scholarly journals VARIABLES RELATED TO GINGIVITIS IN CHILDREN WITH PYELONEPHRITIS AND NEPHROTIC SYNDROME

2021 ◽  
Vol 27 (3) ◽  
pp. 3955-3967
Author(s):  
Sirma T. Angelova ◽  
Keyword(s):  
Nephrotic Syndrome ◽  
Statistical Methods ◽  
Excretory System ◽  
Healthy Children ◽  
Gingival Index ◽  
Renal Disorders ◽  
Environmental Matter ◽  
The Subject ◽  
Healthy Participants

Purpose: The purpose of the research is to be investigated and assessed the significance of variables related to gingivitis in children with diagnosed pyelonephritis and nephrotic syndrome. Materials and Methods: The subject of the study is represented by participants in the age interval from 0 to 18 years. They are divided into two main groups, namely a group of 92 children with diagnosed pyelonephritis and 24 children with nephrotic syndrome. There is a group of 41 healthy children. Clinical, para-clinical, sociological and statistical methods are implemented in association with the study’s aim. The model of the research is based on an investigation of the significance of definite variables: gingival index GI Lõe-Silness, level of salivary leucocytes, salivary blood and salivary glucose. In addition to these indicators are recorded some patterns of environmental matter. Results: Among the participants with the diagnosis of nephrotic syndrome is recorded the maximal value of GI= 2.04. A similar maximal value of GI=2.00 corresponds to the group of children with pyelonephritis. In both of the subgroups of children suffering from renal disorders is registered the considerable maximal value of salivary blood equal to 250.00 RBC/µl, compared to the maximal value of 50.00 RBC /µl for healthy participants. It is ascertained that the variables of salivary blood and salivary leucocytes correspond to the condition of gingivitis in children with diagnosed pyelonephritis and nephrotic syndrome. Conclusion: A definite impingement of excretory system disorders upon gingiva, especially among children suffering from nephrotic syndrome, is ascertained.

scholarly journals Folate and Cobalamin Serum Levels in Healthy Children and Adolescents and Their Association with Age, Sex, BMI and Socioeconomic Status

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 546
Author(s):  
Paulina Kreusler ◽  
Mandy Vogel ◽  
Anja Willenberg ◽  
Ronny Baber ◽  
Yvonne Dietz ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Children And Adolescents ◽  
Serum Levels ◽  
Population Based ◽  
Research Centre ◽  
Healthy Children ◽  
Serum Samples ◽  
Lms Method ◽  
Healthy Participants ◽  
Age And Sex

This study proposes age- and sex-specific percentiles for serum cobalamin and folate, and analyzes the effects of sex, age, body mass index (BMI), and socioeconomic status (SES) on cobalamin and folate concentrations in healthy children and adolescents. In total, 4478 serum samples provided by healthy participants (2 months–18.0 years) in the LIFE (Leipzig Research Centre for Civilization Diseases) Child population-based cohort study between 2011 and 2015 were analyzed by electrochemiluminescence immunoassay (ECLIA). Continuous age-and sex-related percentiles (2.5th, 10th, 50th, 90th, 97.5th) were estimated, applying Cole’s LMS method. In both sexes, folate concentrations decreased continuously with age, whereas cobalamin concentration peaked between three and seven years of age and declined thereafter. Female sex was associated with higher concentrations of both vitamins in 13- to 18-year-olds and with higher folate levels in one- to five-year-olds. BMI was inversely correlated with concentrations of both vitamins, whilst SES positively affected folate but not cobalamin concentrations. To conclude, in the assessment of cobalamin and folate status, the age- and sex-dependent dynamic of the respective serum concentrations must be considered. While BMI is a determinant of both vitamin concentrations, SES is only associated with folate concentrations.

scholarly journals Special features of designing a correction program for adolescents who have signs of psychosomatic disorders

2020 ◽  
pp. 19-38
Author(s):  
Iryna ROZINA
Keyword(s):  
Drug Addiction ◽  
Healthy Children ◽  
Negative Consequences ◽  
Psychosomatic Disorders ◽  
Effective Response ◽  
Neurotic Disorders ◽  
Correction Program ◽  
The Subject ◽  
The Impact

