ROLE OF FIBRIN GLUE FOR BETTER SUCCESS RATE IN MYRINGOPLASTY

Objective: To see graft uptake success rate in platelet rich fibrin aided underlay myringoplasties using temporalis fascia graft compared to conventional underlay myringoplasties. Study Design: Double blind randomized controlled trial study. Place and Duration of Study: ENT department, Pakistan Naval Ship Shifa Hospital, from Jan to Jun 2019. Methodology: Sixty cases with dry central tympanic membrane perforations were recruited. The patients suffering from sensori-neural hearing loss and co-morbidities like diabetes were excluded. The sampling technique was probability simple random. Patients were divided into two groups by lottery method. Statistical analysis was performed by using SPSS. The chi square test was applied to calculate p-value. Results: Out of total 60 patients 38 were males and 22 were females. Study group’s (Fibrin) mean age was 31.77 ± 12.43 years and Control group’s mean age was 27.53 ± 11.41 years. All the patients in platelet rich fibrin group had successful graft uptake at 2 months follow-up. In control group with conventional technique 23 out of 30 patients had successful graft uptake and rest 7 patients had different issues leading to graft rejection. Conclusion: In under lay myringoplasty procedure, application of platelet rich fibrin on temporalis fascia graft edge and perforation edges has significantly improved the successful uptake rate of graft.

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The Effects of Clinical Hypnosis versus Neurolinguistic Programming (NLP) before External Cephalic Version (ECV): A Prospective Off-Centre Randomised, Double-Blind, Controlled Trial

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2012/626740 ◽

2012 ◽

Vol 2012 ◽

pp. 1-6 ◽

Cited By ~ 3

Author(s):

Joscha Reinhard ◽

Swati Peiffer ◽

Nicole Sänger ◽

Eva Herrmann ◽

Juping Yuan ◽

...

Keyword(s):

Medical Care ◽

Success Rate ◽

Controlled Trial ◽

Randomised Trial ◽

External Cephalic Version ◽

Control Group ◽

Amniotic Fluid Index ◽

Double Blind ◽

Standard Medical Care ◽

Clinical Hypnosis

Objective. To examine the effects of clinical hypnosis versus NLP intervention on the success rate of ECV procedures in comparison to a control group.Methods. A prospective off-centre randomised trial of a clinical hypnosis intervention against NLP of women with a singleton breech fetus at or after 370/7(259 days) weeks of gestation and normal amniotic fluid index. All 80 participants heard a 20-minute recorded intervention via head phones. Main outcome assessed was success rate of ECV. The intervention groups were compared with a control group with standard medical care alone ().Results. A total of 42 women, who received a hypnosis intervention prior to ECV, had a 40.5% (), successful ECV, whereas 38 women, who received NLP, had a 44.7% () successful ECV (). The control group had similar patient characteristics compared to the intervention groups (). In the control group () 27.3% () had a statistically significant lower successful ECV procedure than NLP () and hypnosis and NLP ().Conclusions. These findings suggest that prior clinical hypnosis and NLP have similar success rates of ECV procedures and are both superior to standard medical care alone.

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Effects of Bupropion on Cognitive Function in Schizophrenia: A Double Blind Randomized Controlled Trial

Global Journal of Health Science ◽

10.5539/gjhs.v9n5p67 ◽

2016 ◽

Vol 9 (5) ◽

pp. 67

Author(s):

Mansoureh Mirzadeh ◽

Najmeh Shahini ◽

Masoud Kashani Lotf Abadi ◽

Maryam Tavakoli ◽

Arash Javanbakht ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Cognitive Function ◽

