Haemato-biochemical and blood gas changes in bovines under   multimodal anaesthesia

The study was conducted in six crossbred female cattle aged nine months to five years and weighing between 82-375 kg, to evaluate haematobiochemical and blood gas changes in during multimodal general anaesthesia. The animals were premedicated by intravenous administration of butorphanol (0.05mg/kg body weight) immediately followed by xylazine (0.02 mg/kg body weight). On achieving sedation, the animals were controlled in left lateral recumbency and induction of anaesthesia was carried out by intravenous administration of ketamine and midazolam at the dose rate of 4.0 and 0.2 mg/kg body weight respectively. Endotracheal intubation was performed and maintenance of general anaesthesia was carried out using isoflurane in 100% oxygen. The variation in total erythrocyte count, total leukocyte count, volume of packed red cells, platelet count and haemoglobin were non-significant before and after anaesthesia. A non-significant lymphocytopaenia with neutrophilia and mild variations in aspartate aminotransferase and alanine aminotransferase enzyme levels were also noticed. Blood pH reduced significantly (p<0.05) after induction of anaesthesia and returned to baseline values after recovery whereas PvCO2 (p<0.05) and base excess (p<0.01) values increased significantly after induction of anaesthesia. The blood bicarbonate did not alter significantly following induction of anaesthesia.

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The effect of pre- and post-natal nutrition on the growth of beef cattle. 3. The effect of severe restriction in early post-natal life on the development of the body components and chemical composition

Australian Journal of Agricultural Research ◽

10.1071/ar9800191 ◽

1980 ◽

Vol 31 (1) ◽

pp. 191 ◽

Cited By ~ 29

Author(s):

GD Tudor ◽

DW Utting ◽

PK O'Rourke

Keyword(s):

Body Weight ◽

Carcass Composition ◽

The Body ◽

Fat Free Mass ◽

Carcass Weight ◽

Feeding Period ◽

Castrate Male ◽

Before And After ◽

Body Components ◽

Female Cattle

The effects of restricted growth of cattle both before and after birth, of the method of their realimentation, and of sex on (1) body and carcass composition, (2) the weights of visceral components, (3) the weights of selected individual muscles and bones, and (4) the heights of the animals at the withers and pelvis were ascertained. Castrate male and entire female cattle were slaughtered when their liveweights reached 400 and 370 kg respectively. Other male and female calves were slaughtered at 200 days of age following a controlled feeding period on either a high or a low plane diet. Although pre-natal nutrition significantly (P < 0.05) affected the height of the calves at 3 days of age, it had no lasting effect on this or other components. When adjusted to the same empty body weight or carcass weight, animals restricted in growth then intensively realimented had (P < 0.01) more fat and less protein, water and ash than animals unrestricted in growth and later fed intensively. Animals finished on pasture had (P < 0.01) less fat and more protein, water and ash than the intensively finished calves, but their composition was unaffected by the controlled feeding treatments. Significant differences (P < 0.01) between restricted and unrestricted animals in the percentage water or protein in the fat-free mass at the end of the controlled feeding period were eliminated when the animals had recovered. The weights of visceral components, individual muscles and bones were not influenced by the level of nutrition during the controlled feeding period. Animals finished on pasture had (P < 0.01) more blood, heavier livers, heavier individual muscles and bones than the intensively finished animals. They also had (P < 0.01) lighter fasted liveweight, empty body weight, hot carcass weight, dressing percentage and heavier wet rumen-reticulum contents than the intensively finished cattle. Although the pasture finished animals were (P < 0.01) shorter at 200 and 300 days of age than the intensively finished animals, they were (P < 0.01) taller just prior to slaughter. It is suggested that meat-producing animals can overcome restrictions imposed on growth immediately after birth to attain marketable weight on either pasture or intensive feeding.

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Hemodynamic and Laboratory Changes during Incremental Transition from Twice to Thrice-Weekly Hemodialysis

Cardiorenal Medicine ◽

10.1159/000504383 ◽

2020 ◽

Vol 10 (2) ◽

pp. 97-107

Author(s):

Inkyong Hur ◽

Cachet Wenziger ◽

Yoshitsugu Obi ◽

Hamid Moradi ◽

Elani Streja ◽

...