The relevance of the research is related to the need for studying the character of psychosomatic disorders in adolescence, which is insufficiently investigated and requires more in-depth research, in particular designing a comprehensive program that includes a system of training exercises to overcome psychosomatic disorders. The problem of studying psychosomatic relationships is one of the most difficult problems of modern psychology and medicine, despite the fact that the close connection between mental and somatic has been studied for several centuries. Mental trauma is a leading cause of neuroses formation and progress, its pathogenic significance is determined by the complex interaction with many other factors being a result of an individual’s life, formation of his body and personality, especially in adolescence. The subject of the research is to study special features of psychosomatic disorders, as well as to design a program for adolescents with signs of neurotic disorders. The subject matter of the research is the peculiarities of psychosomatic disorders manifestation and neurotic signs in adolescence. The article presents a theoretical analysis of modern approaches in psychology to the study of psychosomatic disorders peculiarities, their classification, considering the signs of neurotic disorders in adolescence. The work analyzes age characteristics of psychosomatic disorders in adolescence. Modern adolescents are exposed to various stressors, to the impact of audiovisual information, school overload, extra classes, exams, and a special problem that is a change in quality of life and prevalence of alcoholism, smoking, drug addiction, especially drug addiction among adolescents. The complex of these factors has negative consequences both on a psychological and physical level. Most authors who study the causes of psychosomatic illnesses recognize the important role of parents in the development of mentally and physically healthy children. Many studies highlight the role of early mother-child relationships in the formation of psychosomatic pathology. Various violations of this relationship usually lead to abnormalities in a child’s development. (M. Mahler, E. T. Eidemiller, Yustitskis, D. Winnicott, M. Klein). The results of an empirical study aimed at identifying signs of psychosomatic disorders are considered. The following methods were used: observation, questionnaires, and such methods as diagnosis of neurotic disorders in adolescence (DND), diagnosis of the level of school anxiety by Phillips, “Non-existent animal” by M.Z. Drukarevich. The peculiarities of designing and testing the correction program, which is aimed at reducing the signs of neurotic manifestations in adolescence, are revealed. Objectives of the correction program are: searching for interaction of adolescents with society, finding and testing skills of effective response to external stimuli; increasing the level of self-esteem; removal of emotional tension; reducing anxiety. The results confirm the possibility of reducing the signs of neurotic manifestations of adolescents and help to delay or completely stop a possible personality disorder.

scholarly journals Modelisation Hydraulique Mono Dimensionnel Par HEC RAS, Application Sur L’oued Aggay (Ville De Sefrou)

2018 ◽  
Vol 14 (18) ◽  
pp. 110 ◽  
Author(s):  
Meriam Lahsaini ◽  
Hassan Tabyaoui
Keyword(s):  
Urban Planning ◽  
Cultural Heritage ◽  
Statistical Methods ◽  
Flood Risk ◽  
Water Levels ◽  
Hydrological Study ◽  
Geographical Position ◽  
The Subject ◽  
Flooded Area ◽  
The City

The city of Sefrou, because of its geographical position, its cultural heritage and urban planning, than economically, is classified as one of the sites with a vulnerability particular to floods. Oued Aggay, the subject of this study, constitutes a danger potential because of the violence of its floods. In this perspective that comes this study that part of the creation and management of a spatial database on flood risk in the Sebou basin. It aims to spatialize the extent of the floods of Oued Aggay and propose solutions to protection the city of Sefrou against floods. The chosen approach goes through a hydrological study, the choice of profiles and the construction of onedimensional model from HEC RAS hydrology software. This study allowed us to simulate floods by statistical methods, identify flood zones and determine the different water levels in the flooded area for the Oued Aggay watershed.

Gut Microbiota Dysbiosis in Children with Relapsing Idiopathic Nephrotic Syndrome

2018 ◽  
Vol 47 (3) ◽  
pp. 164-170 ◽  
Author(s):  
Shoji Tsuji ◽  
Chikushi Suruda ◽  
Masaki Hashiyada ◽  
Takahisa Kimata ◽  
Sohsaku Yamanouchi ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Gut Microbiota ◽  
Butyric Acid ◽  
Idiopathic Nephrotic Syndrome ◽  
Flow Cytometric Analysis ◽  
Metagenomic Analysis ◽  
Healthy Children ◽  
Cd4 Cells ◽  
Acid Producing Bacteria ◽  
Gut Microbiota Dysbiosis

Background: While the etiology of idiopathic nephrotic syndrome (idiopathic nephrotic syndrome [INS]; characterized by repeated relapses and comorbid allergic conditions) remains unknown, recent evidence suggests that dysfunction in regulatory T cells (Tregs) plays an important role in the development of INS as well as allergic diseases. We hypothesized that dysbiosis involving decreased butyric acid-producing gut microbiota leads to defective induction and differentiation of peripherally induced Tregs, resulting in INS relapse. Methods: Study subjects were 12 children with INS, 8 classified as relapsing (R group; median age: 3.0 years) and 4 as non-relapsing (NR group; median age: 4.3 years), and 11 healthy children (HC group; median age: 5.1 years) serving as normal controls. Measurement of microbiota was performed using 16S ribosomal RNA metagenomic analysis, and fecal butyric acid was measured using high performance liquid chromatography. Flow-cytometric analysis of Tregs and CD4-positive (CD4+) cells in peripheral blood was also performed. Results: Metagenomic analysis of gut microbiota using feces showed that the proportion of butyric acid-producing bacteria was significantly lower in R (median 6.36%) than HC (median 18.84%; p = 0.0013), but no different between NR (median 16.71%) and HC (p = 0.29). Fecal organic acid analysis revealed significantly lower butyric acid quantities in R than HC (medians: 0.48 vs. 0.99 mg/g, p = 0.042). Circulating Tregs as a proportion of CD4+ cells were decreased in 75% of R and NR. Conclusion: Pediatric relapsing INS patients show gut microbiota dysbiosis, characterized by a decreased proportion of butyric acid-producing bacteria and lower fecal butyric acid quantities, concomitant with reduced circulatory Tregs.

