Effects of Ampicillin/Sulbactam and Enrofloxacin on the Blood Pressure of Isoflurane Anesthetized Dogs

2013 ◽  
Vol 49 (5) ◽  
pp. 293-300 ◽  
Author(s):  
Jeremiah D. Moorer ◽  
Heather A. Towle-Millard ◽  
Marjorie E. Gross ◽  
Mark E. Payton
Keyword(s):  
Blood Pressure ◽  
Control Group ◽  
Control Groups ◽  
Significant Difference ◽  
Anesthetized Dogs ◽  
Healthy Dogs ◽  
End Tidal ◽  
End Tidal Co2 ◽  
Randomized Crossover Study ◽  
Over Time

A blinded, prospective, randomized crossover study was performed to determine the effects of ampicillin Na/sulbactam Na and enrofloxacin on the blood pressure (BP) of healthy anesthetized dogs. Eight dogs were anesthetized three different times. They randomly received enrofloxacin, ampicillin Na/sulbactam Na, and saline. Systolic, diastolic, and mean arterial BPs (SAP, DAP, and MAP, respectively), heart rate (HR), O2 saturation of hemoglobin, end-tidal CO2 (ETCO2) concentration, inspired isoflurane concentration, end-tidal isoflurane (ETiso) concentration, respiratory rate, electrocardiogram, and body temperature were measured for 20 min prior to administration of treatment, during administration over 30 min, and for 30 min after administration. There was no significant difference in the SAP or ETiso. There was no significant change in the arterial pressure values over time in the enrofloxacin and ampicillin Na/sulbactam Na groups. The control group’s MAP increased over time and was increased compared with the enrofloxacin group at times 25, 35, 45, and 55. The statistical difference between the enrofloxacin and the control groups was due to an increase in the MAP in the control group, not a decrease in the enrofloxacin group’s BP. Neither enrofloxacin nor ampicillin Na/sulbactam Na caused hypotension in healthy dogs anesthetized with isoflurane and fentanyl.

scholarly journals Investigation of the effect of the virtual reality application on experimental pain severity in healthy

2019 ◽  
Vol 65 (3) ◽  
pp. 446-451
Author(s):  
Dilek Karaman ◽  
Funda Erol ◽  
Dilek Yılmaz ◽  
Yurdanur Dikmen
Keyword(s):  
Blood Pressure ◽  
Virtual Reality ◽  
Control Group ◽  
Control Groups ◽  
Adult Type ◽  
Significant Difference ◽  
The Mean ◽  
And Control ◽  
Experimental Group ◽  
Virtual Reality Application

SUMMARY OBJECTIVE: This study aimed to investigate the effect of virtual reality application on experimental ischemic pain created with a blood pressure instrument in healthy volunteers. METHODS: The research sample consisted of 172 volunteer adult students who conformed to the inclusion criteria. These individuals were assigned into an experimental (n=86) and a control group (n=86) by a simple randomization method. All individuals in the experimental and control groups wereexperimentally subjected to pain for two minutes by applying 260 mmHg of pressure 3-4 cm above the antecubital region of the left arm with an aneroid adult-type blood pressure instrument. During the procedure, the volunteers in the experimental group watched virtual reality images, while those in the control group received no intervention. Immediately after the procedure, the pain levels of the individuals in both groups were assessed with a Visual Analog Scale (VAS). RESULTS: We found that the mean pain score of the individuals in the experimental group was 2.62±1.82, and that of individuals in the control group was 5.75±1.65. Results of the statistical analysis showed a statistically significant difference between the mean pain scores of the individuals in the experimental and control groups (p<0.001). CONCLUSION: This study found that the use of virtual reality was effective in reducing the level of pain in healthy individuals. This method used a smartphone with widespread availability and ease of transportation, which can be used by health professionals as a non-pharmacological method in the management of pain.

scholarly journals Safety and Efficacy of Ginkgo-Damole and Nitroglycerin or Sodium Nitroprusside on Hypertensive Cerebropathies: A Meta-Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Li Peng ◽  
Wei-kun Zhao ◽  
Tong-tong Xu ◽  
Qi Wu ◽  
Pan Lu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Sodium Nitroprusside ◽  
Meta Analysis ◽  
Control Group ◽  
Clinical Effects ◽  
Observation Group ◽  
Control Groups ◽  
Safety And Efficacy ◽  
Significant Difference ◽  
And Control

