FETAL ECHOCARDIOGRAPHY: 12 YEARS EXPERIENCE AT AFIC /NIHD

Objective: To determine the frequency of congenital cardiac lesions in pregnant women reporting for fetal echocardiogram and correlate with obstetrical risk factors. Study Design: Descriptive cross-sectional study. Place and Duration of Study: To be conducted at pediatric cardiology and obstetrical unit of AFIC/NIHD and CMH Rawalpindi, from Jan 2009 to Jan 2020. Methodology: Pregnant women referred for fetal echocardiogram from 19-49 years of age were enrolled. Echo was done between 20 to 36 weeks gestation. Primary outcome was the nature of cardiac lesion and gestation at diagnosis. Neonatal scan was done at follow up to confirm cardiac diagnosis. Secondary outcome was obstetrical risk factors which were the reason for referral. This included age consanguinity, family history, previous history of intrauterine death or early neonatal death, maternal and paternal diseases. Data was collected and analyzed n frequencies and percentage. Chi-square was applied for association between variable and p-valve 0.05 was considered significant. Results: A total of n=967 pregnant women referred to outpatient department for fetal echocardiogram. Congenital cardiac lesion were detected in n=83 patients. Majority of patients had CAVSD (1.2%) CCAVB (1.2%) followed by ASD (1.1%) VSD (0.9%) Abnormal heart rate (0.8%) Single ventricle (0.3%). Most significant maternal age group was between 21 to 30 and 30-40 years (43.7 and 46.2%). Only 3% below 20 years and 6.7% above40 years of age. Most important maternal risk factor was previous off spring 0.5% past family history 0.3% and abnormal obstetrical ultrasound 0.3% Followed by maternal diabetes 0.1% and maternal hypertension 0.1%. The yield of detection of congenital cardiac lesions was 8.3%. Conclusions: Congenital cardiac diseases are the second most common congenital anomaly and huge burden n pediatric population. Timely diagnosis and referral can be lifesaving.

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Risk Factors Associated with Gestational Diabetes among Pregnant Women in Owerri Municipal Council, Southeastern Nigeria

Asian Journal of Medical Sciences ◽

10.3126/ajms.v5i1.8302 ◽

2013 ◽

Vol 5 (1) ◽

pp. 39-46 ◽

Cited By ~ 1

Author(s):

JC Nwaokoro ◽

CO Emerole ◽

SNO Ibe ◽

AN Amadi ◽

INS Dozie

Keyword(s):

Risk Factors ◽

Family History ◽

Gestational Diabetes ◽

Pregnant Women ◽

Significant Relationship ◽

Previous History ◽

Southeastern Nigeria ◽

Family History Of Diabetes ◽

Factors Associated ◽

History Of

Background Gestational diabetes is emerging as a serious public health problem in Nigeria where the largest number of people with diabetes in Africa occurs. Current studies in Nigeria give an overall prevalence of gestational diabetes as 13.4% among pregnant women with unidentified risk factors. Aims and Objectives This study aimed at investigating the risk factors associated with gestational diabetes. Materials and Methods A cross-section analytical study design was adopted for this research and comprising a total of 100 pregnant women receiving ante-natal health care service at the Federal Medical Center, Owerri. A structured questionnaire including a set of detailed pre-determined questions was administered on the subjects. Data collected were analyzed statistically, using chi-square and T test. Results The results obtained suggest that there is a significant relationship (p<0.05) between previous macrosomic baby, parity, previous history of caesarean section, family history of diabetes and occurrence of gestational diabetes, respectively. However, there is no significant relationship (p>0.05) between history of miscarriages and stillbirth, socioeconomic status and occurrence of gestational diabetes. A family history of diabetes is independently and significantly associated with the development of gestational diabetes itself even after adjusting for other risk factors. Conclusion This study will be a working tool to guide obstetricians and midwives in counseling and advising women of their risk of developing GDM. DOI: http://dx.doi.org/10.3126/ajms.v5i1.8302 Asian Journal of Medical Science Vol.5(1) 2014 pp.39-46

