scholarly journals FORMULASI TABLET HISAP EKSTRAK RIMPANG TEMULAWAK (Curcuma xanthorrhiza Roxb) DENGAN BAHAN PENGISI SORBITOL DAN LAKTOSA

2021 ◽  
Vol 3 (2) ◽  
pp. 9-14
Author(s):  
Nafisah isnawati ◽  
Mega Fitriya Purnama Dewi
Keyword(s):  
Moisture Content ◽  
Angle Of Repose ◽  
Wet Granulation ◽  
Food Ingredient ◽  
Disintegration Time ◽  
Flow Angle ◽  
Curcuma Xanthorrhiza ◽  
The One ◽  
Tablet Hardness

Abstrak Temulawak adalah tanaman yang tumbuh berumpun, yang telah dimanfaatkan oleh sebagian masyarakat Indonesia, baik sebagai obat tradisional, sebagai pewarna maupun sebagai bahan pangan. Perlu dibuat sediaan tablet hisap agar dapat digunakan dengan nyaman dan praktis. Tujuan penelitian ini adalah untuk menguji pengaruh kombinasi bahan pengisi sorbitol dan laktosa terhadap karakteristik granul ekstrak rimpang temulawak dan terhadap mutu fifik tablet hisap ekstrak temulawak. Tablet hisap esktrak rimpang temulawak dibuat dengan campuran bahan pengisi sorbitol dan laktosa dengan konsentrasi berbeda yaitu F1 (sorbitol 5%: laktosa 95%), F2 (Sorbitol 10% dan laktosa 90%), F3 (Sorbitol 15%: Laktosa 85%), F4 (Sorbitol 20% : laktosa 80%), F5 (Sorbitol 25%: laktosa 75%). Tablet dibuat dengan granulasi basah. Penelitian ini menggunakan desain eksperimental laboratorium dengan melakukan pengamatan dan pencatatan hasil dari formulasi tablet hisap ekstrak rimpang temulawak (Curcuma xanthorrhiza Roxb) dengan bahan pengisi sorbitol dan laktosa. Data yang diperoleh dianalisis menggunakan SPSS versi 21 dengan metode ANOVA oneway dengan tingkat kepercayaan 95%. Hasil dari penelitian ini yaitu konsentrasi sorbitol dan laktosa terbaik untuk menghasilkan tablet hisap ekstrak temulawak adalah konsentrasi sorbitol (5%) dan laktosa (95%) dengan kecepatan alir 16,5±0,304 g/detik, persen kompresibilitas 6,57±0,069%, kadar lembab 1,47±0,06%, kekerasan 10,25±0,79 kP. Dari penelitian ini dapat disimpulkan bahwa penambahan konsentrasi sorbitol dapat menurunkan sifat tabletasi dan memperbaiki sifat fisik dari granul, makin tinggi konsentrasi sorbitol kekerasan tablet semakin menurun, dan meningkatkan kerapuhan dan waktu hancur tablet. Sedangkan semakin banyak konsentrasi laktosa meningkatkan sifat alir sudut diam, persen kompresibilitas dan menurunkan kadar lembab. Kata kunci : Temulawak, Tablet hisap, Sorbitol, Laktosa   Abstrak Temulawak is a plant that grows in clumps, which has been used by some Indonesian people, both as traditional medicine, as a dye and as a food ingredient. It is necessary to make lozenges so that they can be used comfortably and practically. The purpose of this study was to examine the effect of the combination of sorbitol and lactose as fillers on the granule characteristics of the temulawak rhizome extract and on the physical quality of the lozenges of the temulawak extract. Temulawak rhizome extract lozenges were made with a mixture of sorbitol and lactose as fillers with different concentrations, namely F1 (sorbitol 5%: lactose 95%), F2 (Sorbitol 10% and lactose 90%), F3 (Sorbitol 15%: Lactose 85%), F4 (Sorbitol 20%: lactose 80%), F5 (Sorbitol 25%: lactose 75%). Tablets are prepared by wet granulation. This study used a laboratory experimental design by observing and recording the results of the formulation of lozenges of temulawak rhizome extract (Curcuma xanthorrhiza Roxb) with sorbitol and lactose as fillers. The data obtained were analyzed using SPSS version 21 with the one-way ANOVA method with a 95% confidence level. The results of this study are the best concentrations of sorbitol and lactose to produce lozenges of temulawak extract are concentrations of sorbitol (5%) and lactose (95%) with a flow rate of 16.5±0.304 g/second, percent compressibility 6.57±0.069%, moisture content 1.47±0.06%, hardness 10.25±0.79 kP. From this research, it can be concluded that the addition of sorbitol concentration can decrease the tableting properties and improve the physical properties of the granules, the higher the sorbitol concentration, the lower the tablet hardness, and increase the friability and disintegration time of the tablets. Meanwhile, the more lactose concentration increases the flow angle of repose, the percent compressibility and reduces the moisture content   Keywords : Temulawak, Lozenges, Sorbitol, Lactose   Keywords : Temulawak, Lozenges, Sorbitol, Lactose

