scholarly journals Endometrial Cancer Patients: A Cohort Previous to Changes in Tumour Behaviour and Treatment Strategies

2011 ◽  
Vol 2011 ◽  
pp. 1-6
Author(s):  
F. K. L. Tournois ◽  
H. J. M. M. Mertens
Keyword(s):  
Endometrial Cancer ◽  
Cancer Treatment ◽  
Treatment Strategies ◽  
Patient Characteristics ◽  
National Guidelines ◽  
Treatment Regimens ◽  
Time Period ◽  
New Treatment ◽  
Figo Classification

Nowadays, the incidence of endometrial cancer is rising, especially of high-grade endometrial tumours. Recently, the FIGO classification of endometrial cancer has changed worldwide. Besides that, treatment strategies are changing. The purpose of this study was to analyse the adherence to the national guidelines of cancer treatment and to analyse patterns of disease relapse and survival. We focused on a group of patients () with endometrial cancer, in a time period in which new treatment strategies are not yet completely implemented. Because of multiple upcoming changes in patient characteristics, tumour classification, as well as treatment regimens, a more heterogeneous cohort of patients diagnosed with endometrial cancer will appear. From now on, all those changes will have their effects on the followup of conventional endometrial cancer treatment. In our opinion, it is, therefore, valuable to have the current, more homogenous, cohort clearly described.

scholarly journals Acute Lymphoblastic Leukemia, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology

2021 ◽  
Vol 19 (9) ◽  
pp. 1079-1109
Author(s):  
Patrick A. Brown ◽  
Bijal Shah ◽  
Anjali Advani ◽  
Patricia Aoun ◽  
Michael W. Boyer ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Supportive Care ◽  
Lymphoblastic Leukemia ◽  
Philadelphia Chromosome ◽  
Treatment Strategies ◽  
Adolescent And Young Adult ◽  
Cancer Center ◽  
Nccn Guidelines ◽  
Treatment Regimens

The NCCN Guidelines for Acute Lymphoblastic Leukemia (ALL) focus on the classification of ALL subtypes based on immunophenotype and cytogenetic/molecular markers; risk assessment and stratification for risk-adapted therapy; treatment strategies for Philadelphia chromosome (Ph)-positive and Ph-negative ALL for both adolescent and young adult and adult patients; and supportive care considerations. Given the complexity of ALL treatment regimens and the required supportive care measures, the NCCN ALL Panel recommends that patients be treated at a specialized cancer center with expertise in the management of ALL This portion of the Guidelines focuses on the management of Ph-positive and Ph-negative ALL in adolescents and young adults, and management in relapsed settings.

Endometrial Cancer State of the Science Meeting

2009 ◽  
Vol 19 (1) ◽  
pp. 134-140 ◽  
Author(s):  
Henry C. Kitchener ◽  
Edward L. Trimble
Keyword(s):  
Endometrial Cancer ◽  
Current Knowledge ◽  
Gynecological Cancer ◽  
Treatment Strategies ◽  
List Type ◽  
Uterine Carcinosarcoma ◽  
National Cancer Research Institute ◽  
Key Issues ◽  
New Treatment ◽  
State Of The Science

There is a pressing need to improve our understanding of endometrial cancer (EC) and uterine carcinosarcoma and to develop new treatment strategies to improve outcomes. In recognition of this, a State of the Science meeting on EC was held last November 28 and 29, 2006, in Manchester, United Kingdom. The meeting was cosponsored by the National Cancer Research Institute (UK), the National Cancer Institute (US), and the Gynecological Cancer Intergroup.The objectives of the meeting were as follows: To review current knowledge and understanding of EC and its treatments.To identify key issues for translational research and clinical trials.To identify the most important trials for women with endometrial carcinoma and uterine carcinosarcoma, both those already underway or to be done, for which the Gynecological Cancer Intergroup might facilitate international cooperation.

