scholarly journals Evaluation of the adaptogenic propertries of the Quark product enriched with probiotics, polyphenols and vitamins

10.5219/1156 ◽  
2019 ◽  
Vol 13 (1) ◽  
pp. 713-719 ◽  
Author(s):  
Zinaida Zobkova ◽  
Liliy Fedulova ◽  
Tatyana Fursova ◽  
Daria Zenina ◽  
Elena Kotenkova
Keyword(s):  
Magnetic Field ◽  
Blood Serum ◽  
Dairy Product ◽  
Low Frequency ◽  
Free Radical Oxidation ◽  
Variable Magnetic Field ◽  
The Body ◽  
Radical Oxidation ◽  
And Control ◽  
The Impact

The aim of the study is to evaluate protective properties of the quark product manufactured with transglutaminase and enriched with probiotics, oligomerous proanthocyanidines and vitamins; the biological experiment on the growing laboratory Wistar stock rats has been carried out. The rats of two from three groups subjected within 21 days to the effect of low-frequency weak variable magnetic field received in semi-synthetic diet composition extra experimental and control samples of the quark product. The index of feed intake and the rats’ body mass growth was registered within 32 days. At the end of the experiment blood serum biochemical index was evaluated. It was revealed that the animals consuming the experimental product substantially gained the mass before the effect (gain from the 1st up to 10th days made up 12%) as well as after effect (gain from 11th up to 32nd days – 10.3%); upon completion of the experiment the gains of these animals exceeded the gains of the rats consuming the control product by more than 28%. The experiment revealed the lipolipedemic and hypoglycemic effect of the experimental quark product that has been evidenced by the significant reduction of cholesterol (by more than 20%), glucose (up to 40%) in the rats’ blood serum. On administration of the experimental dairy product in the animals’ diet subjected to the impact of low-frequency weak magnetic field the effect of the broken balance recovery in antioxidant/pro-oxidant system was observed due to reduction of pro-oxidant load at the enzymatic as well as low molecular links of the antioxidant system. The identified antioxidant and adaptogenic effect of the developed dairy product promoting to reduce the intensity of free-radical oxidation at the impact of low-frequency electromagnetic field on the body make it possible recommend it in dietotherapy for correction of antioxidant/pro-oxidant status.

scholarly journals Association between Malondialdehyde and Glutathione (L-gamma-Glutamyl-Cysteinyl-Glycine/GSH) Levels on Workers Exposed to Benzene in Indonesia

2019 ◽  
Vol 7 (7) ◽  
pp. 1198-1202 ◽  
Author(s):  
Abdul Rohim Tualeka ◽  
Tri Martiana ◽  
Ahsan Ahsan ◽  
Syamsiar S. Russeng ◽  
Wulan Meidikayanti
Keyword(s):  
Free Radicals ◽  
Free Radical Oxidation ◽  
Thiobarbituric Acid ◽  
The Body ◽  
Radical Oxidation ◽  
Benzene Concentration ◽  
Flame Ionisation Detector ◽  
Glutathione Enzymes ◽  
The Impact ◽  
Detoxification Process

BACKGROUND: Chemicals that enter the body, especially benzene, will undergo a detoxification process. Unfortunately, at the detoxification process, sometimes benzene can produce free radicals. Free radical oxidation of lipids produces MDA compounds (malondialdehyde). To overcome these free radicals, the body will adapt to produce Glutathione (GSH) enzymes. AIM: The purpose of this study was to analyse the relationship between benzene concentration, MDA levels and glutathione enzymes in Shoe-Maker Home Industry workers exposed to benzene for more than 10 years. METHODS: Measurement of benzene concentration using a gas chromatography-flame ionisation detector (GC-FID). MDA levels used a modified spectrophotometric and GSH method of thiobarbituric acid (TBA) test. RESULT: The results showed that the majority of respondents had benzene concentrations still below the TLV value, mean of MDA levels were 6.94 mg/ml, while GSH was 4.54 mg/ml. Benzene concentration did not have a significant correlation with MDA and glutathione levels, whereas MDA levels had a strong correlation with glutathione levels (p = 0.000; r = -0.947). CONCLUSION: Workers should always use PPE and always eat foods that contain lots of glutathione enzymes such as spinach or broccoli to reduce the impact of free radicals from benzene inhalation.

