scholarly journals MODERN POSSIBILITIES OF INTERVENTION RADIOLOGY IN THE TREATMENT OF ACUTE PANCREATITIS AND ITS COMPLICATIONS (literature review)

2017 ◽  
pp. 4-9
Author(s):  
V. M. Mayorov ◽  
Z. A. Dundarov
Keyword(s):  
Pancreatic Necrosis ◽  
Inflammatory Diseases ◽  
Celiac Trunk ◽  
Arterial Infusion ◽  
Chronic Inflammatory Diseases ◽  
Severe Pancreatitis ◽  
The World ◽  
Percutaneous Punctures ◽  
Surgical Tactics ◽  
Omental Bursa

Wide use of interventional radiology methods is one of the promising trends in the improvement of the treatment of patients with severe pancreatitis. The minimally invasive interferences carried out under beam rider guidance, such as percutaneous punctures and percutaneous drainage, endovascular hemostasis and endovascular catheterization of celiac trunk, are effective at all stages of the course of severe pancreatitis, and make it possible to avoid open operational interference in 40-90 % cases and to decrease mortality up to 8-9 %. The article presents the review of national and foreign publications dealing with controversial questions of surgical tactics in sharp liquid formations of the pancreas and omental bursa, effectiveness of the use of percutaneous draining operational interference in infected pancreatic necrosis and parapancreatitis. The world experience of endovascular stoppage of major haemorrhagic complications in patients with acute and chronic inflammatory diseases of the pancreas has been summarized. Questions of the selective intra-arterial infusion of medicines in severe pancreatitis have been studied.

scholarly journals Cáncer en fauna silvestre

2021 ◽  
Vol 5 (13) ◽  
pp. 47-60
Author(s):  
Marina Guadarrama Olhovich
Keyword(s):  
Animal Species ◽  
Inflammatory Diseases ◽  
Environmental Pollutants ◽  
Genetic Alterations ◽  
Infectious Agents ◽  
Chronic Inflammatory Diseases ◽  
The World ◽  
Different Types

There are different types of cancer that occur for different reasons: genetic alterations, environmental pollutants, infectious agents, chronic inflammatory diseases, and so on. Although not exactly known all the causes that can trigger it, it has been proven that in many cases its origin can be the same in humans and animals, not only domestic, but also wild, including rhinos, jaguars, deer, elephants, which can develop this disease but because of the conditions where they live, it is difficult to care for them. Here we will review how some animal species in certain parts of the world have some types of cancer, that being in other places or if they were of another species they would not develop it, and we can also understand how there are families of individuals with cancer and others not. As well as the influence of the environment and certain diseases that can lead to this condition.

Rhinoscleroma and Rhinosporidiosis

1992 ◽  
Vol 101 (10) ◽  
pp. 879-882 ◽  
Author(s):  
John G. Batsakis ◽  
Akel K. El-Naggar
Keyword(s):  
Differential Diagnosis ◽  
Nasal Cavity ◽  
North American ◽  
Inflammatory Diseases ◽  
Upper Airway ◽  
Chronic Inflammatory Diseases ◽  
Rhinosporidium Seeberi ◽  
The World

For North American otolaryngologists, rhinoscleroma and rhinosporidiosis are moving more into the differential diagnosis of chronic inflammatory diseases of the upper airway, particularly the nasal cavity. This change is occasioned by the influx of immigrants from parts of the world to which the diseases are endemic. Diagnosis is established by identification of the causal organisms, the readily seen Rhinosporidium seeberi for rhinosporidiosis and the more elusive Klebsiella rhinoscleromatis for rhinoscleroma.

