scholarly journals Multidrug-resistant klebsiella pneumoniae-induced sepsis with multiple abscesses: A case report

2021 ◽  
Vol 2 (4) ◽  
Author(s):  
Ye Xiong ◽  
◽  
Jianrong Huang ◽  
Keyword(s):  
Case Report ◽  
Antimicrobial Resistance ◽  
Klebsiella Pneumoniae ◽  
Oral Cavity ◽  
Multidrug Resistant ◽  
Drug Resistant ◽  
Human Intestine ◽  
Gram Negative ◽  
Negative Bacillus ◽  
Gram Negative Bacillus

Klebsiella pneumoniae, a Gram-negative bacillus which exists widely in nature, is generally colonized in the human intestine and oral cavity and does not cause disease [1]. However, the emergence and global expansion of hypervirulent and multidrug-resistant clones of K. pneumoniae have been increasingly reported in community-acquired and nosocomial infections. Management of antimicrobial resistance in multi-drug-resistant-K. pneumoniae (MDR-KP) is a major challenge for clinicians [2]. The optimal treatment option for MDR-KP infections is still not well established, which brings huge challenges to clinical treatment [2].

scholarly journals Intraocular lipopolysaccharide examination for early diagnosis of Stenotrophomonas maltophilia endophthalmitis: a case report

2020 ◽  
Vol 48 (8) ◽  
pp. 030006052092986
Author(s):  
Li Chen ◽  
Zhuo Zai Xu ◽  
Yong Tao
Keyword(s):  
Visual Acuity ◽  
Case Report ◽  
Early Diagnosis ◽  
Stenotrophomonas Maltophilia ◽  
Gram Negative ◽  
Hand Motion ◽  
Bacterial Endophthalmitis ◽  
Negative Bacillus ◽  
Gram Negative Bacillus ◽  
Intraocular Fluid

This report describes the presence of Stenotrophomonas maltophilia endophthalmitis after phacoemulsification in a 66-year-old woman. The patient presented with ocular redness and pain, as well as hypopyon in the anterior chamber and reduction of visual acuity to hand motion. Intraocular fluid examination revealed a lipopolysaccharide level of >2.5, which suggested bacterial endophthalmitis. The patient was promptly treated with intravitreal ceftazidime 2 mg and vancomycin 1 mg, as well as intravenous infusion of cefuroxime 750 mg, all administered simultaneously at 12-hour intervals. She also received topical levofloxacin eyedrops, once per hour. Subsequently, pathology culture confirmed the presence of the Gram-negative bacillus, S. maltophilia. The presence of lipopolysaccharide in intraocular fluid is an important early indicator of bacterial endophthalmitis, which can provide guidance for clinical treatment.

scholarly journals Dokdonella KoreensisBacteremia: A Case Report and Review of the Literature

2014 ◽  
Vol 25 (5) ◽  
pp. 255-256 ◽  
Author(s):  
Boeun Lee ◽  
Mitchell R Weinstein
Keyword(s):  
Case Report ◽  
Hematological Malignancy ◽  
Review Of The Literature ◽  
Gram Negative ◽  
Negative Bacillus ◽  
Gram Negative Bacillus

Dokdonella koreensisis a non-spore-forming, aerobic, Gram-negative bacillus that was initially isolated from soil. The pathogenicity of this organism in humans remains unclear. The authors report a case of successfully treatedD koreensisbacteremia in a patient with a hematological malignancy who presented with a fever and palmar-plantar erythrodysesthesia.

scholarly journals A Global Overview of β-lactam Resistance Genes in Klebsiella pneumoniae

2019 ◽  
Vol 11 (1) ◽  
pp. 22-34
Author(s):  
Yone da Silva ◽  
Rafaela Ferrari ◽  
Victor Augustus Marin ◽  
Carlos Adam Conte Junior
Keyword(s):  
Klebsiella Pneumoniae ◽  
Resistance Genes ◽  
Public Interest ◽  
Bacterial Isolate ◽  
Public Health Problem ◽  
Gram Negative ◽  
Negative Bacillus ◽  
Gram Negative Bacillus ◽  
The Subject ◽  
Over Time

Klebsiella pneumoniae is a gram-negative bacillus of the Enterobacteriaceae family, commonly associated with nosocomial infections. This pathogen is a serious public health problem as some of its strains are resistant to about 95% antimicrobials of the pharmaceutical market. This resistance is promoted by the production of the β-lactamase extended spectrum (ESBL) enzymes, one of the major causes of therapeutic failure. This review evaluated the incidence and distribution of resistance genes from Klebsiella pneumoniae to β-lactams worldwide. Our study was conducted with the subject the organism K. pneumoniae and β-lactamic resistance. The most reported genes were blaSHV-12, blaCTX-M-2 and blaSHV-5; with blaSHV-12 being the most described. The last two were present in all continents, characterizing its cosmopolitan profiles. The greatest genetic diversity was observed in the Asian and Oceania, where 41 different genes were isolated. Additionally, our review points out the coexistence of different classes of β-lactamases in a single bacterial isolate. Finally, knowledge of mechanisms associated with resistance of K. pneumoniae is of great public interest and the verification of resistance genes shows a variation over time and location highlights the importance of evaluating the mechanisms or strategies by which these variations occur.

scholarly journals Sphingomonas paucimobilis bacteraemia and septic arthritis in a diabetic patient presenting with septic pulmonary emboli

