The Relationship between Serum Levels of Oxidative Stress Biomarkers and Dysmenorrhea, Dyspareunia and Pelvic Pain in Women with Endometriosis

Background: Oxidative stress may play an important role in the pathogenesis of pulmonary tuberculosis (PTB). To our knowledge there is paucity of data on the status of oxidative stress biomarkers among PTB patients in Gombe, North-eastern Nigeria. Our study was designed to evaluate the oxidative stress biomarkers in pulmonary tuberculosis patients in Gombe, North-eastern Nigeria. Aims and Objectives: To determine the serum levels of oxidative stress biomarkers among patients with pulmonary tuberculosis in Gombe metropolis, North-eastern Nigeria and to assess the correlation between the oxidative stress biomarkers in pulmonary tuberculosis patients. Materials and Methods: A cross sectional comparative study was conducted in a tertiary health care facility with 40 pulmonary tuberculosis (PTB) patients on anti-TB drugs treatment (ATT), 40 newly diagnosed PTB patients not yet on anti-TB drugs treatment (ATT-naïve) and 40 age- and sex-marched apparently healthy subjects (controls). Serum total antioxidant status (TAS), total oxidant status (TOS), malondialdehyde (MDA), nitric oxide (NO) and oxidative stress index (OSI) determined using standard techniques. Data was analysed using INSTAT® (Graph Pad Software Inc., La Jolla, CA, USA). Results: Serum levels of TOS, OSI, MDA and NO were significantly (p ˂ 0.001) increased in PTB patients (ATT and ATT-naïve) when compared with healthy individuals. Serum TAS and body mass index (BMI) were significantly (p ˂ 0.001) decreased in PTB patients when compared with healthy individuals. Serum TOS significantly correlated with serum OSI, MDA and NO in ATT-naïve PTB patients. Conclusion: This study observed an increased oxidative stress biomarkers and decreased total antioxidant status in newly diagnosed pulmonary tuberculosis patients and those on treatment. Our findings suggest that antioxidants supplementation and improved nutrition in the management of pulmonary tuberculosis patients may go a long way in preventing the oxidative onslaught and further complications in PTB patients.

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A Novel Systematic Oxidative Stress Score Predicts the Prognosis of Patients with Operable Breast Cancer

Oxidative Medicine and Cellular Longevity ◽

10.1155/2021/9441896 ◽

2021 ◽

Vol 2021 ◽

pp. 1-14

Author(s):

Kaiming Zhang ◽

Liqin Ping ◽

Tian Du ◽

Yan Wang ◽

Ya Sun ◽

...

Keyword(s):

Breast Cancer ◽

Oxidative Stress ◽

Cancer Patients ◽

Operable Breast Cancer ◽

Breast Cancer Patients ◽

Training Set ◽

Oxidative Stress Biomarkers ◽

Stress Biomarkers ◽

Validation Set ◽

The Relationship

Background. Breast cancer was associated with imbalance between oxidation and antioxidation. Local oxidative stress in tumors is closely related to the occurrence and development of breast cancer. However, the relationship between systematic oxidative stress and breast cancer remains unclear. This study is aimed at exploring the prognostic value of systematic oxidative stress in patients with operable breast cancer. Methods. A total of 1583 operable female breast cancer patients were randomly assigned into the training set and validation set. The relationship between systematic oxidative stress biomarkers and prognosis were analyzed in the training and validation sets. Results. The systematic oxidative stress score (SOS) was established based on five systematic oxidative stress biomarkers including serum creatinine (CRE), serum albumin (ALB), total bilirubin (TBIL), lactate dehydrogenase (LDH), and blood urea nitrogen (BUN). SOS was an independent prognostic factor for operable breast cancer patients. A nomogram based on SOS and clinical characteristics could accurately predict the prognosis of operable breast cancer patients, and the area under the curve (AUC) of the nomogram was 0.823 in the training set and 0.872 in the validation set, which was much higher than the traditional prognostic indicators. Conclusions. SOS is an independent prognostic indicator for operable breast cancer patients. A prediction model based on SOS could accurately predict the outcome of operable breast cancer patients.

