Association between peripheral lncRNA expression and coping style in schizophrenia patients

2021 ◽  
Vol 1 (1) ◽  
pp. 024-030
Author(s):  
Ling Ming Kong ◽  
Xiao Li Zhu ◽  
Li Yi Zhang
Keyword(s):  
Coping Style ◽  
Mononuclear Cells ◽  
Control Group ◽  
Peripheral Blood Mononuclear ◽  
Lncrna Expression ◽  
Positive Coping ◽  
Negative Coping ◽  
And Coping ◽  
The Relationship ◽  
Lower Expression

In order to explore the relationship between peripheral lncRNA expression and coping style in schizophrenia patients, this study screened the peripheral blood mononuclear cells in 5 patients and 5 controls, and 10 differentially expressed lncRNAs were selected and validated in 96 patients and 50 controls by qPCR. Compared to control group, three lncRNAs (NONHSAT089447, NONHSAT021545, NONHSAT041499) were up-regulated in schizophrenia group. Among them, NONHSAT089447, NONHSAT021545 were negatively associated with positive coping style, and other four lncRNAs (ENST00000394742, NONHSAT089447, NONHSAT021545, NONHSAT041499) were positively related to negative coping style. Positive coping style scores in higher-expression of PR4 and PR6 subgroup were significantly lower than those in lower-expression subgroup. While on the other hand, negative coping style scores in higher-expression of NONHSAT089447, NONHSAT021545, NONHSAT041499 subgroup were significantly higher than those in lower-expression subgroup. In conclusion, three lncRNAs (NONHSAT089447, NONHSAT021545, NONHSAT041499) were over-expressed in schizophrenia patients, probably playing a role in the epigenetic process of choosing coping style.

scholarly journals Psychological Endurance, Anxiety, and Coping Style among Journalists Engaged in Emergency Events: Evidence from China

2019 ◽  
Author(s):  
Long WANG ◽  
Canhua KANG ◽  
Zongyi YIN ◽  
Fang SU
Keyword(s):  
Coping Style ◽  
Emotional State ◽  
Hubei Province ◽  
Highly Educated ◽  
Positive Coping ◽  
Emergency Events ◽  
Negative Coping ◽  
And Coping ◽  
Relationship Of ◽  
The Relationship

Background: During reports of emergency events, journalists experience psychological crisis and negative emotions aroused by the events. The psychological endurance of journalists, which is induced by high risks of the career, has attracted widespread attention. Emotional state and coping style are important factors that influence the psychological endurance of individuals. This study aimed to analyze the relationship of psychological endurance with anxiety and coping style among journalists engaged in emergency events. Methods: A total of 296 journalists in Hubei Province of China who participated in reports on emergency events from August to December 2017 were selected. Journalists were assessed using the Psychological Endurance Scale, Self-rating Anxiety Scale, and Simple Coping Style Questionnaire. Results: The total score of the psychological endurance of journalists engaged in emergency events is slightly lower than that of the Chinese norm. Score of anxiety of highly educated journalists is significantly higher than that of lowly educated journalists. Psychological endurance of journalists is negatively correlated with negative coping style and anxiety, but it is positively correlated with positive coping style. Positive coping style of journalists engaged in emergency events partially mediates the effects of psychological endurance on anxiety. Conclusion: Among journalists engaged in emergency events, the highly educated group presents obvious anxiety and negative coping style. Psychological endurance indirectly affects through positive coping style and directly affects anxiety of journalists.

scholarly journals The correlation between mobile phone addiction and coping style among Chinese adolescents: a meta-analysis

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Guang-Li Lu ◽  
Yue-Ming Ding ◽  
Yi-Ming Zhang ◽  
Hai-Tao Huang ◽  
Yi-Pei Liang ◽  
...  
Keyword(s):  
Mobile Phone ◽  
Coping Style ◽  
Meta Analysis ◽  
Moderating Effect ◽  
Smartphone Addiction ◽  
Positive Coping ◽  
Mobile Phone Addiction ◽  
Negative Coping ◽  
And Coping ◽  
The Relationship

