scholarly journals Serum levels of inflammasome pathway factors in clinically isolated syndrome and multiple sclerosis patients: a pilot study

2020 ◽  
Vol 45 (2) ◽  
pp. 237-240 ◽  
Author(s):  
Yusuf Tamam ◽  
Hande Yüceer ◽  
Berna Düzel ◽  
Melis Şen ◽  
Canan Ulusoy ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Pilot Study ◽  
Serum Levels ◽  
Clinically Isolated Syndrome ◽  
Multiple Sclerosis Patients

scholarly journals Comparison of Antioxidant Status and Vitamin D Levels between Multiple Sclerosis Patients and Healthy Matched Subjects

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Ehsan Hejazi ◽  
Reza Amani ◽  
Naser SharafodinZadeh ◽  
Bahman Cheraghian
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Dietary Intake ◽  
Antioxidant Status ◽  
Sun Exposure ◽  
Total Antioxidant Status ◽  
Serum Levels ◽  
Study Groups ◽  
Vitamin D Levels ◽  
Multiple Sclerosis Patients

Objective. The aim of the present study was to compare the serum levels of total antioxidant status (TAS) and 25(OH) D3 and dietary intake of multiple sclerosis (MS) patients with those of normal subjects.Method. Thirty-seven MS patients (31 women) and the same number of healthy matched controls were compared for their serum levels and dietary intake of 25(OH) D3 and TAS. Sun exposure and the intake of antioxidants and vitamin D rich foods were estimated through face-to-face interview and food frequency questionnaire.Results. Dietary intake of antioxidants and vitamin D rich foods, vitamin C, vitamin A, and folate was not significantly different between the two groups. There were also no significant differences in the mean levels of 25(OH) D3 and TAS between the study groups. Both groups had low serum levels of 25(OH) D3 and total antioxidants.Conclusion. No significant differences were detected in serum levels and dietary intake of vitamin D and antioxidants between MS patients and healthy controls. All subjects had low antioxidant status and vitamin D levels.

Decreased soluble IFN-β receptor (sIFNAR2) in multiple sclerosis patients: A potential serum diagnostic biomarker

2016 ◽  
Vol 23 (7) ◽  
pp. 937-945 ◽  
Author(s):  
Teresa Órpez-Zafra ◽  
Jose Pavía ◽  
Isaac Hurtado-Guerrero ◽  
Maria J Pinto-Medel ◽  
Jose Luis Rodriguez Bada ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
First Year ◽  
Diagnostic Biomarker ◽  
Lower Serum ◽  
Cross Sectional ◽  
Treatment Naïve ◽  
Β Receptor ◽  
Multiple Sclerosis Patients

Background: The soluble isoform of the interferon-β (IFN-β) receptor (sIFNAR2) could modulate the activity of both endogenous and systemically administered IFN-β. Previously, we described lower serum sIFNAR2 levels in untreated multiple sclerosis (MS) than in healthy controls (HCs). Objective: To assess sIFNAR2 levels in a new cohort of MS patients and HCs, as well as in patients with clinically isolated syndrome (CIS) and with other inflammatory neurological disorders (OIND) and to assess its ability as a diagnostic biomarker. Methods: The cross-sectional study included 148 MS (84 treatment naive and 64 treated), 87 CIS, 42 OIND, and 96 HCs. Longitudinal study included 94 MS pretreatment and after 1 year of therapy with IFN-β, glatiramer acetate (GA), or natalizumab. sIFNAR2 serum levels were measured by a quantitative ELISA developed and validated in our laboratory. Results: Naive MS and CIS patients showed significantly lower sIFNAR2 levels than HCs and OIND patients. The sensitivity and specificity to discriminate between MS and OIND, for a sIFNAR2 cutoff value of 122.02 ng/mL, were 70.1%, and 79.4%, respectively. sIFNAR2 increased significantly in IFN-β-treated patients during the first year of therapy in contrast to GA- and natalizumab-treated patients who showed non-significant changes. Conclusion: The results suggest that sIFNAR2 could be a potential diagnostic biomarker for MS.

Relation of serum levels of homocysteine, vitamin B12 and folate to cognitive functions in multiple sclerosis patients

2018 ◽  
Vol 128 (9) ◽  
pp. 835-841 ◽  
Author(s):  
Ebtesam Mohamed Fahmy ◽  
Nervana Mohamed Elfayoumy ◽  
Ahmed Mohamed Abdelalim ◽  
Sahar Abdel-aaty Sharaf ◽  
Rania Shehata Ismail ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin B12 ◽  
Cognitive Functions ◽  
Serum Levels ◽  
Multiple Sclerosis Patients

Alterations in circulating T cell functional subpopulations in interferon-beta treated multiple sclerosis patients: A pilot study

2020 ◽  
Vol 339 ◽  
pp. 577113
Author(s):  
Andreia Monteiro ◽  
Pedro Rosado ◽  
Luiza Rosado ◽  
Ana Mafalda Fonseca ◽  
Artur Paiva
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
Pilot Study ◽  
Interferon Beta ◽  
Multiple Sclerosis Patients

scholarly journals Endothelin-1 concentrations in the internal jugular and azygous veins in multiple sclerosis patients: the results of a pilot study