Rating Scale ◽

Controlled Trial ◽

Control Group ◽

P Value ◽

Double Blind ◽

Randomized Controlled ◽

Significant Difference ◽

Schizophrenic Patients

Smoking habits are common in schizophrenic patients. Nicotine can suppress negative symptoms and cognitive impairments. The aim of this study was to determine the efficacy of bupropion on cognitive function in schizophrenic patients. This study is a double blind randomized controlled trial in a large referral psychiatric university hospital in Iran. Ninety smoker schizophrenic patients were randomly allocated (based on DSM -IV TR criteria) in two groups (46 patients for case group and 44 patients in control group). They get risperidone up to 6 mg/d and bupropion up to 400 mg/d .clinical assessment (Positive and Negative Syndrome Scale (PANSS), Brief psychiatric rating scale (BPRS) were taken in beginning of study, 14th and 28th days of study. Cognitive assessment (Stroop, Digit Span, and Wechsler, Wisconsin) were taken in begging of study, the days 2nd, 7th, 14th, 28th. All data were analyzed by SPSS Ver. 17 with analytic and descriptive tests. Mean age of patients was 37.66±1.01. Mean duration of disorder was 11.63±.98 years. The scores were significantly lower at the day 28th compared to the beginning of the study in both groups in Wechsler, Stroop color word , Stroop word , Stroop color , BPRS, PANSS p value ≤0.05 .The difference between the two treatments was not significant as indicated by the effect of group, the between-subjects factor p value ≥0.05. In this study, the side effects were examined and there was no significant difference between the two groups p value ≥0.05. Augmentation of bupropion to routine treatment improves cognitive symptoms of schizophrenia in abstinence of tobacco.

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Does Benzocaine Toothpaste Have More Pain-Relieving Effect Compared To Placebo Toothpaste In Orthodontic Patients? A Double-Blind Randomized Controlled Trial

10.21203/rs.3.rs-866567/v1 ◽

2021 ◽

Author(s):

Ladan Eslamian ◽

Sepideh Soheilifar ◽

Sanaz Soheilifar ◽

Seyed Alireza Mortazavi

Keyword(s):

Orthodontic Treatment ◽

Controlled Trial ◽

Repeated Measure ◽

Control Group ◽

P Value ◽

Eligibility Criteria ◽

Double Blind ◽

Important Challenge ◽

Frequent Consumption ◽

And Control

Abstract Background: Pain management in fixed orthodontic treatment is an important challenge. None of the present methods has been successful in pain relief. The objective of this double-blind cross-over trial was to compare the effect of benzocaine-contained toothpaste and placebo toothpaste on relieving pain caused by fixed orthodontic treatment.Methods and material:Patients undergoing fixed orthodontic treatment at Shahid Beheshti University of Medical Sciences with experience of pain in previous appointment were randomly assigned into 3 groups of 5% benzocaine-contained toothpaste, placebo toothpaste and control group. Eligibility criteria included being in leveling and alignment stage, 6-8 mm space deficiency, no acute or chronic pain or frequent consumption of analgesic drugs. Patients were instructed to use toothpastes 3 times in a day. Main outcome was pain experienced by patients according to Visual Analogue Scale at 8 different time intervals in 7 days. Randomization was done with random numbers in opaque envelopes for sequence of appointments. Blinding was applicable for patients, operator and outcome assessor. Data analysis was done with repeated measure ANOVA for assessing overall effect and Bonferroni for pairwise analysis. P value was assigned to be 0.05.Results: From 33 patients who participated in the study, 27 patients (23 females and 4 males) completed the study. Each patient was randomly allocated to all 3 groups in cross-over design. Mean pain in benzocaine group was less than the placebo and control group (28.63± 25.43, 31.31± 22.09 and 31.20 ± 24.09, respectively). Benzocaine toothpaste group experienced statistically significantly less pain than the other two groups at 2 hours (P˂ 0.015). No adverse event was observed in patients.Conclusion:Benzocaine contained toothpaste can decrease pain perceived at first hours after orthodontic appointment. Registration and protocol: This trial was registered in Iranian Registry of Clinical Trials (IRCT2015010120523N1) at 16/04/2015.

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Effectiveness of Distraction Therapy on Pain Relief among Children Undergoing Vein-Puncture in a Selected Hospital, Bhubaneswar

Journal of Advanced Research in Medicine ◽

10.24321/2349.7181.202008 ◽

2020 ◽

Vol 07 (02) ◽

pp. 15-21

Author(s):

Soumika Debnath ◽

Keyword(s):

