Behavior of rats treated with Rhus toxicodendron 200cH

2021 ◽  
Vol 7 (22) ◽  
pp. 3-6
Author(s):  
Marcos Paulo da Silva Rocha ◽  
Fernanda Martins Soares ◽  
Lucienne Colombo Martini ◽  
Leoni Villano Bonamin
Keyword(s):  
Experimental Model ◽  
Open Field ◽  
Animal Behavior ◽  
High Dilution ◽  
Palabras Clave ◽  
Study Results ◽  
Level Of Significance ◽  
Articular Pain ◽  
Initial Pattern ◽  
Behavior Of Rats

One of the main pathogenetic characteristics of Rhus toxicodendron (Rhus-t) is the presence of articular pain and aggravation on standing, which improve only by motion. The present study proposes an experimental model to evaluate the action of Rhus-t 200cH. Rats were divided into 3 groups according to treatment received (Rhus-t, diazepam and water); each group was further divided into two sub-groups according to the initial pattern of behavior (hyperactive and hypoactive) as assessed by open-field procedure. A second evaluation of behavior performed 24 hours later pointed out to the effects of the medications under study. Results were analyzed through Kruskal-Wallis/Dunn’s test, with a level of significance p=0.05. Keywords: Rhus toxicodendron; Animal behavior; Open-field; Idiosyncrasy.   Conduta de ratos tratados com Rhus toxicodendron 200cH Resumo Uma das características patogenéticas principais de Rhus toxicodendron (Rhus-t) é a presença de dor articular e agravação em pé, melhorando exclusivamente com o movimento. O presente estudo propõe um modelo experimental para avaliar a ação de Rhus-t 200cH. Ratos foram divididos em 3 grupos de tratamento (Rhus-t, diazepam e água); cada grupo doi subdividido em 2 subgrupos de acordo com o padrão inicial de conduta (hiper e hipoativos) em procedimento de campo aberto. Uma segunda avaliação da conduta, realizada 24 horas após, indicou o efeito dos medicamentos sob estudo. Os resultados foram analisados pelo teste de Kruskal-Ealis/Dunn com nível de significância p=0,05. Palavras-chave: Rhus toxicodendron; comportamento animal; Campo aberto; idiossincrasia.   Conducta da ratones tratados con Rhus toxicodendron 200cH Resumen Una de las principales características patogenéticas de Rhus toxicodendron (Rhus-t) es la presencia de dolor articular y agravación de pie, que mejora exclusivamente por el movimiento. Este estudio propone un modelo experimental para evaluar la acción de Rhus-t 200cH. Ratones fueron divididos en 3 grupos de tratamiento (Rhus-t, diazepam y agua); cada grupo fue subdividido en 2 subgrupos según el padrón inicial de conducta (hiper e hipoactivos) en procedimiento de campo abierto. Una segunda evaluación de la conducta, realizada 24 horas después, indicó el efecto de los medicamentos en estudio. Los resultados fueron analizados por el test de Kruskal-Wallis/Dunn con nivel de significancia p=0,05. Palabras-clave: Rhus toxicodendron; Comportamiento animal; campo abierto; Idiosincrasia.   Correspondence author: Leoni Villano Bonamin; Universidade Paulista, Brazil; [email protected] How to cite this article: Rocha MPS, Soares FM, Martini LC, Bonamin LV. Behavior of rats treated with Rhus toxicodendron 200cH. Int J High Dilution Res [online]. 2008 [cited YYYY Mmm DD]; 7(22): 3-6. Available from: http://journal.giri-society.org/index.php/ijhdr/article/view/265/333.  

scholarly journals URINARY RETENTION EFFECT IN THE INCREASED OF PSA EXPRESSION WITHIN PROSTATIC TISSUE

2015 ◽  
Vol 22 (2) ◽  
Author(s):  
Wahjoe Djatisoesanto ◽  
Doddy M Soebadi ◽  
I Ketut Sudiana
Keyword(s):  
Urinary Retention ◽  
Blood Circulation ◽  
Acute Inflammation ◽  
Study Data ◽  
Prostatic Tissue ◽  
Control Group ◽  
Systemic Blood ◽  
Study Results ◽  
Level Of Significance ◽  
Prostatic Gland