Keyword(s):

Body Weight ◽

Treatment Frequency ◽

Interdialytic Weight Gain ◽

Weekly Treatment ◽

Before And After ◽

Incremental Hemodialysis ◽

Baseline Values ◽

Stage Renal Disease ◽

End Stage ◽

Laboratory Changes

Objective: Incremental hemodialysis (HD) is a strategy utilized to gradually intensify dialysis among patients with incident end-stage renal disease. However, there are scarce data about which patients’ clinic status changes by increasing treatment frequency. Methods: We retrospectively examined statistically de-identified data from 569 patients who successfully transitioned from twice- to thrice-weekly HD (2007–2011) and compared the differences in monthly-averaged values of hemodynamic and laboratory indices during the 3 months before and after the transition with the values at 1 month prior to transition serving as the reference. Results: At 3 months after transitioning from twice- to thrice-weekly HD, ultrafiltration volume decreased by 0.5 (95% CI 0.3–0.6) L/session among 189 patients (33%) with weekly interdialytic weight gain (IDWG) ≥5.4 kg/week, and increased by 0.4 (95% CI 0.3–0.5) L/session among 186 patients (33%) with weekly IDWG <3.3 kg/week. Weekly IDWG consistently increased after the transition irrespective of baseline values (1.7 [95% CI 1.5–1.9] kg/week). Pre-HD systolic blood pressure (SBP) decreased by 12 (95% CI 9–14) mm Hg among 177 patients (31%) with baseline pre-HD SBP ≥160 mm Hg, which coincided with a decreasing trend in post-HD body weight (1.3 [95% CI 0.8–1.7] kg). Discussion: In conclusion, patients who increased HD frequency from twice to thrice weekly treatment experienced increased weekly IDWG and better pre-HD SBP control with lower post-HD body weight.

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The Effect of Adrenaline Infusions on Blood Coagulation in Normal and Haemophilia B Dogs

Thrombosis and Haemostasis ◽

10.1055/s-0038-1649437 ◽

1966 ◽

Vol 15 (03/04) ◽

pp. 349-364 ◽

Cited By ~ 5

Author(s):

A.H Özge ◽

H.C Rowsell ◽

H.G Downie ◽

J.F Mustard

Keyword(s):

Body Weight ◽

Factor Viii ◽

Factor Ix ◽

Clotting Factor ◽

Blood Ph ◽

Order Of Magnitude ◽

Dose Dependent ◽

Generation Test ◽

Plasma Activity

SummaryThe addition of trace amounts of adrenaline to whole blood in plasma in vitro increased factor VIII, factor IX and whole plasma activity in the thromboplastin generation test. This was dose dependent.Adrenaline infusions less than 22 (μg/kg body weight in normal dogs accelerated clotting, increased factor IX, factor VIII and whole plasma activity in the thromboplastin generation test and caused a fall in blood pH. In a factor IX deficient dog, there was no increase in factor IX activity. After adrenaline infusions, however, the other changes occurred and were of the same order of magnitude as in the normal. Adrenaline in doses greater than 22 μg/kg body weight did not produce as great an effect on clotting in normal or factor IX deficient dogs. The platelet count in the peripheral blood was increased following the infusion of all doses of adrenaline. These observations suggest that the accelerating effect of adrenaline on clotting is not mediated through increase in activity of a specific clotting factor.

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NUTRITION ASSESSMENT IN HEAD AND NECK CANCER PATIENTS PRE and POST CHEMORADIOTHERAPY.

SRMS Journal of Medical Science ◽

10.21761/jms.v2i02.5 ◽

2019 ◽

Vol 2 (2) ◽

Author(s):

