Comparison of Serum Vitamin D and Calcium Levels Between Children with Longer Than Normal Eruption Time of First Deciduous Tooth and Control Group

Objective: To investigate the levels of serum vitamin D and IgE in infants with different allergic risks and to analyze their correlations. Methods: In the present study, the participants were selected and recruited from the infant ward of our hospital from February 2012 to December 2012. A total of 120 patients were selected and recruited. Among these patients, 64 patients with symptoms of allergic diseases were assigned to the experimental group. The remaining 56 patients who had respiratory infections, but without other symptoms of allergic diseases, were assigned to the control group. The serum 25-hydroxyvitamin D3 levels were measured using liquid chromatography tandem mass spectrometry and the IgE levels were measured using radioimmunoassay in both experimental and control groups. Subsequently, the serum 25-hydroxyvitamin D3 levels and IgE levels were compared between the experimental group and control group. Results: The following findings were obtained through data comparison. The serum 25-hydroxyvitamin D3 level in the experimental group was 18.19 ± 7.84 ng/mL, and the IgE level was 551.51 ± 705.88 IU/mL. The serum 25-hydroxyvitamin D3 level in the control group was 21.95 ± 7.834 ng/mL, IgE level was 49.39 ± 32.46 IU/mL. The data comparison indicates that the serum 25-hydroxyvitamin D3 level in the control group was higher than the experimental group, and the IgE level in the control group was lower than the experimental group (P<0.05). Conclusion: The level of vitamin D3 in patients with allergic symptoms is relatively low. This may be one of the causes leading to allergies. At the same time, IgE is also one of the causes contributing to allergies. An elevation of the IgE level is very likely to cause the allergic, and there is a correlation between serum vitamin D and IgE levels. At the same time, research has found that proper supplementation of vitamin D3 can help prevent allergic diseases, and can be considered in a new and high-quality program for the prevention of allergic diseases.

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The Association of Serum Vitamin D Levels with Pseudoexfoliation Glaucoma/Syndrome

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530319666181128105911 ◽

2019 ◽

Vol 19 (2) ◽

pp. 166-170 ◽

Cited By ~ 2

Author(s):

Seyhan Dikci ◽

Emrah Öztürk ◽

Penpe G. Fırat ◽

Turgut Yılmaz ◽

Mehmet Ç. Taşkapan ◽

...

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Glaucoma Surgery ◽

Control Group ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Significant Difference ◽

The Mean ◽

And Control ◽

Glaucoma Group

Objective: To investigate whether serum vitamin D levels have an effect on pseudoexfoliation (PEX) glaucoma/syndrome development and on the control of glaucoma in these cases. </P><P> Method: A total of 31 cases with PEX glaucoma, 34 cases with the PEX syndrome and 43 control subjects of similar age and sex were included in the study. Vitamin D levels were compared between the groups and also between the cases where glaucoma surgery was performed or not. Results: PEX glaucoma group consisted of 17 males and 14 females, PEX syndrome group of 27 males and 7 females, and the control group of 27 males and 16 females. The mean age was 70.9±8.9 years, 72.1±7.3 years, and 67.9±9.1 years in PEX glaucoma, syndrome and control group, respectively. Mean vitamin D levels were 9.4±7.7 ng/mL, 7.9±6,1 ng/mL, 11.5±14.2 ng/mL in PEX glaucoma, syndrome and control group, respectively (p>0.05). The mean serum vitamin D level was 8.04±4.7 ng/mL in those who underwent glaucoma surgery and 10.1±8.7 ng/mL in those who didn't undergo glaucoma surgery in PEX glaucoma group (p>0.05). No difference was found between the PEX glaucoma subgroups in terms of the mean deviation when classified according to vitamin D levels (<10 ng/mL, ≥10 ng/mL) (p>0.05). Conclusion: Although we found no statistically significant difference between the PEX syndrome/ glaucoma, and control group in terms of serum vitamin D levels, serum vitamin D levels were lower in PEX syndrome and glaucoma group than control group. Our results indicate that serum vitamin D levels have no effect on the development of PEX glaucoma/syndrome or the control of the disorder in cases with PEX glaucoma. However, these results need to be supported with further studies on a larger number of patients and with longer follow-up.