scholarly journals Uji Mutu Fisik Metoklopramid HCl Tablet Chewable dengan Variasi Jenis Pengisi sebagai Diluent menggunakan Metode Granulasi Basah

2021 ◽  
Vol 1 (2) ◽  
pp. 76-85
Author(s):  
Umi Latifiana ◽  
Deny Budi Legowo ◽  
Erna Fitriany ◽  
Andri Priyoherianto ◽  
Muhammad Novianto Ainul Huri
Keyword(s):  
New Product ◽  
Wet Granulation ◽  
Test Results ◽  
Quality Test ◽  
Disintegration Time ◽  
Chewable Tablet ◽  
Physical Quality ◽  
Chewable Tablets ◽  
Tablet Hardness

Metoclopramide HCl are used to reduce vomiting and nausea. The availability on the market in the form of tablet, syrup and injection. Patient tend to prefer take drugs by oral use because it was easier. Chewable tablet is the new product as the alternative ways to treatment children and adult patient who had difficulity problem of swallowing drugs. Objectives: This research aims to formulate the chewable metoclopramide HCl tablets using diluent variations to get a better physical quality test. Chewable tablets of metoclopramide HCl are made using diluent variations, they are mannitol, sucrose, lactose. Formula I mannitol, formula II sucrose, and formula III lactose. Chewable tablet preparations are made by the wet granulation method. Data collection was performed on physical characteristics including organoleptic, weight uniformity, uniformity of size, tablet hardness, tablet fragility, disintegration time, metoclopramide HCl levels. Physical quality test results were statistically analyzed to determine the effect of variations in the diluent on the characteristics of chewable tablets. The results of this research have an influence on the physical quality and uniformity of contents of various types of diluent variations between each formulation. In this research, fillers have an important role in the preparation of chewable metoclopramide tablets to determine the physical quality of the tablets and the uniformity of their contents. The variation of diluent that gives better results is mannitol. This is because formulas that use mannitol have uniformity in content that meets the requirements, faster disintegration time, and physical quality of tablets that still meet the requirements, when compared to the first and second formulations. The variation of diluent that gives better results is mannitol.

Formulation and Evaluation of Immediate Release Tablets of Etizolam

2021 ◽  
pp. 281-284
Author(s):  
Abhishek Kumar Singh ◽  
Kasif Shakeel
Keyword(s):  
Immediate Release ◽  
Magnesium Stearate ◽  
Angle Of Repose ◽  
In Vitro Dissolution ◽  
Wet Granulation ◽  
Dissolution Profile ◽  
Compressibility Index ◽  
Tablet Hardness ◽  
In Vitro Disintegration

In the present investigation, immediate release tablet formulation of etizolam was developed for management of insomnia and anxiety using different Superdisintegrants (Sodium Starch Glycolate, Croscarmellose, Crospovidone), Povidone K-30 and Magnesium stearate by wet granulation method. The drug-excipients interaction was investigated by UV spectrophotometer. The granules and tablets of Etizolam were evaluated for various pre and post compression parameters like angle of repose, compressibility index, hausners ratio, tablet hardness, friability and in vitro disintegration and dissolution studies and their results were found to be satisfactory. These results suggest that maximum in vitro dissolution profile of formulation F6 were found to have equivalent percentage of drug release and concluded that F6 is better and similar to innovator product.

scholarly journals Isolation and preliminary evaluation of Mulva Neglecta mucilage: a novel tablet binder

2016 ◽  
Vol 52 (1) ◽  
pp. 201-210 ◽  
Author(s):  
Haroon Rahim ◽  
Abdul Sadiq ◽  
Shahzeb Khan ◽  
Kamran Ahmad Chishti ◽  
Fazli Amin ◽  
...  
Keyword(s):  
Binding Capacity ◽  
Diclofenac Sodium ◽  
Angle Of Repose ◽  
Binding Potential ◽  
Wet Granulation ◽  
Preliminary Evaluation ◽  
Disintegration Time ◽  
Tablet Dosage ◽  
Tapped Density ◽  
Pvp K30