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Seroprevalence of Toxoplasma gondii among pregnant women attending antenatal clinics at Hawassa University comprehensive specialized and Yirgalem General Hospitals, in Southern Ethiopia

BMC Infectious Diseases ◽

10.1186/s12879-019-4694-8 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 3

Author(s):

Demissie Assegu Fenta

Keyword(s):

Risk Factors ◽

Toxoplasma Gondii ◽

Pregnant Women ◽

Southern Ethiopia ◽

Enzyme Linked Immunosorbent Assay ◽

Intrauterine Death ◽

Domestic Cats ◽

Unpasteurized Milk ◽

Antenatal Clinics ◽

Undercooked Meat

Abstract Background Toxoplasmosis is caused by infection with the protozoan parasite Toxoplasma gondii. It is acquired by consumption of raw or undercooked meat containing tissue cyst, food or water contaminated with oocyst and congenital infection through the placenta leading to serious congenital abnormalities in the fetus like miscarriage, stillbirth, intrauterine death and neurologic defects. Therefore; this study was aimed to determine the prevalence of toxoplasmosis infection and its possible risk factors associated with pregnant women attending antenatal clinics in Hawassa and Yiregalem Hospitals, Southern Ethiopia. Methods A hospital-based cross-sectional study was conducted from December 2016 to May 2017. The study was done in antenatal care clinics of Hawassa and Yiregalem Hospitals in Southern, Ethiopia. Five hundred pregnant women were interviewed with a pretested structured questionnaire to collect risk factors and socio-demographic data. Blood samples were collected and serum was separated and tested for anti- Toxoplasma gondii antibodies using ELISA (Enzyme-linked Immunosorbent Assay). Data were analyzed using SPSS version 20 statistical software. The risk factors were tested for significance using Bivariate and multivariate analysis. P-value < 0.05 was considered statistically significant. Results The weighted prevalence of this study was 81.8% for the anti- Toxoplasma gondii antibody. Almost all participants (99.6%) had no information about the disease. A significant association was observed between seroprevalence and contact with domestic cats (OR = 1.206, 95% CI (1.627–2.206, P = 0.043), consumption of raw meat (OR = 0.848, 95% CI: 1.517–2.941, P = 0.019) and unpasteurized milk (OR = 0.871, 95% CI 1.531–2.221, P = 0.032). A significant association was not observed between seroprevalence and age, history of abortion, and blood transfusion. Conclusions The findings of this study demonstrated a relatively higher prevalence of seropositivity than studies reported from other countries. Existence of domestic cats at home, consumption of undercooked meat and unpasteurized milk were identified as risk factors for T. gondii infection. Therefore, a health education program to increase the mother’s knowledge about toxoplasmosis towards avoiding eating undercooked meat, contact with cats and consumption of unpasteurized milk during pregnancy is recommended. Furthermore, our results suggested that the implementation of newborn screening and follow-up testing can lead to reducing of toxoplasmosis associated complications.

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Frequency of Placenta Previa in Multigravida at Tertiary Care Hospital

TAJ Journal of Teachers Association ◽

10.3329/taj.v25i0.37560 ◽

2018 ◽

Vol 25 ◽

pp. 59-63

Author(s):

Mst Rokeya Khatun ◽

KS Nasrin Lina ◽

S Gul Nahar

Keyword(s):