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Unhealthy dietary patterns are related to low ceruloplasmin in female nurses

BMJ Military Health ◽

10.1136/jramc-2019-001157 ◽

2019 ◽

Vol 166 (5) ◽

pp. 307-311

Author(s):

Karolin Abashzadeh ◽

M Abshirini ◽

F Siassi ◽

M Qorbani ◽

F Koohdani ◽

...

Keyword(s):

Oxidative Stress ◽

Dietary Patterns ◽

Linear Regression Analysis ◽

Dietary Intakes ◽

Food Groups ◽

Oxidative Stress Biomarkers ◽

Stress Biomarkers ◽

Female Nurses ◽

The Relationship ◽

And Oxidative Stress

Background and objectiveFew studies have examined the relationship between dietary patterns and antioxidant status. We aimed to explore the association between major dietary patterns and oxidative stress biomarkers including serum protein carbonyl (PC), ceruloplasmin and total antioxidant capacity (TAC).MethodIn this cross-sectional study, we randomly selected 320 female nurses aged 20–45 years. General information of participants was collected by trained interviewers. Their weight and height were measured and dietary intakes were determined by the 147-food-item semiquantitative food frequency questionnaire. Dietary patterns were derived by principal component analysis of yielding 25 food groups. In this study, 90 subjects were randomly selected from all participants with serum levels of PC, ceruloplasmin and TAC measured further. To determine the association between dietary patterns’ score and oxidative stress biomarkers, multiple linear regression analysis was conducted.ResultsThree dietary patterns were derived: healthy, unhealthy and traditional. After adjusting for several confounding factors, the unhealthy dietary pattern was inversely related to the serum concentration of ceruloplasmin and PC (p<0.05). The relationship between other dietary patterns and antioxidant biomarkers was not significant.ConclusionsAccording to the results of this study, unhealthy dietary patterns may have an adverse effect on serum ceruloplasmin.

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Changes of Inflammatory and Oxidative Stress Biomarkers in Dogs with Different Stages of Heart Failure

10.21203/rs.3.rs-24928/v1 ◽

2020 ◽

Author(s):

Camila Peres RUBIO ◽

Ahmet SARIL ◽

Meriç KOCATURK ◽

Ryou TANAKA ◽

Jorgen KOCH ◽

...

Keyword(s):

Oxidative Stress ◽

Heart Failure ◽

Acute Phase Proteins ◽

Staging System ◽

Serum Levels ◽

Left Ventricular ◽

Oxidative Stress Biomarkers ◽

Stress Biomarkers ◽

Anti Oxidant ◽

And Oxidative Stress

Abstract Background: Heart failure (HF) has been associated with changes in inflammatory and oxidative-stress biomarkers. This study aimed to evaluate the changes of a panel of inflammatory and oxidative stress biomarker in dogs with different stages of HF and its relation with the severity of the disease and the echocardiographic changes. Dogs with HF as a result of myxomatous mitral valve degeneration or dilated cardiomyopathy were included. A total of 29 dogs were classified as stage-A (healthy), B (asymptomatic dogs), C (symptomatic dogs) and D (dogs with end-stage-HF) according to the ACVIM-staging-system. Serum cytokines, and inflammatory and oxidative stress markers were evaluated.Results: KC-like as an inflammatory cytokine was significantly increased in dogs of stage-C (P < 0.01) and -D (P < 0.05) compared with stage-A and -B. Stage-D Dogs showed significantly higher serum CRP and Hp (P < 0.05) but lower serum anti-oxidant capacity (PON1, TEAC, CUPRAC, and thiol) compared to stage-A and -B (P < 0.05). After the treatment, serum levels of CRP, Hp and KC-like decreased but serum anti-oxidant levels increased compared to their pre-treatment values. Left ventricular dimension and LA/Ao ratio correlated positively with CRP, MCP-1, and KC-like but negatively with PON1, GM-CSF, IL-7 and antioxidant biomarkers (P < 0.01).Conclusion: our results indicated that dogs with advanced-stages of HF show increases in positive acute-phase proteins and selected inflammatory cytokines (KC-like), and decreases in antioxidant biomarkers, indicating that inflammation and oxidative-stress act as collaborative partners in the pathogenesis of HF. KC-like may be a more useful parameter to monitor disease progression and treatment efficacy of dogs with severe-HF.