Abstract Background Mobile phone addiction has become a social problem that affects the healthy growth of adolescents, and it may be correlated with coping style. The aim of this study was to investigate the relationship between mobile phone addiction and coping style and the influencing factors for adolescents. Methods A meta-analysis was conducted by searching China National Knowledge Infrastructure (CNKI), WANFANG DATA and Chongqing VIP Information Co., Ltd. (VIP), PubMed, Web of Science, Embase, and PsycINFO. Stata 16.0 was used to analyse the overall effect and test the moderating effect. Results Thirty-three studies were included, involving a total of 20,349 subjects. There was no significant correlation between adolescents’ mobile phone addiction and positive coping style (r =  − 0.02, 95% CI =  − 0.06 to 0.02, P > 0.05), but there was a moderate positive correlation between adolescents’ mobile phone addiction and negative coping style (r = 0.31, 95% CI = 0.26 to 0.36, P < 0.001). The moderating effect analysis showed that the effect of dissertations on mobile phone addiction and positive coping style among adolescents was significantly larger than that of journal articles. The Smartphone Addiction Scale for College Students (SAS-C) showed the largest effect on mobile phone addiction and positive coping style among adolescents. The time of publication significantly positively moderated the relationship between mobile phone addiction and negative coping style among adolescents. The Simplified Coping Style Questionnaire (SCSQ) showed the largest effect on adolescents’ mobile phone addiction and negative coping style. However, the correlation between adolescents’ mobile phone addiction and coping style was not affected by age or gender. Conclusions There was a close relationship between mobile phone addiction and coping style among adolescents. In the future, longitudinal research should be carried out to better investigate the dynamic changes in the relationship between mobile phone addiction and coping style.

Coping strategies and quality of life in schizophrenia outpatients treated by Psychopharmacs - cross-sectional study

2016 ◽  
Vol 33 (S1) ◽  
pp. s252-s253
Author(s):  
M. Holubova ◽  
J. Prasko ◽  
R. Hruby ◽  
D. Kamaradova ◽  
M. Ociskova ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Regression Analysis ◽  
Coping Strategies ◽  
Positive Coping ◽  
Negative Coping ◽  
Image Position ◽  
Self Instruction ◽  
And Coping ◽  
The Relationship

IntroductionThe modern psychiatric view of schizophrenia spectrum disorders and their treatment has led to an increasing focus on coping strategies and quality of life of these patients.ObjectivesUnderstanding the relationship between quality of life and coping strategies can help in finding those coping strategies that enhance the quality of life. It is important to study the inner experience and striving of patients because of connection with well-being and treatment adherence.Aims:In the present study, the authors examined the relationship between demographic data, the severity of symptoms, coping strategies, and quality of life in psychotic outpatients.MethodsPsychiatric outpatients who met ICD-10 criteria for a psychotic disorder (schizophrenia, schizoaffective disorder, or delusional disorder) were recruited in the study. Questionnaires measuring the coping strategies (SVF-78), the quality of life (Q-LES-Q), and symptoms severity (objective and subjective clinical global impression–objCGI; subjCGI) were assessed. Data were analysed using one-way ANOVA, Mann-Whitney U-test, Pearson and Spearman correlation coefficients, and multiple regression analysis.ResultsOne hundred and nine psychotic outpatients were included in the study. The QoL was significantly related to the Positive and Negative coping strategies. The severity of disorder highly negatively correlated with the QoL score. Stepwise regression analysis showed that symptoms severity (subjCGI), Positive coping strategies (especially Positive Self-instruction), Difference between the objCGI and subjCGI and Negative coping strategies explain totally 53.8% of variance of the QoL (Tables 1–3).Table 1Description of the sample, demographic and clinical data. Table 2Description of using coping strategies and quality of life in schizophrenic outpatients. Average use of coping 40-60 T-score, more than 60 overusing, less than 40 reduced use of coping strategy.Table 3Correlations between quality of life and coping strategies. *P < 0.05; **P < 0.01; ***P < 0.001.ConclusionsOur study suggests the importance of utilizing the Positive coping strategies in improving the quality of life in patients with psychotic disorders.Disclosure of interestThe authors have not supplied their declaration of competing interest.

