Abstract P172: Birth Weight, Maternal Pre-pregnancy Body Mass Index and Adulthood Vitamin D Levels: The Jerusalem Perinatal Study

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Amy Moore ◽  
Hagit Hochner ◽  
Colleen Sitlani ◽  
Michelle A Williams ◽  
David S Siscovick ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Birth Weight ◽  
Chronic Diseases ◽  
Body Mass ◽  
Study Data ◽  
P Value ◽  
Total Vitamin ◽  
Maternal Characteristics ◽  
Vitamin D Levels

Background: The intrauterine experience and pre-pregnancy maternal characteristics have demonstrated importance in the development of life course risk for chronic diseases. Vitamin D has been associated with several chronic diseases including cardiometabolic diseases. Whether offspring birth weight and maternal pre-pregnancy body mass index (BMI) are associated with adulthood vitamin D levels is unknown. Further, the role of adulthood BMI in these relationships is not clear. Methods: We examined associations of offspring birth weight and maternal pre-pregnancy BMI with offspring adulthood vitamin D levels among a subset of the Jerusalem Perinatal Study (JPS) population, a birth cohort of Jerusalem residents born between 1974 and 1976. Offspring aged 30-35 years, sampled based on maternal pre-pregnancy body mass index (BMI) and offspring birth weight, and their mothers were recruited as part of the JPS-1 study. Data were collected using interviews and field physical examinations. Fasting blood specimens were obtained for vitamin D measurements. We used liquid chromatography-tandem mass spectroscopy to measure total vitamin D (25-[OH] D). Sample-weighted multiple regression models, adjusted for potential confounders, were used to examine associations, and determine coefficients and 95% confidence intervals. Results: Mean total vitamin D levels was 23.48ng/ml among study participants. Birth weight was not related to vitamin D levels in adulthood. Pre-pregnancy BMI was inversely associated with offspring adulthood vitamin D levels, both before (β=-0.24, p-value=0.005) and after adjustment for birth weight (β=-0.24, p-value=0.015). However, the association was attenuated by including current offspring BMI in the models (β=-0.17, p-value=0.061) or both current BMI and birth weight (β=-0.16, p-value=0.120). In addition, the association between maternal pre-pregnancy BMI with current offspring BMI was not altered by adulthood vitamin D level. Conclusion: Maternal pre-pregnancy is potentially associated with adulthood vitamin D levels. This association may be mediated at least in part by offspring current BMI. Future studies are warranted to investigate whether the observed associations are due to genetic factors or other characteristics of the intrauterine environment.

Role of Vitamin D in the Management of COVID-19 Patients Regarding Morbidity and Mortality

2021 ◽  
Vol 15 (6) ◽  
pp. 1231-1233
Author(s):  
A. W. Khan ◽  
H. T. Hussain ◽  
Z.U. Mustafa ◽  
M. A. Qamar ◽  
M. A. Qamar ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Body Mass ◽  
Morbidity And Mortality ◽  
P Value ◽  
Mortality And Morbidity ◽  
Severe Vitamin ◽  
Vitamin D Levels

Aim: To determine the role of vitamin D in the management of COVID-19 patients regarding morbidity and mortality. Study Design: Prospective/Observational Place and Duration: Departments of Medicine & Pulmonology, Allama Iqbal Memorial Teaching Hospital, Sialkot and Department of Medicine, Sughra Shafi Medical Complex Narowal from 1st November 2020 to 30th April 2020. Methodology: One hundred and sixty patients of both genders diagnosed to have COVID-19, were enrolled. Patient’s ages were ranging from 17 to 70 years. The detailed demographics such as age, sex, and body mass index were recorded. 5 ml blood samples were taken from all the patients to check their vitamin D levels. Severe Vitamin D deficiency was defined as 25(OH)D <25 nmol/L (10 ng/dl). Association between mortality and morbidity was examined. Results: Ninety (56.25%) were males while 70 (43.75%) were females with mean age 40.15±17.37 years. Mean body mass index of patients was 24.16±7.26 kg/m2. Severe vitamin D deficiency was observed in 80 (50%) patients. Mortality found in 30 (18.75%) patients. Frequency of morbidity was among 66 (41.25%) patients. Patients with severe vitamin D deficiency had high rate of mortality 20 (25%) and morbidity 50 (62.5%) as compared to patients with no vitamin D deficiency had 10 (8%) mortality and 16 (20%) morbidity. A significant association was observed between severe vitamin D deficiency regarding morbidity and mortality among patients with covid-19 disease with p-value <0.05. Conclusion: The vitamin-D has strongest relationship among patients with covid-19 disease to reduce mortality and morbidity. Keywords: Morbidity, COVID-19, Vitamin D, Mortality

scholarly journals FREQUENCY OF VITAMIN D DEFICIENCY IN PATIENTS PRESENTING WITH FIBROMYALGIA

