Cryodestruction of recurrent malignant skin tumors of different localizations in polyclinics

Introduction. Skin cancer is one of the most common types of malignant neoplasms in Russia. Radiation therapy, surgical intervention, and combined treatment are usually used for skin cancer. Unfortunately, the above methods are not always successful. The reason for the incomplete effect of surgical treatment may be insufficient radicalism of the intervention due to the doctor's desire to cause the least trauma to the surrounding healthy tissues in order to obtain a good cosmetic result. Selective destruction of tumor tissue in cryogenic exposure with minimal damage to surrounding healthy tissues is accompanied by a hemostatic effect, which is especially important in the treatment of both primary and recurrent decaying tumor ulcers. Aim — to evaluate the effectiveness of cryodestruction as the method of choice in the outpatient treatment of recurrent skin cancer. Materials and methods. The study was controlled, non-randomized. The criterion for inclusion in the study was the establishment of the diagnosis of recurrent skin cancer at the application and subsequent treatment in the outpatient clinic of the State Budgetary Institution "Oncologic Dispensary" in Novocherkassk from 2016 to 2020. A total of 532 patients were studied. Patients were planned to undergo tumor cryodestruction with several freeze-thaw cycles, lasting 2-5 minutes. Results. The results of the study indicate high efficiency of cryodestruction. Complete recovery in the treatment of recurrent skin cancer was observed in 446 (83.4%) patients. Repeated cryodestruction was performed in 86 (16.6%) patients, who experienced continued growth and recurrence after cryodestruction within 1 to 18 months. Subsequently, 38 of 86 patients (7.2%) did not experience continuation of growth and new recurrences. Discussion. Based on the literature data and our treatment results it was determined that cryodestruction is the most acceptable and simple method of treatment for this category of patients. Conclusion. In the presence of limited recurrences of skin cancer of various localizations, cryogenic exposure is effective (in 90.6% of the outcome — recovery) in patients of different sex and age, regardless of the location and prevalence of the tumor process and is the method of choice of treatment in an outpatient setting.

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PARP1 inhibitors in breast cancer therapy. Mechanism of action and clinical use

Tumors of female reproductive system ◽

10.17650/1994-4098-2020-16-1-55-64 ◽

2020 ◽

Vol 16 (1) ◽

pp. 55-64

Author(s):

D. S. Dolgasheva ◽

A. M. Pevzner ◽

M. K. Ibragimova ◽

N. V. Litvyakov ◽

M. M. Tsyganov

Keyword(s):

Breast Cancer ◽

High Efficiency ◽

Parp Inhibitor ◽

Combined Treatment ◽

Parp Inhibitors ◽

Response To Treatment ◽

Malignant Neoplasms ◽

Brca1 And Brca2 ◽

System A ◽

Parp1 Inhibitors

It is known that currently PARP inhibitors are actively used in the treatment of tumors of the female reproductive system. A large number of studies have been presented demonstrating the effectiveness of PARP inhibitors in the treatment of BRCA-associated ovarian cancer. It was found that mutations in the BRCA1 and BRCA2 genes are also characteristic of breast cancer (BC). However, PARP inhibitors are rarely used in clinical practice in the treatment of BC. So far, only olaparib has become the first PARP inhibitor approved for the treatment of metastatic BC. This review presents data over the past ten years showing the high efficiency of PARP inhibitors in the treatment of malignant neoplasms of the mammary gland. In 7 of 28 studies analyzed, positive results were achieved with combined treatment with chemotherapeutic drugs and PARP inhibitors. So, for example, in two studies in the treatment of BRCA-associated BC, the response to treatment in patients was 72.5–73.2 %. Thus, PARP inhibitors are of great interest and are of practical value in the treatment of patients with BC.