Intervention Group ◽

Sampling Technique ◽

Pain Scale ◽

Control Group ◽

P Value ◽

Double Blind ◽

Significant Difference ◽

Post Test ◽

And Control ◽

Experimental Group

Aim: The present study is aimed to assess the effect of distraction therapy during venipuncture in reducing pain among 6-12 years children in the selected hospital at Bhubaneswar. Methods: The study was a double blind; Randomized control trial design was used and the formal consent was obtained from Pradyumna Bal Memorial Hospital and the investigator selected 182 samples using consecutive sampling technique and then randomized into experimental and control groups. The intervention group and the control were having 91 samples each. Measurement of pain experienced by the school going children was assessed with the help of Wong-Baker Faces Pain Scale. Descriptive and inferential statistics were used to analyze the data. Result: The mean pain score of children in experimental group was 2.571 and the standard deviation was 2.006. The p value in comparing the pain level of children in control and experimental group was <0.01, which was statistically significant at p<0.05 (confidence interval 95%) level indicating that there was significant difference in the post test level of pain between the experimental and control group. Conclusion: Hence the distraction therapy was responsive in reducing the vein-puncture pain among school going children.

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Tranexamic acid for reducing blood loss following vaginal delivery: a double-blind randomized controlled trial.

10.21203/rs.3.rs-586942/v1 ◽

2021 ◽

Author(s):

Francis Igboke ◽

Lucky Lawani ◽

Vitus Obi ◽

Ikechukwu Dimejesi

Keyword(s):

Treatment Group ◽

Blood Loss ◽

Tranexamic Acid ◽

Vaginal Delivery ◽

Controlled Trial ◽

Controlled Study ◽

Control Group ◽

P Value ◽

Double Blind ◽

Estimated Blood Loss

Abstract Background: Postpartum haemorrhage (PPH) is a major cause of maternal morbidity and mortality worldwide with the highest incidence in the developing countries. Tranexamic acid (TXA) is a useful drug for prevention of PPH and merits evaluation in our environment. This study evaluates the efficacy of TXA in reducing blood loss following vaginal delivery.Methods: This was a double-blind randomized placebo-controlled study on the efficacy and safety of intravenous TXA in reducing blood loss in women undergoing vaginal delivery in a tertiary hospital. Data analysis was conducted with IBM SPSS software (version 20, Chicago II, USA). P-value <0.05 was considered statistically significant.Results: The mean estimated blood loss was lower in TXA compared with the placebo group (174.87±119.84 ml versus 341.07±67.97 ml respectively; P<0.0001). PPH (blood loss >500ml) was 5.13% in the study arm compared to the control arm 7.14%- risk ratio (RR) 0.82; 95% [CI 0.38 – 1.79, p=0.5956]. Additional uterotonics was required more in the control group compared to the treatment group 14(16.67%) versus 3(3.85%) of the treatment group, p-value of 0.007. There were no major complications noticed in the treatment group.Conclusion: This study demonstrated that intravenous administration of TXA acid following vaginal delivery reduced blood loss following vaginal delivery. It also reduced the need for additional uterotonics. However, blood loss greater than 500 was not significantly reduced.Pan African Clinical Trial Registry: PACTR202010828881019

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EFFICACY OF PROPHYLACTIC INTRAVENOUS ADMINISTRATION OF ONDANSETRON FOR PREVENTION OF SPINAL ANESTHESIA INDUCED HYPOTENSION IN ELDERLY PATIENTS

10.36106/ijar/4614203 ◽

2021 ◽

pp. 47-48

Author(s):

Smriti Anand ◽

Arjun Prasad ◽

Debarshi Jana

Keyword(s):