2021 ◽  
Vol 71 (5) ◽  
pp. 1544-47
Author(s):  
Samina Rashid ◽  
Khuram Haq Nawaz ◽  
Amer Fakhr ◽  
Hammad Ather ◽  
Farzana Hakeem ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Body Mass ◽  
High Body Mass Index ◽  
Common Finding ◽  
Military Hospital ◽  
P Value ◽  
Cross Sectional ◽  
Vitamin D Levels

Objective: To determine frequency of vitamin D deficiency in patients presenting with fibromyalgia and its association with various factors. Study Design: Cross sectional study. Place and Duration of Study: Medicine department, Pak Emirates Military Hospital Rawalpindi, from Sep 2018 to Feb 2019. Methodology: Ninety patients of fibromyalgia were included in the study. Diagnosis of fibromyalgia was made by the consultant rheumatologist on the basis of American College of Rheumatology Criteria needed for fibromyalgia diagnosis and classification. Vitamin D levels <20ng/ml were considered as deficient. Age, education, marital status, menstrual abnormallities and body mass index were correlated with the presence of vitamin D deficiency among the patients suffering from fibromyalgia. Results: Out of 90 patients of fibromyalgia, 57 (63.3%) showed the presence of vitamin D deficiency while 33 (36.7%) had no deficiency of vitamin D. Among the study participants 88 (97.8%) patients were females and only 2 (2.2%) patients were males. Mean age of the patients was 39.4 ± 3.365 years. After applying the binary logistic regression, we found that presence of menstrual abnormalities and high body mass index had significant association with the presence of vitamin D deficiency among the patients of fibromyalgia (p-value<0.05). Conclusion: Vitamin D deficiency emerged as a common finding among the patients of fibromyalgia in a teaching hospital of Pakistan. Vitamin D deficiency should be screened at the rheumatology clinics and special attention should be paid to the patients who are overweight or obese and female patients with the menstrual abnormalities.

scholarly journals Asthma control status in pregnancy, body mass index, and maternal vitamin D levels

2017 ◽  
Vol 140 (5) ◽  
pp. 1453-1456.e7 ◽  
Author(s):  
Hooman Mirzakhani ◽  
George O'Connor ◽  
Leonard B. Bacharier ◽  
Robert S. Zeiger ◽  
Michael X. Schatz ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Asthma Control ◽  
Body Mass ◽  
Maternal Vitamin ◽  
Vitamin D Levels ◽  
In Pregnancy

Body mass index determines sunbathing habits: implications on vitamin D levels

2009 ◽  
Vol 39 (4) ◽  
pp. 256-258 ◽  
Author(s):  
M. Kull ◽  
R. Kallikorm ◽  
M. Lember
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Body Mass ◽  
Vitamin D Levels

Bone mineral density, vitamin D levels, body mass index and exocrine pancreatic function in patients with chronic pancreatitis

Pancreatology ◽  
2017 ◽  
Vol 17 (5) ◽  
pp. S2
Author(s):  
A.D. Polanco Jiménez ◽  
A. López Serrano ◽  
P. Latorre Año ◽  
A. Pascual Romero ◽  
M.J. Suárez Dávalos ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Body Mass Index ◽  
Vitamin D ◽  
Chronic Pancreatitis ◽  
Body Mass ◽  
Bone Mineral ◽  
Exocrine Pancreatic Function ◽  
Pancreatic Function ◽  
Mineral Density ◽  
Vitamin D Levels

scholarly journals Serum Osteocalcin, P1NP, Alkaline Phosphase, and CrossLaps in Humans.The relationship with body mass index

2019 ◽  
Vol 70 (5) ◽  
pp. 1615-1618
Author(s):  
Mara Carsote ◽  
Smaranda Adelina Preda ◽  
Mihaela Mitroi ◽  
Adrian Camen ◽  
Lucretiu Radu
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Biochemical Markers ◽  
Mean Value ◽  
Normal Weight ◽  
P Value ◽  
Biochemical Bone Marker ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Coefficient Of Regression