Objective. To systematically evaluate the safety and efficacy of ginko-damole combined with nitroglycerin or unitary sodium nitroprusside on hypertensive cerebropathy. Methods. Four Chinese databases (VIP, CBM, Wanfang database, and CNKI database) and three English databases (Cochrane, PubMed, and EMBASE) were used to screen randomised controlled trials (RCTs) on treatments of hypertensive cerebropathy using both ginko-damole and nitroglycerin or unitary sodium nitroprusside. Outcomes included clinical effect, blood pressure after treatment, and adverse effects. These indicators were then analysed statistically using the RevMan 5.3 and Stata 12.0 software. Results. Altogether, 16 RCTs including 1507 patients with hypertensive cerebropathy were included in the present meta-analysis, of which, 755 patients treated with combined ginko-damole and nitroglycerin were included in the observation group and 752 patients treated with sodium nitroprusside were included in the control group. The curative effect of the observation group was significantly better than that of the control group (RR: 1.115 [1.077, 1.155], p<0.05). DBPs of the observation and control groups were both lower after treatment, and no significant difference was observed between the observation and control groups (MD: −1.072 [−2.578, 0.434], p>0.05). SBPs in the observation group were significantly lower than those in the control group (MD: −2.842 [−5.222, −0.462], p<0.05). The probability of adverse response in both groups did not differ significantly (RR: 0.752 [0.412, 1.374], p>0.05). Conclusion. Compared with sodium nitroprusside, the combined ginkgo-damole and nitroglycerin could better control blood pressure in patients with hypertensive cerebropathy and showed enhanced clinical effects and improved safety. However, due to poor quality of the included studies, results of the present meta-analysis should be confirmed by more stringent RCTs.

The Comparison on Changes of the Body Heats in Electroacupuncture Analgesia and Anesthesia by Ketamine Hydrochloride in Dogs

2006 ◽  
Vol 34 (01) ◽  
pp. 69-76 ◽  
Author(s):  
Sang-Eun Lee ◽  
Ji-Min Seo ◽  
Jianzhu Liu ◽  
Min-Sung Hong ◽  
Young-Won Lee ◽  
...  
Keyword(s):  
The Body ◽  
Control Group ◽  
Control Groups ◽  
Significant Difference ◽  
Ketamine Hydrochloride ◽  
Ketamine Anesthesia ◽  
Healthy Dogs ◽  
And Control ◽  
Experimental Group ◽  
Body Heat

This study was performed to clarify the differences of the body heats between electroacupuncture analgesia (EA) and anesthesia by ketamine hydrochloride (ketamine anesthesia) in dogs. Nine clinically healthy dogs were divided into ketamine anesthesia (control: 5 heads) and EA (experimental: 4 heads) groups, respectively. The acupoints GV-5 and Bai-Hui were used. The infrared thermographic system was used to determine the body heats. The body heats was determined at areas such as the dorsocranial (DCr), dorsocaudal (DCd), ventrocranial (VCr) and ventrocaudal (VCd) regions, on pretreatment, 10, 20, 30, 50 and 90 minutes after treatments, respectively in control and experimental groups. The body heats showed decreasing tendency until 30 minutes after ketamine injection, and then showed increasing pattern until 90 minutes after at all areas investigated in the control group. However, no significant differences of the body heats in the DCr, DCd, VCr and VCd regions were found in the control group. On the other hand, the body heats showed increasing tendency until 30 minutes, and then showed decreasing pattern until 90 minutes after EA, in the experimental group. The significant difference was observed at 30 minutes in the DCr region, and also at 10, 20 and 30 minutes in the DCd regions in the experimental group ( p < 0.05). The significant differences of the body heats were detected at 20 minutes in the DCr region, at 30 minutes in the DCd region and at 30 minutes in the VCd region between the experimental and control groups ( p < 0.05). In conclusion, EA increases of the body heat in the contrary to that of ketamine anesthesia.

