scholarly journals Gestational diabetes, insulin resistance and physical activity in pregnancy in a multi-ethnic population – a public health perspective

2013 ◽  
Vol 23 (1) ◽  
Author(s):  
Anne Karen Jenum ◽  
Kåre Rønn Richardsen ◽  
Sveinung Berntsen ◽  
Kjersti Mørkrid
Keyword(s):  
Physical Activity ◽  
Insulin Resistance ◽  
South Asian ◽  
Cell Function ◽  
South Asians ◽  
Asian Women ◽  
South Asian Women ◽  
Β Cell ◽  
Iadpsg Criteria ◽  
Β Cell Function

Aims: To summarize findings from the STORK-Groruddalen Study regarding ethnic differences in the prevalence of gestational diabetes (GDM) by the WHO and modified International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria (no one hour value), insulin resistance, β-cell function and physical activity (PA) level. Methods: Population-based cohort study of 823 healthy pregnant women (59% ethnic minorities). Data from questionnaires, fasting blood samples, anthropometrics and objectively recorded PA level (SenseWear Armband), were collected at <20 (Visit 1) and 28±2 (Visit 2) weeks of gestation. The 75-g OGTT was performed at Visit 2. Insulin resistance (HOMA-IR) and β-cell function (HOMA-β) were estimated from venous fasting plasma glucose and C-peptide. Results: The GDM prevalence was 13.0% with the WHO and 31.5% with the IADPSG criteria. The ethnic minority women, especially South Asians, had highest figures. South and East Asian women had highest HOMA-IR at Visit 1 after adjustment for BMI. HOMA-IR increased from Visit 1 to Visit 2 irrespective of ethnic origin. Compared with Western European women, the absolute and percentage increase in HOMA-β from Visit 1 to Visit 2 was poorest for the South and East Asian women. All ethnic groups walked less and spent less time in moderate-to-vigorous physical activity (MVPA) during weekend days compared with weekdays. South Asian women were least active, measured by steps and by time spent in MVPA. Conclusion: Alarmingly high rates of GDM were found, highest among South Asians. South Asian women were less physically active, more insulin resistant and showed poorer β-cell compensation compared with Western Europeans.

scholarly journals Failure to increase insulin secretory capacity during pregnancy-induced insulin resistance is associated with ethnicity and gestational diabetes

2012 ◽  
Vol 167 (4) ◽  
pp. 579-588 ◽  
Author(s):  
Kjersti Mørkrid ◽  
Anne K Jenum ◽  
Line Sletner ◽  
Mari H Vårdal ◽  
Christin W Waage ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Gestational Diabetes ◽  
Pregnant Women ◽  
South Asia ◽  
Cell Function ◽  
Post Partum ◽  
South Asians ◽  
Β Cell ◽  
Insulin Resistant ◽  
Β Cell Function

ObjectiveTo assess changes in insulin resistance and β-cell function in a multiethnic cohort of women in Oslo, Norway, from early to 28 weeks' gestation and 3 monthspost partumand relate the findings to gestational diabetes mellitus (GDM).MethodPopulation-based cohort study of 695 healthy pregnant women from Western Europe (41%), South Asia (25%), Middle East (15%), East Asia (6%) and elsewhere (13%). Blood samples and demographics were recorded at mean 15 (V1) and 28 (V2) weeks' gestation and 3 monthspost partum(V3). Universal screening was by 75 g oral glucose tolerance test at V2, GDM with modified IADPSG criteria (no 1-h measurement): fasting plasma glucose (PG) ≥5.1 or 2-h PG ≥8.5 mmol/l. Homeostatic model assessment (HOMA)-β (β-cell function) and HOMA-IR (insulin resistance) were calculated from fasting glucose and C-peptide.ResultCharacteristics were comparable across ethnic groups, except age (South Asians: younger,P<0.001) and prepregnant BMI (East Asians: lower,P=0.040). East and South Asians were more insulin resistant than Western Europeans at V1. From V1 to V2, the increase in insulin resistance was similar across the ethnic groups, but the increase in β-cell function was significantly lower for the East and South Asians compared with Western Europeans. GDM women compared with non-GDM women were more insulin resistant at V1; from V1 to V2, their β-cell function increased significantly less and the percentage increase in β-cell function did not match the change in insulin resistance.ConclusionPregnant women from East Asia and South Asia were more insulin resistant and showed poorer HOMA-β-cell function than Western Europeans.

Effects of Ovariectomy on Insulin Resistance and β-Cell Function and Mass

2004 ◽  
Vol 9 (4) ◽  
pp. 367-373
Author(s):  
Soo-Bong Choi ◽  
Chun-Hee Park ◽  
Dong-Wha Jun ◽  
Jin-Sun Jang ◽  
Sun-Min Park
Keyword(s):  
Insulin Resistance ◽  
Cell Function ◽  
Β Cell ◽  
Β Cell Function

scholarly journals Physical Activity in First Generation South Asian Women Living in Canada: Barriers and Facilitators to Participation

2016 ◽  
Vol 24 (2) ◽  
pp. 110-119 ◽  
Author(s):  
Kiruthika Rathanaswami ◽  
Enrique Garcia Bengoechea ◽  
Paula Louise Bush
Keyword(s):  
Physical Activity ◽  
Focus Group ◽  
South Asian ◽  
Living Environment ◽  
Barriers And Facilitators ◽  
Asian Women ◽  
South Asian Women ◽  
Family Responsibilities ◽  
Women Employees ◽  
The Individual