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Determination of Cytokines and Oxidative Stress Biomarkers in Cognitive Impairment Induced by Methylmalonic Acidemia

NeuroImmunoModulation ◽

10.1159/000511590 ◽

2021 ◽

Vol 28 (3) ◽

pp. 178-186

Author(s):

Qiliang Li ◽

Hong Jin ◽

Ying Liu ◽

Yu Rong ◽

Tana Yang ◽

...

Keyword(s):

Oxidative Stress ◽

Cognitive Impairment ◽

Methylmalonic Acid ◽

Serum Levels ◽

High Concentration ◽

Oxidative Stress Biomarkers ◽

Stress Biomarkers ◽

Tnf Α ◽

Iq Scores ◽

And Oxidative Stress

Objective: Methylmalonic acidemia (MMA) is the most common organic acidemia in children. Many patients with MMA suffered from cognitive impairments. The aim of this study was to identify the significance of cytokines and oxidative stress biomarkers in MMA-induced cognitive impairment. Methods: We enrolled 64 children with combined MMA and homocystinuria and 64 age- and sex-matched healthy volunteers. Participants were subsequently classified as with or without cognitive impairments using a uniform neuropsychological assessment test. Serum samples were collected. The serum levels of cytokines and oxidative stress biomarkers were measured using the ELISA or chemical methods. Results: Compared to control group, the serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, malondialdehyde (MDA), and nitric oxide (NO) in the MMA patients increased markedly (p < 0.05); glutathione (GSH) and superoxide dismutase (SOD) decreased obviously (p < 0.01). The levels of IL-6, TNF-α, NO, and MDA in the serum were negatively associated with DQ or IQ scores. The levels of GSH and SOD in the serum were positively correlated with DQ or IQ scores. After receiver operating characteristic curve analysis, NO was the most useful individual marker for distinguishing the cognitive dysfunction, corresponding to the area under ROC curve (AUC) of 0.82 (95% CI, 0.74–0.91), sensitivity of 76.60%, and specificity of 80.25%. GSH and MDA were also useful for diagnosis of MMA-induced cognitive dysfunction, corresponding to the AUC of 0.80 (95% CI, 0.70–0.89), and 0.73 (95% CI, 0.63–0.82), respectively. The sensitivity and specificity of GSH were 72.34 and 80.25%, respectively. The sensitivity and specificity of MDA were 85.11 and 51.85%, respectively. Conclusions: The high-concentration methylmalonic acid in the blood induced immune cells to release pro-inflammatory cytokines such as TNF-α and IL-6. These cytokines and high-concentration methylmalonic acid stimulated the immune cells to produce reactive oxygen species (ROS) and reactive nitrogen species (RNS). The serum methylmalonic acid, cytokines, ROS, and RNS were across the blood-brain barrier and induced cognitive impairment. The small molecule substances such as serum NO, MDA, and GSH participated in the process of neuroinflammation and oxidative stress injury induced by MMA and could be useful for distinguishing the cognitive impairment.

