The current strategy of sustainable development of Ukraine should include the development of a nationally consolidated, spiritual-intellectual, open-democratic, cultural-diverse, creative and informational society where the main dominant is the harmonization of the social environment with active horizontal and vertical ties, which are based on a well-grounded institutional provision. The objective of this strategy, given the loss of much of the economic potential, tragic victims and forcible migration from Crimea and East Ukraine, is to ensure the national identity, historical catholicity, comprehensive self-realization, socialization and a decent standard of living, security, formation of an innovatively dynamic economy and the system of national education, science, culture, medicine, physical culture and sports, recreation, and information integration of Ukrainian nation into a civilized world. The purpose of this article is to study the peculiarities of the manifestation of the socio-humanitarian space for the sustainable development of the regions of Ukraine and to develop a spatial model for the organization of social infrastructure under conditions of decentralized management based on the experience of the Republic of Poland. Structural-functional and space-regulating components of the socio-humanitarian space are determined. It is determined that institutions of social infrastructure are characterized by diversified properties, which are the basis for determining the spatial model of the organization of social infrastructure. This model depends on the interconnection of infrastructure facilities with the service space, as well as the number and structure of the population of this space. Based on Poland’s experience, a spatial model for the organization of the social infrastructure of the socio-humanitarian space of Ukraine is developed; the model grounds on a clear delineation of tasks and responsibilities between central and local authorities. The vectors of modernization of social infrastructure of the socio-humanitarian space of regions of Ukraine are determined.