
Early Identification ◽  
Disease Onset ◽  
P Value ◽  
Modifiable Risk Factors ◽  
Proper Treatment ◽  
Contributing Factors ◽  
The Social ◽  
The Mean

Background: Dyslipidemias are one of the major modifiable risk factors for cardiovascular disease. Familial hypercholesterolemia (FH) is the most common genetic metabolic disorder; it is estimated that around 14-34 million people worldwide have FH but only 25% of FH patients have been diagnosed. Aim: The aim of the present study was to explore the prevalence of FH in Attica region, Greece.Methods: Attica region was divided into 8 regional units. A predesigned questionnaire was used to collect demographic and clinical data. Data analysis was performed by using the Statistical Package for the Social Sciences (SPSS), ver. 20.Results: The studied sample consisted of 1578 Greek inhabitants of Attica region. The majority of the sample was women (59.9%). The mean age of the studied participants was 47.1 (±14.9) years. According to Simon Broome criteria, the probability of an FH diagnosis as unlikely is determined in 98.7% of the studied sample, probable in 0.8% of the participants or definite in 0.5% of the participants, based on this data, the prevalence of FH in Attica region, Greece is 1:200. Qualitative factors found to be associated with the onset of the disease were medication (p-value = 0.001) and hypolipidemic therapy (p-value = 0.001). The quantitative factors found to be associated with disease onset were body mass index (p-value = 0.044), and systolic (p-value = 0.001) and diastolic (p-value = 0.007) pressure.Conclusions: Based on our data, the prevalence of FH in Attica region, Greece is 1:200. Early identification of contributing factors in FH development and proper treatment is vital and reduce the risk of premature and severe atherosclerotic disease.

scholarly journals Assessment of Posterior Segment Using Spectral Domain OCT in Highly Myopic Eyes

2017 ◽  
Vol 11 (1) ◽  
pp. 334-345 ◽  
Author(s):  
Heba Radi AttaAllah ◽  
Ismail Ahmed Nagib Omar ◽  
Ahmed Shawkat Abdelhalim
Keyword(s):  
Social Sciences ◽  
Posterior Vitreous Detachment ◽  
Spectral Domain ◽  
Spherical Equivalent ◽  
Spearman Correlation ◽  
Spectral Domain Oct ◽  
Full Thickness Macular Hole ◽  
The Social ◽  
Sd Oct

Purpose: Spectral Domain Optical Coherence Tomography (SD-OCT) was used to evaluate retinal and vitreo-retinal changes that occur in highly myopic patients. Methods: This prospective study included 472 eyes of 472 patients suffering from high myopia (> -6.00 D), between May 2012 and December 2015. All patients were examined, using Cirrus HD OCT (Zeiss Cirrus TM HD-OCT model 4000), to detect any retinal or vitreo-retinal interface abnormalities. All obtained data was analyzed using Statistical Package for the Social Sciences software version 17 (SPSS Inc, Chicago, IL, USA) and the paired two-sided t-test. Bivariate correlations were performed between different parameters using the Spearman correlation coefficient (r). Results: Mean spherical equivalent (MSE) was -13.11± 4.35D. Mean axial length (AL) was 28.5±1.62 mm. Posterior vitreous detachment (PVD) was the most frequent OCT finding; representing 33.4% of the cases, 13.7% of them were associated with macular traction. A statistically significant positive correlation was found between AL and MTM, full thickness macular hole, PVD with traction, and dome shaped macula (r = 0.49 and P = 0.001, r = 0.422 and P = 0.0001, r = 0.25 and P = 0.03, r=0.475, P=0.001 respectively) Conclusion: OCT is a valuable tool in detecting retinal and vitreo-retinal interface abnormalities in highly myopic eyes, and it can be used for follow up of those patients to avoid advanced retinal damage.

scholarly journals Investigation of Olfactory Function Following Septorhinoplasty in Iranian Population by Rapid Smell Test (RST)

2020 ◽  
pp. 1-6
Author(s):  
Amir Yarahmadi ◽  
Kamran Kamrava ◽  
Ali Shafee ◽  
Maryam Milanifard ◽  
Mohammad Aghajanpour ◽  
...  
Keyword(s):  
Social Sciences ◽  
Olfactory Function ◽  
P Value ◽  
Clinical Tool ◽  
Smell Test ◽  
Before And After ◽  
The Mean ◽  
The Difference ◽  
Smell Identification