Objective: To determine whether the increased of PSA expression within prostatic tissue and subsequent systemic blood circulation in acute urinary retention cases of nonmalignant origin were caused by acute inflammation on the prostatic gland. Following this inflammation, PSA willincrease, producing byacinar epitelial cells in the gland and continue to capillary vessels before entering the blood circulation. Material & method: Thirty male Rattus Norvegicus were randomly allocated into 3 groups. A control group underwent urethral manipulation, treatment-1 group and -2 group underwent proximal urethral ligation. Prostatectomy was performed after 24 hours in the control and treatment-1 group. Ligation was removed after 24 hours in treatment-2 group, and prostatectomy performed after 4x24 hours. Each prostate specimen was examined for PSA expression by immunohistochemistry methods in the prostatic gland. Statistical analysis of study data was analyzed by descriptive statistics and performed ANOVA with level of significance α = 0.01.Results: Study results showed an increase PSA expression significantly after urinary retention and returned to normal values four days later after relief of retention.Conclusion: Urinary retention caused acute inflammation on the prostatic gland and increased PSA expression within prostatic tissue. Entry of PSA into stroma and subsequent systemic blood circulation occur through significant increase in PSA production by acinar epithelial cells.

scholarly journals Effect of Threonine and the Bioactive Component of Saccharomyces Cerevisiae on the Productive Performance of the Broiler Cobb 500

2021 ◽  
Author(s):  
J. Encalada Álvarez ◽  
P. Toalombo Vargas ◽  
C. Vimos Abarca ◽  
J. Trujillo Villacís ◽  
L. Silva Deley
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Broiler Chickens ◽  
Cost Benefit ◽  
Experimental Unit ◽  
Control Group ◽  
Productive Performance ◽  
Growth Promoters ◽  
Bioactive Component ◽  
Palabras Clave ◽  
Level Of Significance

This study was conducted in Chimborazo province, Riobamba Canton to evaluate the effect of threonine and the bioactive component of Saccharomyces cerevisiae on the productive performance of the broiler Cobb 500. A total of 270 one-day-old broiler chicken of both sexes were included, which corresponded to an experimental unit size of 15 birds. Two growth promoters were used for the treatments -- T1: Threonine (aminoacid) 200 g/Tn; and T2: bioactive oligosaccharides, obtained from the cell wall of selected strains of S. Cerevisiae (probiotic) 750 g/Tn. These were compared to a control group. The data were analyzed through Analysis of Variance (ADEVA). The separation of means was performed using the Tukey statistic at a level of significance of p < 0.05 and p < 0.01. The data were processed using the Infostat software version 2010. The results showed that the best productive yields were with treatment 2; the values for this treatment were: weight at 28 days: 1369.42 g; weight gain at 28 days: 48.90 g; food conversion at 28 days: 1.39 points; carcass weight: 2527.05 g; and yield to the carcass: 83.85%. Through the economic analysis, it was determined that the highest cost-benefit index was 1.30 USD with the application of T2. So according to the results, a better use of the nutrients that are present in the feed is achieved when bioactive components of S. cerevisiae are supplied in the diet of broiler chickens. Keywords: Threonine, Saccharomyces cerevisiae, productive performance, broiler, Cobb 500. RESUMEN Se realizó un experimento en la provincia de Chimborazo, Cantón Riobamba, para evaluar los efectos de treonina y componentes bioactivos de Saccharomyces cerevisiae sobre el comportamiento productivo en aves Cobb 500. Se utilizaron 270 pollitos mixtos Cobb 500 de un día de edad de ambos sexos, con un tamaño de unidad experimental de 15 aves. Para los tratamientos se manejaron dos promotores de crecimiento, T1: Treonina (aminoácido) 200 g/Tn y T2: Oligosacáridos bioactivos, obtenidos a partir de la pared celular de cepas seleccionadas de S. Cerevisiae750 g/Tn; frente a un testigo (T0). Los datos obtenidos fueron sometidos a Análisis de Varianza (ADEVA); la separación de medias se realizó mediante el estadístico Tukey a un nivel de significancia (p < 0,05) y (p < 0,01); los datos se procesaron mediante el software Infostat versión 2010. Los resultados muestran los mejores rendimientos productivos con el Tratamiento 2, para los parámetros: peso a los 28 días 1369,42 g; ganancia de peso a los 28 días 48,90 g; y conversión alimenticia a los 28 días con 1,39 puntos; así como peso a la canal 2527,05 g; y rendimiento a la canal 83,85%. Mediante el análisis económico se determinó que el mayor índice beneficio costo fue de 1,30 USD con la aplicación del T2. Lo que brinda un indicativo que mediante el suministro de componentes bioactivos de S. cerevisiae en la dieta de pollos broiler, se logra un mejor aprovechamiento de los nutrientes que se encuentran presentes en el alimento, lo que se refleja en los parámetros productivos. Palabras clave: treonina, Saccharomyces cerevisiae, comportamiento productivo, broilers, Cobb 500.