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Evaluation of vitamin D status, parathyroid hormone, and calcium among Iranian pregnant women with preeclampsia: A case-control study

International Journal of Reproductive BioMedicine ◽

10.18502/ijrm.v17i10.5494 ◽

2019 ◽

Cited By ~ 1

Author(s):

Laaya Hamedanian ◽

Bita Badehnoosh ◽

Niloofar Razavi-Khorasani ◽

Zinat Mohammadpour ◽

Hassan Mozaffari-Khosravi

Keyword(s):

Vitamin D ◽

Pregnant Women ◽

Serum Vitamin ◽

Multivariate Logistic Regression Analysis ◽

Control Group ◽

Vitamin D Status ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

The Mean ◽

And Control

Background: Preeclampsia is considered as a serious life-threatening condition that could affect both maternal and fetal outcome. Many studies have examined the association of nutritional factors with the incidence of preeclampsia. However, little is known about the possible role of vitamin D in the development of preeclampsia among the Iranian population. Objective: The aim of the present study was to evaluate the association between vitamin D status and preeclampsia. Materials and Methods: A total of 120 pregnant women who were referred to Kamali and Alborz General Hospital located in the Karaj City were enrolled in this study and categorized into preeclamptic and control groups (n = 60/each). The clinical details of patients such as demographic characteristics and laboratory findings were obtained from the patients. The serum levels of vitamin D, calcium, phosphorus, and parathormone were also measured. Multivariate logistic regression analysis was used to assess for independent predictors of preeclampsia. Results: The mean age among pregnant women with preeclampsia and control group were 31.48 ± 5.25 and 29.01 ± 5.28, respectively. The mean body mass index among the preeclamptic group was 27.92 ± 4.98, which was significantly higher compared to the control group (p < 0.001). The serum vitamin D levels were significantly lower in women with preeclampsia compared to the control subjects (p = 0.007). Moreover, no correlation between vitamin D deficiency and predisposing factors of preeclampsia was observed after adjusting for confounding factors. Conclusion: Our study revealed that serum vitamin D level is significantly lower in among the pregnant women diagnosed with preeclampsia compared to the healthy subjects. However, no correlation was observed between the vitamin D status and the risk of preeclampsia development. Key words: Preeclampsia, Vitamin D, 25-Hydroxyvitamin D, Pregnancy.

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Association of Vitamin D Deficiency in Newly Diagnosed Pulmonary Tuberculosis

10.53350/pjmhs2115102572 ◽

2021 ◽

Vol 15 (10) ◽

pp. 2572-2573

Author(s):

Khalil Ullah ◽

Sajid Ur Rehman ◽

Ramsha Nadeem ◽

Muhammad Abubakar ◽

Qasim Raza

Keyword(s):

Vitamin D ◽

Pulmonary Tuberculosis ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Sampling Technique ◽

Hypovitaminosis D ◽

Control Group ◽

Sputum Smear ◽

Study Group ◽

Serum Vitamin D

Aim: Relationship between Vitamin D deficiency and pulmonary tuberculosis. Methodology: Study duration: November 2020 to April 2021 Sampling technique: A case-control study Setting: Hayatabad Medical Complex, Peshawar It included 30 adult newly identified sputum-quality pulmonary tuberculosis patients and 30 age and sex matched healthy cases as controls. All cases had undergone a thorough medical examination and repeated laboratory tests, including vitamin D, calcium, and sputum for AFB and X-ray chest. Results: Majority were males (88%). In the Study group, BMI decreased significantly i.e. 19.0 vs 23.5. Serum vitamin D concentrations were significantly lower in the tuberculosis group i.e. 17.9ng/dl than in the control group 24.8ng/dl. Mean of serum albumin in the control group was 3.9 ng/dl whereas 2.9 ng/dl in the study group. Conclusion: Hypovitaminosis D was associated with more severe medical symptoms, increased sputum smear positivity and large lesions on chest radiographs in patients with pulmonary tuberculosis. Keywords: Vitamin D, Pulmonary Tuberculosis, Sputum

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Assessment of 25 Hydroxy Cholecalceferol Level in Autistic Children; is there a role for it in Treatment of Autism Spectrum Disorder?