Effect of General Impact of Weak Low Frequency Vortex Magnetic Field on the System of Natural Antitumor Resistance of the Body

2019 ◽  
Vol 64 (6) ◽  
pp. 44-50
Author(s):  
Yu. Rybakov ◽  
V. Gukasov ◽  
Yu. Kozlov
Keyword(s):  
Breast Cancer ◽  
Magnetic Field ◽  
Functional Activity ◽  
Low Frequency ◽  
The Body ◽  
General Effect ◽  
Healthy Donors ◽  
The Impact ◽  
Observation Period

Purpose: Experimental study of the antitumor mechanism of increasing the functional activity of phagocytes with a general effect on the body of a weak low-frequency vortex magnetic field (VMP). Material and methods: The functional activity of phagocytes was assessed upon activation by the intensity of chemiluminescence (CHL) on a Biolumat instrument (model LB 9500, by Berthold, Germany). Samples for in vitro and in vivo experiments were prepared according to generally accepted protocols. The impact of the VMP (Vmax = 3.0 mTl, f = 100 Hz) was performed using a Magnitoturbotron magnetotherapeutic installation (developed by NPF Az). Results: It was found in vitro experiments that the exposure of a suspension of VMP cells stimulated an increase in CHL by 58 % relative to the control, while the main contribution to the intensity of the signal of the CHL was made by neutrophils. In the study of the blood CHL of mice with subcutaneously inoculated melanoma B-16, it was established that the value of the specific CHL in the experiment with VFM by the end of the observation period (day 17) increased sharply (3 times) relative to the beginning of the observation and to the control at the same observation period was 3.3 times more. Experiments with whole blood of healthy donors and patients with breast cancer showed that the CHL curves over time were biphasic in nature and had two maxima, but the phase ratio was different. At donors, the main luminescence developed by the 100th minute, and a maximum of 30–40 min was mild. In patients with breast cancer, the first maximum at 30–40 min was the main, the second maximum was weak and came later than that of donors. Experiments with the effects of VMP on the organism of healthy and patients with breast cancer of people showed an increase in the functional activity of neutrophils as a result of exposure to VMP, but in patients with breast cancer, the level of CHL was significantly (3 times) higher than of healthy donors. Based on the research, it was concluded that exposure to the VMP is able to form a priming neutrophil. Сonclusion: It is shown that the overall effect of weak low-frequency VFM increases the level of nonspecific resistance of the organism to the tumor process, which expands the possibilities of rehabilitation of patients, allows expanding the compensatory capabilities of the body and reduce the risk of disease.

scholarly journals Peculiarities of lipid peroxidation processes in the body of cats with urinary tract diseases and their correction with commercial feeds

2021 ◽  
pp. 37-40
Author(s):  
Olga Andreevna Vorontsova ◽  
Nikolay Alexandrovich Pudovkin ◽  
Vladimir Vasilievich Salautin ◽  
Sergey Dmitrievich Klyukin
Keyword(s):  
Urinary Tract ◽  
Blood Serum ◽  
Catalase Activity ◽  
Free Radical Oxidation ◽  
The Body ◽  
Diene Conjugates ◽  
Radical Oxidation ◽  
Mda Content ◽  
Peroxidation Processes ◽  
Commercial Feeds

The article presents the results of studies on the effect of commercial food on the processes of free radical oxidation of lipids in the body of cats with urinary tract pathology. It has been found that the concentration of diene conjugates in the blood serum of sick animals increases significantly by 15.1 - 36.7% relative to healthy ones. The MDA content in the blood serum of healthy animals was 6.05 ± 0.28 nmol / g. In animals with urolithiasis, this indicator increased by about 2 times. When feeding with commercial food and homemade food, LPO processes normalize, which is most pronounced on the 21st day. The average activity of catalase in the blood serum of sick animals was increased from 30.6% to 40.2% relative to healthy ones (15.15 ± 0.61 ?mol / ml). After feeding with therapeutic and prophylactic fodders, by the 7th day, the catalase activity did not significantly decrease compared to the initial level, but remained higher than in control animals by 19.6% - 37.1%. On the 14th day, the catalase activity did not change significantly compared with the 7th day and was higher than the control values by 21.5% - 27.5%.

scholarly journals Innovative approaches to identifying the relationship between the distribution of the concentration of enzymes in the blood serum and skeletal muscle tissue of rats

