scholarly journals The association between consanguineous marriage and offspring with congenital hearing loss

2020 ◽  
Vol 40 (6) ◽  
pp. 456-461
Author(s):  
Aljohara M. Almazroua ◽  
Luluh Alsughayer ◽  
Rayanh Ababtain ◽  
Yazeed Al-shawi ◽  
Abdulrahman A. Hagr
Keyword(s):  
Hearing Loss ◽  
Cross Sectional Study ◽  
Consanguineous Marriage ◽  
Auditory Neuropathy ◽  
Congenital Hearing Loss ◽  
Inherited Disorders ◽  
Cross Sectional ◽  
Consanguineous Marriages ◽  
Parents And Children ◽  
Significant Difference

ABSTRACT BACKGROUND: Consanguinity is a commonly recognized practice among marriages in the Middle East and may lead to an increase in the prevalence of inherited disorders. Autosomal recessive deafness is the most common form of inherited congenital hearing loss (CHL). OBJECTIVES: Determine the association of consanguineous marriages with congenital sensorineural hearing loss (SNHL) and auditory neuropathy. DESIGN: Descriptive and analytical cross-sectional study. SETTING: Ear specialist hospital. PATIENTS AND METHODS: Children with severe-to-profound congenital SNHL, who had been referred to the specialist hospital for cochlear implant were analyzed. Patients were divided into subgroups based on degree of consanguinity. MAIN OUTCOME MEASURE: The relative risk of having more than one child with SNHL in offspring of a consanguineous marriage. SAMPLE SIZE: 189 parents and children with CHL. RESULTS: The parents of 157 children (83.1%) were blood-related. Of those, 48 had more than one child with CHL (31.4%), while only two parents who were not blood-related had more than one child with CHL (6.25%; P =.005). Among the 189 children, 131 (69.3%) parents were direct cousins. Only 39 (20.6%) and 43 (22.8%) children had family histories of CHL on the paternal and maternal sides, respectively. There was no statistically significant difference in the prevalence of auditory neuropathy between the offspring of consanguineous and non-consanguineous marriages ( P =.648). CONCLUSION: The risk of having more than one child with SNHL in the offspring from a consanguineous marriage is 3.5 times higher than that of a non-consanguineous mating. LIMITATION: The association of hearing loss degree with consanguinity was not studied. CONFLICT OF INTEREST: None.

scholarly journals Comparison of sensorineural hearing loss characteristics in different hemodialysis vascular accesses

2020 ◽  
Author(s):  
Behieh Kohansall ◽  
Nasser Saeedi ◽  
Moeinoddin Hossein Beigi ◽  
Azam Moslemi ◽  
Akram Valizadeh
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Vascular Access ◽  
Demographic Data ◽  
Life Quality ◽  
Cross Sectional Study ◽  
Sensorineural Hearing ◽  
Moderate Degree ◽  
Cross Sectional ◽  
Significant Difference

Background and Aim: Sensorineural hearing loss (SNHL) is one of the complications in hemodialysis patients. Vascular access (VA) represents a lifeline for these patients affecting their life quality and clinical outcomes. Arterio­venous fistula is the gold standard of VAs with minor complications and better hemodialysis adequacy. There is no study investigating hearing differences in hemodialysis VAs. Hence, this study aimed to compare SNHL characteristics amongst hemodialysis VAs. Methods: This cross-sectional study conducted on 64 patients aged 18−60 years received regular hemodialysis in 2019. Demographic data and comorbid conditions were recorded based on patients’ case records and electronic databases. After a physical examination, otoscopy, tympa­nometry, and conventional audiometry, patients were divided into fistula (n = 26), permanent catheter (n = 36), and temporary catheter (n = 2) groups according to vascular access type. Results: Prevalence rate of SNHL was 63.89%, 50% and 50% in the permanent catheter, fistula and temporary catheter groups, respectively. Most patients had mild sloping-SNHL in the per­manent catheter and fistula groups as against moderate degree in the other group. There was no significant difference in hearing thresholds, deg­ree and audiogram shape among VA groups. No significant relation was found between age, sex, hemodialysis duration and disease duration with hearing loss in all groups (p > 0.05). Conclusion: More patients had SNHL in per­manent catheter group. Vascular access types, longer duration of hemodialysis and disease dur­ation do not seem to be associated with SNHL. However, further investigation is needed to cla­rify the relationship. Keywords: Sensorineural hearing loss; vascular access; chronic renal failure; hemodialysis