Risk Factors ◽

Pregnant Women ◽

Gestational Age ◽

Placenta Previa ◽

Tertiary Care ◽

Previous History ◽

Pelvic Surgery ◽

Treatment Modalities ◽

Care Hospital ◽

Current Frequency

Background: Placenta previa is a localization of placenta in the lower uterine segment, near or over the internal os. Multigravida is one of the risk factors of placenta previa. The aim of study is to look for current frequency of placenta previa in multigravida, so that further improvement in diagnosis and treatment modalities can be made in order to decrease the morbidity & mortality related to it in this group.Objective: To determine the frequency of various grades of placenta previa in multigravida at a tertiary care center.Methodology: This is a cross sectional study conducted from December 2014 to June 2015 at the department of Gynecology and Obstetrics, Rajshahi Medical College Hospital. A total of 208 patients enrolled in the study with non -probability purposive sampling technique. All pregnant women with singleton pregnancy of 25-35 years of age in their second or more pregnancy with gestational age ≥ 34 weeks were included. Exclusion criteria observed for patients with multifetal pregnancy, previous history of cesarean section, dilatation and curettage, cervical cone biopsy, myomectomy or any pelvic surgery. All pregnant women had trans-abdominal ultrasound. The presence or absence of placenta previa was reported by an experienced sonologist. The data was analyzed using SPSS version 12.Results: Among the total recruited patients, mean age of these multigravidas was 30.1±5.6 years. The mean parity of our population was 4.02±1.2. The gestational age noted was 38±1.4 weeks as mean.. The frequency of placenta previa was 13 (6.3%) and type IV was the most common type.Conclusion: It is concluded from this study that the frequency of placenta previa in patients of multigravida was 6.3% and apart from other risk factors, multigravidity is an independent risk factor for placenta previa.TAJ 2012; 25: 59-63

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NEONATAL HYPOGLYCEMIA

The Professional Medical Journal ◽

10.29309/tpmj/2014.21.04.2312 ◽

2018 ◽

Vol 21 (04) ◽

pp. 745-749

Author(s):

Sikandar Ali Bhand ◽

Farzana Sheikh ◽

Abdul Rehman Siyal ◽

Muhammad Akber Nizamani ◽

Muhammad Saeed

Keyword(s):

Risk Factors ◽

Birth Weight ◽

Family History ◽

Low Birth Weight ◽

Gestational Age ◽

Metabolic Disorder ◽

Maternal Risk Factors ◽

Diabetic Mellitus ◽

Maternal Risk ◽

History Of

… Objective: To determine the presenting features and assessment of the neonateswith hypoglycemia along with maternal and neonatal risk factors for hypoglycemia. Subjects &methods: All consecutive neonates with hypoglycemia admitted were included in the study.Demographic characteristics of the mothers and their babies, past medical history and illnessesduring pregnancy especially that, of diabetes mellitus and duration, details of the management oflabour and place of delivery, birth asphyxia as well as history of feeding prior to admission. All therisk factors and clinical features were documented. Results: From presenting features neonateswere most common temperature instability 32% of the neonates. Maternal risk factors were asMaternal diabetic mellitus, Intrapartum administration of glucose , Maternal drug uses as: (Betablockers, Oral hypoglycemic agents, Valproate), family history of metabolic disorder and withoutany factors with the percentage 13%, 17%, (15%, 08%, 07%) , 27% and 13% respectively.Neonatal risk factors of the patients were found low birth weight 49%, small gestational age 26%,macrosomia 11%, respiratory distress 32%, sepsis 20%, hypothermia 25%, congenital cardiacabnormalities 4%, endocrine disorder 4%, family history of metabolic disorder 7%, inborn errorsof metabolism 4%, rhesus hemolytic disease 5%, erythroblastosis fetalis 1%, inadequate feeding35% and neonates without factors were 6%. Conclusions: The risk factors associate withneonatal hypoglycemia are, low birth weight, small gestational age, macrodome, respiratorydistress, sepsis, hypothermia and inadequate feeding , and maternal risk factors associate toneonatal hypoglycemia was Eclampsia, Maternal diabetic mellitus, and maternal drug uses

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Maternal Risk Factors Associated with Low Birth Weight in Indonesia

The Open Public Health Journal ◽

10.2174/1874944501811010376 ◽

2018 ◽

Vol 11 (1) ◽

pp. 376-383 ◽

Cited By ~ 1

Author(s):