scholarly journals Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A Review

2019 ◽  
Vol 9 (5) ◽  
pp. 311-328 ◽  
Author(s):  
Rufin Marie Kouipou Toghueo
Keyword(s):  
Side Effects ◽  
Inflammatory Diseases ◽  
The Other ◽  
Bioactive Metabolites ◽  
Chronic Inflammatory Diseases ◽  
The Past ◽  
The World ◽  
The Status ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract Leishmaniases and chronic inflammatory diseases are the cause of millions of deaths in the world each year. The treatment of leishmaniasis is facing serious drawbacks particularly due to the limited number of effective medicines, the resistance, and the toxicity of available drugs. On the other hand, many drugs are used for the management of inflammatory disorders. However, the most commonly prescribed although efficient is highly toxic with multiples side effects. New leads compounds for the development of new anti-leishmanial and anti-inflammatory drugs are needed. Over the past decade, several studies on the potential of endophytes to produce bioactive metabolites have been reported. We are presenting in the present review the status of research from 2000 to 2019 on the anti-leishmanial and anti-inflammatory metabolites isolated from endophytes from diverse habitats. An emphasis was put on existing gaps in the literature to inspire and guide future investigations. We hope that this review will help accelerate the drug discovery against leishmaniases and inflammation-associated disorders. Graphic Abstract

Chronic Inflammatory Diseases: Progress and Prospect with Herbal Medicine

2015 ◽  
Vol 22 (2) ◽  
pp. 247-264 ◽  
Author(s):  
Nilanjan Ghosh ◽  
Asif Ali ◽  
Rituparna Ghosh ◽  
Shaileyee Das ◽  
Subhash C. Mandal ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Inflammatory Diseases ◽  
Chronic Inflammatory Diseases

Exploiting Anti-Inflammation Effects of Flavonoids in Chronic Inflammatory Diseases

2020 ◽  
Vol 26 (22) ◽  
pp. 2610-2619 ◽  
Author(s):  
Tarique Hussain ◽  
Ghulam Murtaza ◽  
Huansheng Yang ◽  
Muhammad S. Kalhoro ◽  
Dildar H. Kalhoro
Keyword(s):  
Oxidative Stress ◽  
Chronic Diseases ◽  
Inflammatory Diseases ◽  
Therapeutic Option ◽  
Cellular Level ◽  
Antiinflammatory Drugs ◽  
Suitable Alternative ◽  
Chronic Inflammatory Diseases

Background: Inflammation is a complex response of the host defense system to different internal and external stimuli. It is believed that persistent inflammation may lead to chronic inflammatory diseases such as, inflammatory bowel disease, neurological and cardiovascular diseases. Oxidative stress is the main factor responsible for the augmentation of inflammation via various molecular pathways. Therefore, alleviating oxidative stress is effective a therapeutic option against chronic inflammatory diseases. Methods: This review article extends the knowledge of the regulatory mechanisms of flavonoids targeting inflammatory pathways in chronic diseases, which would be the best approach for the development of suitable therapeutic agents against chronic diseases. Results: Since the inflammatory response is initiated by numerous signaling molecules like NF-κB, MAPK, and Arachidonic acid pathways, their encountering function can be evaluated with the activation of Nrf2 pathway, a promising approach to inhibit/prevent chronic inflammatory diseases by flavonoids. Over the last few decades, flavonoids drew much attention as a potent alternative therapeutic agent. Recent clinical evidence has shown significant impacts of flavonoids on chronic diseases in different in-vivo and in-vitro models. Conclusion: Flavonoid compounds can interact with chronic inflammatory diseases at the cellular level and modulate the response of protein pathways. A promising approach is needed to overlook suitable alternative compounds providing more therapeutic efficacy and exerting fewer side effects than commercially available antiinflammatory drugs.

scholarly journals Lipid, fatty acid, carnitine- and choline derivative profiles in rheumatoid arthritis outpatients with different degrees of periodontal inflammation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kathrin Beyer ◽  
Stein Atle Lie ◽  
Bodil Bjørndal ◽  
Rolf K. Berge ◽  
Asbjørn Svardal ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Fatty Acid ◽  
Mitochondrial Dysfunction ◽  
Inflammatory Diseases ◽  
Whole Body ◽  
Cross Sectional ◽  
Chronic Inflammatory Diseases ◽  
Periodontal Inflammation ◽  
Inflammatory Status ◽  
Lipid Fatty Acid