QJM ◽

10.1093/qjmed/hcab113.039 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Martina Alfred Youssef Nakhla ◽

Eman Ahmed Zaky ◽

Enas Samir Nabeh ◽

Asmaa Wafeeq Abd El Aziz

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Autism Spectrum ◽

Laboratory Evaluation ◽

Control Group ◽

Autistic Children ◽

Serum Vitamin D ◽

Group I ◽

Egyptian Children ◽

Therapeutic Doses

Abstract Background Autism is a group of neurodevelopmental disabilities with various genetic and environmental risk factors. Vitamin D is an important neurosteroid hormone which can affect brain development and function, but research on its use in treating autism has been limited. Objectives The current study aimed at assessing the level of 25 OH vit D3level in a group of autistic infants and children compared to controls and correlating it with the severity of autistic manifestations and evaluation of the role of therapeutic doses of vitamin D on the severity of autistic manifestations. Methodology Thirty autistic Egyptian children (group I) and 30 clinically healthy age and sex matched controls were enrolled (group II). Therapeutic doses of vitamin D were given for autistic children who showed insufficient levels of 25 OH cholecalceferol for a period of 4-6 weeks followed by maintenance doses for another 6 weeks. Psychometric and laboratory evaluation for this group was done thrice: at the onset of study, at 6 week after enrollment in the study, and at 12 weeks after that enrollment. Results Serum vitamin D level was substantially reduced in patients with ASD in comparison to control group, and on the other hand, 25 (OH) vitamin D level was significantly negatively correlated with ATEC score and Total CARS score. Autistic children who received vitamin D3 treatment had significant improvement of CARS and ATEC scores. Conclusion vitamin D supplementation significantly improved the outcome of enrolled autistic children. It is recommended to follow up our studied sample to check the consolidation of improvement for how long it will be needed.

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Oral Vitamin D3 Supplementation for Femtosecond LASIK–Associated Dry Eye

10.21203/rs.3.rs-517022/v1 ◽

2021 ◽

Author(s):

Ying Lin ◽

Huanjun Su ◽

Jianbin Wu ◽

Muzhi Yuan ◽

Yong Zhang

Keyword(s):

Vitamin D ◽

Dry Eye ◽

Vitamin D3 ◽

Serum Vitamin ◽

Control Group ◽

Oral Vitamin ◽

Serum Vitamin D ◽

The Mean ◽

Experimental Group ◽

Schirmer I Test

Abstract Purpose: To assess the effect of oral vitamin D3 supplementation in dry eye after femtosecond laser-assisted in situ keratomileusis (FS-LASIK).Setting: Liuzhou Worker’s Hospital.Design: This prospective study included 90 patients selected between January and December in 2019, who underwent fs-lasik operation in our hospital and had obvious symptoms indicating dry eyes one month after operation. The subjects were randomly divided into two groups: the experimental group (n = 45) received vitamin D3 2000 IU / D continuously for 12 weeks; the control group (n = 45) did not take vitamin D3 orally. Ocular surface disease index（OSDI）, tear breakup time（TBUT）and Schirmer’s Test I were evaluated pre-medication and 1,3,6 months after treatment. Serum vitamin D level, and the mean concentration of cytokine IL-6, IL-17, IL-23 in tears were also measured. Results: One month after treatment, the mean OSDI score of the experimental group (11.67 ± 8.53) was significantly lower than that of the control group (23.82 ± 13.22) (P = 0.007). TBUT (10.71±1.02s) and Schirmer I (9.36±0.40mm) of the experimental group were higher than those of the control group (7.49±1.29 s and 7.51±0.44 mm). The OSDI (10.25 ± 5.49), TBUT (10.75±1.09 seconds) and Schirmer I test value (11.34±0.39 mm) of the experimental group were significantly lower than those of the control group (20.22±6.23, 8.36±1.23， 8.12±0.50) at 3 months after treatment. There were significant differences in OSDI, TBUT (P ＜ 0.05) and Schirmer I test value between the two groups at 6 months after treatment. Serum vitamin D3 level was negatively correlated with OSDI score (r=-0.90；P=0.00), and positively correlated with Schirmer I test (r=0.88；P=0.00), TBUT score (r=0.89；P=0.00) and TMH (r=0.80；P=0.00). IL-17 level was shown to be significantly correlated with TBUT (r=-0.25, P=0.014) and Schirmer I test (r=-0.21, P=0.018). IL-6 level was significantly correlated with OSDI (R=0.18, P = 0.020) and TBUT (R=0.20, P = 0.019).