Piyush Kumar ◽

Bhavya P Pateneedi ◽

Dharam P Singh ◽

Arvind K Chauhan

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Cancer Patients ◽

Neck Cancer ◽

Nutritional Risk ◽

Total Leukocyte Count ◽

Risk Indicator ◽

Anthropometric Parameters ◽

Skin Fold Thickness ◽

Before And After

INTRODUCTION: Head and neck cancer patients are frequently malnourished at the time of diagnosis and prior to the beginning of treatment. Deterioration of the nutritional status results in an increase in chemo radiotherapy related toxicity and this may increase the prolonged treatment time, which has been associated with poor clinical outcome. The present study aims to do nutritional assessment before and after chemo radiotherapy in head and neck cancer patients. MATERIAL AND METHODS: The present study was undertaken at the Department of Radiation Oncology, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly. In this study, 50 patients of Head and neck tumours were enrolled and their nutrition was assessed before and after chemoradiotherapy. Nutrition assessment was done using different laboratory parameters like haemoglobin, total leukocyte count, blood urea, serum creatinine and serum bilirubin. Anthropometric parameters used are Body mass index, Skin fold thickness, and Mid-arm circumference. Nutritional risk indicator and PG-SGA score is measured before and after chemoradiotherapy. All the parameters were assessed and analysed using different statistical tests- Chi-square test, Fisher Exact test and paired t test.RESULTS: Haemoglobin decrease was statistically significant during treatment (p less than 0.001) and the decrease in total leukocyte count during treatment was showing trend towards significance (p value-0.056). There was deterioration in other parameters like blood urea, serum creatinine and serum bilirubin but was not statistically significant. Anthropometric parameters- Body mass index, mid-arm circumference and skin fold thickness and percent body fat showed a significant change (p less than 0.00001). Nutritional risk indicator and PG-SGA class has decreased for majority of patients during treatment, the change is statistically significant (p less than 0.00001 and p=0.0251) respectively.CONCLUSION: The nutrition has important role to play in the management of head and neck cancers by chemo radiotherapy. It helps to reduce the complications and improve the tolerance of chemo radiotherapy, thus avoiding treatment breaks which may lead to failure of treatment.

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Evaluation of Dexmedetomidine Dosing in Obese Critically Ill Patients

Journal of Pharmacy Practice ◽

10.1177/08971900211021578 ◽

2021 ◽

pp. 089719002110215

Author(s):

Sara A. Atyia ◽

Keaton S. Smetana ◽

Minh C. Tong ◽

Molly J. Thompson ◽

Kari M. Cape ◽

...

Keyword(s):

Body Weight ◽

Critically Ill ◽

Critically Ill Patients ◽

Statistical Difference ◽

Ideal Body Weight ◽

Weight Percentage ◽

Before And After ◽

Light Sedation ◽

Icu Sedation ◽

Dose Dependent

Background: Dexmedetomidine is a highly selective α2-adrenoreceptor agonist that produces dose-dependent sedation, anxiolysis, and analgesia without respiratory depression. Due to these ideal sedative properties, there has been increased interest in utilizing dexmedetomidine as a first-line sedative for critically ill patients requiring light sedation. Objective: To evaluate the ability to achieve goal intensive care unit (ICU) sedation before and after an institutional change of dosing from actual (ABW) to adjusted (AdjBW) body weight in obese patients on dexmedetomidine. Methods: This study included patients ≥ 18 years old, admitted to a surgical or medical ICU, required dexmedetomidine for at least 8 hours as a single continuous infusion sedative, and weighed ≥ 120% of ideal body weight. Percentage of RASS measurements within goal range (−1 to +1) during the first 48 hours after initiation of dexmedetomidine as the sole sedative agent or until discontinuation dosed on ABW compared to AdjBW was evaluated. Results: 100 patients were included in the ABW cohort and 100 in the AdjBW cohort. The median dosing weight was significantly higher in the ABW group (95.9 [78.9-119.5] vs 82.2 [72.1-89.8] kg; p = 0.001). There was no statistical difference in percent of RASS measurements in goal range (61.5% vs 69.6%, p = 0.267) in patients that received dexmedetomidine dosed based on ABW versus AdjBW. Conclusion: Dosing dexmedetomidine using AdjBW in obese critically ill patients for ongoing ICU sedation resulted in no statistical difference in the percent of RASS measurements within goal when compared to ABW dosing. Further studies are warranted.

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Antitumor effects of Auraptene in 4T1 tumor‐bearing Balb/c mice

Hormone Molecular Biology and Clinical Investigation ◽

10.1515/hmbci-2020-0090 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Mohammad Reza. Shiran ◽

Davar Amani ◽

Abolghasem Ajami ◽

Mahshad Jalalpourroodsari ◽

Maghsoud Khalizadeh ◽

...