Effect of a mobile-based educational app on blood pressure of patients with hypertension

2020 ◽  
pp. e001577
Author(s):  
Fereshteh Falah ◽  
S A Sajadi ◽  
A H Pishgooie
Keyword(s):  
Blood Pressure ◽  
Military Personnel ◽  
Intervention Group ◽  
Control Group ◽  
Control Groups ◽  
Chi Square ◽  
Significance Level ◽  
Significant Difference ◽  
And Control ◽  
Paired T Test

BackgroundHypertension is known as one of the most important non-communicable pervasive diseases.ObjectiveThe purpose of the present study was to determine the effect of a mobile-based educational app on the blood pressure (BP) of patients with hypertension.MethodsThis clinical trial was conducted on 66 military personnel who were definitively diagnosed with hypertension by a physician, and then assigned randomly into two groups as intervention (receiving mobile-based educational app) and control (receiving standard medical management but no app). Before the intervention, BP levels of both groups were measured with a calibrated sphygmomanometer. After 6 weeks, the BPs of both groups were remeasured using the same sphygmomanometer. Thereafter, descriptive and inferential statistics, including paired t-test, Mann-Whitney, Chi-square and Wilcoxon tests, were used. The data obtained were analysed using SPSS-21 software at a significance level of p<0.05.ResultsComparison of the intervention and control groups showed no statistically significant difference between the groups in systolic BP (p=0.479) and diastolic BP (p=0.851) in the pre-intervention phase, but after the intervention, systolic and diastolic BP levels were significantly lower in the intervention group than in the control group (p=0.0001).ConclusionThe results suggested that the mobile-based educational app had a significant effect on reducing BP in patients with hypertension. Therefore, using this app is recommended for those military personnel with hypertension.

scholarly journals Hypercapnia counteracts captopril-induced depression of gastric mucosal oxygenation

2013 ◽  
Vol 218 (3) ◽  
pp. 245-253 ◽  
Author(s):  
Christian Vollmer ◽  
Ingo Schwartges ◽  
Robert Behmke ◽  
Inge Bauer ◽  
Olaf Picker
Keyword(s):  
Blood Pressure ◽  
Ace Inhibition ◽  
Left Ventricular ◽  
Control Group ◽  
Ventricular Contractility ◽  
Hemodynamic Variables ◽  
Systemic Oxygen ◽  
Healthy Dogs ◽  
Baseline Values ◽  
End Tidal

Hypercapnia (HC) increases systemic oxygen delivery (DO2) and gastric mucosal oxygenation. However, it activates the renin–angiotensin–aldosterone system (RAAS), which conversely reduces mesenteric perfusion. The aims of this study were to evaluate the effect of RAAS inhibition during normocapnia and HC on oral and gastric mucosal oxygenation (μHbO2) and to assess the effect of blood pressure under these circumstances. Five dogs were repeatedly anesthetized to study the effects of ACE inhibition (ACE-I; 5 mg/kg captopril, followed by 0.25 mg/kg per h) on μHbO2(reflectance spectrophotometry) and hemodynamic variables during normocapnia (end-tidal CO2=35 mmHg) and HC (end-expiratory carbon dioxide (etCO2)=70 mmHg). In the control group, the dogs were subjected to HC alone. To exclude the effects of reduced blood pressure, in one group, blood pressure was maintained at baseline values via titrated phenylephrine (PHE) infusion during HC and additional captopril infusion. ACE-I strongly reduced gastric μHbO2from 72±2 to 65±2% and mean arterial pressure (MAP) from 64±2 to 48±4 mmHg, while DO2remained unchanged. This effect was counteracted in the presence of HC, which increased gastric μHbO2from 73±3 to 79±6% and DO2from 15±2 to 22±4 ml/kg per min during ACE-I without differences during HC alone. However, MAP decreased similar to that observed during ACE-I alone from 66±3 to 47±5 mmHg, while left ventricular contractility (dPmax) increased from 492±63 to 758±119 mmHg/s. Titrated infusion of PHE had no additional effects on μHbO2. In summary, our data suggest that RAAS inhibition reduces gastric mucosal oxygenation in healthy dogs. HC not only abolishes this effect, but also increases μHbO2, DO2, and dPmax. The increase in μHbO2during ACE-I under HC is in accordance with our results independent of blood pressure.

scholarly journals Relationship of Lead Exposure with Workers' Blood Pressure and Blood Components: A Case Study

2020 ◽  
Author(s):  
Salman Torabi Goodarzi ◽  
Farideh Golbabaei ◽  
Bahram Harati ◽  
Robabeh Chang ◽  
Vahid Ahmadi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Lead Exposure ◽  
The Body ◽  
Control Group ◽  
Blood Components ◽  
Control Groups ◽  
Significant Difference ◽  
Exposed Workers ◽  
And Control