ABSTRACT The aim of this study was to evaluate binding potential of Mulva neglecta mucilage (MNM) with subsequent comparison to PVP K30. Eight batches of Diclofenac sodium tablets were prepared by wet granulation technique keeping different concentrations (4, 6, 8 & 10% w/w) of Mulva neglecta mucilage (extracted from leaves of Mulva neglecta) and PVP K30 as standard binder. The granules of formulated batches showed bulk density (g/mL) 0.49 ± 0.00 to 0.57 ± 0.00, tapped density (g/mL) 0.59 ± 0.01 to 0.70 ± 0.01, Carr's index 09.27 ± 0.95 to 19.65 ± 0.59, Hausner's ratio 1.12 ± 0.00 to 1.24 ± 0.01 and angle of repose 30.37 ± 2.90 °C to 36.86 ± 0.94 °C. Tablets were compressed to hardness 7.50 to 7.95 kg/cm2. The tablets showed 0.39 ± 0.02 to 0.39 ± 0.01% friability and 7:20 to 14:00 min disintegration time. Granules and post-compression evaluation revealed that parameters assessed were all found to be within the pharmacopoeial limits. The results (hardness, disintegration and dissolution) proved that Mulva neglecta mucilage has better binding capacity for preparation of uncoated tablet dosage form as compared to PVP K30. Among all the formulations, MN-1 to MN-4 showed slow release as compared to PV-1 to PV-4 and thereby Mulva neglecta mucilage exhibited satisfactory drug release phenomenon tablets of diclofenac sodium.

scholarly journals FORMULATION AND CHARACTERIZATION OF HERBAL TABLETS FOR THE MANAGEMENT OF DENGUE

2021 ◽  
pp. 104-113
Author(s):  
Shikha Thakur ◽  
Brisha Bhardwaj ◽  
Shouvik Kumar Nandy
Keyword(s):  
Carica Papaya ◽  
Hardness Test ◽  
Herbal Extract ◽  
Angle Of Repose ◽  
Wet Granulation ◽  
Disintegration Time ◽  
Weight Variation ◽  
Phosphorus Iron ◽  
Fresh Pulp ◽  
Tapped Density

Tablets are used as formulation and are prepared by using plant extracts i.e., Carica papaya and Embelica officinalis. These tablets were prepared by using wet granulation method. In this article the extract of leaves of Carica papaya and fruits of Embelica officinalis were used for making herbal tablets. Extracts of leaves of Carica papaya was obtained by cold extraction and through maceration method and the extract of fruits of Embelica officinalis was obtained by maceration process. Both extracts were dried and mixed. These extracts were then impregnated with the excipients like diluents, binding agents, super disintegrating agent, lubricants, etc. to make granules. These granules were then evaluated by using various parameters like Angle of repose, tapped density, bulk density, Carr’s Index, Hausner’s Ratio and void volume. These granules were then used for the making of tablets of desired size and shape by punching in the machine. After preparation of the tablets their evaluation parameters were studied like physical appearance, weight variation, friability, disintegration time, hardness test and thickness. Also the parameters for the acceptance of the tablets is also done like flavor and sweetness. Recent studies have shown that herbal extract of leaves of papaya has beneficial effect as an anti-inflammatory agent, for its wound healing properties, anti-tumor as well as Immunomodulatory effects and as an antioxidant. Amla fruit is a rich natural source of vitamin C (Ascorbic acid) and contains 600-750 mg/100 g of the fresh pulp. Also it is rich in minerals matters like phosphorus, iron and calcium. Amla is used as an Immunomodulatory agent and hence enhance the immunity of the patient. Aim of the study is to design develop and optimize the dosage form to cure dengue and is based on the use of natural plant ingredients to intermingle with chemical as well as synthetic ingredients to develop an effective unit dosage forms for better patient compliance. KEYWORDS: Papaya, Amla, Extracts, Herbal tablet, Dengue, Immunomodulatory, Platelets.

scholarly journals Design, development and in vivo pharmacokinetic of telmisartan loaded oral disintegration tablets