CHANGES IN BEHAVIOR OF LABORATORY RATS WHEN EXPOSED TO VARIOUS SENSORY ORGANS: VISION, TASTE, SMELL

2021 ◽  
Author(s):  
Алина Викторовна Свиридова ◽  
Дарья Сергеевна Николенко ◽  
Мария Владимировна Абрамян ◽  
Владимир Вячеславович Алексеев
Keyword(s):  
Field Experiment ◽  
Open Field ◽  
Chronic Exposure ◽  
Stressful Situation ◽  
Sensory Organs ◽  
Laboratory Rats ◽  
Adaptive Nature ◽  
Behavior Of Rats

В работе представлены выявленные изменения поведения крыс при проведении эксперимента «Открытое поле» с хроническим воздействием на различные анализаторы крыс. Предположен адаптивный характер полученных результатов, связанный со стрессовой ситуацией при воздействии на органы чувств крыс. The paper presents the revealed changes in the behavior of rats during the "Open Field" experiment with chronic exposure to various rat analyzers. The adaptive nature of the results obtained is assumed to be associated with a stressful situation when exposed to the sensory organs of rats.

scholarly journals Analysis of Key Failure Factors in Construction Partnering—A Case Study of Taiwan

2019 ◽  
Vol 11 (14) ◽  
pp. 3994
Author(s):  
Wei Tong Chen ◽  
Hew Cameron Merrett ◽  
Shih Tong Lu ◽  
Leonard Mortis
Keyword(s):  
Construction Projects ◽  
Organizational Management ◽  
Careful Planning ◽  
Principle Components Analysis ◽  
Study Results ◽  
Using Data ◽  
Level Of Significance ◽  
The Relationship ◽  
Failure Factors

Construction partnering is commonly touted as a win-win arrangement for project owners and contractors alike. The failure or success of construction partnering arrangements is contingent upon a multitude of influences, many of which can be controlled through careful planning and active project management. This study examines the key failure factors (KFFs) of construction partnering projects based on data collected from a survey of industry professionals in Taiwan. Methods: Factor analysis is performed using data gathered from a survey of industry practitioners operating in Taiwan to identify KFFs and better understand the level of significance of each factor. A total of 15 failure variables (FV) were included in the survey. This study applied Principle Components Analysis to classify groups of crucial FV relevant to construction partnering based on their relative perceived contribution to project failure. Study results confirm that there are four KFFs to partnering failure in construction projects; they are absence of agility, collaboration barriers, partnering barriers, and organizational management barriers. The biggest influencer on partnership failure in construction projects is the association between absence of agility and organizational management barriers, while the next most significant is the relationship between collaboration barriers and partnering barriers. Avoiding failure of construction partnering requires careful planning and management considerations of the four KFFs found.

A Phase III randomized study comparing the effects of oxandrolone (Ox) and megestrol acetate (Meg) on weight (wt), lean body mass (LBM) and quality of life (QOL) in solid tumor patients (pts) receiving chemotherapy (chemo)

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 18546-18546 ◽  
Author(s):  
G. J. Lesser ◽  
D. Case ◽  
S. Sharp ◽  
J. Choksi ◽  
A. Miller ◽  
...  
Keyword(s):  
Body Composition ◽  
Treatment Options ◽  
Randomized Study ◽  
Bioelectrical Impedance ◽  
Impedance Analysis ◽  
Hematologic Malignancies ◽  
Phase Iii ◽  
Standards Of Care ◽  
Study Results ◽  
Level Of Significance

