scholarly journals The Association of Blood Concentrations of Healvy Metals and Blood Pressure in Residents Living Near Janghang Copper Smelter in Korea

2017 ◽  
Vol 42 (1) ◽  
pp. 13-23 ◽  
Author(s):  
Sang-Yong Eom ◽  
Dong-Hyuk Yim ◽  
Sun-In Moon ◽  
Bolormaa Ochirpurev ◽  
Young-Sook Choi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Copper Smelter ◽  
Blood Concentrations

scholarly journals Effect of intravenous oxycodone on the physiologic responses to extubation following general anesthesia

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Menglu Jiang ◽  
Jiawei Ji ◽  
Xin Li ◽  
Zhenqing Liu
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
General Anesthesia ◽  
Control Group ◽  
Study Group ◽  
Clinical Trial Registry ◽  
Blood Oxygen Saturation ◽  
Blood Concentrations ◽  
Number Of Patients ◽  
Blood Hormones

Abstract Background Endotracheal intubation and extubation may cause undesirable hemodynamic changes. Intravenous oxycodone has recently been introduced and used for relieving hemodynamic alterations in response to intubation, but there is insufficient information regarding its application in stabilizing hemodynamics during extubation in the patients emerging from general anesthesia. Methods One hundred patients, who had undergone assorted laparoscopic surgeries under general anesthesia, were randomly assigned to Control group (saline injection, 50 cases) and Study group (intravenous injection of 0.08 mg/kg oxycodone immediately after completion of the surgical procedure, 50 cases). Blood pressure, heart rate, blood oxygen saturation (SpO2) as well as blood concentrations of epinephrine, norepinephrine, and cortisol were recorded or measured immediately before extubation (T0), during extubation (T1), as well as one minute (T2), 5 min (T3), and 10 min after extubation (T4). In addition, coughing and restlessness, time of eye-opening, and duration from completing surgery to extubation as well as Ramsay Sedation Scale were analyzed. Results Blood pressure and heart rate as well as blood concentrations of epinephrine, norepinephrine, and cortisol were significantly higher in the Control group compared with the Study group at the time of extubation as well as 1, 5, and 10 min after extubation (P < 0.05). When the patients emerged from general anesthesia, 70 % of the Control group had cough, which was significantly higher than that of Study group (40 %, P < 0.05). Significantly higher number of patients manifested restlessness in the Control group before (40 %) and after extubation (20 %) compared with that in the Study group (20 and 2 %, respectively, P < 0.05). In addition, patients of Control group had lower Ramsay score at extubation (1.7 ± 0.7) as well as 30 min after extubation (2.4 ± 0.9) compared to that of the patients of Study group (2.2 ± 0.9, and 3.0 ± 0.8, respectively, P = 0.003 and 0.001). Conclusions Intravenous oxycodone attenuated alterations of hemodynamics and blood hormones associated with extubation during emergence from general anesthesia. Trial registration Chinese Clinical Trial Registry: ChiCTR2000040370 (registration date: 11-28-2020) “‘retrospectively registered”.

scholarly journals Diabetes Mellitus and Hypertension—A Case of Sugar and Salt?

2020 ◽  
Vol 21 (15) ◽  
pp. 5200
Author(s):  
Marcus Sondermann ◽  
Michał Holecki ◽  
Andrea Marita Kirsch ◽  
Manuela Bastian ◽  
Dagmar-Christiane Fischer ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Glucose Metabolism ◽  
Volume Regulation ◽  
Plasma Osmolality ◽  
Sodium Retention ◽  
Specific Mechanism ◽  
Blood Concentrations ◽  
Fluid Status ◽  
Patients With Diabetes

The majority of patients with diabetes mellitus (DM) have hypertension (HTN). A specific mechanism for the development of HTN in DM has not been described. In the Zucker, Endothel, und Salz (sugar, endothelium, and salt) study (ZEuS), indices of glucose metabolism and of volume regulation are recorded. An analysis of these parameters shows that glucose concentrations interfere with plasma osmolality and that changes in glycemic control have a significant impact on fluid status and blood pressure. The results of this study are discussed against the background of the striking similarities between the regulation of sugar and salt blood concentrations, introducing the view that DM is probably a sodium-retention disorder that leads to a state of hypervolemia.

