scholarly journals The Relationship of Ghrelin Level with Levels of Cluster of Differentiation 4 (CD4) in Human Immunodeficiency Virus (HIV) Patients Receiving Antiretroviral (ARV) Therapy

2021 ◽  
Vol 8 (12) ◽  
pp. 650-656
Author(s):  
Ibrahim Tanaka ◽  
Dharma Lindarto ◽  
Santi Syafril

Background: Ghrelin is primarily involved in the secretion of growth hormone (GH), glucose and lipid metabolism. HIV infection is thought to affect ghrelin levels in HIV patients, especially in patients with lipodystrophy. However, this effect is still unclear because many studies have obtained different results about low or high levels of ghrelin in people with HIV. Suppression of HIV replication with ART rapidly increases CD4 cell count. However, data on the effect of antiretroviral therapy on ghrelin levels is still scant. Aim: To examine the relationship between ghrelin levels and CD4 levels in HIV patients receiving ARV therapy. Method: This research is an observational analysis study, with cross-sectional design, implemented start from April 2020 in Tropical Diseases & Infection Polyclinic, H. Adam Malik Hospital. Blood samples were taken and examined at the Clinical Pathology Laboratory. Primary and secondary data collection from interviews and direct observation. Data will be analyzed with Pearson correlation test if normally distributed or Spearman's test if the data is not normally distributed using SPSS software. Results: A total of 43 the sample consists of 38 patient who received the AFC, 3 patients received Duviral + Efafirens, 1 patient received Tenofovir + Hiviral + Aluvia dan 1 patient received Tenofovir + Hiviral + Neviral. Demographic characteristics based on th highest ages group are 21-30 years and 31-40 years, each of which is 17 people. The correlation of ghrelin level with levels of CD4 on the HIV patient taking ARV shows a significance value of 0.943, it can be concluded that there was no significant relationship between Ghrelin levels and CD4. Conclusion: There was no correlation between ghrelin levels with CD4 levels on HIV patient receiving ARV therapy. Keywords: Ghrelin, HIV, CD4, Antiretrovirals.

2021 ◽  
Vol 8 (11) ◽  
pp. 10-16
Author(s):  
Husni Gunawan Hasibuan ◽  
Syafrizal Nasution ◽  
Radar Radius Tarigan

Background: Anemia appears in the early stages of CKD and its prevalence increases as kidney function declines. Ret-HE can be used to diagnose iron-deficiency anemia. Indonesia does not yet have appropriate research data on RET-He levels in CKD patients undergoing hemodialysis as a parameter to assess iron. Therefore, this study aims to examine the ability of RET-He as an alternative parameter to assess iron deficiency in hemodialysis patients. Method: This research is a correlation analytic study with a cross-sectional design, carried out in February-May 2021 at the Hemodialysis Installation of H. Adam Malik Hospital. Blood sample collection and examination are carried out at the Clinical Pathology Laboratory. Primary and secondary data were collected from interviews, questionnaires, or patient medical records. The data will be analyzed by Pearson correlation test using SPSS software. Results: A total of 41 samples consisted of 31 anemic patients and 10 anemic patients with normal RET-He levels. Demographic characteristics based on age group with an average of 47±13.28 years. The correlation of Ret-HE and TSAT levels in CKD patients undergoing hemodialysis shows a significance value of 0.000, so it can be concluded that there is a correlation between RET-HE and TSAT levels with a significance value of <0.05. According to the Pearson correlation number of 0.618 which is in the range of 0.61 to 0.80. Conclusion: There is a positive correlation between Ret-HE levels and iron deficiency anemia in CKD patients undergoing regular hemodialysis. Keywords: CKD, RET-HE, Hemodialysis.


Author(s):  
Misnah Misnah ◽  
Agus Alim Abdullah ◽  
Mansyur Arif ◽  
Burhanuddin Bahar

Prothrombin Time (PT) and an activated Partial Thromboplastin Time (aPTT) are routine coagulation tests used for pre-operative screening. The analytical step as one of the laboratory test’s stage that plays the role in the determination of the test is influenced by several factors, one of them is choosing its proper devices. The aim of this study was to know the correlation of the PT and aPTT test’s result using Humaclot VA and Sysmex CA 500 devices. A cross sectional study has been done at the Clinical Pathology Laboratory of Wahidin Sudirohusodo Hospital Makassar started from May 2009 until June 2009. The data were analyzed with T and Pearson’s Correlation test. From the 50 samples were obtained the percentage of the corresponding frequency of the PT results between Humaclot VA and Sysmex CA 500 about 84%, whereas the frequency of the corresponding results aPPT between Humaclot VA and Sysmex CA 500 is 76%, the Pearson correlation test for PT=0.58, and aPTT=0.38. There were found the suitability of PT, aPTT of Humaclot VA with CA 500 and both tools have a positive correlation.


