scholarly journals A Global Overview of β-lactam Resistance Genes in Klebsiella pneumoniae

2019 ◽  
Vol 11 (1) ◽  
pp. 22-34
Author(s):  
Yone da Silva ◽  
Rafaela Ferrari ◽  
Victor Augustus Marin ◽  
Carlos Adam Conte Junior
Keyword(s):  
Klebsiella Pneumoniae ◽  
Resistance Genes ◽  
Public Interest ◽  
Bacterial Isolate ◽  
Public Health Problem ◽  
Gram Negative ◽  
Negative Bacillus ◽  
Gram Negative Bacillus ◽  
The Subject ◽  
Over Time

Klebsiella pneumoniae is a gram-negative bacillus of the Enterobacteriaceae family, commonly associated with nosocomial infections. This pathogen is a serious public health problem as some of its strains are resistant to about 95% antimicrobials of the pharmaceutical market. This resistance is promoted by the production of the β-lactamase extended spectrum (ESBL) enzymes, one of the major causes of therapeutic failure. This review evaluated the incidence and distribution of resistance genes from Klebsiella pneumoniae to β-lactams worldwide. Our study was conducted with the subject the organism K. pneumoniae and β-lactamic resistance. The most reported genes were blaSHV-12, blaCTX-M-2 and blaSHV-5; with blaSHV-12 being the most described. The last two were present in all continents, characterizing its cosmopolitan profiles. The greatest genetic diversity was observed in the Asian and Oceania, where 41 different genes were isolated. Additionally, our review points out the coexistence of different classes of β-lactamases in a single bacterial isolate. Finally, knowledge of mechanisms associated with resistance of K. pneumoniae is of great public interest and the verification of resistance genes shows a variation over time and location highlights the importance of evaluating the mechanisms or strategies by which these variations occur.

scholarly journals Multidrug-resistant klebsiella pneumoniae-induced sepsis with multiple abscesses: A case report

2021 ◽  
Vol 2 (4) ◽  
Author(s):  
Ye Xiong ◽  
◽  
Jianrong Huang ◽  
Keyword(s):  
Case Report ◽  
Antimicrobial Resistance ◽  
Klebsiella Pneumoniae ◽  
Oral Cavity ◽  
Multidrug Resistant ◽  
Drug Resistant ◽  
Human Intestine ◽  
Gram Negative ◽  
Negative Bacillus ◽  
Gram Negative Bacillus

Klebsiella pneumoniae, a Gram-negative bacillus which exists widely in nature, is generally colonized in the human intestine and oral cavity and does not cause disease [1]. However, the emergence and global expansion of hypervirulent and multidrug-resistant clones of K. pneumoniae have been increasingly reported in community-acquired and nosocomial infections. Management of antimicrobial resistance in multi-drug-resistant-K. pneumoniae (MDR-KP) is a major challenge for clinicians [2]. The optimal treatment option for MDR-KP infections is still not well established, which brings huge challenges to clinical treatment [2].

scholarly journals Thoracic Complications of Lemierre Syndrome

2000 ◽  
Vol 7 (6) ◽  
pp. 481-485 ◽  
Author(s):  
Russell Thomas Gowan ◽  
Reza John Mehran ◽  
Pierre Cardinal ◽  
Gwynne Jones
Keyword(s):  
Jugular Vein ◽  
Fusobacterium Necrophorum ◽  
Review Of The Literature ◽  
Septic Thrombophlebitis ◽  
Lemierre Syndrome ◽  
Gram Negative ◽  
Negative Bacillus ◽  
Oropharyngeal Infection ◽  
Gram Negative Bacillus ◽  
The Subject

Lemierre syndrome is a severe, septicemic illness most commonly caused by the anaerobic Gram-negative bacillusFusobacterium necrophorum. It is characterized by an acute oropharyngeal infection, with secondary septic thrombophlebitis of the internal jugular vein and frequent metastatic infections. This report of a patient with the Lemierre syndrome is complemented by a review of the literature on the subject.

MENINGITIS IN PREMATURE INFANTS

PEDIATRICS ◽  
1949 ◽  
Vol 4 (4) ◽  
pp. 479-483
Author(s):  
B. M. KAGAN ◽  
J. H. HESS ◽  
B. MIRMAN ◽  
EVELYN LUNDEEN
Keyword(s):  
Premature Infant ◽  
Premature Infants ◽  
Spinal Fluid ◽  
Review Of The Literature ◽  
Gram Negative ◽  
Negative Bacillus ◽  
Gram Negative Bacillus ◽  
The Subject ◽  
Symptoms And Signs