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Serum Levels of Stress Hormones and Oxidative Stress Biomarkers Differ according to Sasang Constitutional Type

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2015/737631 ◽

2015 ◽

Vol 2015 ◽

pp. 1-6 ◽

Cited By ~ 3

Author(s):

Hyeong Geug Kim ◽

Yoon Jung Kim ◽

Yo Chan Ahn ◽

Chang Gue Son

Keyword(s):

Oxidative Stress ◽

Stress Hormones ◽

Serum Cortisol ◽

Serum Levels ◽

Oxidative Stress Biomarkers ◽

Stress Biomarkers ◽

Constitutional Type ◽

Sasang Constitutional Types ◽

And Oxidative Stress ◽

Better Than

Objectives.This study investigated whether Sasang constitutional type is associated with differences in the serum levels of stress hormones and oxidative stress.Methods.A total of 236 participants (77 males and 159 females) were enrolled. The serum levels of cortisol, adrenaline, reactive oxygen species (ROS), and malondialdehyde (MDA) were analyzed.Results.The distribution of Sasang constitutional types was as follows: Taeumin, 35.6%; Soumin, 33.0%; and Soyangin, 31.4%. The serum cortisol levels of Taeumin were significantly lower than Soumin (p<0.1in both sexes) and Soyangin (p<0.05in males andp<0.1in females). The adrenaline levels were also significantly lower in Taeumin than in Soumin (p<0.05in males andp<0.1in females) and Soyangin (p<0.1in males). Serum ROS levels were significantly higher in Soyangin than in Taeumin and Soumin (p<0.05in males), whereas MDA levels were significantly lower in Taeumin compared with Soumin and Soyangin (p<0.05in males andp<0.1in females).Conclusion.Taeumin type may tolerate psychological or oxidative stress better than other types, which suggests a biological mechanism to explain the different pathophysiological features of Sasang constitutional types.

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Oxidative Stress Biomarkers and Peripheral Endothelial Dysfunction in Rheumatoid Arthritis: A Monocentric Cross-Sectional Case-Control Study

Molecules ◽

10.3390/molecules25173855 ◽

2020 ◽

Vol 25 (17) ◽

pp. 3855

Author(s):

Stefania Bassu ◽

Angelo Zinellu ◽

Salvatore Sotgia ◽

Arduino Aleksander Mangoni ◽

Alberto Floris ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Oxidative Stress ◽

Endothelial Dysfunction ◽

Reactive Hyperemia ◽

Pulse Amplitude ◽

Oxidative Stress Biomarkers ◽

Cross Sectional ◽

Stress Biomarkers ◽

Atherosclerotic Burden ◽

The Relationship

Previous studies have suggested that oxidative stress may heighten atherosclerotic burden in rheumatoid arthritis (RA), but direct evidence is lacking. Objective: To evaluate the relationship between established plasma oxidative stress biomarkers and peripheral endothelial dysfunction (ED), a marker of early atherosclerosis, in RA. Methods: Paroxonase-1 (PON-1), protein-SH (PSH), and malondialdehyde (MDA) were measured in 164 RA patient s and 100 age- and sex-matched healthy controls without previous cardiovascular events. Peripheral ED, evaluated by flow-mediated pulse amplitude tonometry, was defined by log-transformed reactive hyperemia index (Ln-RHI) values < 0.51. Results: PON-1 activity and PSH concentrations were significantly reduced in RA patients compared to controls. In regression analysis, increased plasma MDA levels were significantly associated with reduced Ln-RHI [B coefficient (95% CI) = −0.003 (−0.005 to −0.0008), p = 0.008] and the presence of peripheral ED (OR (95% CI) = 1.75 (1.06–2.88), p = 0.028). Contrary to our expectations, increased PON-1 activity was significantly associated, albeit weakly, with the presence of ED (OR (95% CI) = 1.00 (1.00–1.01), p = 0.017). Conclusions: In this first evidence of a link between oxidative stress and markers of atherosclerosis, MDA and PON-1 showed opposite associations with peripheral vasodilatory capacity and the presence of ED in RA. Further studies are needed to determine whether this association predicts atherosclerotic events in the RA population.

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Changes of inflammatory and oxidative stress biomarkers in dogs with different stages of heart failure

BMC Veterinary Research ◽

10.1186/s12917-020-02650-7 ◽

2020 ◽

Vol 16 (1) ◽

Author(s):

Camila Peres Rubio ◽

Ahmet Saril ◽

Meriç Kocaturk ◽

Ryou Tanaka ◽

Jorgen Koch ◽

...