2021 ◽  
Vol 9 (2) ◽  
pp. 73-84
Author(s):  
Budi Kristanto

Latar belakang : saat ini prevalensi hipertensi secara global sebesar 22% dari total penduduk dunia. Dari sejumlah penderita tersebut, hanya kurang dari seperlima yang melakukan upaya pengendalian terhadap tekanan darah yang dimiliki. Adapun faktor yang terkait dengan tekanan darah sangat kompleks, baik yang dapat dikontrol maupun tidak dapat dikontrol. Salah satu kebiasaan yang diduga terkait dengan hipertensi adalah kebiasaan konsumsi kopi. Tujuan : mengetahui hubungan antara kebiasaan konsumsi kopi dengan kejadian hipertensi. Subjek dan Metode : responden penelitian ini adalah  warga Desa Ngringo RW 22 dan 29 Kecamatan Jaten Karanganyar sejumlah 45 responden. Jenis penelitian adalah analitik observasional, desain korelasi dengan pendekatan cross sectional untuk mengetahui hubungan antara kebiasaan konsumsi kopi dengan kejadian hipertensi. Teknik sampling menggunakan total sampling, Data dianalisis menggunakan uji Pearson Corelation. Hasil : mayoritas responden memiliki kebiasaan konsumsi kopi dalam kategori ringan (1-3 cangkir perhari) sebesar 97,8%, sedangkan yang kategori sedang (4-6 cangkir perhari) sebesar  2,2%. Mayoritas responden dengan tekanan darah yang normal yaitu 82,2%, dan hipertensi 17,8%. Kesimpulan : tidak ada hubungan antara kebiasaan konsumsi kopi dengan kejadian hipertensi (p : 0,058).   Kata kunci : konsumsi kopi, hipertensi   THE RELATIONSHIP OF COFFEE CONSUMING HABITS WITH HYPERTENSION   Budi Kristanto, Diyono   Astract   Background : currently the global prevalence of hypertension is 22% of the total world population. Of the number of sufferers, only less than a fifth who make efforts to control their blood pressure. The factors associated with blood pressure are very complex, both controllable and uncontrollable. One of the habits thought to be associated with hypertension is the habit of consuming coffee. The aims of the study: knowing the relationship between coffee consumption habits and the incidence of hypertension. Subject and Methods : the respondents of this research were 45 respondents in Ngringo Village RW 22 and 29, Jaten, Karanganyar District. This research used observational analytic method, correlation design with cross sectional approach to determine the relationship between coffee consumption habits and the incidence of hypertension. The sampling technique used total sampling. Data were analyzed using the Pearson Correlation test. Result : the majority of respondents have a habit of consuming coffee in the light category (1-3 cups per day) of 97.8%, while the moderate category (4-6 cups per day) is 2.2%. The majority of respondents with normal blood pressure were 82.2%, and hypertension 17.8%. Conclusion : There is no relationship between coffee consumption habits and the incidence of hypertension (p: 0.058).   Keywords: coffee consumption, hypertension  


2019 ◽  
Vol 19 (2) ◽  
pp. 120-124 ◽  
Author(s):  
Arun G. Maiya ◽  
Anche Parameshwar ◽  
Manjunath Hande ◽  
Vinayak Nandalike

Foot ulcers, infections, and deformity are some of the major sources of mortality and morbidity among the diabetic population. The relationship between glycated hemoglobin (HbA1c) and diabetic peripheral neuropathy (DPN) has been well established. There is a dearth of literature on the relationship between vibration perception threshold (VPT) and HbA1c values. So, the objective of the study was to determine the strength of linear relationship between HbA1c levels and vibration perception threshold in DPN. This cross-sectional study was conducted at Kasturba Hospital, Manipal, and diabetic foot screening camps held at various parts of Udupi district. Ethical approval was obtained from the Institutional Ethics Committee, Kasturba Hospital, Manipal (IEC:281/2017). A total of 534 participants ranging from 30 to 70 years of age and were diagnosed with type 2 diabetes mellitus on medications were included in the study. Neuropathy assessment consisting of monofilament and vibration perception threshold was done using Neurotouch beta version (Yostra Labs, Bengaluru, India). HbA1c measurement was done using turbidimetric inhibition immunoassay technique (Roche Diagnostics, Mannheim, Germany). Pearson correlation coefficient showed a moderate to good correlation between HbA1c and VPT ( r = .0.753, P < .001). Linear regression result has shown a significant relationship of VPT with HbA1c (4.033 [95% confidence interval = 3.67-4.39]). The present study has concluded that there is strong relationship between HbA1c values and VPT and could be a predictor for complications in the foot following DPN.