The Influence of Group Psychotherapy to Crisis Frangibility and Coping Style in Community Residents

2011 ◽  
Vol 26 (S2) ◽  
pp. 1132-1132
Author(s):  
J. Weidong ◽  
Z. Guoquan ◽  
G. Yunqing ◽  
Z. Hong ◽  
T. Hua ◽  
...  
Keyword(s):  
Group Psychotherapy ◽  
Coping Style ◽  
Psychological Theory ◽  
Theory And Practice ◽  
List Type ◽  
Positive Coping ◽  
Community Residents ◽  
Before And After ◽  
Negative Coping ◽  
And Coping

ObjectiveTo understood the influence of group psychotherapy to crisis frangibility and coping style in community residents,seek the methods and value of community psychological coping intervention,and provide the basis of psychological theory and practice for the work of community mental health.MethodsThe scale of crisis frangibility and BCQ were employed to evaluate and compare the mental state before and after intervention.Results1)Crisis frangibility of residents was negatively correlated with positive coping,positively correlated with negative coping.2)After group psychotherapy,scores of scale for crisis vulnerability and negative coping droped.3)Through the regression model analysis, the linear relationship between positive coping factor and the crisis vulnerable is closest.Conclusion9 Group psychotherapy in community is a effective method to reduce resident's crisis frangibility,and the setup of experimental model has provided the theory and the practice basis for development psychology counseling in community.

scholarly journals The Mediating Role of Resilience and Self-Esteem Between Life Events and Coping Styles Among Rural Left-Behind Adolescents in China: A Cross-Sectional Study

2020 ◽  
Vol 11 ◽  
Author(s):  
Juan Li ◽  
Yi-ping Chen ◽  
Jie Zhang ◽  
Meng-meng Lv ◽  
Maritta Välimäki ◽  
...  
Keyword(s):  
Life Events ◽  
Coping Style ◽  
Coping Styles ◽  
Self Esteem ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Left Behind ◽  
Positive Coping ◽  
Negative Coping ◽  
And Coping

Objective: This study aims to explore the association between life events and coping styles, and how resilience and self-esteem mediate the association.Methods: A cross-sectional study was conducted among 981 left-behind adolescents (LBAs) in five junior high schools in Hunan Province, China, from April 13 to April 20, 2020. We utilized self-designed sociodemographic questionnaire, Adolescent Self-Rating Life Events Checklist, Resilience Scale Chinese Adolescent, Rosenberg Self-Esteem Scale, and Simplified Coping Style Questionnaire to assess the mental health of LBAs. Statistic description, Pearson correlation analysis, and structural equation model were adopted to analyze the data.Results: Results revealed that life events could negatively predict resilience (β = −0.29, P &lt; 0.001) and self-esteem (β = −0.39, P &lt; 0.001) and positively predict LBAs' positive coping style (β = 0.28, P &lt; 0.001) and negative coping style (β = 0.21, P &lt; 0.001). Self-esteem could also positively predict the resilience of LBAs (β = 0.62, P &lt; 0.001); resilience could negatively predict the negative coping style (β = −0.21, P &lt; 0.001) and positively predict the positive coping style (β = 0.79, P &lt; 0.001). Life events not only have direct effects on negative coping style (β = 0.21) and positive coping style (β = 0.28) but also have indirect effects on coping styles by affecting resilience (β = −0.29) and self-esteem (β = −0.39). The total effect of life events on coping styles was 0.32, where 34.37% was mediated by resilience and self-esteem.Conclusion: We proved that resilience and self-esteem mediated most of the effects of life events on coping styles. The findings had important implications for interventions to promote mental health of LBAs, particularly the enhancement of resilience and self-esteem.