Keyword(s):

Breast Cancer ◽

Body Weight ◽

Tumor Volume ◽

Serum Levels ◽

Ki 67 ◽

Tumor Bearing ◽

Paraffin Oil ◽

Anti Cancer ◽

Before And After ◽

Ifn Γ

Abstract Objectives Breast cancer is a common malignant tumor in women with limited treatment options and multiple side effects. Today, the anti-cancer properties of natural compounds have attracted widespread attention from researchers worldwide. Methods In this study, we treated 4T1 tumor-bearing Balb/c mice with intraperitoneal injection of Auraptene, paraffin oil, and saline as two control groups. Body weight and tumor volume were measured before and after treatment. Hematoxylin and eosin (H & E) staining and immunohistochemistry of Ki-67 were used as markers of proliferation. In addition, ELISA assays were performed to assess serum IFN-γ and IL-4 levels. Results There was no significant change in body weight in all animal groups before and after treatment. 10 days after the last treatment, Auraptene showed its anti-cancer effect, which was confirmed by the smaller tumor volume and H & E staining. In addition, Ki-67 expression levels were significantly reduced in tumor samples from the Auraptene-treated group compared to the paraffin oil and saline-treated groups. In addition, in tumor-bearing and normal mice receiving Auraptene treatment, IL-4 serum production levels were reduced, while serum levels of IFN-γ were significantly up-regulated in tumor-bearing mice after Auraptene treatment. Conclusions In the case of inhibition of tumor volume and Ki-67 proliferation markers, Auraptene can effectively inhibit tumor growth in breast cancer animal models. In addition, it might increases Th1 and CD8 + T cell responses after reducing IL-4 serum levels and IFN-γ upregulation, respectively. However, further research is needed to clarify its mechanism of action.

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Hemodynamic Responses in Lower Limb Lymphedema Patients Undergoing Physical Therapy

Biology ◽

10.3390/biology10070642 ◽

2021 ◽

Vol 10 (7) ◽

pp. 642

Author(s):

Bianca Brix ◽

Olivier White ◽

Christian Ure ◽

Gert Apich ◽

Paul Simon ◽

...

Keyword(s):

Physical Therapy ◽

Lymphatic System ◽

Orthostatic Intolerance ◽

Hemodynamic Responses ◽

Stand Test ◽

Beneficial Effects ◽

Sit To Stand ◽

Complete Decongestive Therapy ◽

Before And After ◽

Baseline Values

Background: Lymphedema arises due to a malfunction of the lymphatic system, leading to extensive tissue swelling. Complete decongestive therapy (CDT), which is a physical therapy lasting for 3 weeks and includes manual lymphatic drainages (MLD), leads to fluid mobilization and increases in plasma volume. Here, we investigated hemodynamic responses induced by these fluid shifts due to CDT and MLD. Methods: Hemodynamic parameters were assessed continuously during a sit-to-stand test (5 min baseline, 5 min of standing, and 5 min of recovery). This intervention was repeated on days 1, 2, 7, 14, and 21 of CDT, before and after MLD. Volume regulatory hormones were assessed in plasma samples. Results: A total number of 13 patients took part in this investigation. Resting diastolic blood pressure significantly decreased over three weeks of CDT (p = 0.048). No changes in baseline values were shown due to MLD. However, MLD led to a significant decrease in heart rate during orthostatic loading over all epochs on therapy day 14, as well as day 21. Volume regulatory hormones did not show changes over lymphedema therapy. Conclusion: We did not observe any signs of orthostatic hypotension at rest, as well as during to CDT, indicating that lymphedema patients do not display an elevated risk of orthostatic intolerance. Although baseline hemodynamics were not affected, MLD has shown to have potential beneficial effects on hemodynamic responses to a sit-to-stand test in patients undergoing lymphedema therapy.

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Serum HIV-1 p24 levels and body weight measurements before and after 4 weeks of diethylcarbamazine treatment given to HIV-1 seropositive persons

International Journal of Antimicrobial Agents ◽

10.1016/0924-8579(94)90055-8 ◽

1994 ◽

Vol 3 (4) ◽

pp. 275-278 ◽

Cited By ~ 2

Author(s):

Eduardo G. Arathoon ◽

Carlos R. Mejía ◽

Rosa María Estrada y Martín ◽

Jaime E. Hernández ◽

Gwynn J. Turner ◽

...

Keyword(s):

Body Weight ◽

Before And After ◽

Hiv 1

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Thiamine Diphosphate Status and Dialysis-Related Losses in End-Stage Kidney Disease Patients Treated with Hemodialysis

Blood Purification ◽

10.1159/000480651 ◽

2017 ◽

Vol 44 (4) ◽

pp. 294-300 ◽

Cited By ~ 5

Author(s):

Magdalena Jankowska ◽

Paweł Rudnicki-Velasquez ◽

Hanna Storoniak ◽

Przemysław Rutkowski ◽

Bolesław Rutkowski ◽

...