2013 ◽  
Vol 84 (2) ◽  
pp. 279-285 ◽  
Author(s):  
Ana Carla Raphaelli Nahás-Scocate ◽  
Aluana de Siqueira Brandão ◽  
Mayara Paim Patel ◽  
Michel Eli Lipiec-Ximenez ◽  
Israel Chilvarquer ◽  
...  

ABSTRACT Objective: To evaluate the amount of buccal and lingual supporting bone tissue of 60 upper central incisors and the relationship with their inclination. Materials and Methods: Thirty healthy adult patients with no previous orthodontic treatment were evaluated using cone-beam computed tomography. Cross-sectional views were analyzed to check the amount of the bone tissue on the cervical (cervical buccal thickness/CBT; lingual/CLT), middle (middle buccal thickness/MBT; lingual/MLT), and apical regions (apical buccal thickness/ABT; lingual/ALT). The Pearson correlation, linear regression, and analysis of variance tests were used (P &lt; .05). Results: The values of ABT of both teeth (11, right upper central incisor; 21, left upper central incisor) were significantly increased with the increase in the angle between the axis of the upper central incisor and the palatal plane (1/PP) (tooth 11 P  =  .034; tooth 21 P  =  .009), yet without a strong linear correlation. At the buccal and lingual surfaces, the mean apical supporting bone tissue was significantly greater than the other areas, and the middle region significantly greater than the cervical (P &lt; .001). Conclusions: For both surfaces (buccal and lingual), the amount of bone tissue in the apical region was significantly higher than the middle and cervical regions, and the middle region was significantly higher than the cervical region. In relation to the upper central incisor's inclination, the higher the 1/PP the higher was ABT. However, the coefficient values for both teeth were low.


2002 ◽  
Vol 5 (4) ◽  
pp. 553-560 ◽  
Author(s):  
Davide Arcella ◽  
Livia Ottolenghi ◽  
Antonella Polimeni ◽  
Catherine Leclercq

AbstractObjective:To propose an approach for investigation of the relationship between the frequency of carbohydrates intake and dental caries in real-life conditions.Design:The frequency of separate eating events (with the exclusion of lunch and dinner) and their sugars and starch content were assessed on the basis of diaries collected for seven consecutive days. The total number of decayed, missing and filled teeth (DMFT) was assessed through clinical examination. The interrelation between DMFT and frequency of eating events was analysed through Pearson correlation coefficient and stepwise forward linear regression analysis.Setting:Italy.Subjects:One hundred and ninety-three students (males and females, mean age 16 years) of a secondary school.Results:Individual DMFT varied between 0 (24% of subjects) and 12, with a mean of 3. Once lunch and dinner were excluded, the mean number of separate eating events was 2.9. A statistically significant relationship was found between DMFT and eating frequency thus defined. Correlations were calculated considering only eating events containing a proportion of sugars or starch higher than different cut-off levels. In a stepwise multiple regression model for DMFT, the frequency of ‘high sugars and high starch events’ accounted for 8% of the DMFT variance. Overall frequency of separate eating events defined according to their content of both sugars and starch accounted for 18% of the DMFT variance. A stronger correlation was found among males only.Conclusions:The precise characterisation of eating events in terms of their sugars and starch content allows us to explain a consistent percentage of the variability in DMFT.


2015 ◽  
Vol 42 (4) ◽  
pp. 404-420 ◽  
Author(s):  
Stephen Korutaro Nkundabanyanga ◽  
Julius Opiso ◽  
Waswa Balunywa ◽  
Isaac Nabeeta Nkote

Purpose – The purpose of this paper is to establish the relationship between managerial competence, managerial risk-taking behaviour and financial service outreach of microfinance institutions (MFIs). Design/methodology/approach – In this cross-sectional and correlational study, the authors surveyed 52 branches of MFIs from a population of 60 branches of 20 MFIs in eastern Uganda. Two respondents, a branch manager and a senior loan officer, were the units of enquiry for each branch. The authors put forward and tested four hypotheses relating to the significance of the relationship between perceived managerial competence, risk-taking behaviour and financial service outreach using SPSS version 20. The authors established the hypothesized relationships using Pearson correlation coefficients and obtain a mediating effect of risk-taking behaviour using partial corrections and regression analysis. Findings – The results suggest positive and significant relationships between perceived managerial competence, risk-taking behaviour and financial service outreach. However, while the direct relationship between managerial competence and financial service outreach without the mediation effect of risk-taking behaviour of managers was found to be significant, its magnitude reduces when mediation of risk-taking behaviour is allowed. Thus the entire effect does not only go through managerial competence but majorly also, through risk-taking behaviour of managers. Research limitations/implications – This study did not control for environmental factors such as laws and regulations. As such the model may have been under fitted. Nevertheless, the study has introduced a clearer understanding that outreach performance in MFIs rests with competent managers in strategic positions operating in synergy with their risk-taking behaviour. The study informs policy makers that outreach performance of the MFIs depends on the quality of the competence managers have in addition to their risk-taking propensities. Practical implications – Efforts by the stakeholders to improve financial service outreach must be matched with appropriate competences and risk-taking behaviour of managers. Originality/value – The results contribute to extant literature by investigating two explanatory variables for financial service outreach and provide initial evidence of the mediating effect of intrinsic high risk-taking behaviour of managers. Results add to the conceptual improvement in risk-taking behaviour and lend considerable support for the behavioural perspective in the study of financial service outreach of MFIs.


