scholarly journals Evaluasi Pengaruh Konsentrasi Pati Biji Cempedak (Artocarpus champeden) sebagai Bahan Pengisi pada Formulasi Tablet Paracetamol

2021 ◽  
Vol 6 (2) ◽  
pp. 111-118
Author(s):  
Noval Noval ◽  
Rizka Appriliani ◽  
Husda Oktaviannoor

Cempedak plants are widely distributed in Indonesia, one of which is Kalimantan. Cempedak is a tropical plant, so its potential can be used as an additive in the manufacture of pharmaceutical preparations. Previous studies used cempedak seed starch as a binding agent in tablet formulations. This study aims to determine the effect of variations in concentration and optimum concentration of Cempedak seed starch (Artocarpus champeden) as a filler for Paracetamol tablets. The study used a True Experimental Design design with a posttest-only control group design. Making tablets using the wet granulation method. Data analysis used the one-way ANOVA test followed by the LSD test and the Kruskal-Wallis H test which continued with the Mann Whitney Test as a derivative test of the one-way ANOVA. Granule evaluation includes organoleptic, flow properties, tapping test, and stationary angle test. The results of the evaluation of the granules produced granules produced from each formulation are in accordance with the requirements. Tablet evaluation included organoleptic, uniformity in weight, the hardness of tablet, friability, and disintegration time. The results of the tablet evaluation showed that the maximum concentration of cempedak seeds was found in F1 because it showed the evaluation results that were in accordance with the requirements. In evaluating the uniformity of weight and hardness of tablets with the Kruskal Wallis H test and the Mann Whitney test, the results show that there are differences in each formula with a P-value <0.05. The results of the evaluation of tablet friability and disintegration time with one-way ANOVA test and LSD test showed differences in each formula with a P-value <0.05. Cempedak seed starch (Artocarpus champeden) can be used as a filler in the loading of Paracetamol tablets by the wet granulation method.

2018 ◽  
Vol 6 (1) ◽  
pp. 36
Author(s):  
Maruli Taufandas ◽  
Elsye Maria Rosa ◽  
Moh Afandi

Salah satu penyakit degeneratif pada lansia yang sering dialami yaitu osteoartritis, yang ditandai dengan adanya nyeri pada ekstremitas bawah dan prevalensinya semakin meningkat dengan bertambahnya usia. Penatalaksanaan non farmakologi merupakan komponen yang sangat penting dalam mengatasi nyeri, salah satu bentuknya adalah latihan Range of Motion. Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh Range of Motion untuk menurunkan nyeri sendi pada lansia dengan osteoartritis di wilayah kerja Puskesmas Godean I Sleman Yogyakarta. Metode :Penelitian ini adalah study intervensi berupa penelitian kuantitatifdengan rancangan Quasi Eksperiment Design: Pretest-Posttest Control Group Design. Penelitian dilakukan di dua dusun di Kabupaten Sleman yaitu di dusun Mertosutan dan dusun Ngabangan.Sampel pada penelitian ini sebanyak 36 orang lansia dengan masing-masing 18 lansia sebagai kelompok intervensi dan 18 lansia sebagai kelompok kontrol.Pengambilan sampel menggunakan teknik purposive sampling.Analisis data yang digunakan adalah Wilcoxon Test dan Mann Whitney Test. Hasil : Setelah melakukan latihan Range of Motionselama 4 minggu, didapatkan hasil bahwa terdapat pengaruh Range of Motion terhadap skala nyeri sendi pada lansia dengan osteoartritis dengan p value 0,000 (α < 0,05). Kesimpulan :Range of Motion berpengaruh secara signifikan terhadap penurunan tingkat skala nyeri sendi pada lansia dengan osteoartritis


2016 ◽  
Vol 39 (4) ◽  
Author(s):  
Uttam Bandyopadhyay ◽  
Atanu Biswas ◽  
Dhiman Dutta

Some adaptive test procedures are developed for the generalized Behrens-Fisher problem. The one having a deterministic approach is based on calculating a measure of symmetry from each sample and using them as a basis for choosing between the modifiedWilcoxon-Mann-Whitney test (Fligner and Policello, 1981) and the modified Mood’s median test (Fligner and Rust, 1982). The other one is a probabilistic approach which also uses a combination of the modified Wilcoxon-Mann-Whitney test and the modified Mood’smedian test according to an evidence of asymmetry provided by the p-value from the triples test for symmetry given in Randles, Fligner, Policello, and Wolfe (1980). This probabilistic approach is further modified by using a suitable function of the p-value from the triples test. A simulation study reveals that the modified procedure performs reasonably well in terms of power and attainment of the nominal size.