This is a clinical study on 56 subjects included in normal weight (NW) group (N=17), overweight (OW) group (N=19) and grade I obese (O) group (N=20), based on BMI (Body Mass Index) values: NW group had a mean BMI of 22.2 � 2.14 kg/sqm, OW group had a BMI of 25.89 � 1.04 kg/sqm, and O group had an average BMI of 32.2 � 2.09 kg/sqm (p-value NW-OW, NW-O, respective OW-O groups was p[0.0005). The 3 groups were similar as age (p-value NW-OW groups = 0.7, between NW- O groups = 0.8, respective between OW - O group = 0.7). The circulating bone formation (osteocalcin, P1NP alkaline phosphatase) and resorption profile (CrossLaps) indicated no statistical significant difference between groups while the coefficient of regression r between each biochemical bone marker and BMI in every BMI group exceeded the value of p]0.05. All the 3 groups had a mean value of 25-hydroxycholecalciferol in deficiency ranges ([ 30 ng/mL, normal recommended values are above 30 ng/mL) without significant differences regarding BMI groups, except for obese group when compare to the other two groups. No secondary hyperparathyroidism was associated in any group despite low vitamin D levels. Based on our observation, bone turnover biochemical markers are not influenced by BMI.

scholarly journals Correlation of Vitamin D and Body Mass Index in Term Normotensive and Pre -Eclamptic Women

2015 ◽  
Vol 3 (4) ◽  
pp. 21-25
Author(s):  
Taru Gupta ◽  
Nupur Gupta ◽  
Leena Wadhwa ◽  
Sarika Arora ◽  
Jyoti Bagla ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Body Mass ◽  
Serum Alkaline Phosphatase ◽  
Vitamin D Supplementation ◽  
Control Group ◽  
Maternal Body Mass Index ◽  
Study Group ◽  
Percentage Body Fat ◽  
Vitamin D Levels

INTRODUCTION: Obesity is associated with alteration in the vitamin D levels and has been related to vitamin D status. Lower vitamin D levels in higher BMI individuals may be secondary to an alteration in tissue distribution resulting from an increase in adipose mass. Therefore women with higher BMI need higher vitamin D supplementation as compared to women with BMI within normal range.  MATERIAL AND METHOD: This was a case control study carried out in Department of Obstetrics and Gynaecology, ESIC-PGIMSR, New Delhi from August 2012-April 2014. A total of 100 patients were divided into two equal groups (control and study groups of 50 each). Control group had women with singleton uncomplicated term normotensive pregnant women in labour while the study group comprised of term preeclamptic women in labour.In all the patients their BMI was analysed .Blood samples for vitamin D, serum calcium, serum phosphorus, serum parathormone, serum alkaline phosphatase levels were drawn and subsequently their levels were evaluated in cord blood; correlation studied between vitamin D & BMI. RESULTS: The mean BMI was relatively higher in the study group (26.34 ± 4.12)kg/m2 than in the control group ( 24.24 ± 3.13)kg/m2. Thus in our study a prevalence of higher BMI was seen in patients of preeclampsia. When all the 100 women are being considered, median vitamin D levels were found to be higher (6.6ng/ml) in normal BMI patients (n=55) as compared to levels (5.6ng/ml) in patients with higher BMI(n=45).  CONCLUSION: Vitamin D levels are related to maternal body mass index. Individuals with higher percentage body fat may require higher vitamin D intake to attain optimal 25(OH) D levels, compared with lean individuals and thereby may prevent pregnancy complications like Pre eclampsia.

scholarly journals Assessment of serum vitamin D levels in Egyptian children with beta-thalassemia major

2021 ◽  
Vol 69 (1) ◽  
Author(s):  
Ghada Saad Abdelmotaleb ◽  
Ola Galal Behairy ◽  
Khalid Eid Abd El Azim ◽  
Dalia Mohamed Abd El-Hassib ◽  
Tasbeh Mohamed Hemeda
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Body Mass ◽  
Serum Calcium ◽  
Serum Levels ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Beta Thalassemia Major ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D

Abstract Background Beta-thalassemia major patients are at increased risk of complications including endocrinopathies and bone disease due to iron overload. So, this study aimed to assess the growth parameters, serum levels of 25-OH-vitamin D, calcium, and phosphorous in children with beta-thalassemia major. This was a case-control study that included 55 children with beta-thalassemia major compared with 30 sex- and age-matched healthy children that served as a control group. All enrolled children were subjected to full history taking, clinical examination including anthropometric measurements, and laboratory investigations including complete blood count, serum ferritin, levels of serum calcium, phosphorus, and 25-OH-vitamin D. Results Body mass index was statistically significantly lower in the thalassemic group (P < 0.001). It was observed that vitamin D levels were significantly lower in thalassemic patients than in controls (P value < .0001). The mean serum 25-OH-vitamin D levels were 19.84 ± 5.79 ng/ml and 44.98 ± 5.77 ng/ml, respectively; 22 cases (40%) had insufficient vitamin D, and 5 cases (9%) had deficient vitamin D. Regarding serum calcium and phosphorous, there was no significant difference between the thalassemic and control groups. Conclusion Children with beta-thalassemia major had low body mass index and metabolic abnormality in the form of lower serum levels of vitamin D that signify the importance of therapeutic interventions.

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