PREVALENCE OF CONSANGUINEOUS MARRIAGES AMONG IRANIAN GEORGIANS

2010 ◽  
Vol 43 (1) ◽  
pp. 47-50 ◽  
Author(s):  
LALEH RAFIEE ◽  
MOSTAFA SAADAT
Keyword(s):  
Cross Sectional Study ◽  
Consanguineous Marriage ◽  
Cross Sectional ◽  
Isfahan Province ◽  
Consanguineous Marriages ◽  
Adverse Health Outcomes ◽  
Present Cross Sectional Study ◽  
Study Population ◽  
The Mean ◽  
High Level

SummaryConsanguineous marriage – marriage between relatives – has received a great deal of attention as a potential risk factor for many adverse health outcomes. The present cross-sectional study was done in order to illustrate the prevalence and types of consanguineous marriages among Iranian Georgians living in Frydoonshahr (Isfahan province, central Iran). Data on consanguineous marriages were collected using a simple questionnaire. The total number of couples in this study was 646. Consanguineous marriage was classified by the degree of relationship between couples. First cousin marriages (14.2%) were the most common type of consanguineous marriages, followed by second cousin (7.0%), beyond second cousin (1.5%) and first cousin once removed (0.6%). The mean inbreeding coefficient (α) was calculated as 0.0104 for the population. The present study shows that the study population, as other Iranian populations, has a high level of consanguinity.

scholarly journals Outcomes of Automated Auditory Evoked Potential Performed in Different Settings and the Factors Associated with Referred Cases

2017 ◽  
Vol 22 (04) ◽  
pp. 342-347
Author(s):  
Daniela Silva ◽  
Georgea Ribeiro ◽  
Gustavo Castilho ◽  
Jair Mantovani
Keyword(s):  
Hearing Loss ◽  
Evoked Potential ◽  
Cross Sectional Study ◽  
Auditory Evoked Potential ◽  
Sectional Study ◽  
Cross Sectional ◽  
Factors Associated ◽  
Hearing Status ◽  
Significant Difference ◽  
Age Of Diagnosis

Introduction For the population with risk factors for hearing loss, the first option to assess the hearing status is the performance of the automated brainstem auditory evoked potential (BAEP) test because of its efficacy in identifying retrocochlear hearing loss. Objective To verify the outcomes of automated BAEP performed in different settings as well as the factors associated with the prevalence of hearing impairment. Methods Cross-sectional study conducted from October of 2014 to May of 2015. The sample consisted of 161 infants with at least one risk factor for hearing loss who underwent automated BAEP during the hospital stay or at the outpatient clinic. After 30 days, the altered cases were referred for BAEP diagnosis. Results One hundred and thirty-eight infants (86%) had a result of “pass” and 23 (14%) of “failure” in the automated BAEP. There was no statistically significant difference in the rate of “referred” results between examinations performed in different settings. The infants' ages did not influence the number of abnormal cases. All of the 23 infants who presented a “referred” result in the automated BAEP, unilateral or bilateral, were sent for BAEP diagnosis, and out of these, 9 (39%) remained with at least some degree of alteration. The average age of diagnosis was 2.7 months. Conclusion The results of the automated BAEP were similar when performed during hospitalization or after discharge. Neither the age at the examination nor the gender of the patient influenced the prevalence of hearing loss.

scholarly journals Public awareness of ear health and hearing loss in Jeddah, Saudi Arabia

2019 ◽  
Vol 66 (1) ◽  
Author(s):  
Khalid A. Alshehri ◽  
Waleed M. Alqulayti ◽  
Bassam E. Yaghmoor ◽  
Hisham Alem
Keyword(s):  
Hearing Loss ◽  
Saudi Arabia ◽  
Family History ◽  
Public Awareness ◽  
Cross Sectional Study ◽  
World Health ◽  
Public Knowledge ◽  
Cross Sectional ◽  
Significant Difference ◽  
Health Organization