The role of melatonin supplement in metabolic syndrome

2019 ◽  
Vol 49 (5) ◽  
pp. 965-977 ◽  
Author(s):  
Mina Bahrami ◽  
Makan Cheraghpour ◽  
Sima Jafarirad ◽  
Pejman Alavinejad ◽  
Bahman Cheraghian
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Study Groups ◽  
The Body ◽  
Double Blind ◽  
Blood Concentrations ◽  
Content Type ◽  
Metabolic Syndrome Components

PurposeMetabolic syndrome contains metabolic disorders that have association with other chronic diseases. Melatonin is a bioactive compound which is found in plants and also produced in the body. The purpose of this paper is to assess the effect of melatonin supplement on metabolic syndrome components, also leptin and adiponectin blood concentrations in patients with metabolic syndrome.Design/methodology/approachA double blind, placebo-controlled, randomized clinical trial was conducted on 70 subjects with metabolic syndrome. Participants received 6 mg/day melatonin or placebo before bedtime for 12 weeks. At the beginning and end of treatment period, blood samples were collected and biochemical parameters were measured. In addition, blood pressure and anthropometric indices were examined before and after the supplementation. Independent samplet-test was used to compare changes in metabolic syndrome components between the two study groups.FindingsResults showed a significant reduction in waist circumference (−1.54 vs −0.04 cm;p= 0.036), systolic blood pressure (−3.52 vs 0.79 mmHg;p= 0.020), diastolic blood pressure (−1.50 vs 1.73 mmHg;p= 0.014), serum leptin concentration (−2.54 vs 0.27ng/ml;p= 0.041) and an elevation in high-density lipoprotein cholesterol (2.19 vs −0.79 mg/dl;p= 0.038) in the melatonin group compared to the placebo.Research limitations/implicationsIf insulin concentration had been measured, it might have revealed better interpretation of melatonin effect on fasting blood glucose.Originality/valueThis study showed that melatonin as a nutritional supplement improved most metabolic syndrome components and concentration of leptin in the melatonin group compared to the placebo.

Pharmacokinetics and Arteriovenous Differences in Clevidipine Concentration following a Short- and a Long-term Intravenous Infusion in Healthy Volunteers

2000 ◽  
Vol 92 (4) ◽  
pp. 993-1001 ◽  
Author(s):  
Hans Ericsson ◽  
Ulf Bredberg ◽  
Ulf Eriksson ◽  
Åse Jolin-Mellgård ◽  
Margareta Nordlander ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Steady State ◽  
Healthy Volunteers ◽  
Venous Blood ◽  
Volume Of Distribution ◽  
Pharmacokinetic Parameters ◽  
Blood Levels ◽  
Blood Concentrations ◽  
Arterial Blood ◽  
The Mean

Background Clevidipine is an ultra-short-acting calcium antagonist developed for reduction and control of blood pressure during cardiac surgery. The objectives of the current study were to determine the pharmacokinetics of clevidipine after 20-min and 24-h intravenous infusions, and to determine the relation between the arterial and venous concentrations and the hemodynamic responses to clevidipine in healthy volunteers. Methods Four volunteers received clevidipine for 20 min, and eight subjects were administered clevidipine intravenously for 24 h at two different dose rates. Arterial and venous blood samples were drawn for pharmacokinetic evaluation, and blood pressure and heart rate were recorded. Results A triexponential disposition model described the pharmacokinetics of clevidipine. The mean arterial blood clearance of clevidipine was 0.069l/kg-1/min-1 and the mean volume of distribution at steady state was 0.19 l/kg. The duration of the infusion had negligible effect on the pharmacokinetic parameters, and the context-sensitive half-time for clevidipine, simulated from the mean pharmacokinetic parameters derived after 24 h infusion at the highest dose, was less than 1 min. The arterial blood levels reached steady state within 2 min of the start of infusion and were about twice as high as those in the venous blood at steady state. The peak response preceded the peak venous concentration and was slightly delayed from the peak arterial blood concentration. Conclusion Clevidipine is a high clearance drug with a small volume of distribution, resulting in extremely short half-lives in healthy subjects. The initial rapid increase in the arterial blood concentrations and the short equilibrium time between the blood and the biophase suggest that clevidipine can be rapidly titrated to the desired effect.