2020 ◽  
Vol 11 (4) ◽  
pp. 8108-8118
Author(s):  
Arindam Chatterjee ◽  
Shaik Mohammad Abdulla ◽  
Nagarajan G ◽  
Birendra Shrivastava
Keyword(s):  
Angle Of Repose ◽  
Wet Granulation ◽  
Average Weight ◽  
Content Uniformity ◽  
Design Development ◽  
Disintegration Time ◽  
Dsc Studies ◽  
Elimination Half ◽  
Powder Characteristics

Orodispersible Tablets (ODT) is a novel tableting technology which is formulated, and it overcomes the difficulties of other multi compressed tablets. Telmisartan has a bioavailability of 42-100 percent and a 24-hour elimination half-life. It excretes the majority of drugs through the faeces, which accounts for 97 percent of total drug excretion. The objective of this research is to formulate and evaluate Telmisartan loaded ODT and to prove the enhancement of dissolution and bioavailability of Telmisartan. From the DSC studies, it was confirmed that Telmisartan and excipients used in the formulation are compatible to each other and suitable for the manufacturing process. Telmisartan loaded ODT was formulated by wet granulation technique and evaluated for powder characteristics and release characteristics. About 9 formulations were formulated in each ODT, and all the formulation obeys a good powder flow characteristic from the angle of repose, Carr’s index and Hausner’s ratio. All the experimental formulation batches have been subjected to various evaluations viz, average weight, friability, disintegration, thickness, hardness, dissolution, content uniformity. Among this nine Telmisartan ODT formulations (F1-F9), F7 possess an expected release pattern and disintegration time in a short time period (i.e., 101.8 ± 2.72 in 5th min and disintegration time at 5 seconds), which may fastens the absorption and bioavailability of Telmisartan. It was concluded that ODT was a suitable dosage form to enhance the solubility at the same time the bioavailability of BCS class II drugs like Telmisartan.

scholarly journals PENGARUH PENGGUNAAN PATI KULIT NANAS (Ananas comosus (L.) Merr.) SEBAGAI BAHAN PENGIKAT PADA GRANUL CTM

PHARMACON ◽  
2019 ◽  
Vol 8 (1) ◽  
pp. 203
Author(s):  
Tekla Kalalo ◽  
Paulina V. Y. Yamlean ◽  
Gayatri Citraningtyas
Keyword(s):  
Moisture Content ◽  
High Water ◽  
Flow Time ◽  
Angle Of Repose ◽  
Ananas Comosus ◽  
High Water Content ◽  
Wet Granulation ◽  
Water Density ◽  
Pineapple Peel ◽  
Binder Solution

ABSTRACTThe biggest component found in pineapple peel are water and starch. One of the excipient that usually used in granule is starch that can used as disintegrant, filler and binder. This study aims to formulate and evaluate granule preparations with Pineapple peel starch binder at concentration of 4%, 6%, 8% and 10%. The Pineapple peel dried with oven and then mashed up with blender and precipitated in water until obtained starch. The Pineapple peel starch made as a binder in four formulations of granule based on different concentrate of Pineapple peel starch, they are F I 4%, F II 6%, F III 8% and F IV 10%. The Granules made by method of wet granulation by adding binder solution of pineapple peel starch to four formulations, and then dried and evaluated. The result evaluation of organoleptic gave the best result in formula III and IV, flow time of each formula has time a flow time that not too far different, 5.04-5.57 seconds, angle of repose in formula I-IV meet the requirements and formed the smallest angle in formula I 28°, real density of each formula about 1.09-1.82 g/ml and meet the requirements because they are bigger than water density, while the moisture content and loss on drying doesn’t meet the requirements because has high water content. The conclusion is Pineapple peel starch can’t be used as a binder in CTM granule. Keywords : Pineapple, Starch, Binder, Granules, Wet Granulation ABSTRAKKomponen terbesar yang terdapat dalam kulit Nanas ialah air dan pati. Salah satu bahan tambahan yang sering digunakan dalam pembuatan granul ialah pati yang dapat berfungsi sebagai bahan penghancur, bahan pengisi dan bahan pengikat. Penelitian ini bertujuan untuk memformulasikan dan mengevaluasi sediaan granul CTM dengan bahan pengikat pati kulit Nanas pada konsentrasi 4%, 6%, 8% dan 10%. Kulit nanas dikeringkan dengan oven kemudian dihaluskan dengan blender dan diendapkan dalam air sampai diperoleh butiran pati. Pati kulit Nanas dibuat sebagai bahan pengikat pada empat formulasi granul berdasarkan konsentrasi pati kulit Nanas yang berbeda yaitu F I 4%, F II 6%, F III 8% dan F IV 10%. Granul dibuat dengan metode granulasi basah yaitu dengan menambahkan larutan pengikat pati kulit Nanas pada empat formulasi, kemudian dikeringkan dan dievaluasi. Hasil evaluasi organoleptis memberikan hasil terbaik pada formula III dan IV, waktu alir dari tiap formula memiliki waktu yang tidak jauh berbeda yaitu 5,04-5,57 detik, sudut diam pada formula I-IV memenuhi persyaratan dan membentuk sudut terkecil pada formula I yaitu 28°, BJ sejati dari tiap formula berkisar dari 1,09-1,82 g/ml sehingga memenuhi persyaratan karena lebih besar dari BJ air, porositas dari formulasi I-IV memenuhi persyaratan yang memiliki range 46%-67,4%, sedangkan pada kandungan lembab dan kadar air tidak memenuhi persyaratan karena memiliki kandungan air yang terlalu tinggi. Kesimpulannya pati kulit Nanas tidak dapat digunakan sebagai bahan pengikat pada granul CTM.Kata Kunci : Nanas, Pati, Bahan Pengikat, Granul, Granulasi Basah