Effects of Nephrotic Syndrome on the Family: A Controlled Study

PEDIATRICS ◽  
1980 ◽  
Vol 65 (5) ◽  
pp. 948-955 ◽  
Author(s):  
John C. Vance ◽  
Louis E. Fazan ◽  
Betty Satterwhite ◽  
Ivan B. Pless
Keyword(s):  
Nephrotic Syndrome ◽  
Rating Scales ◽  
Psychosocial Problems ◽  
Chronic Illnesses ◽  
Stressful Events ◽  
Controlled Study ◽  
Healthy Children ◽  
Personality Profiles ◽  
Parent Rating ◽  
Parent Rating Scales

The hypothesis that the parents and siblings of children with nephrotic syndrome are more likely to develop psychosocial problems than those of healthy children was tested. Seventy-nine siblings from 36 such families were compared with 79 healthy children from closely matched families using interviews, parent rating scales, teachers' reports, and psychological tests. Although few striking differences were found between the two groups, the findings suggest several areas of increased vulnerability among the parents and siblings of children with nephrosis. Parents often denied the existence of apparently stressful events, but the personality profiles of the siblings suggested decreased social confidence and a lesser degree of self-acceptance. Evidence of inhibition, such as less aggression and poorer academic performance, were also described in response to questions in the interview. These results should prove useful to clinicians in the management of families of children with this or other chronic illnesses.

Aspects of the Determination of the Strength of Materials

1947 ◽  
Vol 51 (433) ◽  
pp. 65-68
Author(s):  
E. W. J. Mardles
Keyword(s):  
Brittle Fracture ◽  
Statistical Methods ◽  
Mechanical Test ◽  
Microscopical Examination ◽  
Test Results ◽  
Strength Of Materials ◽  
Recent Developments ◽  
The Subject ◽  
Griffith Theory

Some aspects of the determination of the strength of materials formed the subject of two meetings held jointly with the British Rheologists’ Club (President, Prof. E. N. da C. Andrade) and the Royal Aircraft Establishment in the Assembly Hall, Farnborough, on the 16th June, 1945, and with the Royal Aeronautical Society in the library at 4, Hamilton Place, on the 19th February, 1946, under the chairmanship of Sir Ben Lockspeiser.At the Farnborough meeting three papers were read, namely, “The investigation of failures in wood by microscopical examination” by M. C. Pryor and A. Rayne; “The effect of duration of loading on the strength of brittle materials” by C. Gurney; and “Application of statistical methods to mechanical test results” by B. Chalmers and E. R. W. Jones. At the London meeting Prof. N. F. Mott of Bristol University spoke on the “Griffith theory of cracks in solids and recent developments of this theory, with application to brittle fracture in glass and in metals.”

scholarly journals Development of Speaking Skills Assessment Criteria for Engineering Students

2021 ◽  
Author(s):  
Zoia Kornieva ◽  
Olha Vashchylo
Keyword(s):  
Statistical Methods ◽  
Mechanical Engineering ◽  
Engineering Students ◽  
Industrial Engineering ◽  
Assessment Criteria ◽  
Skills Assessment ◽  
Applied Mechanics ◽  
Teaching English ◽  
Subject Areas ◽  
The Subject

The purpose of the article is to put forward English monologue production assessment criteria to verify the efficiency of the devised methodology of teaching English for future mechanical engineers. In the course of the research, theoretical, empirical, and statistical methods have been used. Various approaches to identifying the assessment criteria have been thoroughly analyzed. Seven criteria to assess the monologue production skills, five primary and two secondary ones, have been suggested. The allocation of the points by every criterion according to the devised scales have been elucidated. The proposed assessment criteria were used in the methodological experiment that was held at Igor Sikorsky Kyiv National Technical University. The experiment in question aimed to verify the efficiency of the devised methodology of teaching English monologue production to students majoring in mechanical engineering. Three experimental groups, 34 students in total, studying in their final year of Bachelor studies within the Subject Areas of Applied Mechanics and Industrial Engineering, participated in the methodological experiment. The conducted experiment confirmed the efficiency of the methodology proposed.