Issara Siramaneerat ◽

Farid Agushybana ◽

Yaowaluck Meebunmak

Keyword(s):

Risk Factors ◽

Birth Weight ◽

Low Birth Weight ◽

Pregnant Women ◽

Maternal Education ◽

Pregnancy Complication ◽

Maternal Risk Factors ◽

Maternal Risk ◽

Factors Associated ◽

Logistic Analysis

Background: Low birth weight (LBW) is a major risk factor for death and disease in the fetus and newborn infant. However, the study about LBW and maternal risk factors involved in Indonesia is still limited. Objective: The present study attempted to examine the association of maternal risk factors including mother’s age, mother and husband education, mother and husband occupation and wealth, ANC visit, desired pregnancy and obstetric complication toward the occurrence of low birth weight infant across region and family wealthy. Methods: This study employed the data from the national survey of Indonesia Demographic and Health Survey (IDHS). The latest births from married women who gave birth within 2 years (2011 and 2012) preceding the IDHS were considered as sample selection. It was approximately 15,126 respondents. The predicted risks of low birth weight were estimated using multilevel logistic analysis. Results: Data were collected on 15,126 pregnant women who reported 10.2% were with LBW infants. When using the multilevel logistic analysis, the factors associated with LBW were maternal delivery-baby age, mother’s education, antenatal care and pregnancy complication at significant levels of 0.01. Conclusion: The prevalence of preterm infants in this study was quite high. Factors affecting LBW were maternal age, maternal education, ANC visits and pregnancy complication. The ANC visit of pregnant women is a potential and feasible activity to reduce the incidence of LBW.

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FGR: Risk Factors and Outcomes

QJM ◽

10.1093/qjmed/hcaa056.019 ◽

2020 ◽

Vol 113 (Supplement_1) ◽

Author(s):

G M A Elbishry ◽

R R Ali ◽

R T Ramadan

Keyword(s):