Seven days of mindfulness-based cognitive therapy improves attention and coping style

2018 ◽  
Vol 46 (3) ◽  
pp. 421-430 ◽  
Author(s):  
Peng Quan ◽  
Wenna Wang ◽  
Chengjing Chu ◽  
Lingfengz Hou
Keyword(s):  
Cognitive Therapy ◽  
Executive Control ◽  
Coping Style ◽  
Control Group ◽  
Test Results ◽  
Short Term ◽  
Positive Coping ◽  
And Coping ◽  
Short Time ◽  
And Control

We designed a short-term training course in mindfulness-based cognitive therapy (MBCT) for use with busy people with little time. We examined whether or not MBCT training would affect people's cognition. We assigned 44 participants with no prior experience with mindfulness techniques randomly to either an MBCT group or a control group. These participants then completed the Trait Coping Style Questionnaire (TCSQ). After having undergone 7 days of training, we assessed participants again with the TCSQ and they also completed the Attention Network Test. Results showed that orienting and executive control differed between the MBCT and control groups, but there was no difference between the 2 groups in alerting. The score for positive coping style was significantly enhanced in the group who had undergone MBCT training. Our findings suggest that MBCT can be an effective approach to improve individuals' attentional subsystem and coping style in a short time.

Linking Childhood Maltreatment and Psychological Symptoms: The Role of Social Support, Coping Styles, and Self-Esteem in Adolescents

2020 ◽  
pp. 088626052091857
Author(s):  
Shanshan Wang ◽  
Huiqiong Xu ◽  
Shichen Zhang ◽  
Rong Yang ◽  
Danlin Li ◽  
...  
Keyword(s):  
Social Support ◽  
Childhood Maltreatment ◽  
Coping Style ◽  
Psychological Symptoms ◽  
Coping Styles ◽  
Self Esteem ◽  
Mediating Effect ◽  
Positive Coping ◽  
Negative Coping ◽  
The Relationship

Psychological symptoms are common among adolescents in China, which are associated with various negative consequences. There has been a pressing need for additional research of factors responsible for the occurrence of psychological symptoms during this developmental period, among which childhood maltreatment, personal coping style, one’s levels of social support, and self-esteem deserve our attention. The association between childhood maltreatment and psychological symptoms is evident; however, the possible mediating effect of the other three factors mentioned above remains unclear. Hence, the current study aims to investigate the possible mediating roles of social support, coping style, and self-esteem in the relationship between childhood maltreatment and the development of psychological symptoms among adolescents. An adolescent-based health survey was conducted between 2013 and 2014 in 15 schools in China. A total of 9,704 students (aged 11–19 years) were enrolled and measures on childhood maltreatment, social support, coping styles, self-esteem, and psychological symptoms were completed. It was found that childhood maltreatment was positively correlated with psychological symptoms and negative coping styles, and negatively correlated with social support, positive coping styles, and self-esteem ( p < .001). Social support, coping styles, and self-esteem mediated the relationship between childhood maltreatment and psychological symptoms. The estimated effect of childhood maltreatment on the occurrence of psychological symptoms could be explained by the mediation of social support, positive coping styles, negative coping styles, and self-esteem, whose ratio of roles came to 13.8%, 7.5%, 20.9%, and 10.3%, respectively. These findings indicate a need to promote social support, self-esteem, and positive coping styles, and decrease the level of negative coping styles, to markedly reduce the impact of psychological symptoms of childhood maltreatment among adolescents.

scholarly journals The Relationship Between State Loneliness and Depression Among Youths During COVID-19 Lockdown: Coping Style as Mediator