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Treatment of Symptomatic Hemorrhoids by Baron’s Band Ligation

10.53350/pjmhs2115113355 ◽

2021 ◽

Vol 15 (11) ◽

pp. 3355-3356

Author(s):

Fazal-e- Nauman ◽

Sirajud din ◽

Shandana Gul ◽

Mahwash Anjum Shafiq

Keyword(s):

Rubber Band Ligation ◽

Symptomatic Treatment ◽

Rubber Band ◽

Outpatient Setting ◽

Simple Method ◽

Duration Of Symptoms ◽

Band Ligation ◽

Medical College ◽

Normal Functional ◽

One Year

Haemorrhoids are a clinical symptom of a change in the normal functional architecture of the inflamed and swollen veins known as the anal cushion. Numerous treatment opportunities are available for this communal issue, but Baron's Gum Ligation (RBL) is the utmost frequently used technique for second- and third-degree haemorrhoids because it treats hemorrhoidal disease without anaesthesia, hospitalization, minimal complications, and ooutpatient discharge is uneventful compared to conventional surgery. Purpose: We conducted this study to evaluate the effectiveness of rubber band ligation in the treatment of second- and third-degree haemorrhoids. Methodology: This prospective study was performed on 76 patients over a six-month period at the Department of General Surgery from January 2021 to June 2021 at Islam Medical College and Teaching Hospital Sialkot. Rubber rubber ligation was used in all patients. A maximum of two haemorrhoids in one session were banded, and third as needed in a check-up done two weeks later. At the end of the fourth week, post-banding assessments were made for the presence and absence of bleeding, pain, and haemorrhoidal prolapse. Results: Of the 76 patients, 60 (78.9%) were male and 16 (21.1%) were female. The M:F ratio was 5.0: 1.0. 37.85 years was the mean age of patients (range 15 to 68). The duration of symptoms in approximately 48 patients (63.2%) was less than one year old, and in 18 (23.7%) patients ranged from 1 to 3 years and 10 (13.2%) patients had symptoms for more than 4 years. Complications occurred in 23 patients, bleeding in three patients, pain in 18 patients, 2 patients have prolapsed. Conclusion: RBL is effective, safe and simple method of symptomatic treatment for 2nd and 3rd degree haemorrhoids in an outpatient setting.

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Heterogeneous Catalytic Synthesis of 2-Methylbenzimidazole from 2-Nitroaniline and Ethanol Over Mg Modified Cu-Pd/γ-Al2O3

Catalysts ◽

10.3390/catal9010008 ◽

2018 ◽

Vol 9 (1) ◽

pp. 8 ◽

Cited By ~ 4

Author(s):

Feng Feng ◽

Yaqin Deng ◽

Zheng Cheng ◽

Xiaoliang Xu ◽

Qunfeng Zhang ◽

...

Keyword(s):

Active Sites ◽

Hydrogen Transfer ◽

High Efficiency ◽

Simple Procedure ◽

Direct Synthesis ◽

Reaction System ◽

Simple Method ◽

Heterogeneous Catalytic ◽

Coupled Reaction ◽

Al2o3 Catalyst

The direct synthesis of benzimidazoles from 2-nitroaniline and ethanol over Cu-Pd/γ-Al2O3 catalysts has the advantages of requiring easily available starting materials, having high efficiency, and a simple procedure. The modification by Mg of the Cu-Pd/γ-Al2O3 catalyst could improve the catalytic activity significantly. The addition of Mg to the Cu-Pd/γ-Al2O3 catalyst could maintain and promote the formation of CuPd alloy active sites. Meanwhile, the basicity of the support was enhanced appropriately by Mg, which generated more basic sites (Al-Oδ−) to accelerate the dehydrogenation of alcohol and increased the rate of the whole coupled reaction. The 2-nitroaniline was completely converted over Cu-Pd/(Mg)γ-Al2O3 after reacting for six hours, and the yield of 2-methylbenzimidazole was 98.8%. The results of this work provide a simple method to develop a more efficient catalyst for the “alcohol-dehydrogenation, hydrogen transfer and hydrogenation” coupled reaction system.