2019 ◽  
Vol 135 ◽  
pp. 01098
Author(s):  
Pavel Boriskin ◽  
Olga Gulenko ◽  
Anatoliy Deviatkin ◽  
Rufia Karimova ◽  
Olga Pavlova
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Blood Serum ◽  
Muscle Tissue ◽  
Functional Activity ◽  
Active Oxygen Species ◽  
Free Radical Oxidation ◽  
The Body ◽  
Skeletal Muscle Tissue ◽  
Radical Oxidation

One of the reasons for the increase in disability and mortality among the working population is cardiovascular diseases. Long-term studies of the nature of diseases belonging to this group hypertension, renovascular and malignant arterial hypertension, dyslipidemia, diabetic and dilatational cardiomyopathy, atherosclerosis, ischemic heart disease show that the main cause of pathogenesis is the formation of oxidative stress under the influence of internal and external environmental factors. Mismatch between the processes of free-radical oxidation caused by such active oxygen species as superoxide-anion radical, hydroxide-radical radical, lipid radical, hydrogen peroxide, peroxynitrite, chloric acid and the capabilities of the antioxidant system leads to a disruption of the functional activity of cell structures, displacement of homeostatic balance in the body. Despite the rather deep study of cardiovascular system pathologies, data on the functional activity of myocardial cells under destructive effects and oxidative stress are still insufficient.The article presents the study of the interrelation of the concentration distribution of enzymes of the lipidantioxidant peroxidation system in blood serum and skeletal muscle tissue of white non-pedigree rats. By means of Spearman, Gamma and Kendel Tau correlation coefficients it was revealed a reliable presence of a weak force of inverse correlation between the concentration of catalase in blood serum and skeletal muscle (Spearman R = -0.21 at p < 0.011749, Gamma = -0.14 at p < 0.010977; Kendall Tau = -0.14 at p < 0.010977).

scholarly journals Numerical Analysis of Unsteady Hybrid Nanofluid Flow Comprising CNTs-Ferrousoxide/Water with Variable Magnetic Field

Nanomaterials ◽  
2022 ◽  
Vol 12 (2) ◽  
pp. 180
Author(s):  
Muhammad Sohail Khan ◽  
Sun Mei ◽  
Shabnam ◽  
Unai Fernandez-Gamiz ◽  
Samad Noeiaghdam ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Carbon Nanotubes ◽  
Velocity Profile ◽  
Variable Magnetic Field ◽  
The Body ◽  
Hybrid Nanofluid ◽  
Nano Fluid ◽  
Highly Nonlinear ◽  
The Impact ◽  
The Magnetic Field

The introduction of hybrid nanofluids is an important concept in various engineering and industrial applications. It is used prominently in various engineering applications, such as wider absorption range, low-pressure drop, generator cooling, nuclear system cooling, good thermal conductivity, heat exchangers, etc. In this article, the impact of variable magnetic field on the flow field of hybrid nano-fluid for the improvement of heat and mass transmission is investigated. The main objective of this study is to see the impact of hybrid nano-fluid (ferrous oxide water and carbon nanotubes) CNTs-Fe3O4, H2O between two parallel plates with variable magnetic field. The governing momentum equation, energy equation, and the magnetic field equation have been reduced into a system of highly nonlinear ODEs by using similarity transformations. The parametric continuation method (PCM) has been utilized for the solution of the derived system of equations. For the validity of the model by PCM, the proposed model has also been solved via the shooting method. The numerical outcomes of the important flow properties such as velocity profile, temperature profile and variable magnetic field for the hybrid nanofluid are displayed quantitatively through various graphs and tables. It has been noticed that the increase in the volume friction of the nano-material significantly fluctuates the velocity profile near the channel wall due to an increase in the fluid density. In addition, single-wall nanotubes have a greater effect on temperature than multi-wall carbon nanotubes. Statistical analysis shows that the thermal flow rate of (Fe3O4-SWCNTs-water) and (Fe3O4-MWCNTs-water) rises from 1.6336 percent to 6.9519 percent, and 1.7614 percent to 7.4413 percent, respectively when the volume fraction of nanomaterial increases from 0.01 to 0.04. Furthermore, the body force accelerates near the wall of boundary layer because Lorentz force is small near the squeezing plate, as the current being almost parallel to the magnetic field.