Introduction: All surgical procedures on nose affect the olfactory function to some extent. There are different viewpoints about olfactory function after septorhinoplasty. We aim to investigate smell perception changes in patients following septorhinoplasty. In this study the use of Rapid Smell Test (RST) as a fast and reliable clinical tool was investigated. Methods: A prospective cohort study was done in Rasool Akram teaching hospital in 2018 and 2019. Group of 74 septorhinoplasty candidates aged over 18 was selected by convenience. Persian Smell Identification Test (PSIT) and rapid smell test (RST) was obtained from patients before surgery and one month after, if needed three months after and six months after. In addition for patients with dysfunction in any of follow up periods (one month, 3 months and 6 months after surgery) smell magnitude test (SMT) was used. All data were analyzed using Statistical Package for Social Sciences, version 24.0 (IBM SPSS Statistics Inc., Chicago, IL, USA). Results: Out of 74 patients participating in this study 67 were female. Mean age of 25.68±5.18 years was recorded for participants. All patients before surgery had PSIT score more than 19 and the mean PSIT score before operation was 22.63±1.39. Also all patients scored 5 out of 5 in RST before surgery. Mean PSIT score one month after surgery decreased to 22.21±2.20 but still 93 percent (69 patients) of participants were in range for normal olfactory function. We recorded this to be significant (p value = 0.044). RST after one month showed the same results. The difference between RST before and after surgery was also significant (p value = 0.024). For those 5 patients with abnormal olfactory function PSIT and RST were done 3 months after operation which determines normal olfactory function for all of them. As well as PSIT, RST also shows the same results and five participants recorded 5 out of 5 three months after surgery. Conclusion: This study showed changes in olfactory function after septorhinoplasty will resolve at most 3 months after surgery and it is safe to say there is no effect on olfactory function three months after operation. Also we demonstrated that RST can be a fast and reliable tool for assessing patients’ olfactory function in clinical setting.

scholarly journals CONHECIMENTOS SOBRE BENEFÍCIOS DO ALEITAMENTO MATERNO E DESVANTAGENS DA CHUPETA RELACIONADOS À PRÁTICA DAS MÃES AO LIDAR COM RECÉM-NASCIDOS PRÉ-TERMO

2017 ◽  
Vol 35 (4) ◽  
pp. 399-406 ◽  
Author(s):  
Elâine Cristina Vargas Dadalto ◽  
Edinete Maria Rosa
Keyword(s):  
Social Sciences ◽  
The Social ◽  
E 52 ◽  
Terapia Intensiva

RESUMO Objetivo: Avaliar conhecimentos e expectativas de mães de recém-nascidos pré-termo (RNPT) internados em unidade de terapia intensiva neonatal (UTIN) sobre aleitamento materno (AM) e uso de chupeta; e analisar sua vivência ao lidar com a necessidade de sucção nos primeiros meses. Métodos: As mães foram entrevistadas durante a internação dos recém-nascidos (RN) na UTIN e quando eles completaram seis meses de idade. Foram incluídas todas as mães com disponibilidade para participar do estudo. Os critérios de exclusão englobaram RNs com síndromes ou distúrbios neurológicos e mães com comprometimento cognitivo, depressão e usuárias de drogas. Os dados tabulados no programa Statistical Package for the Social Sciences (SPSS) foram analisados por estatística descritiva e teste qui-quadrado. Resultados: Foram entrevistadas 62 mães inicialmente e 52 no follow-up de seis meses. As expectativas das participantes quanto à amamentação foram positivas, visto que elas relataram benefícios para mãe (90,3%) e bebê (100%), mas tiveram dificuldades para manter o aleitamento exclusivo, intr oduzindo a mamadeira (75,0%), já adquirida pela maioria (69,4%) antes do nascimento. O fato de haver chupeta no enxoval do RN (43,6%) não influenciou seu uso (p=0,820), tendo ocorrido também quando as mães não iriam ofertá-la devido às desvantagens para mãe (80,7%) e bebê (96,8%). A expectativa prévia de que a chupeta pudesse trazer benefícios para mãe e bebê não influenciou seu uso (p=0,375 e p=0,158). Conclusões: As mães demonstraram conhecimentos prévios sobre benefícios do aleitamento materno e desvantagens da chupeta; entretanto, elas modificaram sua concepção ao lidar com o bebê, recorrendo à introdução de mamadeira e chupeta.

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