18546 Background: Involuntary wt loss is a significant problem in pts with cancer and may lead to a decline in QOL, limit treatment options and reduce survival. Wt loss in these pts disproportionately represents a loss of muscle mass. Meg, a synthetic progesterone derivative, promotes wt gain mostly through an increase in adipose tissue rather than in LBM. Ox is a potent oral anabolic steroid with minimal androgenic activity which promotes wt gain primarily through increased LBM. Methods: Prospective, randomized phase III trial comparing the effects of Ox and Meg on wt, body composition and QOL in pts with solid tumors and wt loss receiving chemo. Body composition was serially assessed by Bioelectrical Impedance Analysis. QOL was evaluated with the FACT-G and the Anorexia/Cachexia subscale (FAACT). Eligibility: age ≥18; PS: 0–2; life expectancy ≥6 mos; near normal organ function; and progressive wt loss on chemo. Ineligibility: full dose anticoagulation; hormonally responsive or hematologic malignancies; and ongoing or planned treatment with corticosteroids (antiemetic use allowed), estrogens or progestins. The primary endpoint was LBM after 12 wks of drug therapy. Study design allowed 90% power for detecting a 1.5 kg difference between treatment groups using a 5% two-sided level of significance. A max of 155 pts were to be accrued. An interim analysis was planned after 62 pts had completed 12 wks on study. Results: As of 12/05, 74 pts have been accrued (72 eligible): median age 64 yrs, 42% females and 62% stage 4 disease. 25 pts (arm 1:8, arm 2:17) have completed 12 wks of therapy and 20 remain on study. 76 Grade 3/4 toxicities (arm 1:23, arm 2:53) and 1 grade 5 arrhythmia (arm 2) have been recorded. Accrual is ongoing and differing trends in wt gain and body composition between arms are emerging. Conclusions: This is the first and only trial comparing these two commonly utilized therapies for cancer-related anorexia/cachexia. Differences in efficacy, particularly effects on LBM, QOL and toxicity which emerge from this trial are likely to influence symptom management standards of care in the oncology community. Supported by Savient Pharmaceuticals and NCI grant 1 U10 CA81851. No significant financial relationships to disclose.

Systemic administration of endorphins selectively alters open field behavior of rats

1978 ◽  
Vol 20 (5) ◽  
pp. 539-542 ◽  
Author(s):  
Jane L. Veith ◽  
Curt A Sandman ◽  
J. Michael Walker ◽  
David H. Coy ◽  
Abba J. Kastin
Keyword(s):  
Open Field ◽  
Systemic Administration ◽  
Open Field Behavior ◽  
Field Behavior ◽  
Behavior Of Rats

scholarly journals REDIMEH Project:Ibero-American Integrative Network for Clinical Research in Homeopathy

2021 ◽  
Vol 8 (27) ◽  
pp. 50-52
Author(s):  
José Eizayaga
Keyword(s):  
Atopic Dermatitis ◽  
Clinical Research ◽  
Clinical Data ◽  
Daily Practice ◽  
Randomized Control Trials ◽  
High Dilution ◽  
High Quality ◽  
Palabras Clave ◽  
Randomized Control ◽  
Integrative Network

If there were one lacking or insufficient issue which conscious medical orientated homeopaths could regret, it would be probably high quality clinical research. A big part of the homeopathic community still insists in the traditional ways of building knowledge, leading us nowhere. There is now an agreement between clinical researchers that there have been done enough efforts with Randomized Control Trials (RCT). But what we need today is good quality scientific research that could improve our daily practice. This article introduce the REDIMEH, an Ibero-American Integrative Network for Clinical Research in Homeopathy, horizontal in structure, with no political objectives, with the only intention of joining efforts in order to obtain enough clinical data to draw out valid conclusions. Keywords: REDIMED, atopic dermatitis, clinical research.  Projeto REDIMED: Red Integrada Ibero-Americana para Pesquisa Clínica em Homeopatia ResumoSe pudermos apontar uma questão, a qual os verdadeiros médicos homeopatas podem se lamentar, esta deveria ser a falta ou insuficiéncia de pesquisas clínicas de alta qualidade. Uma grande parte da comunidade homeopática ainda insiste nas formas tradicionais de construção de conhecimento, levando-nos a lugar algum. Existem pontos bem estabelecidos pelos pesquisadores clínicos que tem se esforçado muito com a realização de Ensaios Controlados Randomizados (RCT). O que mais precisamos hoje é de investigação científica de boa qualidade, que possa melhorar a nossa prática diária. Este artigo apresenta o projeto REDIMEH, uma Rede Integrada Ibero-Americana para Pesquisa Clínica em Homeopatia, de estrutura horizontal, sem objetivos políticos, com a intenção de unir esforços no sentido de obter dados clínicos suficientes para chegarmos a conclusões válidas para a prática clínica diária. Palavras-chave: REDIMED, dermatite atópica, investigação clínica.  Proyecto REDIMEH: Red Iberoamericana Integrativa de Investigación Clínica en Homeopatía ResumenSi hubiera uma cuestión de la cual los médicos homeopatas podrían pesar, sería probablemente la investigación clínica de alta calidad. Una gran parte de la comunidad homeopática sigue insistiendo en las formas tradicionales de construcción del conocimiento, que nos conduce a ninguna parte. En la actualidad, existe un acuerdo entre los investigadores clínicos, que ya se han hecho lo suficiente con los esfuerzos de control de ensayos aleatorios (RCT). Pero lo que necesitamos hoy es la investigación científica de buena calidad que pueda mejorar nuestra práctica diaria. Este artículo presentará el REDIMEH, uma Red Iberoamericana Integrativa de Investigación Clínica en Homeopatía, con una estructura horizontal, sin objetivos políticos, con la única intención de unir esfuerzos con el propósito de obtener datos clínicos suficientes para sacar conclusiones válidas. Palabras-clave: REDIMED, dermatitis atópica, investigación clínica  Correspondence author: Jose Eizayaga, [email protected], www.maimonides.edu How to cite this article: Eizayaga J. REDIMEH Project: Ibero-American Integrative Network for Clinical Research in Homeopathy. Int J High Dilution Res [online]. 2009 [cited YYYY Month dd]; 8(27): 50-52. Available from: http://journal.giri-society.org/index.php/ijhdr/article/view/340/392.  