2019 ◽  
Vol 12 (2) ◽  
Author(s):  
Trina Kurniawati ◽  
Titih Huriah ◽  
Yanuar Primanda

AbstrakEdukasi kepada pasien Diabetes Mellitus (DM) yang dapat memperbaiki hasil klinis adalah Diabetes Self Management Education (DSME). DSME merupakan salah satu metode yang dapat memfasilitasi pengetahuan dan keterampilan. Penelitian ini bertujuan untuk mengetahui pengaruh Diabetes Self Management Education terhadap Self Management pada pasien DM. Penelitian ini menggunakan metode penelitian quasi experimental dengan control group pre test- post test design. Teknik pengambilan sampel menggunakan teknik Simple random sampling dengan jumlah sampel sebanyak 46 orang yang terbagi menjadi 23 orang pada kelompok intervensi mendapatkan DSME sebanyak 4 sesi dalam satu bulan dan 23 orang pada kelompok kontrol mendapatkan edukasi dari Program PERSADIA. Instrumen yang digunakan menggunakan kuesioner. Analisis statistik menggunakan Wilcoxon dan Mann Whitney test. Hasil penelitian menunjukkan bahwa P value uji Wilcoxon test sebesar 0,000 pada kelompok intervensi, P value uji Mann Whitney test adalah 0,000 pada variabel self management. Berdasarkan hasil uji statistik didapatkan p<0,05 yang menunjukkan bahwa terdapat perbedaan nilai self management antara kelompok intervensi dengan kelompok kontrol secara signifikan. Kesimpulan penelitian ini adalah DSME dapat meningkatkan self management pada pasien DM. Disarankan petugas kesehatan dapat memberikan DSME untuk meningkatkan self management pasien diabetes dan menggunakan DSME sebagai program promosi kesehatan.Kata kunci: Diabetes Mellitus; DSME;Self Management  The Influnce of Diabetes Self Management Education (DSME) to the Self Management on the Diabetes Patient AbstractEducation to patients Diabetes Mellitus (DM) who can improve clinical outcomes is Diabetes Self Management Education (DSME). DSME is one method that can facilitate knowledge and skills. The purpose of this research is to determine the effect of Diabetes Self Management Education (DSME) to Self Management on the diabetes patients. This study is used the quasi experimental research method with control group pre test post test design. The sampling technique used Simple random sampling with a samples of 46 people and it is devided 23 people in the intervention group get DSME as much as 4 sessions in one month and 23 people in the control group get education programe at PERSADIA. The instrument used was questionnaire. Statistical analysis used Wilcoxon and Mann Whitney test. The results showed that P value of Wilcoxon test  was 0.000 in the intervention group, P test value of Mann Whitney test was 0.000 in self management variable. Based on statistical test results obtained p <0.05 which indicates that there are differences in self-management value between the intervention group and the control group significantly. The conclusions of this research is DSME can improve self-management on the patients with diabetes. It is recommended that health workers can provide DSME to improve self-management  in diabetic patients and use DSME as a health promotion program.Keywords  : Diabetes Mellitus, DSME, Self Management


2021 ◽  
Vol 8 (1) ◽  
pp. 7-14
Author(s):  
Yohana Putri Apryanti ◽  
Siti Choirul Dwi astuti

Nyeri adalah hal yang fisiologis yang akan dihadapi oleh seorang ibu bersalin. Nyeri merupakan pengalaman sensorik yang. Penelitian yang diterbitkan oleh Journal of Physiotherapy membuktikan bahwa massage yang dilakukan selama 30 menit pada saat pembukaan serviks 4-5cm selama kontraksi rahim berlangsung dapat menurunkan intensitas nyeri.  Begitu juga dengan penelitian yang diterbitkan oleh Pasific Journal of Tropical Biomedicine menjelaskan bahwa penggunan esensial oil secara inhalasi dapat merangsang pusat penciuman diotak (olfactory Bulb) dapat memberikan rasa nyaman. Tujuan penelitian ini dilakukan untuk mengidentifikasi penurunan intensitas nyeri pada ibu bersalin yang diberikan perlakuan dan tidak diberikan perlakuan metode endorphine massage dan aromaterapi lemon. Penelitian ini dilakukan dengan menggunakan desain penelitian Eksperimen semu (Quasy Eksperimen) dengan rancangan yang digunakan adalah pretest-post test control group design. Teknik pengambilan sampel yaitu puprposive sample sebanyak 30 responden di BPM wilayah kerja Puskesmas Simalingkar yang terbagi menjadi  15 responden sebagai kelompok intervensi dan 15 responden sebagai kelompok kontrol Adapun hasil penelitian dari uji Mann-Whitney Test diperoleh p value sebesar 0,000 ≤ 0,05 yang berarti Ho ditolak yaitu: intensitas nyeri pada kelompok intervensi lebih menurun dibandingkan dengan intensitas nyeri pada kelompok kontrol. Sehingga tenaga kesehatan dapat memberikan kedua terapi ini dapat membantu ibu mengurangi rasa nyeri persalinan