2009 ◽  
Vol 58 (9) ◽  
pp. 1259-1263 ◽  
Author(s):  
I-Ching Kuo ◽  
Po-Liang Lu ◽  
Wei-Ru Lin ◽  
Chun-Yu Lin ◽  
Yu-Wei Chang ◽  
...  
Keyword(s):  
Case Report ◽  
Septic Arthritis ◽  
Human Infection ◽  
Sphingomonas Paucimobilis ◽  
Pulmonary Emboli ◽  
Gram Negative ◽  
Negative Bacillus ◽  
First Case ◽  
Gram Negative Bacillus ◽  
Immunocompromised Hosts

Sphingomonas paucimobilis, a yellow-pigmented, aerobic, glucose non-fermenting, Gram-negative bacillus, is a rare cause of human infection normally associated with immunocompromised hosts. We report a case of bacteraemia and septic arthritis in a 47-year-old diabetic man who presented with septic pulmonary emboli due to S. paucimobilis. The patient had an initial presentation of fever, right knee pain, coughing, dyspnoea and chest pain. The infection was treated successfully by surgical debridement combined with meropenem plus ciprofloxacin, based on the patient's antibiotic susceptibility profile. To our knowledge, this is the first case report for septic pulmonary emboli having arisen from an S. paucimobilis infection.

scholarly journals Bacterial Endocarditis Caused by Sphingomonas paucimobilis: A Case Report and Literature Review

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
Kara Rognrud ◽  
Andrew M. Diaz ◽  
Collin Hill ◽  
Melissa A. Kershaw
Keyword(s):  
United States ◽  
Case Report ◽  
Literature Review ◽  
Medical History ◽  
The United States ◽  
Bacterial Endocarditis ◽  
Sphingomonas Paucimobilis ◽  
Gram Negative ◽  
Negative Bacillus ◽  
Gram Negative Bacillus

A 47-year-old male with no significant medical history was hospitalized for bacteremia and diagnosed with endocarditis. The organism isolated was a Gram-negative bacillus—Sphingomonas paucimobilis. There are only a few reported cases of endocarditis caused by S. paucimobilis, and to our knowledge, this is the first in the United States.

scholarly journals Bartonella henselae infection presenting as cervical spine osteomyelitis: case report

2018 ◽  
Vol 22 (2) ◽  
pp. 189-194
Author(s):  
Syed Hassan A. Akbari ◽  
Christine E. Averill ◽  
Jarod L. Roland ◽  
Rachel Orscheln ◽  
Jennifer Strahle
Keyword(s):  
Case Report ◽  
Cervical Spine ◽  
Bartonella Henselae ◽  
Pediatric Population ◽  
Cat Scratch Disease ◽  
Neck Swelling ◽  
Gram Negative ◽  
Negative Bacillus ◽  
First Case ◽  
Gram Negative Bacillus

Bartonella henselae is a gram-negative bacillus implicated in cat-scratch disease. Cat-scratch disease is usually self-limiting and results in local lymphadenopathy. In rare circumstances, patients may develop endocarditis, neuroretinitis, or osteomyelitis. Osteomyelitis of the cervical spine is exceedingly rare, especially in the pediatric population, and to date there have been only 4 previously reported cases of cervical spine osteomyelitis caused by B. henselae, all of which were treated surgically. In this article, the authors report the case of a 7-year-old boy who presented with neck swelling and was found to have a C2–4 paravertebral B. henselae abscess with osteomyelitis of C-3 and epidural extension. To the authors’ knowledge, this represents the first case in the literature of a cervical spine B. henselae infection managed conservatively.

scholarly journals Multidrug-Resistant Klebsiella Pneumoniae: A Retrospective Study in Manaus, Brazil

2021 ◽  
Author(s):  
Rafael Nakamura-Silva ◽  
Louise Cerdeira ◽  
Mariana Oliveira-Silva ◽  
Karen Regina Carim da Costa ◽  
Elder Sano ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Klebsiella Pneumoniae ◽  
Resistance Genes ◽  
Opportunistic Pathogen ◽  
Multidrug Resistant ◽  
Drug Resistant ◽  
Extensively Drug Resistant ◽  
Antimicrobial Resistance Genes ◽  
Northern Brazil ◽  
The City

Abstract Klebsiella pneumoniae is an opportunistic pathogen that can cause several infections, mainly in hospitalised or immunocompromised individuals. The spread of K. pneumoniae emerging virulent and multidrug-resistant clones is a worldwide concern and its identification is crucial to control these strains especially in hospitals. This article reports data related to multi-resistant K. pneumoniae strains, isolated from inpatients in the city of Manaus, Brazil, harbouring virulence and antimicrobial resistance genes, including high-risk international clones belonging to clonal group (CG) 258. Twenty-one strains isolated from different patients admitted to four hospitals in the city of Manaus, located in the state of Amazonas, Northern Brazil (Amazon Rainforest region) were evaluated. The majority of strains (61.9 % n = 13) were classified as multidrug-resistant (MDR), and five strains (23.8 %) as extensively drug-resistant (XDR). Several virulence and antimicrobial resistance genes were found among the strains and eight strains (38.1 %) presented the hypermucoviscous phenotype. MLST analysis demonstrated a great diversity of STs among the strains, totaling 12 different STs (ST11, ST23, ST198, ST277, ST307, ST340, ST378, ST462, ST502, ST3991, ST3993 and ST5209). Four of these (ST11, ST23, ST307 and ST340) belong to CG258.

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