Author(s):  
Ana Zakiyah ◽  
Duwi Basuki ◽  
Windu Santoso

Discharge planning is one of the activities in the provision of nursing care on patients in the hospital, it will have a shortening impact on patient care in the hospital and reduce the patient's recurrence rate, but the implementation is not appropriate. so far, implementation of Discharge planning is still to be done after the patient finished having treatment by making a summary of the recording of patients return. Various characteristic factors of nurses can influence the implementation of discharge planning in hospital. The research purpose was to know the relationship of factors that influence discharge planning with the implementation of discharge planning. The research design used was cross-sectional, the instrument used was the questionnaire about the characteristics of the nurses and the implementation of discharge planning. The population of research was nurses who served in the inpatient room RSI Sakinah Mojokerto number of 80 nurses and obtained the number of 67 samples with proportional random sampling technique. The result of analysis with pearson correlation for age, education, length of work and chi-square for marital status showed that the characteristics of nurses related to discharge planning implementation were educational factor with p-value 0,023. The higher the nurse education caused more critical, logical and systematic in thinking so as to improve the quality of its work and the greater the desire to utilize the knowledge and skills it possesses keywords        : discharge planning, nurses, education


2021 ◽  
Vol 7 ◽  
pp. 237796082110626
Author(s):  
Heba E El-Gazar ◽  
Mohamed A Zoromba

Introduction The nursing literature is silent about the relationship between ethical leadership, nurses’ flourishing, and extra-role behavior. This study was carried out to contribute to the relevant field research. Objective The aim of the present study was to investigate the relationship between nurses’ perceptions of their nursing managers’ ethical leadership behavior, nurses’ flourishing, and their extra-role behavior. Methods This was a cross-sectional study involving 302 nurses from six hospitals in Damietta City, Egypt. Data were collected using the following three self-report scales: Ethical Leadership at Work questionnaire, Flourishing Scale, and extra-role behavior scale. The data were analyzed using descriptive statistical, Pearson correlation, regression analysis and the structure equation model. Results There was a significant positive relationship between nursing managers’ ethical leadership, nurses’ flourishing, and extra-role behavior. The regression analysis showed that the ethical leadership of nursing managers and nurses’ flourishing predict extra-role behavior. Conclusion Nurses with a high level of flourishing and who work with a manager exhibiting ethical leadership behavior are more likely to activate extra-role behavior. Hence, it is recommended that nursing managers embrace an ethical approach in their leadership practices and promote flourishing among nurses to encourage them to go the extra the mile in their jobs.


2018 ◽  
Vol 5 (1) ◽  
pp. 114-121
Author(s):  
Betti Rosita ◽  
Ulfa Khairani

Hospital laboratory services is one of the activities in hospitals that support quality health services. One indicator of the success of health services in the field of clinical pathology laboratory services is the waiting time for laboratory services. The standard set for laboratory service outcome waiting time is ≤ 140 minutes for blood chemistry and routine blood. This research analyzed the service time of outpatient laboratory that conducted hematology and clinical chemistry examination in the laboratory of Pasaman Barat Hospital. This research is a type of descriptive analytic research that is quantitative and supported by qualitative using cross sectional approach. The result of the research showed that laboratory service time at RSUD Pasaman Barat fulfilled the standard (≤ 140 minutes) for hematology examination 33.94 minutes, clinical chemistry 83.92 minutes, hematology and clinical chemistry 98 minutes. Based on the results of this study, the stages that contribute to the length of time laboratory services for hematological examination lies in the pre analytical stage, for clinical chemistry examination is located at the analytical stage, as well as for hematology and clinical chemistry examination lies in the analytic stage as well as the factors that affect the length of time laboratory services are human resources that is in the ability of officers and infrastructure facilities


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