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Correlation of psoriasis and serum vitamin D

IP Indian Journal of Clinical and Experimental Dermatology ◽

10.18231/j.ijced.2021.060 ◽

2021 ◽

Vol 7 (4) ◽

pp. 320-323

Author(s):

Ritika Gujrati ◽

Krishnendra Varma ◽

Ujjwal Kumar

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Psoriasis Vulgaris ◽

Systemic Disease ◽

Serum Vitamin ◽

Psoriatic Skin ◽

Control Group ◽

P Value ◽

Serum Vitamin D ◽

Vitamin D Levels

Psoriasis is an immuno-mediated chronic systemic disease involving cytokines of helper Th1 pathway. Vitamin D has an effect on keratinocyte proliferation, differentiation and immune modulation of immune system especially Th1 pathway, which is altered in psoriatic skin suggesting that Vitamin D may have a role in pathogenesis of psoriasis. To study correlation between psoriasis vulgaris and serum vitamin D. To evaluate serum vitamin D level in psoriasis cases and in control group and correlating vitamin D level with severity and duration of the psoriasis. 57 cases (>15years of age) with psoriasis and 57 healthy subjects were recruited. Psoriasis was clinically diagnosed and severity evaluated by PASI scale. Vitamin D was analysed by enhanced chemilumine scence on vitrus Eci autoanalyzer of Orth clinical diagnostic. Vitamin D deficiency defined as <20ng/ml, insufficiency 20-30ng/ml and sufficient 30-100ng/ml. Vitamin D deficiency in the study was 22.8% in patients and 14% in control group. Vitamin D insufficiency was found in 42.1% of cases and 19.3% of control. According to chi-square the p-value is 0.003 showing significant association. There was a tendency towards decrease in vitamin D level with increase in disease duration. There was negative correlation between vitamin D and PASI score. The study found a significant relationship between vitamin D and psoriasis. Further metanalysis involving larger study population will be required to establish whether vitamin D levels benefits patient with psoriasis vulgaris.

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Effect and mechanism of vitamin D activation disorder on liver fibrosis in biliary atresia

Scientific Reports ◽

10.1038/s41598-021-99158-3 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Song Sun ◽

Menghua Xu ◽

Peijun Zhuang ◽

Gong Chen ◽

Kuiran Dong ◽

...

Keyword(s):

Vitamin D ◽

Liver Fibrosis ◽

Biliary Atresia ◽

Transforming Growth Factor ◽

Serum Vitamin ◽

Tissue Inhibitor Of Metalloproteinase ◽

Control Group ◽

Serum Vitamin D ◽

Duct Ligation ◽

Tgf Β1

AbstractTo investigate the mechanism of 25 hydroxyvitamin D (25(OH)D) deficiency in children with biliary atresia (BA) and its effect on liver fibrosis. The serum vitamin D and 25(OH)D, and expression of 25 hydroxylase (CYP2R1 and CYP27A1) in the liver of BA patients were detected and compared with those in the control group. We investigated the effect of differential expression of CYP2R1 in hepatocytes on the expression of genes related to liver fibrosis in primary hepatic stellate cells (HSCs) of BA and animal models of cholestasis. The ratio of 25(OH)D/vitamin D in the BA group was significantly lower than that in the control group. The mRNA and protein expression of CYP2R1 and CYP27A1 in liver tissue of the BA group was significantly lower than that in the control group. Exogenous active vitamin D (calcitriol) inhibited the proliferation and migration of primary HSCs isolated from BA patients, and reduced the expression of fibrosis-related genes in vitro. Downregulation of expression of CYP2R1 in hepatocytes increased expression of transforming growth factor (TGF)-β1, collagen (Col)-1α1 and tissue inhibitor of metalloproteinase (TIMP)-1, and decreased the expression of matrix metalloproteinase (MMP)-2 in cocultured primary HSCs of BA. Upregulation of expression of CYP2R1 in mice with bile duct ligation significantly increased the level of 25(OH)D, decreased the expression of TGF-β1, Col-1α1 and TIMP-1, and increased the expression of MMP-2. Children with BA have impaired vitamin D activation due to CYP2R1 deficiency. The dysactivation of vitamin D can promote the proliferation and activation of HSCs and participate in the development of hepatic fibrosis in BA.