Adherence to Therapy in Tuberculosis

1997 ◽  
Vol 15 (1) ◽  
pp. 153-184 ◽  
Author(s):  
FELISSA L. COHEN
Keyword(s):  
United States ◽  
Treatment Plan ◽  
Patient Characteristics ◽  
The United States ◽  
Directly Observed Therapy ◽  
Treatment Regimens ◽  
Combination Strategies ◽  
Tb Treatment ◽  
Time Period ◽  
Adherence To Therapy

Tuberculosis (TB) is a leading cause of morbidity and mortality worldwide. In the United States, TB has undergone a resurgence and the appearance of multidrugresistant TB has caused new concerns. A critical part of TB treatment is adherence to the prescribed therapy for a considerable time period. Treatment “failure” is often due to nonadherence. Many factors influence adherence to therapy in TB. This chapter reviews research in the area of adherence to the TB treatment plan in the United States and worldwide. It discusses adherence as an outcome related to treatment regimens such as directly observed therapy, patient characteristics, life and family circumstances, motivation, education, incentives, and combination strategies. Themes across studies are compared and suggestions for successful future studies are identified.

scholarly journals Does the use of the 2009 FIGO classification of endometrial cancer impact on indications of the sentinel node biopsy?

BMC Cancer ◽  
2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Marcos Ballester ◽  
Martin Koskas ◽  
Charles Coutant ◽  
Elisabeth Chéreau ◽  
Jeremy Seror ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Sentinel Node ◽  
Sentinel Node Biopsy ◽  
Node Biopsy ◽  
Figo Classification

scholarly journals Expression Pattern of Leptin and Its Receptors in Endometrioid Endometrial Cancer

2021 ◽  
Vol 10 (13) ◽  
pp. 2787
Author(s):  
Dariusz Boroń ◽  
Robert Nowakowski ◽  
Beniamin Oskar Grabarek ◽  
Nikola Zmarzły ◽  
Marcin Opławski
Keyword(s):  
Endometrial Cancer ◽  
Cancer Treatment ◽  
Expression Profile ◽  
Whole Blood ◽  
Leptin Receptor ◽  
Treatment Strategies ◽  
Enzyme Linked Immunosorbent Assay ◽  
Tissue Samples ◽  
Increased Risk ◽  
Risk Of Cancer

The identification of novel molecular markers and the development of cancer treatment strategies are very important as cancer incidence is still very high. Obesity can contribute to cancer progression, including endometrial cancer. Adipocytes secrete leptin, which, when at a high level, is associated with an increased risk of cancer. The aim of this study was to determine the expression profile of leptin-related genes in the endometrial tissue samples and whole blood of patients. The study material included tissue samples and whole blood collected from 30 patients with endometrial cancer and 30 without cancer. Microarrays were used to assess the expression profile of leptin-related genes. Then, the expression of leptin (LEP), leptin receptor (LEPR), leptin receptor overlapping transcript (LEPROT), and leptin receptor overlapping transcript-like 1 (LEPROTL1) was determined by the Real-Time Quantitative Reverse Transcription Reaction (RT-qPCR). The serum leptin concentration was evaluated using Enzyme-linked immunosorbent assay (ELISA). Leptin and its receptors were overexpressed both at the mRNA and protein levels. Furthermore, there were strong positive correlations between leptin levels and patient Body Mass Index (BMI). Elevated levels of leptin and its receptors may potentially contribute to the progression of endometrial cancer. These observations may be useful in designing endometrial cancer treatment strategies.

CD30/CD30 Ligand and CD40/CD40 Ligand in Malignant Lymphoid Disorders

1999 ◽  
Vol 14 (3) ◽  
pp. 135-143 ◽  
Author(s):  
A. Younes ◽  
A. Carbone
Keyword(s):  
Treatment Strategies ◽  
Cd40 Ligand ◽  
Tnf Receptor ◽  
Lymphoid Malignancies ◽  
New Treatment ◽  
Open The Doors ◽  
Tnf Receptor Family ◽  
Necrosis Factor ◽  
Receptor Family

CD30 and CD40 are members of the tumor necrosis factor (TNF) receptor family. These two receptors have pleiotropic biologic functions including induction of apoptosis and enhancing cell survival. This review will discuss the pattern of expression of these receptors in malignant lymphoid disorders and their prospective ligands. Understanding issues related to these two ligands and their receptors in lymphoid malignancies may help to improve the classification of these diseases and could open the doors for new treatment strategies.

scholarly journals Developing a Machine Learning Tool for Dynamic Cancer Treatment Strategies

2020 ◽  
Vol 34 (10) ◽  
pp. 13742-13743
Author(s):  
Jiaming Zeng
Keyword(s):  
Machine Learning ◽  
Decision Analysis ◽  
Cancer Treatment ◽  
Causal Inference ◽  
Medical Records ◽  
Treatment Strategies ◽  
Decision Support Tool ◽  
Patient Characteristics ◽  
Cancer Therapies ◽  
Support Tool

With the rising number and complexity of cancer therapies, it is increasingly difficult for clinicians to identity an optimal combination of treatments for a patient. Our research aims to provide a decision support tool to optimize and supplant cancer treatment decisions. Leveraging machine learning, causal inference, and decision analysis, we will utilize electronic medical records to develop dynamic cancer treatment strategies that advice clinicians and patients based on patient characteristics, medical history, and etc. The research hopes to bridge the understanding between causal inference and decision analysis and ultimately develops an artificial intelligence tool that improves clinical outcomes over current practices.