The aim of this study was to understand the physical activity (PA) experiences of South Asian women employees and their perceptions of new immigrant South Asian women in regards to barriers and facilitators to participation. This was examined using an interpretive description approach where similarities and differences between South Asian Women’s Centre employees and their perception of new South Asian immigrants were explored. Eight South Asian women employees (Mean age = 45.57 years) working at a South Asian Women’s Centre in Canada participated in this study. Five South Asian women employees participated in a focus group, three in an individual interview and one participant from the focus group took part in a follow-up interview to better understand their PA experiences. Barriers found included: family responsibilities, upbringing, feeling guilty, immediate living environment, clothing, cost, and location of activity. PA facilitators found included: help at home, cultural sports events, group support, female only programs, design of PA facilities, health and self-image benefits, providing PA for children at the same time as adults and collaborations. The main differences found between South Asian Women’s Centre employees and their clients concerned time, language and their partners. For this population of women, programs need to be affordable, close to home, female only and allow their own choice of clothing. The results suggest the importance for those working with South Asian women to take into consideration the many factors between the individual and the environment that may inhibit or facilitate PA behavior change in this population.

scholarly journals Association of serum 25-hydroxyvitamin D with insulin resistance and β-cell function in a healthy Chinese female population

2013 ◽  
Vol 34 (8) ◽  
pp. 1070-1074 ◽  
Author(s):  
Min-fang Tao ◽  
Zeng Zhang ◽  
Yao-hua Ke ◽  
Jin-wei He ◽  
Wen-zhen Fu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Cell Function ◽  
Β Cell ◽  
Female Population ◽  
Hydroxyvitamin D ◽  
Β Cell Function ◽  
25 Hydroxyvitamin D ◽  
Healthy Chinese

scholarly journals Maternal high-fat diet induces insulin resistance and deterioration of pancreatic β-cell function in adult offspring with sex differences in mice

2014 ◽  
Vol 306 (10) ◽  
pp. E1163-E1175 ◽  
Author(s):  
Hisashi Yokomizo ◽  
Toyoshi Inoguchi ◽  
Noriyuki Sonoda ◽  
Yuka Sakaki ◽  
Yasutaka Maeda ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Sex Differences ◽  
High Fat Diet ◽  
Cell Function ◽  
Pancreatic Β Cell ◽  
Β Cell ◽  
Plasma Estradiol ◽  
Β Cell Function ◽  
Estradiol Levels

Intrauterine environment may influence the health of postnatal offspring. There have been many studies on the effects of maternal high-fat diet (HFD) on diabetes and glucose metabolism in offspring. Here, we investigated the effects in male and female offspring. C57/BL6J mice were bred and fed either control diet (CD) or HFD from conception to weaning, and offspring were fed CD or HFD from 6 to 20 wk. At 20 wk, maternal HFD induced glucose intolerance and insulin resistance in offspring. Additionally, liver triacylglycerol content, adipose tissue mass, and inflammation increased in maternal HFD. In contrast, extending previous observations, insulin secretion at glucose tolerance test, islet area, insulin content, and PDX-1 mRNA levels in isolated islets were lower in maternal HFD in males, whereas they were higher in females. Oxidative stress in islets increased in maternal HFD in males, whereas there were no differences in females. Plasma estradiol levels were lower in males than in females and decreased in offspring fed HFD and also decreased by maternal HFD, suggesting that females may be protected from insulin deficiency by inhibiting oxidative stress. In conclusion, maternal HFD induced insulin resistance and deterioration of pancreatic β-cell function, with marked sex differences in adult offspring accompanied by adipose tissue inflammation and liver steatosis. Additionally, our results demonstrate that potential mechanisms underlying sex differences in pancreatic β-cell function may be related partially to increases in oxidative stress in male islets and decreased plasma estradiol levels in males.

scholarly journals Common Risk Factors in Relatives and Spouses of Patients with Type 2 Diabetes in Developing Prediabetes

Healthcare ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 1010
Author(s):  
Wei-Hao Hsu ◽  
Chin-Wei Tseng ◽  
Yu-Ting Huang ◽  
Ching-Chao Liang ◽  
Mei-Yueh Lee ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Insulin Sensitivity ◽  
Cell Function ◽  
Diabetic Patients ◽  
Β Cell ◽  
Tyg Index ◽  
Β Cell Function

Prediabetes should be viewed as an increased risk for diabetes and cardiovascular disease. In this study, we investigated its prevalence among the relatives and spouses of patients with type 2 diabetes or risk factors for prediabetes, insulin resistance, and β-cell function. A total of 175 individuals were included and stratified into three groups: controls, and relatives and spouses of type 2 diabetic patients. We compared clinical characteristics consisting of a homeostatic model assessment for insulin resistance (HOMA-IR) and beta cell function (HOMA-β), a quantitative insulin sensitivity check index (QUICKI), and triglyceride glucose (TyG) index. After a multivariable linear regression analysis, the relative group was independently correlated with high fasting glucose, a high TyG index, and low β-cell function; the relatives and spouses were independently associated with a low QUICKI. The relatives and spouses equally had a higher prevalence of prediabetes. These study also indicated that the relatives had multiple factors predicting the development of diabetes mellitus, and that the spouses may share a number of common environmental factors associated with low insulin sensitivity.

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