2021 ◽  
Vol 12 ◽  
Author(s):  
Yayun Zhang ◽  
Lin Huang ◽  
Yuejia Luo ◽  
Hui Ai
Keyword(s):  
Coping Strategies ◽  
Coping Style ◽  
Coping Styles ◽  
Public Mental Health ◽  
Anxiety State ◽  
Mediating Role ◽  
Negative Coping ◽  
And Coping ◽  
The Relationship

The coronavirus disease (COVID-19) pandemic has had a great impact on public mental health. However, loneliness during the lockdown related to depression and whether the relationship would be mediated by coping style or whether sex moderates loneliness and coping style are not clear. The study aimed to examine the mediating role of coping style in the relationship between state loneliness and depression as well as the moderating role of sex in the relationship between state loneliness and coping styles during the COVID-19 lockdown. Participants were 337 college students in China during the COVID-19 pandemic (January–February 2020). States of depression and anxiety, state loneliness, and coping styles with COVID-19 were measured. The results show that loneliness was an effective predictor of depression during self-quarantine. Moreover, coping style mediated the relationship between state loneliness and depression although sex did not moderate the relationship between state loneliness and coping style. Youths were inclined to use more positive coping strategies than negative coping strategies. Our results indicate less loneliness is an effective way to relieve depression, and coping strategies, especially the positive ones, are important for youths to prevent depression and loneliness during the lockdown of the COVID-19 pandemic.

Changes of IL-4 and IFN-g expression in monocytes and T-helper lymphocytes while modeling of systemic juvenile idiopathic arthritis in Wistar rats

2018 ◽  
pp. 61-69
Author(s):  
В.Н. Сахаров ◽  
П.Ф. Литвицкий ◽  
Е.И. Алексеева ◽  
Н.А. Маянский ◽  
Р.Ш. Закиров
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Peripheral Blood Mononuclear Cells ◽  
Wistar Rats ◽  
Mononuclear Cells ◽  
Systemic Juvenile Idiopathic Arthritis ◽  
Control Group ◽  
Peripheral Blood Mononuclear ◽  
Treatment Groups ◽  
Blood Mononuclear Cells ◽  
T Helpers

Цель исследования - изучение перепрограммирования мононуклеарных лейкоцитов на модели системного ювенильного идиопатического артрита (сЮИА), воспроизводимой у крыс Wistar с использованием полного адъюванта Фрейнда и липополисахарида. Методика. сЮИА воспроизведен у 6-месячных крыс-самцов Wistar. На 40-е сут. эксперимента животные были разделены на 3 группы: 1-я группа - контроль; 2-я - группа доксициклина; 3-я - группа дексаметазона. Взятие проб крови у животных проводили на нулевые, 41-е и 55-е сут. Мононуклеарные клетки периферической крови выделяли гравиметрически, после чего окрашивали их на маркеры и внутриклеточные цитокины. Дифференцировали моноциты (CD3-CD4+) и Т-хелперы (CD3+CD4+). Анализировали динамику внутриклеточной экспрессии интерлейкина IL-4 (рассматривали как маркер про-М2 фенотипа, так как в случае выделения из клетки ИЛ-4 служит стимулятором М2 поляризации макрофагов) и IFN-g (как маркер про-М1 фенотипа) по данным проточной цитофлуориметрии. Применяли непараметрический статистический тест Mann-Whitney-Wilcoxon в программе R для статистической обработки данных. Результаты и заключение. При моделировании сЮИА выявлено закономерное изменение фенотипа моноцитов. Применение же доксициклина и дексаметазона приводило к более ранней поляризации их по про-М2-пути в отношении моноцитов (на 41-е сут.) в сравнении с контролем. Про-М1 эффект (на 55-е сут., в сравнении с контролем) выявлен также в группах доксициклина и дексаметазона. У животных разных групп обнаружены характерные динамические изменения внутриклеточной экспрессии цитокинов. Важно, что различная направленность поляризации фенотипа при сЮИА и применении препаратов наблюдается не только у моноцитов, но и у Т-хелперов. The study objective was to evaluate targeted reprogramming of peripheral blood mononuclear cells in systemic juvenile idiopathic arthritis (sJIA) modeled in 6-month-old male Wistar rats by co-administration of complete Freund’s adjuvant and lipopolysaccharide. Methods. On day 40 of the experiment, rats were divided into three groups: control, doxycycline, and dexamethasone groups. Blood samples were collected on days 0, 41, and 55. Peripheral blood mononuclear cells were isolated gravimetrically and stained for markers and cytokines. Monocytes (CD3-CD4+) and T-helpers (CD3+CD4+) were differentiated as target cells. IL-4 was considered a marker for the pro-M2 phenotype since IL-4 can activate M2 macrophage polarization; IFN-g was considered a marker for the pro-M1 phenotype. Time-related changes in the intracellular expression of IL-4 and IFN-g were studied using flow cytometry. Data were analyzed using nonparametric statistical tests (Mann-Whitney-Wilcoxon) in the R environment for statistical computing. Results and conclusions. Monocytes (like macrophages) underwent reprogramming during the development of modeled sJIA disease. In monocytes of doxycycline and dexamethasone treatment groups, pro-M2 effects were observed earlier (day 41) than in the control group. Pro-M1 effects were observed in monocytes of doxycycline and dexamethasone groups on day 55, as compared with the control group. Characteristic time-related changes of intracellular cytokine expression were described for different groups. Importantly, the differently directed phenotype polarization was observed in sJIA and treatment groups for both monocytes and T-helpers.