AbstractRheumatoid arthritis (RA) and periodontitis are chronic inflammatory diseases with several pathogenic pathways in common. Evidence supports an association between the diseases, but the exact underlying mechanisms behind the connection are still under investigation. Lipid, fatty acid (FA) and metabolic profile alterations have been associated with several chronic inflammatory diseases, including RA and periodontitis. Mitochondria have a central role in regulating cellular bioenergetic and whole-body metabolic homeostasis, and mitochondrial dysfunction has been proposed as a possible link between the two disorders. The aim of this cross-sectional study was to explore whole-blood FA, serum lipid composition, and carnitine- and choline derivatives in 78 RA outpatients with different degrees of periodontal inflammation. The main findings were alterations in lipid, FA, and carnitine- and choline derivative profiles. More specifically, higher total FA and total cholesterol concentrations were found in active RA. Elevated phospholipid concentrations with concomitant lower choline, elevated medium-chain acylcarnitines (MC-AC), and decreased ratios of MC-AC and long-chain (LC)-AC were associated with prednisolone medication. This may indicate an altered mitochondrial function in relation to the increased inflammatory status in RA disease. Our findings may support the need for interdisciplinary collaboration within the field of medicine and dentistry in patient stratification to improve personalized treatment. Longitudinal studies should be conducted to further assess the potential impact of mitochondrial dysfunction on RA and periodontitis.

scholarly journals Techniques to Study Inflammasome Activation and Inhibition by Small Molecules

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1704
Author(s):  
Diego Angosto-Bazarra ◽  
Cristina Molina-López ◽  
Alejandro Peñín-Franch ◽  
Laura Hurtado-Navarro ◽  
Pablo Pelegrín
Keyword(s):  
Inflammatory Response ◽  
Small Molecules ◽  
Mechanism Of Action ◽  
Inflammatory Diseases ◽  
Inflammasome Activation ◽  
Chronic Inflammatory Diseases ◽  
Anti Inflammatory ◽  
Inhibitory Molecules ◽  
Inflammasome Inhibitors

Inflammasomes are immune cytosolic oligomers involved in the initiation and progression of multiple pathologies and diseases. The tight regulation of these immune sensors is necessary to control an optimal inflammatory response and recover organism homeostasis. Prolonged activation of inflammasomes result in the development of chronic inflammatory diseases, and the use of small drug-like inhibitory molecules are emerging as promising anti-inflammatory therapies. Different aspects have to be taken in consideration when designing inflammasome inhibitors. This review summarizes the different techniques that can be used to study the mechanism of action of potential inflammasome inhibitory molecules.

scholarly journals Impact of COVID-19 on initiation of biologic therapy prescriptions for chronic inflammatory diseases

2021 ◽  
pp. 105253
Author(s):  
Pascal Richette ◽  
Matthieu Allez ◽  
Vincent Descamps ◽  
Lucas Perray ◽  
Simon Pilet ◽  
...  
Keyword(s):  
Biologic Therapy ◽  
Inflammatory Diseases ◽  
Chronic Inflammatory Diseases

scholarly journals The mercapturomic profile of health and non-communicable diseases

2019 ◽  
Vol 8 (2) ◽  
pp. 10 ◽  
Author(s):  
Gonçalves-Dias ◽  
Morello ◽  
Semedo ◽  
Correia ◽  
Coelho ◽  
...  
Keyword(s):  
Environmental Exposure ◽  
Inflammatory Diseases ◽  
Communicable Diseases ◽  
Non Communicable Diseases ◽  
Chronic Inflammatory Diseases ◽  
Cardiometabolic Diseases ◽  
Health And Disease ◽  
Endogenous Metabolites

The mercapturate pathway is a unique metabolic circuitry that detoxifies electrophiles upon adducts formation with glutathione. Since its discovery over a century ago, most of the knowledge on the mercapturate pathway has been provided from biomonitoring studies on environmental exposure to toxicants. However, the mercapturate pathway-related metabolites that is formed in humans—the mercapturomic profile—in health and disease is yet to be established. In this paper, we put forward the hypothesis that these metabolites are key pathophysiologic factors behind the onset and development of non-communicable chronic inflammatory diseases. This review goes from the evidence in the formation of endogenous metabolites undergoing the mercapturate pathway to the methodologies for their assessment and their association with cancer and respiratory, neurologic and cardiometabolic diseases.

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