Elderly Patients ◽

Spinal Anesthesia ◽

Intravenous Administration ◽

Controlled Trial ◽

Sampling Technique ◽

P Value ◽

Double Blind ◽

Induced Hypotension ◽

Group A ◽

Group B

Objective: Hypotension is the commonest side effect associated with spinal anesthesia. Multiple modalities have been tested to nd adequate preventive measure. Main objective of this study is to nd out the effectiveness of prophylactic administration of inj. ondansetron for prevention of spinal anesthesia induced hypotension in elderly patients.Study design: Double blind, randomized controlled trial. Place and duration of study: This study was conducted in our anesthesiology department from March 2020 to August 2020.Method: 100 patients were selected for the study using non-probability sampling technique, and divided into two groups of 50 each using random numbers table. Each patient was preloaded with ringer's lactate solution in a dose of 10 ml/kg. Patients of Group A received 8 mg of ondansetron IV ve minutes prior to administration of spinal anesthesia; whereas patients of Group B were injected normal saline IV. Data were collected and analyzed using IBM SPSS version 20. Chi square test was used to compare hypotension between two groups. A p-value < 0.05 was taken as signicant. Results: Mean age of Group A was 64.16 ± 8.47 years, whereas that of Group B was 62.58 ± 8.99 (p value=0.39). Mean weight of Group A was 72.64 ± 5.82 kg, whereas that of Group B was 70.66 ± 5.96 kg (p - value=0.295). Hypotension was present in 23 (46%) patients in Group A, where as it was present in 34 (68%) patients in Group B (p value= 0.026). Bradycardia was recorded in 3(06%) vs.11(22%) patients in Group A and B respectively (p=0.021). Conclusion: We conclude that intravenous administration of 8 mg of ondansetron, 5 minutes prior to subarachnoid block, is effective in decreasing frequency of hypotension and bradycardia in elderly patients.

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The Effect of Nanocurcumin in Improvement of Knee Osteoarthritis: A Randomized Clinical Trial

Current Rheumatology Reviews ◽

10.2174/1874471013666191223152658 ◽

2020 ◽

Vol 16 (2) ◽

pp. 158-164

Author(s):

Kamila Hashemzadeh ◽

Najmeh Davoudian ◽

Mahmoud R. Jaafari ◽

Zahra Mirfeizi

Keyword(s):

Placebo Group ◽

Knee Osteoarthritis ◽

Controlled Trial ◽

Intervention Group ◽

Final Analysis ◽

Control Group ◽

P Value ◽

Antiinflammatory Drugs ◽

Double Blind ◽

Womac Questionnaire

Objective: Osteoarthritis is a degenerative disease of the joints. Non-steroidal antiinflammatory drugs (NSAIDs) are being used for the treatment of osteoarthritis. However, their use is limited due to complications, such as gastrointestinal bleeding. Therefore, it is necessary to find alternative treatments for osteoarthritis. Recently, nanomicelle curcumin has been developed to increase the oral bioavailability of curcumin. The aim of this study was to evaluate the effect of nano curcumin on the alleviation of the symptoms of knee osteoarthritis patients. Methods: In this randomized, double-blind controlled trial, the intervention group was administered 40 mg of nanocurcumin capsule every 12 hours over a period of six weeks, and the control group received the placebo (similar components of nanomicelle curcumin capsules yet without curcumin). In the final analysis, 36 patients in the nanocurcumin group and 35 patients in the placebo group were enrolled. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) was filled for patients in their first visit and at the end of six weeks. Differences were statistically significant at P-value < 0.05. Results: There were no significant differences between the two groups regarding gender, age, Kellgren score, and the duration of the disease before the intervention. A significant decrease was observed in the overall score, along with the scores of pain, stiffness and physical activity subscales of the WOMAC questionnaire in patients of the nano curcumin group compared with the placebo group. Conclusion: Nanocurcumin significantly improves the symptoms of osteoarthritis patients.

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Effectiveness of Child to Parent Communication Using Information Package on Food Hygiene

International Journal of Innovative Research in Medical Science ◽

10.23958/ijirms/vol03-i07/02 ◽

2018 ◽

Vol 3 (07) ◽

Author(s):

Ms. Sonam Yangchen Bhutia ◽

Dr. Sushma Kumari Saini ◽

Dr. Manmeet Kaur ◽

Dr. Sandhya Ghai

Keyword(s):

School Children ◽

Home Visit ◽

Controlled Trial ◽

Family Members ◽

Sampling Technique ◽

Control Group ◽

Food Hygiene ◽

Parent Communication ◽

Post Test ◽

Randomised Controlled

School children can act as change agent not only for families but for community. The study aimed to assess effectiveness of information package on knowledge and practices of parents/family members of school children studying in Govt. Sr. Sec. School on food hygiene in Dhanas and Daddu Majra Colony, UT, Chandigarh. A non-randomised controlled trial was conducted on 201 school children studying in VIIth standard and their parents/family members. Purposive sampling technique was utilised to enrol 101 in case and 100 participants in control group. Interview schedule for knowledge assessment and observation checklist for assessing the practices of parents/ family members was used. Pre assessment of both the groups was done by a home visit. Experimental group school children were educated on food hygiene as per the protocol. Pre and post-test knowledge of school children on food hygiene was assessed and were asked to disseminate the information to their parents/family members. After 15 days, second time home visit was done to the parents/family members of both the groups for the post assessment of knowledge and practices. Significant improvement in knowledge and practices of parents/family members related to food hygiene was observed. Hence, school children can be an effective tool in health related knowledge dissemination which can further promote healthy practices.