Abstract P174: Dynamics of the Renin-Angiotensin-Aldosterone System: Implications of Angiotensin-Peptide Fingerprinting on the Clinical Use and Development of Antihypertensive Drugs

2011 ◽  
Vol 109 (suppl_1) ◽  
Author(s):  
Marko Poglitsch ◽  
Manfred Schuster ◽  
Hans Loibner
Keyword(s):  
Blood Pressure ◽  
Antihypertensive Drugs ◽  
Ex Vivo ◽  
Patient Specific ◽  
Turnover Rates ◽  
Renin Angiotensin Aldosterone System ◽  
Blood Concentrations ◽  
Renin Angiotensin ◽  
Angiotensin Peptides ◽  
Angiotensin Peptide

BACKGROUND: The Renin-Angiotensin-Aldosterone-System (RAAS) is an extensively studied peptide hormone system which is critically involved in the regulation of blood pressure and other important physiologic functions. Angiotensin-(1-10) which is liberated from angiotensinogen by kidney secreted Renin, is sequentially metabolized to different N- and C-terminal truncated fragments with partially described biologic activities. Beside Angiotensin II (Ang-(1-8)), various other angiotensin peptides including Ang-(1-7), Ang-(1-9), Ang-(2-8) and Ang-(3-8) are known to possess physiologic activity while Ang-(1-7) and more recently Ang-(1-9) were described to antagonize pathologic effects of Ang-(1-8) via vasodilation and antifibrotic action respectively. The role of Ang-(1-8) in hypertension converts enzymes participating in Ang-(1-8) generation to favorable targets for antihypertensive drugs. METHODS: Human blood was collected from healthy volunteers followed by ex-vivo incubation at 37°C in the presence of different inhibitors of angiotensin metabolism. Angiotensin concentrations were determined employing a novel sensitive LC-MS/MS based method, which allows the simultaneous quantification of a broad panel of angiotensin peptides in human plasma. RESULTS: The investigation of different angiotensin metabolism modifiers revealed agent specific patterns of angiotensin peptide levels reflecting the specificity of these inhibitors. Spiking experiments allowed the determination of turnover rates for distinct angiotensin conversion reactions surrounded by their physiological matrix. CONCLUSION: The measurement of blood concentrations of angiotensin peptides provides important information about the substrate specificities and activities of enzymes involved in their metabolism. This allows the identification of potential causes for pathologic conditions, facilitating a patient specific therapeutic modulation of the RAAS. The overall assessment of angiotensin peptide concentrations (Angiotensin-Peptide-Fingerprinting) represents a powerful tool to gain a more detailed understanding of blood pressure regulation, enabling the pharmacologic characterization of RAAS modifying agents in use and development.

Humoral Response and Blood Pressure Regulation during Hypercapnia and Haemorrhage in Dogs

1976 ◽  
Vol 51 (s3) ◽  
pp. 165s-168s
Author(s):  
G. J. Dusting ◽  
Janina Staszewska-Barczak
Keyword(s):  
Blood Pressure ◽  
Angiotensin Ii ◽  
Arterial Pressure ◽  
Renin Angiotensin System ◽  
Humoral Response ◽  
Experimental Conditions ◽  
Blood Concentrations ◽  
Arterial Blood ◽  
Humoral Mechanism ◽  
Organ Technique

1. The blood-bathed organ technique was used to study the release of catecholamines, angiotensin II and prostaglandin-like (PL) substances into the circulation during hypercapnia and after haemorrhage in anaesthetized dogs. 2. Elevated blood concentrations of noradrenaline, angiotensin II and prostaglandin-like substances have been detected during both experimental conditions. 3. The rise of arterial blood pressure during hypercapnia and after haemorrhage was associated with elevated concentrations of angiotensin II in the blood and could be abolished by inhibition of the angiotensin I-converting enzyme with SQ 20881. 4. The compensation of arterial pressure during both stresses was significantly impaired by release of prostaglandin-like substances; it could be restored by inhibition of prostaglandin biosynthesis with indomethacin. 5. The results indicate that activation of the renin—angiotensin system represents the major humoral mechanism for the maintenance of arterial pressure during hypercapnic acidosis and after haemorrhage.

