scholarly journals Potential of Allicin, Ajoene and Quercetin Contained in Garlic (Allium sativum) as a Promising Anti-Malarial

2021 ◽  
Vol 1 (1) ◽  
pp. 16-21
Author(s):  
Raynald Bagy ◽  
Josef Sem Berth Tuda ◽  
Dimas Prakoso ◽  
Tristan Kantohe
Keyword(s):  
Infectious Disease ◽  
Drug Resistance ◽  
Mortality Rate ◽  
Literature Review ◽  
Allium Sativum ◽  
Relevant Literature ◽  
Anopheles Mosquito ◽  
Morbidity And Mortality ◽  
High Morbidity ◽  
Active Substances

Malaria is an infectious disease with a high morbidity and mortality rate caused by Plasmodium and is transmitted through the Anopheles mosquito. Garlic (Allium sativum) has active substances that can be used as medicinal ingredients. Several active substances, namely allicin, ajoene, and quercetin contained in garlic have the potential to act as an effective and safe anti plasmodium for the host. This writing is a literature review using relevant literature. The results of the study concluded that the active ingredients in garlic have potential to be a new antimalarial agent, and it is hoped that it can be a cheaper and more effective malaria treatment so that drug resistance and morbidity and mortality from malaria can be reduced.

scholarly journals Morbidity and mortality after fragility hip fracture in a Saudi Arabian population: Report from a single center

2017 ◽  
Vol 45 (3) ◽  
pp. 1175-1180 ◽  
Author(s):  
Mir Sadat-Ali ◽  
Moaad Alfaraidy ◽  
Abdulaziz AlHawas ◽  
Ahmed Abdallah Al-Othman ◽  
Dakheel A Al-Dakheel ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Mortality Rate ◽  
Demographic Data ◽  
Femoral Fractures ◽  
Morbidity And Mortality ◽  
High Morbidity ◽  
Fragility Hip Fracture ◽  
Asa Score ◽  
Telephone Interviews ◽  
American Society

Objective To determine the functional morbidity and mortality after fragility hip fracture and compare the mortality with three other common diseases. Methods Data were collected from patients admitted to King Fahd Hospital of the University, AlKhobar from January 2010 to December 2014. Demographic data included the preoperative American Society of Anesthesiologists (ASA) score as assessed by the anesthetist and the type of surgery. Personal and telephone interviews were performed, and data were entered into a database and analyzed. Results We identified 203 patients with fragility proximal femoral fractures, and the data of 189 patients (109 male, 80 female; average age, 66.90 ± 13.43 years) were available for analysis. The overall mortality rate was 26.98% (51 patients). The mortality rate was significantly higher among patients with an ASA score of 4 (36.36%) than 1 (20.45%). With respect to morbidity, only 48.23% of patients were able to return to their pre-fracture status; 32.35% of those who required assisted walking and 83.4% of those who required a wheelchair became bedridden. Conclusions Our data demonstrate that patients with fragility hip fractures have high morbidity and a mortality rate approaching 30%. Age and the ASA score significantly influence this high mortality rate.

scholarly journals Antibacterial Potency of Honey

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Najla A. Albaridi
Keyword(s):  
Infectious Disease ◽  
Drug Resistance ◽  
Antibacterial Activity ◽  
Morbidity And Mortality ◽  
Bacterial Strains ◽  
Large Numbers ◽  
The World ◽  
Scientific Attention ◽  
Treatment Of Infection ◽  
New Strategies

Despite the developments in controlling infectious disease around the world, they are still the second biggest cause of morbidity and mortality due in part to the increase in drug resistance among large numbers of the bacterial strains. This means that new strategies are needed to prevent and treat infectious disease. As a result, several ancient methods have been re-evaluated and the substances/procedures employed historically to cure diseases are now attracting renewed scientific attention. Honey is one such product that used to be widely used to combat bacteria. This review covers the antibacterial activity of honey, its use in the treatment of infection and diseases, and the features that are relevant to its activity.

scholarly journals Cerebral Abscess with Cranial Hypertension in Young Infants: A Case Report and Systematic Review

2021 ◽  
Vol 2 (4) ◽  
Author(s):  
Náthalie Angélica Cardoso Marqui ◽  
Marina Lucca de Campos Lima ◽  
Rafaela de Fátima Ferreira Baptista ◽  
Rawene Elza Veronesi Gonçalves Righetti ◽  
Tauane Rene Martins ◽  
...  
Keyword(s):  
Mortality Rate ◽  
Antibiotic Therapy ◽  
Brain Abscess ◽  
Broad Spectrum ◽  
Central Nervous System Infection ◽  
Mass Effect ◽  
Morbidity And Mortality ◽  
High Morbidity ◽  
Surgical Drainage ◽  
Young Infants