scholarly journals Evaluasi Pengaruh Konsentrasi Pati Biji Cempedak (Artocarpus champeden) sebagai Bahan Pengisi pada Formulasi Tablet Paracetamol

2021 ◽  
Vol 6 (2) ◽  
pp. 111-118
Author(s):  
Noval Noval ◽  
Rizka Appriliani ◽  
Husda Oktaviannoor
Keyword(s):  
Control Group ◽  
P Value ◽  
Wet Granulation ◽  
Disintegration Time ◽  
Anova Test ◽  
Whitney Test ◽  
Mann Whitney Test ◽  
The One ◽  
Artocarpus Champeden ◽  
One Way Anova

Cempedak plants are widely distributed in Indonesia, one of which is Kalimantan. Cempedak is a tropical plant, so its potential can be used as an additive in the manufacture of pharmaceutical preparations. Previous studies used cempedak seed starch as a binding agent in tablet formulations. This study aims to determine the effect of variations in concentration and optimum concentration of Cempedak seed starch (Artocarpus champeden) as a filler for Paracetamol tablets. The study used a True Experimental Design design with a posttest-only control group design. Making tablets using the wet granulation method. Data analysis used the one-way ANOVA test followed by the LSD test and the Kruskal-Wallis H test which continued with the Mann Whitney Test as a derivative test of the one-way ANOVA. Granule evaluation includes organoleptic, flow properties, tapping test, and stationary angle test. The results of the evaluation of the granules produced granules produced from each formulation are in accordance with the requirements. Tablet evaluation included organoleptic, uniformity in weight, the hardness of tablet, friability, and disintegration time. The results of the tablet evaluation showed that the maximum concentration of cempedak seeds was found in F1 because it showed the evaluation results that were in accordance with the requirements. In evaluating the uniformity of weight and hardness of tablets with the Kruskal Wallis H test and the Mann Whitney test, the results show that there are differences in each formula with a P-value <0.05. The results of the evaluation of tablet friability and disintegration time with one-way ANOVA test and LSD test showed differences in each formula with a P-value <0.05. Cempedak seed starch (Artocarpus champeden) can be used as a filler in the loading of Paracetamol tablets by the wet granulation method.

scholarly journals Specifics of soybean seed production and processing in 2019

2020 ◽  
Vol 24 (2) ◽  
pp. 85-88
Author(s):  
Miladin Kostić ◽  
Vojin Đukić ◽  
Aleksandar Ilić ◽  
Danka Dujović ◽  
Velimir Lončarević ◽  
...  
Keyword(s):  
Seed Germination ◽  
Moisture Content ◽  
Seed Production ◽  
Seed Quality ◽  
Soybean Seed ◽  
Seed Processing ◽  
The One ◽  
Very High

The soybean harvest in 2019 began at the end of August. The quality of the natural seed was very high. The moisture content of the harvested seeds ranged from 7.1 % to 14.1 %. Thanks to this humidity, there was no need to dry the seeds, which is very important given the fact that drying soybeans can reduce the quality. Seed germination ranged between 82 % and 96 %. It should be noted that 97 % of seeds were harvested with germination greater than 85 % while about 65 % of seeds had germination above 90 %. The weight of 1000 grains averaged about 160 g. Soybean seed processing started on time and without major problems. The purity of the processed seed was on average 99.4 %. Of the total amount of processed seeds, about 72 % of seeds had germination greater than 85 %. The achieved seed quality was better compared to the one in 2018.