2018 ◽  
Vol 4 (1) ◽  
pp. 26-30
Author(s):  
Yulinda Laska ◽  
Suryono Suryono ◽  
Melyana Nurul Widyawati ◽  
Ari Suwondo ◽  
Suryati Kusworowulan

Background: Prevalence of postpartum blues for Asia between 26-85%, while the prevalence in Indonesia is 50-70%. Of all women postpartum can experience this is experiencing stress, almost 80% of primiparous moms experience feelings of sadness after childbirth. These stresses can trigger an increase in cortisol. Music raises changes in brain wave status and stress hormones. Nature Sound music is music that has a slow tempo and can cause feelings relaxed and comfortable.Objective: To examine the effect of the nature music therapy on on cortisol levels in postpartum primipara.Methods: This was a true experimental study with pretest-posttest control group design. The study was conducted in the postpartum ward in the General Hospital of Semarang from November 2016 to January 2017. There were 39 postpartum primipara recruited in this study using simple random sampling divided into three groups: 1) the experiment group who received the nature music therapy for 15 minutes, 2) the experiment group who received the nature music therapy for 30 minutes, and 3) the control group. One-way ANOVA test was performed for data analysis.Results: One-way anova test showed p-value 0.010 (<0.05), which indicated that there was a statistically significant effect of the nature sound therapy on the cortisol level in the postpartum primipara.Conclusion: There was a significant effect of the nature music therapy on the cortisol levels in postpartum primipara. Thus, the application of nature music therapy can be an alternative therapy especially for postpartum primipara who experience emotional stress, physical, anxiety, and fatigue.


2017 ◽  
Vol 3 (6) ◽  
pp. 697-701
Author(s):  
Fara Imelda Theresia Patty ◽  
Suhartono Suhartono ◽  
Ngadiyono Ngadiyono ◽  
Mardiyono Mardiyono

Background: The prolonged partus is one of the causes of maternal deaths marked by the slow progress of labor. Induction of labor and caesarean section is a common procedure performed on long-term partus events to end pregnancy. The birth acupressure technique is a complementary method to activate the hormone oxytocin at a certain point to use to soften the cervix and increase contraction.Objective: To examine the effect of acupressure point LI4, SP6 and BL60 on the duration of the first stage of labor and APGAR Score of newborn in primigravida.Methods: This research employed a Quasy experimental study with posttest control group design. It was conducted at the Public Health Center of Trauma and Public Health Center of Palaran Samarinda, East Kalimantan. There were 40 respondents selected using purposive sampling, which 20 respondents assigned in the experiment and control group. The duration of the first stage of labor was assessed using partograph and APGAR Score was assessed using APGAR Score assessment sheets. Mann Whitney test was used for data analysisResults: Findings showed that the duration of the first stage of labor in the experiment group was 187 minutes and in the control group was 307 minutes. Mann Whitney test obtained p-value 0.001 (<0.05), which indicated that there was a statistically significant difference of the duration of the first stage of labor between both groups. However, Mann Whitney test for APGAR score showed p-value 0.114 (>0.05), which indicated that there was no significant difference of APGAR score in the experiment and control group.Conclusion: There was a significant effect of acupressure on the duration of the first stage of labor, but no effect of the APGAR score. Therefore, acupressure may be recommended to shorten the duration of the first stage of delivery in primigravida.