Objective: To report a Central Nervous System infection evolving with brain abscess and to address aspects of the treatment of the disease. Results: even with advances in treatment and diagnosis, the pathology has a high mortality. However, the best prognosis is noticed when there is a suspicion through the clinic, neuroradiological images readily available, antimicrobial therapy against commonly encountered agents, and surgical drainage procedures. One study, which combined antibiotic therapy and surgery to drain the abscess, in most of the cases, studied, demonstrated a mortality rate of 12%, and another study, a 42% mortality rate when using antibiotic therapy alone. Another reference suggests the use of antibiotic therapy alone in less severe cases with less neurological impairment. Neurological clinical sequelae can be found in up to 30% of cases. The time of antibiotic therapy still needs to be debated, as well as the surgical indication for drainage. Final Considerations: Pediatric brain abscess is an uncommon disease, still with high morbidity and mortality. Surgical drainage or excision of pediatric abscesses remains the basis of treatment both to relieve the mass effect and to provide a microbiological diagnosis. The literature demonstrates that broad-spectrum antibiotics and access to CT and MRI images decrease the rates of morbidity and mortality. It is concluded that the therapeutic approach involves the administration of broad-spectrum intravenous antibiotics and surgical drainage in more complex cases.

scholarly journals Experience with Tetanus in a Tertiary Care Hospital in Sudan: A Retrospective Review

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Mumen Abdalazim Dafallah ◽  
Esraa Ahmed Ragab ◽  
Omer Ali Mohamed Ahmed Elawad
Keyword(s):  
Mortality Rate ◽  
Rural Areas ◽  
Tertiary Care ◽  
Cardiovascular Complications ◽  
Lower Limbs ◽  
Morbidity And Mortality ◽  
High Morbidity ◽  
Care Hospital ◽  
Female Ratio ◽  
Central Sudan

Introduction. Tetanus is still a major health issue, especially in rural areas, and is associated with high morbidity and mortality rate. This study was conducted to describe the pattern of presentation and treatment outcome among adult patients infected with tetanus in our environment. Materials and Methods. This is a descriptive retrospective hospital-based study conducted in Wad Medani teaching hospital, central Sudan. A total of thirty-one patients were enrolled in this study in the period between January 2018 and December 2020. Results. Thirty-one patients were infected with tetanus during the study period. They were 23 (74.2%) males and 8 (25.8%) females with a male-to-female ratio of 2.875 : 1. Their ages ranged from 20 to 70 years, and most of them (48.4%) were free workers. Acute injuries were the most common portal of entry (64.51%), and commonly involved the lower limbs (48.38%). Lock jaw (54.8%), muscle spasm (51.6%), and neck pain and stiffness (45.2%) were the most common presentation. Supportive measures along with surgical toilet and debridement, human tetanus immunoglobulin, antibiotics, and muscle relaxants were initiated in all patients. The most common antibiotics used were Penicillin V and Ceftriaxone. A muscle relaxant was administered to aid in relieving the spasms. Complication rate was 61.29% and included pulmonary and cardiovascular complications. Fifteen patients died accounting for an overall mortality rate of 48.4%. Conclusions. Tetanus remains a disease with high morbidity and mortality. The unknown/incomplete vaccination status among study participants, inadequate management, and lack of equipped resources lead to a devastating outcome as in Sudan.

scholarly journals The analysis of high cardiovascular morbidity and mortality in the adult population as a medical and social problem and the search for ways to solve it

2021 ◽  
Vol 20 (1) ◽  
pp. 58-64
Author(s):  
V. P. Kosolapov ◽  
M. V. Yarmonova
Keyword(s):  
Mortality Rate ◽  
Russian Federation ◽  
Social Problem ◽  
Adult Population ◽  
Cardiovascular Morbidity ◽  
Morbidity And Mortality ◽  
High Morbidity ◽  
Demographic Situation ◽  
Voronezh Region ◽  
The Russian Federation

Introduction. The article is devoted to the analysis of the state of cardiovascular morbidity (CVD), mortality of the population and the demographic situation, as well as determining the prevalence of CVD as a medical and social problem at the federal and regional levels. The analysis of the implementation of the policy of providing medical care to patients with CVD, modern scientific publications on the indicated problem, and the search for ways to solve the medical and social problem of high morbidity and mortality from CVD are carried out.Materials and methods. The data of official statistical information on the morbidity and mortality of the adult population of the Russian Federation and the Voronezh region for 2010–2019 were used, the works of modern domestic and foreign scientists dealing with the solution of this problem were studied.Results. It has been established that high CVD and mortality are an acute medical and social problem. Mortality from CVD in Russia in 2019 amount to 46.8% of the total number of deaths. The mortality rate from CVD in Russia exceeds that in the developed countries of the European Union. Despite the presence of positive trends in the fight against this disease, the mortality rate from CVD in the Voronezh region is higher than the average for the Russian Federation (601.8 and 573.2 per 100 thousand population, respectively). The deterioration of the demographic situation, the presence of active targeted projects in this area are the basis for conducting scientific research to find ways to duce CVD and mortality in the adult population.Conclusion. The high morbidity and mortality from CVD requires a search for new ways to solve the problem, since the existing approaches to its solution are not holistic and universal. It is urgent to develop an integrated approach that takes into account the medical and social characteristics of the adult population of the region.