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Integrating Peer Learning Activities and Problem-Based Learning in Clinical Nursing Education

SAGE Open Nursing ◽

10.1177/23779608211000262 ◽

2021 ◽

Vol 7 ◽

pp. 237796082110002

Author(s):

Suci Tuty Putri ◽

Sri Sumartini

Keyword(s):

Nursing Education ◽

Problem Based Learning ◽

Sampling Technique ◽

Peer Learning ◽

Average Score ◽

Control Group ◽

P Value ◽

Clinical Learning ◽

Control Group Design ◽

Learning Achievement

Introduction The implementation of nursing clinical learning in Indonesia has several challenges that require innovation in the learning method strategy. The method that has been used so far focuses on the hierarchical relationship between lecturers/preceptors and students, so that there are many shortcomings in learning outcomes. The application of the method of active learning with Peer Learning (PL) and Problem Based Learning (PBL) techniques has proven effective in classroom learning, but its rarely found in clinical learning. Objective The purpose of this study was to determine the effectiveness of the PL and PBL towards the achievement of clinical learning in nursing students. Methods The research method used a true experiment with a posttest only control group design, the sampling technique was taken by randomize control trial. An instrument for clinical learning achievement using AssCE. Results The analysis was carried out as descriptive and bivariate. The results showed the mean in the experimental group was 7.059 and the control group was 6.325. Further statistical test results were obtained p-value = 0.001 (p < 0.05) which showed that the average score there were differences in clinical learning achievement development scores. Conclusion Clinical learning using peer learning and PBL methods can directly improve various aspects of student competency achievement.

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Mobile Health to Improve Adherence and Patient Experience in Heart Transplantation Recipients: The mHeart Trial

Healthcare ◽

10.3390/healthcare9040463 ◽

2021 ◽

Vol 9 (4) ◽

pp. 463

Author(s):

Mar Gomis-Pastor ◽

Sonia Mirabet Perez ◽

Eulalia Roig Minguell ◽

Vicenç Brossa Loidi ◽

Laura Lopez Lopez ◽

...

Keyword(s):

Heart Transplantation ◽

Patient Experience ◽

Mobile Application ◽

Standard Care ◽

Controlled Trial ◽

Intervention Group ◽

Group Versus ◽

Control Group ◽

P Value ◽

Adherence Score

Non-adherence after heart transplantation (HTx) is a significant problem. The main objective of this study was to evaluate if a mHealth strategy is more effective than standard care in improving adherence and patients’ experience in heart transplant recipients. Methods: This was a single-center, randomized controlled trial (RCT) in adult recipients >1.5 years post-HTx. Participants were randomized to standard care (control group) or to the mHeart Strategy (intervention group). For patients randomized to the mHeart strategy, multifaceted theory-based interventions were provided during the study period to optimize therapy management using the mHeart mobile application. Patient experience regarding their medication regimens were evaluated in a face-to-face interview. Medication adherence was assessed by performing self-reported questionnaires. A composite adherence score that included the SMAQ questionnaire, the coefficient of variation of drug levels and missing visits was also reported. Results: A total of 134 HTx recipients were randomized (intervention N = 71; control N = 63). Mean follow-up was 1.6 (SD 0.6) years. Improvement in adherence from baseline was significantly higher in the intervention group versus the control group according to the SMAQ questionnaire (85% vs. 46%, OR = 6.7 (2.9; 15.8), p-value < 0.001) and the composite score (51% vs. 23%, OR = 0.3 (0.1; 0.6), p-value = 0.001). Patients’ experiences with their drug therapy including knowledge of their medication timing intakes (p-value = 0.019) and the drug indications or uses that they remembered (p-value = 0.003) significantly improved in the intervention versus the control group. Conclusions: In our study, the mHealth-based strategy significantly improved adherence and patient beliefs regarding their medication regimens among the HTx population. The mHeart mobile application was used as a feasible tool for providing long-term, tailor-made interventions to HTx recipients to improve the goals assessed.

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