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Pathophysiological justification of the use of photodynamic therapy in the initial stage of squamous cell skin cancer

Problems in oncology ◽

10.37469/0507-3758-2021-67-1-77-84 ◽

2021 ◽

Vol 67 (1) ◽

pp. 77-84

Author(s):

Vladimir Masljakov ◽

Dmitry Grebnev ◽

Larisa Kim

Keyword(s):

Photodynamic Therapy ◽

Surgical Treatment ◽

Skin Cancer ◽

Matrix Metalloproteinases ◽

Squamous Cell ◽

Therapy Group ◽

Combined Treatment ◽

Vascular Wall ◽

Comprehensive Treatment ◽

Initial Stage

The work is based on an analysis of the course of the disease in 185 patients with squamous cell skin cancer. The study program included studies in three major groups. The first included 74 (40%) patients who underwent combined treatment: an operation involving widespread excision of a tumor under intravenous anesthesia + photodynamic therapy (group 1). The second group was 111 (60%) patients with squamous cell carcinoma of the skin who received only operative treatment. To control and compare the obtained laboratory indicators, a second group was created, which included patients without established pathology. This group included 17 people who voluntarily agreed to conduct the study. The study traced the dynamics of changes in hemostasis scores and metalloproteinases in the two groups being compared. In the group of patients with squamous cell skin cancer, there was a statistically significant decrease in the metalloproteinase-1 inhibitor index, which led to an increase in all metalloproteinase-2, -7 and -9 indicators. Performing surgical treatment did not lead to correction of these indicators, both in the near and distant periods after treatment. The mechanism of influence of photodynamic therapy in squamous cell skin cancer can be characterized as follows: there is a decrease in the inhibitor of metalloproteinase-1, which leads to an increase in matrix metalloproteinases-2, -7 and -9 in the blood, as a result of damage to the endothelium of the vascular wall, which is confirmed by an increase in endothelin, this, in turn, led to the development of vasoconstriction and increased procoagulant activity The use of photodynamic therapy restores the index of metalloproteinase-1 inhibitor, this leads to the restoration of matrix metalloproteinases-2, -7 and -9 in the blood and the prevention of damage to the vascular wall. Comprehensive treatment of patients with squamous cell skin cancer in the initial stage of the disease should include photodynamic therapy with simultaneous intravenous blood irradiation, laser tumor training, and then surgical treatment, consisting in excision of the tumor with observance of oncological principles.

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Five Strip-Type Dye Sensitized Solar Cells with Metal Grid Lines

Solid State Phenomena ◽

10.4028/www.scientific.net/ssp.119.315 ◽

2007 ◽

Vol 119 ◽

pp. 315-318

Author(s):

Won Jae Lee ◽

Easwaramoorthi Ramasamy ◽

Dong Yoon Lee ◽

Jae Sung Song

Keyword(s):

Solar Cells ◽

High Efficiency ◽

Dye Sensitized Solar Cells ◽

Standard Condition ◽

Light Condition ◽

Fluorescent Light ◽

Simple Method ◽

Dye Sensitized ◽

Large Size ◽

Sensitized Solar Cells

Dye sensitized solar cells (DSSC) have great potential alternative to expensive conventional solar cells, since high efficiency and relatively simple fabrication process. However, in large size cell, there is a key factor that delayed the entry of such cells in commercial market. Performance of large size cell is lower than small size cells, since a carrier loss occurs in high resistive TCO glass substrate. Here we demonstrate a simple method to reduce resistive loss and efficient collection of photo generated carriers via strip type cells with metal grids. Using strip type cells, we constitute series and parallel type DSSC panels in order to achieve required voltage and current respectively. Stripe cells were prepared from commercial TiO2 powder by screen printing method. In addition, metal grids were established adjacent to sealant line. Using these as unit cell, portable DSSC panels were assembled and I-V performance was carried out in indoor light condition (fluorescent light, 30mW/cm2) and standard condition (Pin 100 mW/cm2, AM 1.5).