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Assessment of Vitamin D Metabolism in Patients with Cushing’s Disease in Response to 150,000 IU Cholecalciferol Treatment

Nutrients ◽

10.3390/nu13124329 ◽

2021 ◽

Vol 13 (12) ◽

pp. 4329

Author(s):

Alexandra Povaliaeva ◽

Viktor Bogdanov ◽

Ekaterina Pigarova ◽

Artem Zhukov ◽

Larisa Dzeranova ◽

...

Keyword(s):

Vitamin D ◽

Cushing’S Disease ◽

Serum Vitamin ◽

Urinary Free Cortisol ◽

Cushing's Disease ◽

Control Group ◽

Vitamin D Metabolites ◽

Vitamin D Metabolism ◽

Serum Vitamin D ◽

Free Cortisol

In this study we aimed to assess vitamin D metabolism in patients with Cushing’s disease (CD) compared to healthy individuals in the setting of bolus cholecalciferol treatment. The study group included 30 adults with active CD and the control group included 30 apparently healthy adults with similar age, sex and BMI. All participants received a single dose (150,000 IU) of cholecalciferol aqueous solution orally. Laboratory assessments including serum vitamin D metabolites (25(OH)D3, 25(OH)D2, 1,25(OH)2D3, 3-epi-25(OH)D3 and 24,25(OH)2D3), free 25(OH)D, vitamin D-binding protein (DBP) and parathyroid hormone (PTH) as well as serum and urine biochemical parameters were performed before the intake and on Days 1, 3 and 7 after the administration. All data were analyzed with non-parametric statistics. Patients with CD had similar to healthy controls 25(OH)D3 levels (p > 0.05) and higher 25(OH)D3/24,25(OH)2D3 ratios (p < 0.05) throughout the study. They also had lower baseline free 25(OH)D levels (p < 0.05) despite similar DBP levels (p > 0.05) and lower albumin levels (p < 0.05); 24-h urinary free cortisol showed significant correlation with baseline 25(OH)D3/24,25(OH)2D3 ratio (r = 0.36, p < 0.05). The increase in 25(OH)D3 after cholecalciferol intake was similar in obese and non-obese states and lacked correlation with BMI (p > 0.05) among patients with CD, as opposed to the control group. Overall, patients with CD have a consistently lower 25(OH)D3/24,25(OH)2D3 ratio, which is indicative of a decrease in 24-hydroxylase activity. This altered activity of the principal vitamin D catabolism might influence the effectiveness of cholecalciferol treatment. The observed difference in baseline free 25(OH)D levels is not entirely clear and requires further study.

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Association of serum vitamin D levels and transient tachypnea of newborn: a case control study

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20171526 ◽

2017 ◽

Vol 4 (3) ◽

pp. 827 ◽

Cited By ~ 1

Author(s):

Gurmeet Singh ◽

Reena Sood ◽

Gursharan Singh Narang ◽

Harnoorjit Kaur Brar ◽

Amanjeet Kaur Bagga

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Transient Condition ◽

Control Group ◽

Term Neonates ◽

Serum Vitamin D ◽

Increased Risk ◽

Vitamin D Levels ◽

Control Study ◽

Structured Questionnaire

Background: Transient tachypnea of newborn (TTN) is a common cause of respiratory distress in newborns with estimated incidence of 1-2% of all newborns. Although a self-limiting transient condition but it may cause severe morbidities. This study was conducted to find association of serum vitamin D levels in neonates who develop TTN as compared to normal healthy neonates.Methods: With thorough history with structured questionnaire and lab tests, serum vitamin D levels of 45 neonates who develop TTN were compared with 56 healthy neonates in control group.Results: Out of 45 neonates who develop TTN 39(86.7%) were deficient in vitamin D as compared to control group where 33(58.9%) out of 56 healthy neonates were deficient in vitamin D.Conclusions: Lower vitamin D levels at birth in term neonates is associated with increased risk of developing TTN and vitamin D may have a role in its pathogenesis.

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