Assessment of Key Elements in the Innate Immunity System Among Patients with HIV, HCV, and Coinfections of HIV/HCV

2020 ◽  
Vol 18 (3) ◽  
pp. 194-200
Author(s):  
Maryam Moradi ◽  
Alireza Tabibzadeh ◽  
Davod Javanmard ◽  
Saied Ghorbani ◽  
Farah Bokharaei-Salim ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Mononuclear Cells ◽  
Hiv Infections ◽  
Control Group ◽  
Peripheral Blood Mononuclear ◽  
Hiv Coinfection ◽  
Tnf Α ◽  
Immunity Genes ◽  
Healthy Control ◽  
Hcv Coinfection

Background: Coinfection of Hepatitis C virus (HCV) with human immunodeficiency virus (HIV) has a higher risk of mortality than HCV or HIV monoinfection. HCV and HIV infections are specified by systemic inflammation, but the inflammation process in HCV/HIV coinfection is much complicated and is not well characterized. Objective: The aim of this study was to analyze the expression of TLR-3, TLR-7, IL-10, IFN-1 (IFN-α, IFN-β), and TNF-α in HIV, HCV and HIV/HCV co-infected patients. Methods: Forty-five patients including HIV group (n=15), HCV group (n=15), HIV/HCV coinfection group (n=15) and healthy control group (n=15) participated. Peripheral blood mononuclear cells (PBMCs) were obtained. PBMC-RNA, HCV and HIV RNA were extracted from all subjects and cDNA was synthesized. The viral load analyzed by reverse transcription-quantitative PCR (RT-qPCR), and the expression levels of IFN-α, IFN-β, TLR-3, TLR-7, TNF, and IL-10 mRNA were quantified in PBMCs. Results: The levels of IFN-I, IL-10, and TNF-α were overexpressed in all patients’ groups (P<0.05), TLR-7 was upregulated in all groups, but this upregulation was not statistically significant (p>0.05). TLR-3 showed a decrease in all patient groups (P<0.05). The statistical analysis demonstrated that TLR-3 has a negative correlation with HIV load, whereas other genes positively correlated with HIV load. In addition, TLR-3, TNF-α, and IFN-I were negatively correlated with HCV load, whereas TLR-7 and IL-10 s were positively correlated with HCV load. Conclusion: Our results showed a significant relationship between the expression level of innate immunity genes and inflammation in HCV, HIV, and HIV/HCV coinfected patients.

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