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Cholestatic Liver Injury: Care of Patients With Primary Biliary Cholangitis or Primary Sclerosing Cholangitis

AACN Advanced Critical Care ◽

10.4037/aacnacc2016202 ◽

2016 ◽

Vol 27 (4) ◽

pp. 441-452 ◽

Cited By ~ 2

Author(s):

Laurie Larson ◽

Michelle James ◽

Andrea Gossard

Keyword(s):

Primary Sclerosing Cholangitis ◽

Sclerosing Cholangitis ◽

Disease Recurrence ◽

Outpatient Setting ◽

Primary Biliary Cholangitis ◽

Malignant Neoplasms ◽

Cholestatic Liver Disease ◽

Gallbladder Polyps ◽

Increased Risk ◽

Common Causes

The most common causes of chronic cholestatic liver disease are primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). Both disease processes are characterized by a destruction of intrahepatic and/or extrahepatic biliary ducts. The etiology is not entirely clear; however, there is an underlying autoimmune component contributing to both disease processes. Although PBC and PSC are often diagnosed and managed in the outpatient setting, in some instances, a patient may have jaundice, fatigue, and pruritus requiring evaluation and determination of the cholestatic cause. Patients with PSC should be monitored for evidence of cholangiocarcinoma, colon cancer, and gallbladder polyps as they are at an increased risk of malignant neoplasms. Liver transplant has the potential for improving quality of life, although disease recurrence is a risk.

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Evaluation of the Service Performance of Ships

Marine Technology and SNAME News ◽

10.5957/mt1.2005.42.4.177 ◽

2005 ◽

Vol 42 (04) ◽

pp. 177-183

Author(s):

Poul Andersen ◽

Anne-Sophie Borrod ◽

Hervé Blanchot

Keyword(s):

Input Data ◽

High Efficiency ◽

Service Performance ◽

The Other ◽

Simple Method ◽

Propulsive Efficiency ◽

Order Of Magnitude ◽

Time Periods

A simple method has been established for the evaluation of the service performance of ships. Input data are easily collected daily on board and transformed to a well-defined condition that makes possible the comparison between ships, for instance, sister ships, and between different time periods of voyages for the same ship. The procedure has been applied to two ships that are identical, with the only exception that one has a conventional propeller, whereas the other one is fitted with a high-efficiency propeller of the KAPPEL type. The results are obtained from a period of 2 years steaming for both vessels. They clearly confirm the increase of propulsive efficiency obtained with the KAPPEL propeller in the order of magnitude of 4%.

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Hyperbaric oxygen therapy in a case of cervical abscess extending to anterior mediastinum, with isolation of Prevotella corporis

BMJ Case Reports ◽

10.1136/bcr-2019-229873 ◽

2019 ◽

Vol 12 (7) ◽

pp. e229873 ◽

Cited By ~ 2

Author(s):

Francesco Ciodaro ◽

Francesco Gazia ◽

Bruno Galletti ◽

Francesco Galletti

Keyword(s):

Hyperbaric Oxygen ◽

Hyperbaric Oxygen Therapy ◽

Oxygen Therapy ◽

Combined Treatment ◽

Complete Recovery ◽

Anterior Mediastinum ◽

Multidisciplinary Teams ◽

Odontogenic Infections ◽

Odontogenic Abscess ◽

Descending Mediastinitis

We present a case of an odontogenic abscess, first spreading at the lateral cervical level and then in mediastinum. We isolated an anaerobic bacterium, Prevotella corporis, rarely documented in literature. The mortality rates of cervical abscesses secondary to odontogenic infections and complicated by mediastinitis vary from 10% to 40%. Treatment of descending mediastinitis involves multidisciplinary teams such as otorhinolaryngology, thoracic surgeons, infectious disease physicians, anesthetists and intensivists. Due to the combined treatment with surgical drainage within 48 hours of hospitalisation, antibiotics and subsequent hyperbaric oxygen therapy, we have achieved complete recovery of the patient.

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Enhanced Microwave Absorption and Electromagnetic Properties of Si-Modified rGO@Fe3O4/PVDF-co-HFP Composites

Materials ◽

10.3390/ma13040933 ◽

2020 ◽

Vol 13 (4) ◽

pp. 933 ◽

Cited By ~ 4

Author(s):

Yuexuan Li ◽

Yugang Duan ◽

Chengmeng Wang

Keyword(s):