Risk Factors ◽

Caesarean Section ◽

Pregnant Women ◽

Fetal Growth ◽

Fetal Growth Restriction ◽

Growth Restriction ◽

Abdominal Circumference ◽

Maternal Risk ◽

The Mean ◽

Estimated Fetal Weight

Abstract Background Fetal Growth Restriction (FGR) is the one of largest contributing factor to perinatal morbidity in non-anomalous fetuses and is associated with an increased risk of stillbirth, neonatal death and short and long-term complications. Fetal growth restriction (FGR) is defined as an estimated fetal weight and/or abdominal circumference (AC) is less than the10th percentile. In order to avoid these adverse outcomes, the management of pregnancies with FGR involves close monitoring of fetal well-being and early delivery when necessary. Screening for FGR during pregnancy is thus a central component of prenatal care, as highlighted in recent national guidelines, first-line tools include risk factor assessment at the beginning and during pregnancy. Hence, in this study we evaluated the maternal risk factors and diagnosis-delivery intervals and perinatal outcomes in FGR. Aim To determine the effect of specific antenatal FGR risk factors on fetal growth trajectory and the outcomes using threshold of estimated fetal weight (EFW) and abdominal circumference (AC) <10th percentile. Methods Prospective observational analytical study was conducted in a tertiary care hospital in Cairo, Egypt on 100 pregnant women with documented fetal growth restriction attended Ain Shams University hospital over a period of 1 year and eight months. All fetuses considered as growth restrictions. Fetuses with multiple pregnancy, congenital malformation, chromosomal abnormality, and premature rupture of membrane were. Socio-demographic, maternal risk, Diagnosis- delivery interval in FGR and neonatal morbidities were studied. Results This study included 100 pregnant women with documented FGR fetuses, the mean maternal age at diagnosis was 28.6±2.7 years, the mean pregnant women weight at diagnosis was 72.7±5.1 (kg) with BMI range 25.6–29.8 (kg/m2) and their pregnancy weight gain was 12.0–25.0 (kg), 50 women used to consume caffeine more than 200 mg/day, and the percentage of nicotine exposure was 22% of total studied pregnants, 19 % were passive smokers and 3% of them were active. 73% were multigravida and the rest were primi-gravida, the mean inter-pregnancy interval was 17.3±4.7 months. Obstetric history of Previous placental mediated diseases included (prior FGR, previous intrauterine fetal death (IUFD), Pre-eclampsia and un-explained antepartum hemorrhage) were distributed as follows 16.0%, 6.0%, 12.0% and 2.0% respectively. Also we found 2.0% had an in vitro fertilization (IVF) and 26 women got regular antenatal care (ANC). At the end of our study 45% of fetuses were delivered at completed 37 weeks and 55% showed pre-term delivery (before 37 weeks). 95% of total were delivered by caesarean section. The indications for caesarean section were different. So, among 100 FGR fetuses, 35 fetus had abnormal Doppler pattern which considered the main indication for termination of pregnancy, the most frequent one was absent/reversed ductus venosus Doppler which was the cause of preterm immediate caesarean section in 4 of fetuses. We also found 2 fetuses with also absent/reversed EDV but with abnormal CTG, we found 20 fetuses with PI > 2SD with preserved EDV and completed 37 weeks, 13% had non-reactive non-stress test (NST) necessitating imminent delivery, also 3 fetuses with absent EDV > 34 weeks while only one fetus with reversed EDV >32 weeks. We found 1 fetus with static growth over 3 weeks during our follow up, also we discovered 1 pregnant women who developed accidental hemorrhage with placental separation and other 3 women developed sever pre-eclampsia who underwent emergency caesarean section after controlling their condition. Conclusion FGR is associated with sociodemographic status and various medical conditions. Analysis of various maternal and familial risk factors is an integral part of in-utero fetal surveillance to identify impending fetal hypoxia. Appropriate management should be offered to these FGR fetuses, is optimizing the timing of delivery to improve perinatal health in FGR.

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Screening of Hemoglobin A1c in Gestational Diabetes among women attending metabolic clinic at a tertiary care hospital in Uttar Pradesh

Asian Journal of Medical Sciences ◽

10.3126/ajms.v10i2.22578 ◽

2019 ◽

Vol 10 (2) ◽

pp. 26-30

Author(s):

Vivek Sinha ◽

Poonam Kachhawa

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Risk Factor ◽

Family History ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnant Women ◽

P Value ◽

Close Monitoring ◽

History Of

Background: Gestational diabetes mellitus (GDM) is a common medical condition that complicates pregnancies..Gestational diabetes mellitus (GDM) is a diabetic metabolic disorder that occurs in 4% of all pregnant women and 14% of ethnic groups with more prevalence of type II diabetes. It can be defined as increased or abnormal insulin resistance, decreased insulin sensitivity or glucose intolerance with first diagnosis during pregnancy. Aims and Objectives: The purpose of this study was to evaluate the diagnostic screening value of the HbA1c, prevalence of GDM and associated risk factors. Materials and Methods: The study was conducted at the metabolic clinic; in the department of Biochemistry located at SIMS, Hapur. A semi-structured pretested questionnaire was used for data collection. Following the DIPSI guidelines, patients with plasma glucose values >140 mg/dl were labeled as GDM. Statistical methods used were OR (CI95%), percentage, Chi square. Results: Out of 500, 6.72% had GDM. Among all GDM patients, 64.71% had age more than 30 years, 70.59% had BMI more than 25, 41.18% had gravida more than 3 and p- value was significant with regard to age and BMI. P value was found to be significant for risk factors namely positive family history of Diabetes Mellitus, history of big baby and presence of more than one risk factor. Conclusion: GDM is associated with high BMI, early pregnancy loss, family history of DM and previous history of big baby and there could be more than one risk factor. Thus universal screening followed by close monitoring of the pregnant women for early detection of GDM may help improving maternal and fetal outcomes.