Background: Lead is one of the most widely used metals in the industries and is the amplest metal element on the Earth’s crust. This metal disrupts the physiological processes of the body due to its accumulation in various tissues. The present study aimed to determining the association of lead exposure with blood pressure and blood components of the lead mine employees in Isfahan City, Iran.  Methods: In this cross-sectional study, 187 workers were investigated; they worked in the lead mines of Isfahan from January to April 2016. The staff was divided into two groups: one was exposed to lead and the other was the control group. The participants' general information was collected in worksheets, including age, work experience, work shift, body mass index, blood pressure, and smoking status. Sampling was carried out by active sampling using the NIOSH 7300 method. Blood samples were taken from all participants and their hematological parameters were evaluated, including red blood cell, platelet count, percent of lymphocytes, and volume of red blood cells. Results: The participants' age means were 34.06 (8.8) and 37.04 (11.48) years in the case and control groups, respectively. The time-weighted average concentration of lead in the breathing zone air of workers was 0.0533 mg/m3. The average systolic blood pressure was 12.01 (1.3) mmHg in exposed workers, while it was 11.78 (1.1) mmHg in the control group. The average diastolic blood pressure was 7.84 (0.71) mmHg in exposed workers and 7.73 (0.54) mmHg in control group. Statistical test results showed a significant difference between the case and control groups with regard to their systolic and diastolic blood pressure (P<0.05). Furthermore, no significant difference was observed between the lead-exposed and non-exposed groups with regard to the hematocrit and hemoglobin levels. Conclusion:  According to the results, lead exposure can cause metabolic changes in blood pressure and some of its features. Considering the importance of this issue, some preventive measures should be taken to maintain and improve the worker's health and well-being, such as increasing the workers' rest time, performing periodic examinations for them, as well as conducting safety workshops and training sessions.  

scholarly journals Yoga, Physical Education, and Self-Esteem

2007 ◽  
Vol 5 (2) ◽  
pp. 13-17 ◽  
Author(s):  
Kaci A. Bridges ◽  
Melody S. Madlem
Keyword(s):  
Physical Activity ◽  
Physical Education ◽  
Self Esteem ◽  
Control Group ◽  
Control Groups ◽  
Significant Difference ◽  
Eighth Grade Students ◽  
Post Test ◽  
And Control ◽  
Over Time

Researchers studied increases in self-esteem of eighth-grade students after participation in regular physical education and yoga-enhanced physical education classes. Self-esteem was measured by the Coopersmith Self-Esteem Inventory. The Coopersmith Self-Esteem Inventory was given pre, mid, and post test in both the experimental and control group. The results showed that over the course of the eightweek intervention, self-esteem did increase in both the experimental and control groups. There was no significant difference in self-esteem between regular physical education activities and yoga. The study revealed the importance of physical activity, including yoga, for enhancing self-esteem. Theories for why self-esteem increased over time are discussed in the study.

scholarly journals Effect of epidural administration of lidocaine, fentanyl and their combination on the minimum alveolar concentration of halothane in dogs

2012 ◽  
Vol 49 (No. 11) ◽  
pp. 421-426
Author(s):  
P. Rauser ◽  
L. Lexmaulova ◽  
M. Vlasin ◽  
T. Fichtel ◽  
J. Lorenzova
Keyword(s):  
Minimum Alveolar Concentration ◽  
Control Group ◽  
Epidural Administration ◽  
General Anesthetics ◽  
Mutual Relationship ◽  
Significant Difference ◽  
Basic Parameters ◽  
Healthy Dogs ◽  
End Tidal ◽  
Vital Parameters

The efficacy of lidocaine, fentanyl, combination of both (2 mg/kg of lidocaine, along with fentanyl in the dose of 0.005 mg/kg) and saline (as a control) administered epidurally to 40 healthy dogs was under investigation, regarding their influence on minimum alveolar concentration (MAC) of halothane. Basic vital parameters, such as heart rate, respiratory rate, saturation of hemoglobin with oxygen and end-tidal partial pressure of CO<sub>2</sub> were recorded. Minimum alveolar concentration of halothane after administration of lidocaine (0.75 ± 0.24%), or the lidocaine/fentanyl combination (0.43 ± 0.08%) was found to be significantly lower (p &lt; 0.05) compare to control group (1.15 ± 0.20%). However, we have not found significant difference in the group given fentanyl alone (0.95 ± 0.35%) compare to control group. Mutual relationship between epidurally given lidocaine and fentanyl (same route of administration) can be called as simply additive. There were no significant deviations in basic parameters within groups. We conclude that epidural administration of combination of these drugs we are able to reduce the dose of general anesthetics, which is important in management of critically ill patients.