Gender differences in biochemical measurement reflecting the state of free-radical oxidation and antioxidant protection among workers in metallurgical production

2019 ◽  
Vol 1 (10) ◽  
pp. 877-881
Author(s):  
I. A. Umnyagina ◽  
L. A. Strakhova ◽  
T. V. Blinova
Keyword(s):  
Oxidative Stress ◽  
Gender Differences ◽  
Free Radical ◽  
Biochemical Parameters ◽  
Free Radical Oxidation ◽  
The Body ◽  
Antioxidant Protection ◽  
Radical Oxidation ◽  
Metallurgical Production ◽  
Production Factors

Introduction. To date, age and sex differences have been established for many biochemical parameters. Gender differences in indicators for systems such as antioxidant, thiol-disulfide, oxidative stress and inflammation systems are absent or under study.The aim of the study was to identify gender differences in biochemical parameters reflecting the functioning of antioxidant systems of the body and free radical oxidation in workers of metallurgical production, in contact with harmful production factors.Materials and methods. The blood of men and women working at the metallurgical enterprise of the Nizhny Novgorod region (n=80) under the influence of a complex of physical and chemical production factors was studied. Total oxidative stress, total antioxidant capacity of serum, glutathione levels were studied by photometric biochemical methods. Levels of C-reactive protein and 8-hydroxy–2-deoxyguanosine were studied by ELISA.Results. The average amount of peroxides in the serum of women exceeded 1.6 times this figure in men. In the group of men, the content of 8-Ondg was higher by 26% (p=0.012), the level of GS-by 12% (p=0.019), the activity of SOD — by 1.5–2 times (p=0.0001), the level of CRP — by 2 times (p=0.008) compared to similar indicators in women.Conclusions. Studies of gender differences in workers under the influence of harmful production factors will allow more effective approach to the etiology, treatment and prognosis of production-related diseases. Indicators of oxidative stress and antioxidant protection can be indicators of the health of workers under the influence of harmful industrial factors and be important in the prevention of diseases associated with oxidative stress.

Assessment of the Biochemical Status of Workers Manufacturing Ethylbenzene and Styrene

2020 ◽  
pp. 40-43
Author(s):  
RR Galimova ◽  
ET Valeeva ◽  
GV Timasheva ◽  
AB Bakirov
Keyword(s):  
Catalase Activity ◽  
Free Radical Oxidation ◽  
The Body ◽  
Atherogenic Index ◽  
Radical Oxidation ◽  
Professional Groups ◽  
Biochemical Status ◽  
The Central Nervous System ◽  
Hepatic Protein Synthesis ◽  
Increased Activity

Introduction: Production of ethylbenzene and styrene (EBS) is one of the most important stages in organic synthesis. The products have general toxic, hepatotoxic, irritating and narcotic effects on the human body. Severe exposures to EВS can induce pronounced disorders of the central nervous system such as styrene sickness and encephalopathy and of peripheral blood such as leukopenia and lymphocytosis. Materials and methods: We studied homeostasis indices in 376 workers of the main professional groups engaged in the production of EBS including equipment operators, repairmen, and instrumentation and automation fitters. Results: We established an increase in lipid peroxidation by the level of malondialdehyde amid an increase in catalase activity and a decrease in blood retinol and α-tocopherol levels. We also noted an increased activity of indicator enzymes including ALT, AST, GGT, and alkaline phosphatase. Significant changes in lipid metabolism in the form of cholesterolemia, triglyceridemia, a higher atherogenic index, and lower cholesterol of non-atherogenic blood serum lipids demonstrating atherogenic changes in the body were revealed. Conclusions: The earliest prenosological disorders in the body of the examined workers included an impaired hepatic protein synthesis, the development of cytolysis processes and a change in the integrity and functional activity of the liver cell in individuals, an imbalance in the oxidant-antioxidant system, one of the reasons of which was the adverse occupational exposure to hazardous chemicals. An increase in catalase activity is a protective compensatory reaction during the activation of free radical oxidation processes.

scholarly journals Features of free oxidation in liver homogenates of rats in combined action of copper and subtoxic level of stearate potassium and sodium

2016 ◽  
Author(s):  
O. V. Lototska
Keyword(s):  
Free Radical ◽  
Liver Homogenate ◽  
Sodium Stearate ◽  
Free Radical Oxidation ◽  
The Body ◽  
Antioxidant Systems ◽  
Radical Oxidation ◽  
Combined Action ◽  
Liver Homogenates ◽  
Free Oxidation