A review of the literature on the subject of meningitis in premature infants revealed 45 cases. In 10 of these cases from which bacterial agents were cultured, six showed a gram negative bacillus. Twelve additional cases are added in this study and Esch. coli was cultured from the spinal fluid of nine (with another organism in three of the nine cases). The symptoms and signs of meningitis in premature infants are discussed. No reports have been found in the literature of recovery from meningitis in premature infants weighing less than 2,500 gm. The course and treatment of a premature infant who weighed less than 1,000 gm. and who recovered from an Esch. coli meningitis is described in detail.

scholarly journals Bipolar staining of gram-negative bacillus in cerebrospinal fluid

Blood ◽  
2014 ◽  
Vol 124 (18) ◽  
pp. 2892-2892
Author(s):  
Lori D. Racsa ◽  
Eileen M. Burd
Keyword(s):  
Cerebrospinal Fluid ◽  
Gram Negative ◽  
Negative Bacillus ◽  
Gram Negative Bacillus

scholarly journals Meningitis Caused by Salmonella Newport in a Five-Year-Old Child

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Ana De Malet ◽  
Sheila Ingerto ◽  
Israel Gañán
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Neurological Disorders ◽  
Invasive Disease ◽  
Salmonella Typhi ◽  
Gram Negative ◽  
Negative Bacillus ◽  
Salmonella Newport ◽  
Gram Negative Bacillus ◽  
The Central Nervous System

Salmonella Newport is a Gram-negative bacillus belonging to the Enterobacteria family and the nontyphi Salmonella (NTS), usually related to gastroenteritis. Main difference between NTS and Salmonella typhi is that the last one evolves to an invasive disease easier than NTS. These can progress to bacteremias in around 5% of cases and secondary focuses can appear occasionally, as in meningitis. An infection of the central nervous system is uncommon, considering its incidence in 0.6–8% of the cases; most of them are described in developing countries and mainly in childhood, especially neonates. Bacterial meningitis by NTS mostly affects immunosuppressed people in Europe. Prognosis is adverse, with a 50% mortality rate, mainly due to complications of infection: hydrocephalus, ventriculitis, abscesses, subdural empyema, or stroke. Choice antibiotic treatments are cefotaxime, ceftriaxone, or ceftazidime. The aim of this paper is to present a case of meningitis caused by Salmonella Newport diagnosed in a five-year-old girl living in a rural area of the province of Ourense (Spain), with favorable evolution and without neurological disorders.

Melioidosis and glanders

2010 ◽  
pp. 768-772
Author(s):  
S.J. Peacock
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Northern Australia ◽  
Gram Negative ◽  
Negative Bacillus ◽  
North East ◽  
Serious Infection ◽  
The World ◽  
Gram Negative Bacillus ◽  
Sixth Decade

Melioidosis is a serious infection caused by the soil-dwelling Gram-negative bacillus Burkholderia pseudomallei. It is most commonly reported in north-east Thailand and northern Australia, but is increasingly recognized around the world. Infection is predominantly acquired through bacterial inoculation, often related to occupation, and mostly affects adults between the fourth and sixth decade who have risk factors such as diabetes mellitus and renal impairment....

scholarly journals Melioidosis with Septic Shock and Disseminated Infection in a Neutropenic Patient Receiving Chemotherapy

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Sitthi Sukauichai ◽  
Chantana Pattarowas
Keyword(s):  
Septic Shock ◽  
Mortality Rate ◽  
Burkholderia Pseudomallei ◽  
Neutropenic Patient ◽  
Pulmonary Nodules ◽  
Severe Infection ◽  
Gram Negative ◽  
Negative Bacillus ◽  
Gram Negative Bacillus ◽  
Chemotherapy Induced Neutropenia

Melioidosis is a bacterial infection, caused by Gram-negative bacillus, Burkholderia pseudomallei, widespread in Southeast Asia and the northern part of Australia, resulting in a high mortality rate in severe infection. However, it has rarely been reported in patients with chemotherapy-induced neutropenia. The authors described a case of melioidosis in a neutropenic patient presenting with septic shock after receiving chemotherapy. Blood and urine cultures were positive for Burkholderia pseudomallei, and CT scan showed multiple pulmonary nodules and hepatosplenic abscesses. The patient was successfully treated with antibiotics for the infection and with combined modalities for a malignancy.

A Gram-negative Bacillus Infection Causing Gill Lesions in Cultured Rockfish Sebastes schlegeli

2005 ◽  
Vol 40 (3) ◽  
pp. 143-145 ◽  
Author(s):  
Tatsuya Kobayashi ◽  
Makoto Imai ◽  
Yoshifumi Kawaguchi
Keyword(s):  
Sebastes Schlegeli ◽  
Gram Negative ◽  
Negative Bacillus ◽  
Gram Negative Bacillus
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