Keyword(s):

Body Weight ◽

Kidney Disease ◽

Dietary Intake ◽

Whole Blood ◽

Vitamin B1 ◽

Thiamine Diphosphate ◽

End Stage Kidney Disease ◽

Before And After ◽

End Stage ◽

The Impact

Aim: (1) To describe the whole blood content of thiamine diphosphate (TDP), a biologically active form of vitamin B1 in end-stage kidney disease patients treated with hemodialysis (HD); (2) to establish the impact of a single HD procedure on TDP blood concentrations; and (3) to describe potential explanatory variables influencing TDP dialysis related losses, including dialysis prescription, vitamin B1 dietary intake and supplementation. Methods: Single-center, cross-sectional study in 50 clinically stable maintenance HD patients. The assessment of whole blood TDP with the High Performance Liquid Chromatography method, before and after a single, middle-week dialysis session and analysis of clinical and laboratory parameters potentially influencing TDP status Results: We report a significant difference in TDP levels before and after HD sessions - 42.5 (95% CI 38.7-46.2) μg/L and 23.6 (95% CI 18.9-28.2) μg/L, respectively (p = 0.000). The magnitude of intradialytic TDP changes is highly variable among individuals and is negatively associated only with the body weight of the patients (p < 0.013). Vitamin B1 dietary intake and supplementation do not influence whole blood TDP and dialysis-related loss of TDP. Conclusions: TDP, a bioactive compound of vitamin B1, is substantially lost during the HD procedure, and the magnitude of its loss is associated with the patient's body weight but it is not influenced by vitamin B1 dietary intake and standard supplementation dose.

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PSXII-28 Effects of the nutritional plane before and after breeding on performance of different hair sheep breeds

Journal of Animal Science ◽

10.1093/jas/skab235.862 ◽

2021 ◽

Vol 99 (Supplement_3) ◽

pp. 489-490

Author(s):

Farida Belkasmi ◽

Raquel V Lourencon ◽

Ryszard Puchala ◽

Terry A Gipson ◽

Luana Ribeiro ◽

...

Keyword(s):

Body Weight ◽

Birth Weight ◽

Wheat Straw ◽

Litter Size ◽

Birth Rate ◽

Average Daily Gain ◽

Breeding Period ◽

Hair Sheep ◽

Cereal Grain ◽

Before And After

Abstract Female hair sheep, 27 Dorper (DOR), 41 Katahdin (KAT), and 39 St. Croix (STC), were used to determine influences of nutritional planes before and after breeding on performance. There were 35 multiparous and 72 primiparous sheep, the latter 2.8±0.20 yr of age. Wheat straw [4% crude protein; dry matter (DM) basis] was consumed ad libitum and supplemented with approximately 0.25% initial body weight (BW) of soybean meal (SBM; Low) or a 1:3 mixture of SBM and rolled corn at 1% BW (High; DM). The supplementation period was 162 d, and with breeding of animals in 2 groups sequentially the pre-breeding period was 84 and 97 d and that after breeding began was 78 and 65 d. Wheat straw DM intake (1.75, 1.30, 1.57, 1.15, 1.80, and 1.38% BW; SEM=0.112), average daily gain (-46, 42, -44, 70, -47, and 51 g; SEM=7.3), and change in body condition score (-0.61, 0.36, -0.53, 0.27, -0.39, and -0.18 for DOR-Low, DOR-High, KAT-Low, KAT-High, STC-Low, and STC-High, respectively; SEM=0.058) were influenced (P < 0.05) by supplement treatment. Birth rate (66.7, 93.5, 84.6, 95.5, 82.8, and 100.0; SEM=9.83) and individual lamb birth weight (4.50, 4.61, 4.28, 3.98, 3.73, and 3.88 kg; SEM=0.201) were not affected by supplement treatment (P = 0.063 and 0.787, respectively), although litter size (0.92, 1.21, 1.17, 1.86, 1.12, and 1.82; SEM=0.221) and total litter birth weight (5.84, 5.74, 5.92, 7.52, 5.04, and 6.78 kg for DOR-Low, DOR-High, KAT-Low, KAT-High, STC-Low, and STC-High, respectively; SEM=0.529) were greater (P < 0.05) for High than for Low. In conclusion, although there was some compensation in wheat straw intake for the different levels of supplementation, SBM given alone rather than with cereal grain adversely affected body weight and condition and reproductive performance, the latter primarily through litter size but also via a trend for an effect on birth rate.

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