scholarly journals Data mining of pediatric reference intervals

2021 ◽  
Vol 45 (6) ◽  
pp. 311-317
Author(s):  
Jakob Zierk ◽  
Markus Metzler ◽  
Manfred Rauh
Keyword(s):  
Data Mining ◽  
Information Systems ◽  
Statistical Methods ◽  
Clinical Decision Making ◽  
Reference Intervals ◽  
Healthy Children ◽  
Test Results ◽  
Young Infants ◽  
Age Related ◽  
Laboratory Test Results

Abstract Laboratory tests are essential to assess the health status and to guide patient care in individuals of all ages. The interpretation of quantitative test results requires availability of appropriate reference intervals, and reference intervals in children have to account for the extensive physiological dynamics with age in many biomarkers. Creation of reference intervals using conventional approaches requires the sampling of healthy individuals, which is opposed by ethical and practical considerations in children, due to the need for a large number of blood samples from healthy children of all ages, including neonates and young infants. This limits the availability and quality of pediatric reference intervals, and ultimately negatively impacts pediatric clinical decision-making. Data mining approaches use laboratory test results and clinical information from hospital information systems to create reference intervals. The extensive number of available test results from laboratory information systems and advanced statistical methods enable the creation of pediatric reference intervals with an unprecedented age-related accuracy for children of all ages. Ongoing developments regarding the availability and standardization of electronic medical records and of indirect statistical methods will further improve the benefit of data mining for pediatric reference intervals.

scholarly journals Easy as pie. How not to treat statistics

2018 ◽  
Vol 9 (3) ◽  
pp. 208-212
Author(s):  
A.N. Krichevets
Keyword(s):  
Data Processing ◽  
Statistical Methods ◽  
Critical Analysis ◽  
Scientific Community ◽  
Meta Analysis ◽  
Series Of Experiments ◽  
The Subject ◽  
Probabilistic Nature ◽  
Statistical Results ◽  
Methodological Difficulties

The article discusses the methodological difficulties associated with the spread of statistical methods of data processing in psychological works. In particular, there is a simplification of the understanding of statistics by researchers, which increasingly leads to the adoption of the hypothesis of the presence of the effect, in a situation where it is not. There is a brief review of publications and examples where this issue is the subject of critical analysis. Presented a research which showed that in the repetition of experiments published in reputable journals, the significance accepted in the scientific community was observed only in 39% of the works — this effect was called the “publication shift”. The article discusses ways to solve this problem, in particular, meta-analysis, through which it is possible to confirm the results of a series of experiments relating to one problem — subject to the availability of information about the design and openness of raw data. An understanding of the probabilistic nature of statistical results must be mandatory for the evaluation of studies

scholarly journals The role of cell signaling molecules in the pathogenesis of glomerulonephritis in children

2021 ◽  
Vol 64 (2) ◽  
pp. 37-41
Author(s):  
Angela Ciuntu ◽  
Keyword(s):  
Nephrotic Syndrome ◽  
Cell Signaling ◽  
Clinical Manifestations ◽  
Signaling Molecules ◽  
Control Group ◽  
Healthy Children ◽  
Steroid Resistant ◽  
Steroid Resistant Nephrotic Syndrome ◽  
Steroid Sensitive Nephrotic Syndrome ◽  
Steroid Sensitive

Background: Cytokines are functional class of tiny proteins and glycoprotein and fundamentally they are monomers that function as soluble mediators in an autocrine or paracrine manner. Cytokines are produced by a number of cell types, predominantly leukocytes, and their targets implicate both immune and non-immune cells. Material and methods: This study was performed on 75 children with glomerulonephritis (GN), aged from 2 up to 17 years. There were 20 children with steroid-sensitive nephrotic syndrome (SSNS), 15 children with steroid-resistant nephrotic syndrome (SRNS), 20 children with chronic glomerulonephritis (CGN) nephrotic form and 20 children with CGN mixed form. This study was performed on patients experiencing disease relapse and clinical remission. The control group consisted of 20 healthy children. Results: The results of this study demonstrated increased levels of cell signaling molecules (IL-8, TNF-α, MCP-1, MIP-1α) in the urine during clinical manifestations, valuable result due to their major role in the immunopathogenic mechanism of proteinuria in nephrotic syndrome. Conclusions: Determination of urinary concentrations of cellular signaling molecules may be useful as a predictive non-invasive method for estimating disease activity, monitoring disease progression, differentiating steroid-sensitive nephrotic syndrome from steroid-resistant nephrotic syndrome, and assessing the effectiveness of treatment in children with different variants of GN

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