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Prevalence and Risk Factors of Amblyopia among Refractive Errors in an Eastern European Population

Medicina ◽

10.3390/medicina54010006 ◽

2018 ◽

Vol 54 (1) ◽

pp. 6 ◽

Cited By ~ 6

Author(s):

Valeria Mocanu ◽

Raluca Horhat

Keyword(s):

Risk Factors ◽

Family History ◽

Maternal Smoking ◽

Smoking History ◽

Maternal Body Mass Index ◽

Refractive Errors ◽

Eastern European ◽

Maternal Risk ◽

Toxic Environment ◽

History Of

Background and objective: Amblyopia is the leading cause of visual impairment in children and adults and is very common during childhood. The aim of this study was to identify the prevalence and the risk factors of amblyopia in a pediatric population with refractive errors from an Eastern European country. Materials and methods: A total of 1231 children aged 5–16 years, who had refractive errors and were examined from January to August 2017, were enrolled in a cross-sectional population-based study. Every child underwent a complete ophthalmological exam. Amblyopia was defined as a visual acuity (VA) of less than 0.63. The study respected the Multi-Ethnic Pediatric Eye Disease Study (MEPEDS) criteria for defining amblyopia (MEPEDS, 2008). Parents participated in a face-to-face interview. The questionnaire contained details about their family history of amblyopia; the child’s maternal nutritional status in the preconception period; their history of maternal smoking or work in a toxic environment; the child’s birth, and the child’s history of congenital naso-lacrimal duct obstruction (CNLDO). Results: Amblyopia was identified in 2.8% of the participants. The ocular conditions hyperopia (p = 0.0079), astigmatism (p = 0.046), anisometropia (p < 0.001), esotropia (p < 0.001), exotropia (p = 0.0195), and CNLDO (p < 0.001), as well as a family history of amblyopia (p < 0.001), were associated with amblyopia. The non-ocular risk factors for amblyopia that were found in the study included low birth weight (p < 0.0009), prematurity (p < 0.001), an Apgar score under 7 (p = 0.0008), maternal age, maternal smoking history or work in toxic environment (p < 0.001), and maternal body mass index in the preconception period (p < 0.003). Conclusions: Some of the risk factors we identified for amblyopia are modifiable factors. This is an important observation as an adequate health education program can provide the relevant information for future mothers that will allow for a better management of the condition. We also wanted to highlight the need for amblyopia screening starting from the age of 3 years in case of significant parental refractive errors, strabismus, prematurity, and maternal risk factors.

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Toxoplasma gondii infection in pregnant women: a cross-sectional study in Matehuala City, Mexico

BMJ Open ◽

10.1136/bmjopen-2019-033995 ◽

2020 ◽

Vol 10 (8) ◽

pp. e033995

Author(s):

Ada-Agustina Sandoval-Carrillo ◽

Angel Antonio Vértiz-Hernández ◽

Jose-Manuel Salas-Pacheco ◽

Olga Edith González-Lugo ◽

Elizabeth-Irasema Antuna-Salcido ◽

...

Keyword(s):