scholarly journals Postoperative outcome and hemodynamic changes in high versus low pressure to pneumoperitoneum in patients undergoing laparoscopic cholecystectomy

2021 ◽  
Author(s):  
Valarmathi Marimuthu ◽  
Bhuvaneswari Murugan
Keyword(s):  
Carbon Dioxide ◽  
Blood Pressure ◽  
Heart Rate ◽  
Abdominal Pain ◽  
Statistical Difference ◽  
Low Pressure ◽  
Abdominal Pressure ◽  
Significant Difference ◽  
End Tidal ◽  
End Tidal Co2

Background: A pneumoperitoneum is created by insufflating a gas (usually carbon dioxide) into the peritoneal cavity during laparoscopic surgery. Intra-abdominal pressure (IAP) rises as a result of this. At a rate of 4–6 liter min-1, carbon dioxide is insufflated into the peritoneal cavity at a pressure of 10–20 mm Hg. Aim of the research was to compare the hemodynamic effects and the level of post-operative symptoms due to high pressure and low-pressure pneumoperitoneum in patients undergoing laparoscopic cholecystectomy.Methods: 60 patients fulfilling inclusion criteria who were posted for elective cholecystectomy under general anaesthesia were divided into two groups, 30 patients in each group. Group L included pneumoperitoneum created with intra-abdominal pressure of 7-10 mmHg, and group H included pneumoperitoneum created with intra-abdominal pressure of 12-14 mmHg. Variables such as the systolic blood pressure, diastolic blood pressure, heart rate, end-tidal CO2, the level of post-operative abdominal pain, shoulder-tip pain, nausea and vomiting, and the liver function test were compared between the two groups.Results: Between groups, no statistical difference has been noted in the demographic characters of the patient. There was a statistical difference of intraoperative and post-operative systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) between groups. End-tidal CO2 was compared between the two groups during the surgery and a significant difference regarding EtCO2. Liver function tests showed a significant difference in all measured factors after surgery between the two groups.Conclusions: Low-pressure pneumoperitoneum decreases hemodynamic complications. Post-operative abdominal pain, shoulder tip pain, nausea and vomiting are reduced.

Effects of Virgin Coconut Oil as Adjunct Therapy in the Treatment of Allergic Rhinitis

2016 ◽  
Vol 1 (1) ◽  
pp. 22
Author(s):  
Nazli Zainuddin ◽  
Nurul Azira Mohd Shah ◽  
Rosdan Salim
Keyword(s):  
Allergic Rhinitis ◽  
Side Effects ◽  
Coconut Oil ◽  
Test Group ◽  
Nasal Symptom ◽  
Control Group ◽  
Virgin Coconut Oil ◽  
Control Groups ◽  
Significant Difference ◽  
And Control

Introduction: The role of virgin coconut oil in the treatment of allergic rhinitis is controversial. Thus, the aim of the present study is to determine the effects of virgin coconut oil ingestion, in addition to standard medications, on allergic rhinitis. We also studied the side effects of consumption of virgin coconut oil. Methods: Fifty two subjects were equally divided into test and control groups. All subjects received a daily dose of 10mg of loratadine for 28 days. The test group was given 10ml of virgin coconut oil three times a day in addition to loratadine. The symptoms of allergic rhinitis were scored at the beginning and end of the study. Results:, the symptom score were divided into nasal and non-nasal symptom scores. Sneezing score showed a significant difference, however the score was more in control group than test group, indicating that improvement in symptom was more in control group. The rest of the nasal symptom and non-nasal symptom score showed no significant difference between test and control groups. Approximately 58% of the test subjects developed side effects from consumption of virgin coconut oil, mainly gastrointestinal side effects. Conclusion: In the present study, ingestion of virgin coconut oil does not improve the overall and individual symptoms of allergic rhinitis, furthermore it has side effects.

Sign in / Sign up

Export Citation Format

Share Document