scholarly journals Red meat from animals offered a grass diet increases plasma and plateletn-3 PUFA in healthy consumers

2010 ◽  
Vol 105 (1) ◽  
pp. 80-89 ◽  
Author(s):  
A. J. McAfee ◽  
E. M. McSorley ◽  
G. J. Cuskelly ◽  
A. M. Fearon ◽  
B. W. Moss ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Dietary Intervention ◽  
Red Meat ◽  
Dietary Intakes ◽  
Post Intervention ◽  
Meat Intake ◽  
Blood Concentrations ◽  
Habitual Diet ◽  
Double Blinded ◽  
Lipids And Lipoproteins

Red meat from grass-fed animals, compared with concentrate-fed animals, contains increased concentrations of long-chain (LC)n-3 PUFA. However, the effects of red meat consumption from grass-fed animals on consumer blood concentrations of LCn-3 PUFA are unknown. The aim of the present study was to compare the effects on plasma and platelet LCn-3 PUFA status of consuming red meat produced from either grass-fed animals or concentrate-fed animals. A randomised, double-blinded, dietary intervention study was carried out for 4 weeks on healthy subjects who replaced their habitual red meat intake with three portions per week of red meat (beef and lamb) from animals offered a finishing diet of either grass or concentrate (n20 consumers). Plasma and platelet fatty acid composition, dietary intake, blood pressure, and serum lipids and lipoproteins were analysed at baseline and post-intervention. Dietary intakes of totaln-3 PUFA, as well as plasma and platelet concentrations of LCn-3 PUFA, were significantly higher in those subjects who consumed red meat from grass-fed animals compared with those who consumed red meat from concentrate-fed animals (P < 0·05). No significant differences in concentrations of serum cholesterol, TAG or blood pressure were observed between groups. Consuming red meat from grass-fed animals compared with concentrate-fed animals as part of the habitual diet can significantly increase consumer plasma and platelet LCn-3 PUFA status. As a result, red meat from grass-fed animals may contribute to dietary intakes of LCn-3 PUFA in populations where red meat is habitually consumed.

scholarly journals Protective effects of omega-3 fatty acids in dogs with myxomatous mitral valve disease stages B2 and C

PLoS ONE ◽  
2021 ◽  
Vol 16 (7) ◽  
pp. e0254887
Author(s):  
Priscilla Regina Nasciutti ◽  
Aline Tavares Moraes ◽  
Thaiz Krawczyk Santos ◽  
Karine Kelly Gonçalves Queiroz ◽  
Ana Paula Araújo Costa ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Mitral Valve ◽  
Mitral Valve Disease ◽  
Antiarrhythmic Effect ◽  
Valve Disease ◽  
Control Group ◽  
Protective Effects ◽  
Omega 3 ◽  
Blood Concentrations ◽  
Arterial Blood

Myxomatous mitral valve disease (MMVD) is characterized by thickening of the valve leaflets and omega-3 (ω-3) supplementation has been associated with modulation of blood pressure (BP) and heart rate, improvement of doppler echocardiographic indices, antiarrhythmic, anti-inflammatory and anti-dislipidemic effects in dogs and humans, although prospective studies of it single use are still absent in the veterinary literature. The objective of this study was to evaluate the influence of ω-3 supplementation in dogs with MMVD. Twenty-nine dogs were followed quarterly for 12 months by clinical evaluation, arterial blood pressure, electrocardiography, doppler echocardiography, thoracic radiography and laboratory tests including inflammatory mediators and cardiac biomarker blood concentrations. The dogs were classified in stages B2 and C, according to the classification proposed by ACVIM 2019. They were randomly assigned to either ω-3 group (ω-3G) or control group (CG). The ingestion of ω-3 reduced the chance of developing arrhythmias by 2.96 times (p = 0.003). The vertebral heart size (VHS) measurements were higher in the control group (p = 0.033). In conclusion, at the dosages used in this study, ω-3 dietary supplementation reduces the volumetric overload, has antiarrhythmic effect and keeps dogs with B2 and C stages of MMVD in milder stages of the disease.

Sign in / Sign up

Export Citation Format

Share Document