scholarly journals Postoperative Complication and Depression: A Literature Review

2021 ◽  
Vol 1 (2) ◽  
pp. 35-37
Author(s):  
Sendy Aditya Nugraha
Keyword(s):  
Postoperative Pain ◽  
Literature Review ◽  
Depressive Disorders ◽  
Malignant Tumors ◽  
Morbidity And Mortality ◽  
High Morbidity ◽  
Patient Morbidity ◽  
Hospitalization Costs ◽  
History Of ◽  
Persistent Postoperative Pain

Surgical procedure is a significant factor for patients and is associated withdepression. The literature review aims to identify depressive conditions inpatients with a history of postoperative hospitalization. Depressive conditions,anesthesia and surgery can lead to a high increase in patient morbidity andmortality. Major depressive disorder is a common complication, which can leadto increased morbidity and mortality. Depressive disorders can cause patients todevelop certain diseases that occur postoperatively, especially in patients whohave malignant tumors or carcinomas that will undergo surgery. Depression isassociated with cognitive impairment, which is exacerbated by postoperativeevents. There is evidence that postoperative pain is seriously depressing anddepression causes pain to worsen. Depression is also said to be a strong predictorand correlates with persistent postoperative pain. Some studies say depressionis an objective risk factor that can lead to a long recovery after surgery.Depression can also occur in patients admitted to the intensive care unit, whichis associated with high morbidity and mortality rates, thereby increasing thepossibility of additional hospitalization costs.

scholarly journals Analysis of the epidemiological profile of patients with traumas: A literature review

2021 ◽  
Vol 8 (4) ◽  
pp. 202-208
Author(s):  
Gustavo Sousa Andrade ◽  
Daniella Antunes Pereira Rocha ◽  
Bruna Da Silva Gusmão ◽  
Beatriz Sousa Andrade Batista ◽  
Hellen Santos Novas ◽  
...  
Keyword(s):  
Literature Review ◽  
Public Health Problem ◽  
Lower Limbs ◽  
Morbidity And Mortality ◽  
High Morbidity ◽  
The World ◽  
Labor System ◽  
Epidemiological Profile ◽  
Motorcycle Accidents ◽  
The Impact

Trauma is a public health problem, with a high morbidity and mortality profile that generates high costs for health systems all over the world. Several factors can trigger the different types of trauma, which may require specific treatments, often even surgical procedures, and may also cause incapacity for work. In light of this, this research was intended to evaluate the epidemiological profile of patients with traumas in different regions of the world. To this end, a systematic literature review was performed by searching the Scielo database, using the descriptors “trauma” and “epidemiology”, finding a total of 270 articles. Subsequently, filters were applied, which allowed 92 scientific articles to be obtained. The titles and abstracts of these articles were analyzed; and, from that, 15 articles were selected, which were read in full and then discussed. The literature analysis allowed us to characterize the epidemiological profile of traumas in Brazil and in other countries around the world, detecting that most trauma affects men at a young age, which can affect the labor system; that the low level of education can influence the trauma profile; and that factors such as car and motorcycle accidents, falls and physical aggressions are the main etiological factors of cranioencephalic, maxillofacial, thoracic, upper limbs and lower limbs traumas, among others. Thus, there is a need to formulate better preventive measures and pre- and in-hospital treatments, aiming at reducing the impact on trauma morbidity and mortality.

scholarly journals A case report of rare fungal pathogens causing recurrent allergic fungal rhinosinusitis and literature review

2021 ◽  
Vol 104 (4) ◽  
pp. 003685042110535
Author(s):  
Ahmad Alroqi
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Aspergillus Nidulans ◽  
Fungal Pathogen ◽  
Fungal Pathogens ◽  
Relevant Literature ◽  
Initial Presentation ◽  
Morbidity And Mortality ◽  
Fungal Rhinosinusitis ◽  
Allergic Fungal Rhinosinusitis

Allergic fungal rhinosinusitis has been well characterized clinically. We report about a patient diagnosed with allergic fungal rhinosinusitis. Nasal cultures revealed a rare fungal pathogen, Aspergillus nidulans. At the time of initial presentation and later recurrence, another rare fungus was found. Trichoderma are unique and have been described in detail. This report describes unique pathogens causing allergic fungal rhinosinusitis. The relevant literature demonstrates the potential morbidity and mortality due to infections from such organisms, indicating the need for physicians to manage and treat this condition carefully to prevent potential complications.

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