2014 ◽  
Vol 1 ◽  
pp. 18-23
Author(s):  
Marian Simka ◽  
Tomasz Ludyga ◽  
Piotr Janas ◽  
Marek Kazibudzki ◽  
Paweł Latacz
Keyword(s):  
Multiple Sclerosis ◽  
Pilot Study ◽  
Endothelin 1 ◽  
Multiple Sclerosis Patients

Interferon beta-1b serum levels in multiple sclerosis patients following subcutaneous administration

Neurology ◽  
1996 ◽  
Vol 46 (6) ◽  
pp. 1639-1643 ◽  
Author(s):  
O. A. Khan ◽  
Q. Xia ◽  
C. T. Bever ◽  
K. P. Johnson ◽  
H. S. Panitch ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Interferon Beta ◽  
Subcutaneous Administration ◽  
Serum Levels ◽  
Multiple Sclerosis Patients

Epstein-Barr virus-specific antibody response in cerebrospinal fluid and serum of patients with multiple sclerosis

2010 ◽  
Vol 16 (7) ◽  
pp. 883-887 ◽  
Author(s):  
Massimiliano Castellazzi ◽  
Carmine Tamborino ◽  
Alice Cani ◽  
Elena Negri ◽  
Eleonora Baldi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Neurological Disorders ◽  
Epstein Barr Virus ◽  
Serum Levels ◽  
Nuclear Antigen ◽  
Enzyme Linked Immunosorbent Assay ◽  
Barr Virus ◽  
Epstein Barr ◽  
Multiple Sclerosis Patients

Cerebrospinal fluid and serum levels and intrathecal synthesis of anti-Epstein—Barr virus (EBV) IgG were measured by enzyme-linked immunosorbent assay in 80 relapsing—remitting multiple sclerosis patients grouped according to clinical and magnetic resonance imaging (MRI) evidence of disease activity. Eighty patients with other inflammatory neurological disorders (OIND) and 80 patients with non-inflammatory neurological disorders (NIND) served as neurological controls. Cerebrospinal fluid concentrations were higher in OIND than in multiple sclerosis ( p < 0.0001) and NIND ( p < 0.01) for anti-viral-capsid-antigen (anti-VCA) IgG, in multiple sclerosis than in NIND ( p < 0.01) and in OIND than in NIND ( p < 0.05) for anti-EBV nuclear antigen-1 (EBNA-1) IgG. Serum levels were more elevated in OIND than in multiple sclerosis ( p < 0.05) and in MRI inactive than in MRI active multiple sclerosis ( p < 0.0001) for anti-VCA IgG, and in multiple sclerosis than in OIND and NIND ( p < 0.01) for anti-EBNA-1 IgG. Serum titres of anti-VCA and anti-EBNA-1 IgG were also positively ( p < 0.05) and inversely ( p < 0.001) correlated, respectively, with the Expanded Disability Status Scale. An intrathecal IgG production of anti-VCA and anti-EBNA-1 IgG, as indicated by Antibody Index, was present only in a limited number of multiple sclerosis patients and controls (range from 1.3 to 6.3%). These findings do not support a direct pathogenetic role of EBV-targeted humoral immune response in multiple sclerosis.

scholarly journals Association of CD58 polymorphism and multiple sclerosis in Malaysia: a pilot study

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Yee Ming Ching ◽  
Shanthi Viswanathan ◽  
Nurhanani Mohamed Nor ◽  
Shuwahida Shuib ◽  
Balqis Kamarudin ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Pilot Study ◽  
Gene Polymorphism ◽  
Age Of Onset ◽  
Nucleotide Polymorphisms ◽  
Healthy Individuals ◽  
Disease Manifestation ◽  
Southeast Asians ◽  
Multiple Sclerosis Patients ◽  
The Impact

Abstract Background Multiple sclerosis is an immune mediated disease targeting the central nervous system. Association of non-human leukocyte antigen gene, CD58, with multiple sclerosis has been reported in several populations but is unclear among Southeast Asians. This pilot study was conducted to explore the association between CD58 polymorphism and multiple sclerosis among the Malay population in Malaysia. Methods Blood samples were collected from 27 multiple sclerosis patients, and compared with 58 age- and gender matched healthy individuals. All patients were tested negative for anti-aquaporin 4. DNA was extracted from the blood and genotyped for 3 single nucleotide polymorphisms rs12044852, rs2300747 and rs1335532 of gene CD58 by real-time PCR. Results The majority of multiple sclerosis patients were female (85.2%). The general mean age of onset was 30.5 years. Genotyping results showed that frequencies of the alleles were between 40 and 50% for MS patients and healthy individuals. Association (allelic model) between multiple sclerosis and CD58 gene polymorphism alleles rs12044852 (p = 0.410), rs2300747 (p = 0.881) and rs1335532 (p = 0.407) were indistinct. Conclusions The impact of the CD58 gene polymorphism was not prominent in this pilot study, implying that genetic composition contributing to multiple sclerosis may be different between different populations, thus results in a heterogeneity of disease manifestation and distribution.

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