scholarly journals The emergence of modern therapeutic similarity

2021 ◽  
Vol 7 (22) ◽  
pp. 22-30
Author(s):  
Silvia Waisse Priven
Keyword(s):  
History Of Medicine ◽  
18Th Century ◽  
Medical Science ◽  
High Dilution ◽  
Palabras Clave ◽  
History Of ◽  
Epistemological Break ◽  
Counter Irritation

One of the roots of modern therapeutic similarity might be retraced to the work of Samuel Hahnemann at the end of the 18th century. His particular formulation arose from an original synthesis of traditional therapeutic similarity, dating from classic Antiquity and mantained as an undercurrent in medical thinking, and contemporary theories, particularly counter-irritation (antagonistic fever) theory. Against historical readings asserting that modern therapeutic similarity is either a mere a continuation of the ancient, or a historical orphan, it is possible to verify that Hahnemann’s work belonged within the specific framework of 18th medical science. The formulation of modern therapeutic similarity is best described as a process combining both continuity and epistemological break. Keywords: History of Medicine; 18th century; Pharmacology; Peruvian bark; Modern therapeutic similarity.   O surgimento da semelhança terapéutica moderna Resumo Uma das raízes da semelhança terapéutica moderna pode ser localizada na obra de Samuel Hahnemann, no final do século XVIII. Sua formulação particular surgiu da síntese original da semelhança terapéutica tradicional, procedente da Antigüidade clássica e conservada subterraneamente no pensamento médico, com teorias contemporâneas, especialmente a teoria da contra-irritação (febre antagonista). Por oposição a leituras históricas que afirmam que semelhança terapéutica moderna é uma mera continuação da antiga ou, alternativamente, um ófão histórico, pode-se constatar que a obra de Hahnemann corresponde ao marco específico da ciéncia médico do século XVIII. A formulação da semelhança terapéutica parece ser melhor compreendida como um processo que combina continuidade e ruptura epistemológicas. Palavras-chave: História da Medicina; século 18; Farmacologia; semelhança terapéutica moderna.   El surgimiento de la similaridad terapéutica moderna Resumen Una de las raíces de la similaridad terapéutica moderna puede ser localizada en la obra de Samuel Hahnemann al final del siglo XVIII. Su formulación particular surgió de la síntesis original de la similaridad terapéutica tradicional, procedente de la Antigüedad clásica y conservada subterráneamente en el pensamiento médico, con teorías contemporáceas, especialmente la de la contrairritación (fiebre antagonista). En oposición a lecturas históricas que afirman que la similaridad terapéutica moderna es una mera continuación de la antigua o un huérfano histórico, se puede constatar que la obra de Hahnemann corresponde al marco específico de la ciencia médica del siglo XVIII. La formulación de la similaridad terapéutica moderna parece ser mejor comprendida como um processo que combina continuidad y ruptura epistemológicas. Palabras-clave: Historia de la Medicina; siglo 18; Farmacología; similitud terapéutica moderna.   Correspondence author: Silvia Waisse Priven, [email protected] ; http://www.pucsp.br/pos/cesima How to cite this article: Waisse Priven S. The emergence of modern therapeutic similarity. Int J High Dilution Res [online]. 2008 [cited DD Mmm YYYY]; 7(22): 22-30. Available from: http://journal.giri-society.org/index.php/ijhdr/article/view/252/335.  

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