Background: Knowledge of ear health and hearing loss is essential for early intervention and treatment, but the state of public knowledge of such in Jeddah, Saudi Arabia, remains unknown.Objectives: To measure public knowledge of ear health and hearing loss.Method: This cross-sectional study was conducted during August 2018 in Jeddah, Saudi Arabia. An electronic survey questionnaire was distributed to 2372 residents of various districts in Jeddah. The survey was created in 2013 by adopting previously published World Health Organization material, designed to assess knowledge and perception of ear health. All males and females aged 10 years or older living in Jeddah had the chance to participate in this study. A total of 2372 people participated. Percentages mean ± standard deviation, one-way analysis of variance (ANOVAs) and independent t-tests were applied to determine the significant difference. p-values of 0.05 or less were considered significant.Results: The overall mean number of correct responses on the survey’s true/false questionnaire was 10.66 ± 1.92 out of 14. Female participants gave a higher mean number of correct answers than did male participants (10.73 ± 2.03 vs. 10.54 ± 2.03, respectively). Participants with a family history of hearing loss gave a higher mean number of correct answers compared with participants who reported a negative family history (10.89 ± 1.82 vs. 10.53 ± 1.97, respectively).Conclusion: Overall awareness of ear health and hearing loss management is fair. However, the results indicate a need for more integrated educational materials to be made available both to the general population as well as to hearing loss individuals and their families.

PREVALENCE OF CONSANGUINEOUS MARRIAGES IN WEST AND SOUTH OF AFGHANISTAN

2012 ◽  
Vol 45 (6) ◽  
pp. 799-805 ◽  
Author(s):  
MOSTAFA SAADAT ◽  
KHADIJEH TAJBAKHSH
Keyword(s):  
Ethnic Groups ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Consanguineous Marriages ◽  
Present Cross Sectional Study ◽  
Significant Difference ◽  
Different Types ◽  
The Mean ◽  
Coefficient Of Inbreeding

SummaryThe prevalence of consanguinity in eight provinces of Afghanistan has recently been reported by Saify & Saadat (2012). The present cross-sectional study was done in order to illustrate the prevalence and types of consanguineous marriages among other populations of Afghanistan. Data on types of marriages were collected using a simple questionnaire. The total number of couples in this study was 5200 from the following provinces: Farah, Ghazni, Herat, Hilmand, Kabul, Kandahar, Logar, Parwan and Wardak. Consanguineous marriages were classified by the degree of relationship between couples: double first cousins, first cousins, first cousins once removed, second cousins and beyond second cousins. The coefficient of inbreeding (F) was calculated for each couple and the mean coefficient of inbreeding (α) estimated for each population. The α in the country was 0.0226, ranging from 0.0203 in Farah province to 0.0246 in Herat province. There were significant differences between provinces for frequencies of different types of marriages (p<0.001). First cousin marriages (21.7%) were the most common type of consanguineous marriages, followed by second cousins (16.0%), first cousins once removed (14.0%), beyond second cousins (6.9%) and double first cousins (1.6%). There was significant difference between ethnic groups for the types of marriages (p<0.001). Tajiks (Soni) and Sadats showed the lowest (α=0.0215) and highest (α=0.0242) levels of consanguinity among ethnic groups in Afghanistan, respectively. The present study shows that the Afghani populations, the same as other Islamic populations, have high levels of consanguinity.

scholarly journals A survey of violence and vulgarity in children television programs: a content analysis, and assessment of perceptions of parents and children (ViCTiM study)

2021 ◽  
Author(s):  
Ashraf Jahangeer ◽  
Manahil Akmal ◽  
Bushra Perveen ◽  
Maaz Bin Nazir ◽  
Faryal Mustafa ◽  
...  
Keyword(s):  
Content Analysis ◽  
Federal Communication Commission ◽  
World Health Organisation ◽  
The United States ◽  
Cross Sectional Study ◽  
World Health ◽  
Television Programs ◽  
Cross Sectional ◽  
Parents And Children ◽  
Significant Difference