2021 ◽  
Vol 7 (1) ◽  
pp. 27
Author(s):  
Happy Marthalena Simanungkalit ◽  
Muliana Muliana

Diarrhea is currently still the third leading cause of under-five mortality after pneumonia. Diarrhea is one of the diseases that causes death and illness in toddlers every year. One result of diarrhea is nutritional disorders due to reduced food intake, vomiting, hypoglycemia, dehydration which causes metabolic balance disorders because fluid intake is not balanced with expenditure through vomiting and diarrhea. The purpose of this study was to determine the difference in the duration of diarrhea when giving tempeh porridge to toddlers at the Puruk Cahu Health Center. The design of this study is analytic research with this type of research is Quasi Experiment using the design of the Group Control Post Test Only Design. The population in this study were toddlers who had acute diarrhea in the working area of ​​Puruk Cahu Health Center, Murung Raya Regency and the sample size was 38 people (19 people as the control group and 19 experimental groups). The statistical test used in this study was the Mann Whitney test. The results of statistical tests using the Mann Whitney test found that p value = 0.002 means the value of p value < alpha (0.05), meaning that there is an effect of giving tempe porridge to the duration of diarrhea at Puruk Cahu Health Center. Diarrhea in the group that was not given tempeh porridge lasted longer than the group that was given tempeh porridge. The Conclusion is that there is a difference in the duration of acute diarrhea in the administration of tempe porridge for toddlers at the Puruk Cahu Health Center.


2015 ◽  
Vol 5 (2) ◽  
pp. 88
Author(s):  
Eka Rhestifujiayani ◽  
Emil Huriani ◽  
Muharriza Muharriza

Background: Hemiparesis is a common problem that can caused disability. ROM Exercise is an exercise that to performed evaluate and to improv the function of the musculoskeletal system and is one of therapies in stroke patients that aim to increase cerebral blood flow, minimize disability caused by stroke, so can refine sensory motoric function.Purpose: The objective of this study was to examine the effect ROM exercises of the extremity muscle strength in patients with stroke Methods: This study was a quasi experimental with non equivalent control group design. The sampling technique was purposive sampling. The number of sample was 20 respondents. The statistical test used are Wilcoxon test and Mann-Whitney test. Result: Wilcoxon test in control group showed p-value in upper extremities was p=0,157 and in lower extremities was p=0,083, it mean that there was no increase in muscle strength in the control group and in experiment group showed p-value in upper extremities was p=0,004 and in lower extremities was p=0,005, it mean that there is increase in muscle strength in the experiment group. The result of Mann-Whitney test showed p-value in upper extremities was p=0,002 and in lower extremities was p=0,006, it means that there were differences in the increase in muscle strength between control group and experiment group. Conclusion: ROM exercises affect the increase in muscle strength in stroke patients with hemiparesis. The ROM exercises can be used as a nursing intervention in the provision of nursing care.


Author(s):  
Rifani Alfian ◽  
Sulaiman Hamzani ◽  
Abdul Khair

Abstract: Effect of Stirring Time Alum And Phosphate Levels In Liquid Waste Martapura Laundry In Central District. One of the wastes produced is phosphate. Disposal of waste which contains phosphates in the water can cause eutrophication processes in the aquatic environment. Therefore it needs proper methods for treating waste that contains a lot of laundry phosphate compounds that safely discharged into the environment. This study aims to determine the effect of the use of alum and alum stirring time on levels of phosphate in laundry wastewater XXX in Martapura, Banjar.This type of research is shaped Experimental research. Design The study design is randomized pretest-posttest control group design. The sample was liquid waste from the laundry XXX Laundry washing process that represents the entire population of data analysis using One Way ANOVA Test. The result of a decrease in the average levels of phosphate in sequence on each variation of stirring time, ie 92.7%; 99.6%; and 96.7%. The statistical test used is One Way Anova test. Based on an analysis using One Way ANOVA in the treatment group p-value (0.00


Author(s):  
Rajesh Dake ◽  
I. Venkata Ramana

Background: The objective of this present study was to determine and evaluate the nature and types of medication errors (MEs) in a tertiary care hospital.Methods: This was a prospective, observational study was conducted on medication errors in a tertiary care hospital, Kakinada during January 2019 to December 2019. MEs were categorized as prescription error (PE), transcription error (TE), dispensing error (DE), and administration error (AE). The case records and treatment charts were reviewed. The one-way ANOVA test for independent measures was done for statistical analysis.Results: A total of 5792 patients were included during the study period. Total numbers of MEs were n=353 (6.10%). The most common ME was TEs n=191 (54%) followed by AEs n=117 (33%). Nursing errors n=316 were more compared to doctors’ errors n=18. The one-way Anova test for independent measures was done for statistical analysis; the f-ratio value is 6.44654. The p-value is 0.004332. The result is significant at p<0.05.Conclusions: There is a need to establish effective ME reporting system to reduce its incidence and improve patient care and safety. Regular trainings and interdepartmental sharing of facts on medication errors should be done at regular intervals.


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