Microwave Absorption ◽

Reflection Loss ◽

High Efficiency ◽

Vinylidene Fluoride ◽

Synergistic Effects ◽

Electromagnetic Properties ◽

Absorption Mechanism ◽

Simple Method ◽

Absorption Frequency ◽

Enhanced Absorption

Graphene has been regarded as one of the most promising two-dimensional nanomaterials. Even so, graphene was still faced with several key issues such as impedance mismatching and narrow bandwidth, which have hindered the practical applications of graphene-based nanocomposites in the field of microwave absorption materials. Herein, a series of Si-modified rGO@Fe3O4 composites were investigated and fabricated by a simple method. On one hand, the degree of defects in graphene carbon could be tuned by different silane coupling reagents, which were beneficial to enhancing the dielectric loss. On the other hand, the spherical Fe3O4 nanoparticles provided the magnetic loss resonance, which contributed to controlling the impedance matching. Subsequently, the electromagnetic absorption (EMA) properties of Si-modified rGO@Fe3O4 composites with poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-co-HFP) were investigated in this work. As a result, the Si(2)-rGO@Fe3O4/PVDF-co-HFP composite exhibited the excellent EMA performance in the range of 2–18 GHz. The maximum reflection loss (RLmax) reached −32.1 dB at 3.68 GHz at the thickness of 7 mm and the effective absorption frequency bandwidth for reflection loss (RL) below −10 dB was 4.8 GHz at the thickness of 2 mm. Furthermore, the enhanced absorption mechanism revealed that the high-efficiency absorption performance of Si(2)-rGO@Fe3O4/PVDF-co-HFP composite was attributed to the interference absorption (quarter-wave matching model) and the synergistic effects between Si(2)-rGO@Fe3O4 and PVDF-co-HFP. This work provides a potential strategy for the fabrication of the high-performance EMA materials.

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Perivascular Hyaluronidase With Alteplase as Treatment for Hyaluronic Acid Thrombosis

Aesthetic Surgery Journal ◽

10.1093/asj/sjz101 ◽

2019 ◽

Vol 40 (5) ◽

pp. 551-559 ◽

Cited By ~ 1

Author(s):

Isaac Baley-Spindel ◽

Eduardo Villaseñor-Villalpando ◽

Cuahutémoc Márquez-Espriella ◽

Ma. Irene Rivera-Salgado ◽

Rodrigo Dávila-Díaz

Keyword(s):

Hyaluronic Acid ◽

Thrombolytic Agent ◽

Combined Treatment ◽

Outpatient Setting ◽

Control Group ◽

Intravascular Injection ◽

Current Management ◽

To Receive ◽

Microscopic Findings ◽

Fibrin Thrombus

Abstract Background Hyaluronic acid fillers are the second-most commonly performed nonsurgical procedure. Arterial thrombosis is their most devastating complication. Recent research shows that along hyaluronic acid thrombi, a platelet/fibrin thrombus forms in the site of injection. This is not addressed by current management protocols, which focus on perivascular hyaluronidase plus adjuvant strategies to increase blood flow. We experimented with an animal model utilizing both hyaluronidase and a thrombolytic agent for treatment of occlusion. Objectives The authors sought to evaluate the efficacy of a combined treatment of hyaluronidase with a thrombolytic agent applied perivascularly to an artery occluded with hyaluronic acid. Methods After direct intravascular injection into the femoral artery, rats were randomized to receive one of the following perivascular solutions: saline, hyaluronidase, alteplase, or hyaluronidase + alteplase. Reperfusion, distal bleeding, and microscopic findings were evaluated 4 hours after intervention. Results None of the subjects in the control group showed signs of reperfusion. In the hyaluronidase group, 60% reperfused, 10% completely, the rest only partially. In the alteplase group, 50% reperfused partially. In the hyaluronidase + alteplase group, 50% had partial and 50% complete prepermeabilization. Kruskal-Wallis test showed a P < 0.0001 favoring hyaluronidase + alteplase. Microscopic findings were compatible with bleeding rates. Conclusions Both hyaluronic acid and red thrombi play a role in the occluded vessel. Perivascular application of hyaluronidase with a thrombolytic agent seems to achieve greater reperfusion rates than either one alone. If proven safe in humans, this strategy could make treatment more effective while still being suitable for an outpatient setting.

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