Progress in global rollout of new multidrug-resistant tuberculosis treatments

2019 ◽  
Vol 23 (9) ◽  
pp. 996-999 ◽  
Author(s):  
K. Held ◽  
S. McAnaw ◽  
C-Y. Chiang ◽  
A. Trebucq ◽  
C. R. Horsburgh
Keyword(s):  
Treatment Strategies ◽  
Multidrug Resistant ◽  
New Drugs ◽  
Internet Survey ◽  
Treatment Regimens ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Mdr Tb ◽  
Global Increase ◽  
New Treatment

SETTING: The global multidrug-resistant tuberculosis (MDR-TB) epidemic has grown over the past decade and continues to be difficult to manage. In response, new drugs and treatment regimens have been recommended.OBJECTIVE: In 2017 and again in 2018, the International Union Against Tuberculosis and Lung Disease (The Union) drug-resistant (DR) TB Working Group collaborated with RESIST-TB to implement an internet survey to members of The Union around the world to assess access to these new treatment strategies.DESIGN: A nine-question survey was developed using SurveyMonkey®. The survey was open for participation to all members of The Union registered under the TB Section. Two reminders were sent during each survey. The responses were analyzed taking into account the WHO Region to which the respondent belonged.RESULTS: The 2018 survey showed a global increase in implementation of the shorter (9-month) MDR-TB regimen (from 33% to 56% of respondents, P < 0.001) and an increase in the use of bedaquiline and/or delamanid (from 25% to 41% of respondents, P < 0.001) compared to 2017. There were substantial variations in roll-out between WHO regions.CONCLUSION: These results demonstrate improvement in global implementation of the new treatment strategies over a 1-year period.

scholarly journals Ten years of experience with endometrial cancer treatment in a single Brazilian institution: Patient characteristics and outcomes

PLoS ONE ◽  
2020 ◽  
Vol 15 (3) ◽  
pp. e0229543
Author(s):  
Cristina Anton ◽  
Rodolpho Truffa Kleine ◽  
Eric Mayerhoff ◽  
Maria del Pilar Esteves Diz ◽  
Daniela de Freitas ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Treatment ◽  
Patient Characteristics ◽  
Years Of Experience

Molecular classification of endometrial cancers translated into practice

2021 ◽  
Vol 86 (4) ◽  
pp. 258-262
Author(s):  
Jiří Presl ◽  
◽  
Tomáš Vaněček ◽  
Michael Michal ◽  
Jiří Bouda ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Current Knowledge ◽  
Molecular Genetic ◽  
Epidemiological Data ◽  
Molecular Classification ◽  
The Cancer Genome Atlas ◽  
Treatment Regimens ◽  
Molecular Features ◽  
Practice Methods

Summary: Objective: The main objective of the article is to clearly inform healthcare professionals about the newly implemented molecular classification of endometrial cancer into practice. Methods: Summary of current knowledge, recommendations and new procedures relating to molecular genetic examination of the tissues of patients with endometrial carcinoma. Results: Endometrial cancer is currently diagnosed on the base of histopathological morphology. According to the classical Bokhman division, we distinguish between two relatively wide groups of tumors which are different in pathogenesis: type I – estrogen-dependent tumors, clinically usually indolent, and type II – non-endometroid tumors, clinically aggressive, without dependence on estrogen stimulation. This classification fulfills a  didactic purpose and provides easy orientation for epidemiological data, but is not suitable for stratification due to the overlap of clinical, pathological and molecular features. The Cancer Genome Atlas project classifies endometrial tumors into 4  groups based on molecular genetic features. Conclusion: Integration of the histopathological findings along with molecular classification appears to be the best approach for evaluating each individual tumor. This will help to achieve the ideal stratifi cation of patients for treatment regimens.

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