Risk Factors ◽

Toxoplasma Gondii ◽

Pregnant Women ◽

Protective Factor ◽

Cross Sectional Study ◽

Secondary Outcome ◽

Sectional Study ◽

Cross Sectional ◽

Infection Age ◽

Igm Antibodies

ObjectivesThis study aimed to determine the seroprevalence of Toxoplasma gondii (T. gondii) infection in pregnant women in Matehuala City, Mexico; and the associated risk factors.DesignA cross-sectional study.SettingMatehuala City, Mexico.Participants311 pregnant women.Primary and secondary outcome measuresSera of women were analysed for anti-T. gondii IgG and IgM antibodies by commercially available immunoassays. Bivariate and multivariate analyses were used to assess the association between T. gondii seroprevalence and the characteristics of the pregnant women.ResultsThirteen (4.2%) of the 311 pregnant women studied were positive for anti-T. gondii IgG antibodies. No anti-T. gondii IgM antibodies were found in anti-T. gondii IgG seropositive women. No association between seropositivity and history of blood transfusion, transplantation, caesarean sections, deliveries, miscarriages or number of pregnancies was found. Logistic regression analysis of sociodemographic, behavioural and housing variables showed that availability of potable water at street represented a risk factor for T. gondii infection (age-adjusted OR=2.18; 95% CI: 1.05 to 4.53; p=0.03), whereas being born in Mexico was a protective factor for infection (age-adjusted OR=0.01; 95% CI: 0.001 to 0.35; p=0.008).ConclusionsIn this first study on the seroepidemiology of T. gondii infection in pregnant women in Matehuala, we conclude that the seroprevalence of T. gondii infection is low and similar to those reported in pregnant women in other Mexican cities. However, the seroprevalence found is lower than those reported in pregnant women in other countries in the Americas and Europe. Two risk factors associated with T. gondii infection were identified. Results of the present study may help for the optimal planning of preventive measures against toxoplasmosis in pregnant women.

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Maternal factors of pre-eclampsia development

Reproductive Endocrinology ◽

10.18370/2309-4117.2021.58.102-106 ◽

2021 ◽

pp. 102-106

Author(s):

L.I. Berlinska ◽

V.G. Marichereda ◽

M.Y. Holubenko ◽

O.M. Pavlovska

Keyword(s):

Risk Factors ◽

Renal Disease ◽

Pregnant Women ◽

Multiple Pregnancy ◽

Chronic Hypertension ◽

Maternal Factors ◽

Previous Pregnancy ◽

Maternal Risk ◽

History Of ◽

Anti Phospholipid Syndrome

Study objective: to determine the most important maternal factors for the pre-eclampsia (PE) prediction, which are used in screening of women when registered for pregnancy.Materials and methods. A prospective cohort study included 91 pregnant women in their first trimester; study period 2018–2020. The main group included 56 (61.54%) women with a number of maternal factors for PE development, and 35 (38.46%) were healthy females in the control group. Subgroups of women formed for females with and without PE – 28.57% and 71.43%, respectively.Results. Statistically significant values in the study of maternal factors were observed between subgroups of patients with and without PE for body mass index (BMI) prior to pregnancy (26.83 ± 1.29 and 26.03 ± 1.05) and height of pregnant women (163.35 ± 1.26 cm and 167.23 ± 1.02 cm), p <0.05. Among the risk factors that led to PE, statistically significant results were observed when combining the first pregnancy with a history of kidney disease (p = 0.033). Recurrent PE was observed when combined with PE history in mother (p = 0.011). Impact of chronic hypertension on the PE development was noted when the disease history was over 5 years. The combination of interval between pregnancies of 10 years and more and age >35 years was associated with PE (p = 0.008).During IVF PE developed in combination with such factors as BMI 30 kg/m2 and the interval between pregnancies over 10 years, 1.1% females had no other factors. History of renal disease and the age >35 years had an impact on the PE development in patients with anti-phospholipid syndrome. Analysis of the odds ratio of the isolated maternal factor showed the following indicators: PE during previous pregnancy – 6, multiple pregnancy – 2.56, anti-phospholipid syndrome – 2.56, first pregnancy – 1.83, in vitro fertilization – 1.72, obesity >30 kg/m2 – 1.65, PE in the mother – 1.57, age >35 years – 1.08, history of renal disease – 1, interval between pregnancies >10 years – 0.77 and chronic hypertension – 0.18.Conclusion. Thorough monitoring of maternal risk factors for PE should focus on PE during previous pregnancy. The second position is occupied by multiple pregnancy and anti-phospholipid syndrome. PE risk is increased for a combination of factors, especially with chronic renal disease and/or elevated BMI.

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