Abstract Objectives: To quantify the depiction of violence and vulgarity in television programmes for children, and to assess the perception and practices of parents and children about television programmes meant for children. Methods:  We conducted this mixed-methods cross-sectional study in Karachi, Pakistan in the months of August-September 2018, after approval from the ethics review board of Dow University of Health Sciences, Karachi. First, a content analysis of over 102 hours of various television programmes meant for children was performed in the light of the guidelines set out by the World Health Organisation, the United States Federal Communication Commission and the Pakistan Electronic Media Regulatory Authority. Seven trained researchers sampled the children prime time throughout a week, including the weekends, using a structured tally sheet. Subsequently, interviews were conducted with dyad of parent-children from the employees’ list of a public-sector university. A questionnaire was also administered to assess the practices and perceptions of the parents-children dyad about the programmes.  Data was analysed using SPSS 24. Results: Of the 173 subjects, 84(48.6%) were parents and 89(51.4%) were children. The mean age of the children was 89 children 9.8±3.7 years. Content analysis comprised 6130 minutes, of which 5442(88.8%) had depictions of violence and vulgarity. Depiction of violence and vulgarity was prevalent on television channels that were watched the most, but there was no significant difference in this regard (p=0.238). Of the parents, 68(81%) expressed concern over the effect of screen time and content on the mental health of their children.

PREVALENCE OF CONSANGUINEOUS MARRIAGES IN SYRIA

2009 ◽  
Vol 41 (5) ◽  
pp. 685-692 ◽  
Author(s):  
HASAN OTHMAN ◽  
MOSTAFA SAADAT
Keyword(s):  
Rural Areas ◽  
Urban Areas ◽  
Cross Sectional Study ◽  
Consanguineous Marriage ◽  
Common Type ◽  
Cross Sectional ◽  
Consanguineous Marriages ◽  
The Mean ◽  
Urban And Rural Areas ◽  
Coefficient Of Inbreeding

SummaryConsanguineous marriage is the union of individuals having at least one common ancestor. The present cross-sectional study was done in order to illustrate the prevalence and types of consanguineous marriages in the Syrian Arab Republic. Data on consanguineous marriages were collected using a simple questionnaire. The total number of couples in this study was 67,958 (urban areas: 36,574 couples; rural areas: 31,384 couples) from the following provinces: Damascus, Hamah, Tartous, Latakia, Al Raqa, Homs, Edlep and Aleppo. In each province urban and rural areas were surveyed. Consanguineous marriage was classified by the degree of relationship between couples: double first cousins (F=1/8), first cousins (F=1/16), second cousins (F=1/64) and beyond second cousins (F<1/64). The coefficient of inbreeding (F) was calculated for each couple and the mean coefficient of inbreeding (α) estimated for the population of each province, stratified by rural and urban areas. The results showed that the overall frequency of consanguinity was 30.3% in urban and 39.8% in rural areas. Total rate of consanguinity was found to be 35.4%. The equivalent mean inbreeding coefficient (α) was 0.0203 and 0.0265 in urban and rural areas, respectively. The mean proportion of consanguineous marriages ranged from 67.5% in Al Raqa province to 22.1% in Latakia province. The α-value ranged from 0.0358 to 0.0127 in these two provinces, respectively. The western and north-western provinces (including Tartous, Lattakia and Edlep) recorded lower levels of inbreeding than the central, northern and southern provinces. The overall α-value was estimated to be about 0.0236 for the studied populations. First cousin marriages (with 20.9%) were the most common type of consanguineous marriages, followed by double first cousin (with 7.8%) and second cousin marriages (with 3.3%), and beyond second cousin was the least common type.

PREVALENCE OF CONSANGUINEOUS MARRIAGES AMONG SHI'A POPULATIONS OF LEBANON

2013 ◽  
Vol 45 (5) ◽  
pp. 675-682 ◽  
Author(s):  
GHADIR EL-KHESHEN ◽  
MOSTAFA SAADAT
Keyword(s):  
Urban Areas ◽  
Cross Sectional Study ◽  
Consanguineous Marriage ◽  
Cross Sectional ◽  
Rural And Urban Areas ◽  
Consanguineous Marriages ◽  
Rural And Urban ◽  
Present Cross Sectional Study ◽  
Different Types ◽  
The Mean