scholarly journals Physicochemical Characterization and Evaluation of the Binding Effect of Acacia etbaica Schweinf Gum in Granule and Tablet Formulations

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Kidan Haily Desta ◽  
Ebisa Tadese ◽  
Fantahun Molla
Keyword(s):  
Water Solubility ◽  
In Vitro Release ◽  
Physicochemical Characterization ◽  
Hot Water ◽  
Angle Of Repose ◽  
Wet Granulation ◽  
Flow Properties ◽  
Disintegration Time ◽  
Binding Effect ◽  
Tablet Formulations

This study is aimed at evaluating the binding effect of Acacia etbaica gum in granule and tablet formulations using paracetamol as a model drug. Some physicochemical properties of the purified gum such as pH, the presence of tannin and dextrin, solubility, viscosity, loss on drying, total ash value, water solubility index, swelling power, moisture sorption, and powder flow properties were investigated. Paracetamol granules were prepared using wet granulation method at 2%, 4%, 6%, and 8% w / w of the Acacia etbaica gum and compared with granules prepared with reference binders (PVP K-30 and Acacia BP) in similar concentrations. The granules were characterized for bulk and tapped densities, compressibility index and Hausner ratio, angle of repose, flow rate, and friability. Finally, the prepared granules were compressed into tablets and evaluated for different tablet characteristics: weight uniformity, thickness, diameter, crushing strength, tensile strength, friability, disintegration time, and in vitro release profile. The physicochemical characterization revealed that tannins and dextrin are absent in the gum, and the gum has acidic pH. Both the moisture content and total ash values were within the official limits. Furthermore, the gum was found to be soluble in cold and hot water but insoluble in organic solvent and exhibited a shear thickening viscosity profile and excellent flow properties with excellent compressibility. The granules prepared with the gum of Acacia etbaica and reference binders showed good particle size distribution and excellent flow and compressibility properties. All the prepared tablets passed pharmacopeial specifications with respect to their uniformity of weight, thickness, and disintegration time. Tablets formulated with Acacia etbaica gum and acacia BP meet the compendial specification for friability at binder concentrations more than 2%. Drug release properties of all the batches formulated with Acacia etbaica, PVP, and acacia BP complied with the pharmacopeial specification. It can be concluded that the gum of Acacia etbaica could be explored as an alternative excipient for its binder effect in granule and tablet formulations.

scholarly journals Physical Properties of the Probiotic Effervescent Tablet from Tapioca and Maltodextrin Coatings

2020 ◽  
Vol 147 ◽  
pp. 03024
Author(s):  
Devi Ambarwaty Oktavia ◽  
Diah Lestari Ayudiarti ◽  
Dita Febrianti
Keyword(s):  
Physical Properties ◽  
Shrimp Farming ◽  
Wet Granulation ◽  
Drying Process ◽  
Disintegration Time ◽  
Brevibacillus Laterosporus ◽  
South Sulawesi ◽  
Coastal Aquaculture ◽  
Effervescent Tablet

The purpose of this study was to determine the physical properties of probiotic effervescent tablets with two different coatings that are tapioca and maltodextrin to improve water quality in shrimp farming ponds. This study used probiotics to improve the environmental quality of shrimp pond waters. Liquid probiotics from Research Institute for Coastal Aquaculture in Maros, South Sulawesi that contain Brevibacillus laterosporus. Probiotics that have been used are liquid and difficult to transport, therefore microencapsulation is carried out on liquid probiotics aimed at facilitating their distribution. The use of microencapsulating materials is to entrap or immobilize probiotic bacteria within microcapsule and to protect the bacteria during the drying process. Effervescent tablets were prepared in a dosage of 800 mg by wet granulation methods. This experiment was replicated 3 times. Tablets were evaluated for their physical properties there are mean weight, friability, hardness, disintegration time and pH. The results showed that mean weight for effervescent tablets with maltodextrin coatings was 796 mg, had a friability value 0.09%, a hardness value of 13.7 N and disintegration time of 10.68 minutes. Both probiotic effervescent tablets meet the standards pH of 7.07 and 6.67. The maltodextrin coatings was the best treatment of this study.

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