Toxic effects of heavy metals on animals and humans is aggravating the presence of surfactants. The aim of our research was to identify the peculiarities of free radical oxidation and antioxidant protection in the use of drinking water with subtoxic doses of potassium and sodium stearates in combination with copper on the body of warmblooded animals, such as the liver of experimental rats. Analysis of indicators allows asserting that in experimental rats liver homogenate observed activation of free radical oxidation, the intensity of which depended on the concentration of stearates in water. More pronounced changes were in animals that consumed water with potassium stearate.The action of potassium stearate observed inhibition of antioxidant systems while under the influence of sodium stearate – its activation. Changes in performance were more pronounced in combination stearates with copper.

scholarly journals NITRIC OXIDE AND ALLYL ALCOHOL INDUCED HEPATOTOXICITY

2014 ◽  
Vol 1 (1) ◽  
Author(s):  
M. M. Korda
Keyword(s):  
Nitric Oxide ◽  
Free Radical ◽  
Blood Serum ◽  
Allyl Alcohol ◽  
Calcium Ionophore ◽  
Free Radical Oxidation ◽  
No Synthase ◽  
Nitrate Content ◽  
Radical Oxidation ◽  
Nos Inhibitors

<p><strong>Background.</strong> Nitric oxide (NO) is an important mediator of hepatotoxicity. NO in liver can be derived from two sources: (1) constitutive NO synthase (eNOS) in endothelial cells, and (2) inducible NO synthase (iNOS) in hepatocytes and Kupffer cells.<br /><strong>Objectives.</strong> The present study was aimed to examine the effect of nonselective NOS inhibitor (L-NAME) and selective iNOS inhibitor (1400W) on the development of allyl alcohol (AA) induced hepatitis in rats.<br /><strong>Methods.</strong> Male Wistar rats were treated with intraperitoneal injection of saline or AA and L-NAME or 1400W. NO in liver was measured by electrochemical method after eNOS stimulation by calcium ionophore. Total NOS activity and nitrite/nitrate content were measured in liver and blood serum. The activity of free radical oxidation in liver was measured by chemiluminescent method. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities were assayed in blood serum<br /><strong>Results.</strong> AA increased the activity of free radical processes in liver and markers of cytolysis in serum, as well as decreased eNOS and increased iNOS activities. L-NAME considerably inhibited eNOS and augmented the necrosogenic properties of AA, whereas 1400W partially prevented liver damage.<br /><strong>Conclusion.</strong> It has been concluded that in AA intoxication NO produced from eNOS is beneficial to the liver, but NO derived from the upregulated iNOS has deleterious effect.</p><p><strong>KEY WORDS:</strong> nitric oxide, toxic hepatitis, NOS inhibitors.<br /><br /></p>

scholarly journals The gravitational imprint on sensorimotor planning and control

2020 ◽  
Vol 124 (1) ◽  
pp. 4-19 ◽  
Author(s):  
O. White ◽  
J. Gaveau ◽  
L. Bringoux ◽  
F. Crevecoeur
Keyword(s):  
Internal Representation ◽  
The Body ◽  
Altered Gravity ◽  
Partial Adjustment ◽  
Gravitational Forces ◽  
Planning And Control ◽  
Biomechanical Constraints ◽  
And Control ◽  
Future Work ◽  
The Impact

Humans excel at learning complex tasks, and elite performers such as musicians or athletes develop motor skills that defy biomechanical constraints. All actions require the movement of massive bodies. Of particular interest in the process of sensorimotor learning and control is the impact of gravitational forces on the body. Indeed, efficient control and accurate internal representations of the body configuration in space depend on our ability to feel and anticipate the action of gravity. Here we review studies on perception and sensorimotor control in both normal and altered gravity. Behavioral and modeling studies together suggested that the nervous system develops efficient strategies to take advantage of gravitational forces across a wide variety of tasks. However, when the body was exposed to altered gravity, the rate and amount of adaptation exhibited substantial variation from one experiment to another and sometimes led to partial adjustment only. Overall, these results support the hypothesis that the brain uses a multimodal and flexible representation of the effect of gravity on our body and movements. Future work is necessary to better characterize the nature of this internal representation and the extent to which it can adapt to novel contexts.

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