SummaryIn genetics, a consanguineous marriage means union between couples who are related as second cousins or closer. The present cross-sectional study was carried out in order to illustrate the prevalence and types of consanguineous marriages in the Shi'a population living in widespread territories in Lebanon including the Bekaa Valley, the south of Lebanon and the southern suburb of Beirut. Data on types of marriages were collected using a simple questionnaire. The total number of couples in the study was 1203. Consanguineous marriage was classified by the degree of relationship between couples. The overall frequency of consanguinity was found to be 28.4%, with first cousin marriages (21.3%) being the most common type followed by first cousins once removed (5.5%), then double first cousins (0.8%). The frequencies of second cousin and beyond second cousin marriages were the same at 0.4% of all the marriages. The mean inbreeding coefficient (α) was estimated at about 0.0161 for the population. There were no significant differences between the three studied territories for frequencies of different types of marriages (p>0.1), nor were there significant differences between the rural and urban areas (p>0.1).

scholarly journals Prevalence and risk factors of hearing loss in children with solid tumors treated with platinum-based chemotherapy

2015 ◽  
Vol 55 (3) ◽  
pp. 121
Author(s):  
Eka D Edward ◽  
Nelly Rosdiana ◽  
Farhat Farhat ◽  
Olga Rasiyanti Siregar ◽  
Bidasari Lubis
Keyword(s):  
Risk Factors ◽  
Hearing Loss ◽  
Solid Tumors ◽  
Otoacoustic Emission ◽  
Cross Sectional Study ◽  
Eligibility Criteria ◽  
Cross Sectional ◽  
Chemotherapy Drugs ◽  
Platinum Based Chemotherapy ◽  
Significant Difference

Background The platinum-based chemotherapy drugs, cisplatin and carboplatin, are widely used in the treatment of several types of solid tumors. However, the treatment has side effects including hearing loss.Objective To evaluate the prevalence of hearing loss related to platinum-based chemotherapy and to identify associated factors.Methods A cross-sectional study was performed in Adam Malik Hospital, Medan, North Sumatera, from April to July 2012. Twenty-two subjects who fulfilled the eligibility criteria underwent otoacoustic emission evaluations. Eleven children had received cisplatin and eleven had received carboplatin. The association between hearing loss and risk factors was assessed using Fisher’s exact and Chi-square tests.Results Seven subjects with hearing loss were identified. Five of these patients (5 out of 11) had received cisplatin and 2 patients (2 out of 11) had received carboplatin. There was no statistically significant difference between carboplatin- and cisplatin-associated hearing loss (P=0.361). Neither gender (P=0.452) nor age (P=0.212) was related to hearing loss. However, higher cumulative chemotherapy doses (cisplatin >600 mg/m² and carboplatin >1800 mg/m²) were associated with hearing loss (P=0.022 and P=0.004, respectively).Conclusion Patients who had higher cumulative doses of platinum-based chemotherapy are at risk for developing hearing loss.

scholarly journals Media use and behavioral disorders among Saudi Arabian children

2021 ◽  
Author(s):  
Salmah Alghamdi ◽  
Duaa Bawageeh ◽  
Hessa Alkhaibari ◽  
Amwaj Almutairi ◽  
Shoug Aljuhani
Keyword(s):  
Behavioral Problems ◽  
Media Use ◽  
Cross Sectional Study ◽  
Healthy Children ◽  
Cross Sectional ◽  
Convenience Sample ◽  
Children's Behavior ◽  
Frequent Use ◽  
Parents And Children ◽  
Significant Difference

Background: Despite children’s frequent use of electronic devices, there is a lack of evidence showing how such media use influences their behavior.Objective: This study was to assess the relationship between media use and behavior among a sample of children aged three to 11 years.Methods: This was a descriptive cross-sectional study. An electronic self-administered questionnaire was completed from January 2020 to March 2020 by a convenience sample of 234 parents with healthy children in the target age group. Descriptive statistics and One-Way Analysis of Variance (ANOVA) were used for data analysis.Results: There was no significant difference in children's behavior according to the type of media [F(3, 230) = 1.673, p = 0.174]. In contrast, there was a significant difference in children's behavior according to hours per day of media use [F(4, 229) = 2.701, p = 0.031]. The most commonly used mobile device was the smartphone (n = 87, 37.2%).  More than a quarter of the children spent three hours a day using media.Conclusions: This study offers insight into associations between children’s frequent media use and their behavior. The results suggest that the significant factor associated with behavioral problems is not the type of media but the time spent using it. Nurses are encouraged to use these findings in developing educational programs that raise awareness among parents and children regarding the consequences of excessive media use. 

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