Keyword(s):

Oxidative Stress ◽

Heart Failure ◽

Acute Phase Proteins ◽

Staging System ◽

Serum Levels ◽

Left Ventricular ◽

Oxidative Stress Biomarkers ◽

Stress Biomarkers ◽

Severity Of The Disease ◽

And Oxidative Stress

Abstract Background Heart failure (HF) is associated with changes in inflammatory and oxidative stress biomarkers. This study aimed to evaluate the changes of a panel of inflammatory and oxidative stress biomarkers in dogs with different stages of HF and its relation with the severity of the disease and echocardiographic changes. A total of 29 dogs with HF as a result of myxomatous mitral valve degeneration or dilated cardiomyopathy were included and classified as stage-A (healthy), B (asymptomatic dogs), C (symptomatic dogs) and D (dogs with end-stage HF) according to the ACVIM staging system. In these dogs an ecnhocardiographic examination was performed and cytokines, and inflammatory and oxidative stress markers were evaluated in serum. Results KC-like was significantly increased in dogs of stage-C (P < 0.01) and -D (P < 0.05) compared with stage-A and -B. Stage-D dogs showed significantly higher serum CRP and Hp (P < 0.05) but lower serum antioxidant capacity (PON1, TEAC, CUPRAC, and thiol) compared to stage-A and -B (P < 0.05). After the treatment, serum levels of CRP, Hp and KC-like decreased and serum antioxidant levels increased compared to their pre-treatment values. Left ventricular dimension and LA/Ao ratio correlated positively with CRP, MCP-1, and KC-like but negatively with PON1, GM-CSF, IL-7 and antioxidant biomarkers (P < 0.01). Conclusion Our results showed that dogs with advanced HF show increases in positive acute-phase proteins and selected inflammatory cytokines such as KC-like, and decreases in antioxidant biomarkers, indicating that inflammation and oxidative stress act as collaborative partners in the pathogenesis of HF. Some of these biomarkers of inflammation and oxidative stress could have the potential to be biomarkers to monitor the severity of the disease and the effect of treatment.

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Assessment of Plasma Oxidative Stress Biomarkers and Metabolic Parameters of Dairy Heifers: Relationship with Success at First Service

Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca Veterinary Medicine ◽

10.15835/buasvmcn-vm:2021.0007 ◽

2021 ◽

Vol 78 (2) ◽

pp. 11

Author(s):

Sofiane BOUDJELLABA ◽

Habiba SAADI ◽

Mohamed ZAOUANI ◽

Lynda AINOUZ ◽

Amira Fatma HANI ◽

...

Keyword(s):

Oxidative Stress ◽

Dairy Herds ◽

Glutathione S Transferase ◽

Oxidative Stress Biomarkers ◽

Dairy Heifers ◽

Stress Biomarkers ◽

Significant Difference ◽

The Difference ◽

The Relationship

First insemination success is considered as good indicator of heifer fertility to ensure renewal of dairy herds. The objective of this study was to determine the relationship between first insemination success and biomarkers of oxidative stress (OS). A total of 25 heifers were divided into two groups according to their success at first insemination: group FS+ (heifers that were pregnant at first service, n = 14) and group FS- (heifers that were not pregnant at first service, n = 11). The serum of these two groups were analyzed for malondialdehyde (MDA), glutathione S-transferase (GST), reduced glutathione (GSH), glutathione peroxidase (GPx), catalase (CAT), myeloperoxidase (MPO), nitric Oxide (NO) and superoxide dismutase (SOD) as oxidative stress biomarkers and biochemical parameters. Heifers in the group FS+ showed no significant difference in all OS parameters compared to heifers in the group FS-. The OS parameters showed almost similar values in both groups except for GST and CAT where the difference was at the limit of significance. The plasma concentration of OS biomarkers assessed in our study were not related to first service success in heifers. Further studies are needed to clarify the role of oxidative status in the reproductive performance of heifers.

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