scholarly journals Intermittent Iron Folate Supplementation: Impact on Hematinic Status and Growth of School Girls

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Aditi Sen ◽  
Shubhada Kanani
Keyword(s):  
Body Mass Index ◽  
Folic Acid ◽  
Weekly Dose ◽  
Folate Supplementation ◽  
Standard Methods ◽  
Pubertal Growth ◽  
School Girls ◽  
Iron Folic Acid ◽  
One Year ◽  
The Impact

In view of high iron needs for adolescent growth, this paper studied the impact of daily vs. intermittent (once and twice weekly) iron folic acid (IFA) supplementation on hemoglobin levels and pubertal growth among primary school girls in early adolescence (9–13 years) of Vadodara, India. Methods. Hemoglobin (Hb), height and weight of the girls were assessed using standard methods. In three experimental schools (ES) IFA tablets in a dose of 100 mg Fe+0.5 mg folic acid was given either daily, once weekly or twice weekly for one year. The fourth school (control: CS) did not receive any intervention. Results. Hb levels significantly improved (P<0.01) in all ES compared to CS. Body Mass Index (BMI) increment in ES vs CS was significant (P<0.05) in twice weekly IFA and daily IFA. Within ES groups, mean Hb and BMI increments were comparable between twice weekly IFA and daily IFA. Anemic ES girls showed higher Hb and BMI increments vs. non-anemic girls. Better the Hb response, greater was the benefit on BMI. Conclusion: Twice-weekly IFA supplementation was comparable to daily IFA as regards impact on Hb and growth; at less cost and greater feasibility. Once-weekly dose was inadequate to significantly improve growth.

scholarly journals The impact of antenatal care, iron–folic acid supplementation and tetanus toxoid vaccination during pregnancy on child mortality in Bangladesh

PLoS ONE ◽  
2017 ◽  
Vol 12 (11) ◽  
pp. e0187090 ◽  
Author(s):  
Tanvir Abir ◽  
Felix Akpojene Ogbo ◽  
Garry John Stevens ◽  
Andrew Nicolas Page ◽  
Abul Hasnat Milton ◽  
...  
Keyword(s):  
Folic Acid ◽  
Antenatal Care ◽  
Child Mortality ◽  
Tetanus Toxoid ◽  
Folic Acid Supplementation ◽  
Acid Supplementation ◽  
Iron Folic Acid Supplementation ◽  
Iron Folic Acid ◽  
The Impact

scholarly journals Facebook Powered Measurement and Evaluation for Iron Folic Acid Health Intervention in India

2019 ◽  
Vol 3 ◽  
pp. 1536
Author(s):  
Drew Bernard ◽  
Chris McCullough ◽  
Sarah Francis ◽  
Avery Holton ◽  
Nadia Diamond-Smith
Keyword(s):  
Social Media ◽  
Folic Acid ◽  
Health Sector ◽  
Uttar Pradesh ◽  
Health Intervention ◽  
Change Communication ◽  
Northern India ◽  
Iron Folic Acid ◽  
Measurement And Evaluation ◽  
The Impact

As the media landscape changes and billions of people around the world turn to Facebook, Instagram, WhatsApp, and other social media platforms for information and social interactions, the need to develop effective methods of leveraging social media for social behavior change communication (SBCC) becomes increasingly important. Yet, in order for the public health sector to embrace social media for SBCC, we must have methods for measuring the impact of social media-based SBCC. In this letter, we share a new approach for measurement and evaluation of social media-based SBCC campaigns. The approach was developed as part of an iron-folic acid health intervention targeting young women in two states in northern India; Uttar Pradesh and Maydar Pradesh.

scholarly journals The impact of body mass index on one-year mortality after spinal cord injury

2019 ◽  
pp. 1-9
Author(s):  
Huacong Wen ◽  
Michael J. DeVivo ◽  
Tapan Mehta ◽  
Navneet Kaur Baidwan ◽  
Yuying Chen
Keyword(s):  
Body Mass Index ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Body Mass ◽  
Cord Injury ◽  
One Year ◽  
The Impact

scholarly journals Moderate Folic Acid Supplementation in Pregnant Mice Results in Behavioral Alterations in Offspring with Sex-Specific Changes in Methyl Metabolism

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1716
Author(s):  
Marta Cosín-Tomás ◽  
Yan Luan ◽  
Daniel Leclerc ◽  
Olga V. Malysheva ◽  
Nidia Lauzon ◽  
...  
Keyword(s):  
Folic Acid ◽  
Motor Development ◽  
Methylenetetrahydrofolate Reductase ◽  
Negative Impact ◽  
Folic Acid Supplementation ◽  
Behavioral Alterations ◽  
Folate Supplementation ◽  
Pregnancy And Lactation ◽  
Behavioural Tests ◽  
The Impact

Fifteen to 20% of pregnant women may exceed the recommended intake of folic acid (FA) by more than four-fold. This excess could compromise neurocognitive and motor development in offspring. Here, we explored the impact of an FA-supplemented diet (5× FASD, containing five-fold higher FA than recommended) during pregnancy on brain function in murine offspring, and elucidated mechanistic changes. We placed female C57BL/6 mice for one month on control diets or 5× FASD before mating. Diets were maintained throughout pregnancy and lactation. Behavioural tests were conducted on 3-week-old pups. Pups and mothers were sacrificed at weaning. Brains and livers were collected to examine choline/methyl metabolites and immunoreactive methylenetetrahydrofolate reductase (MTHFR). 5× FASD led to hyperactivity-like behavior and memory impairment in 3-week-old pups of both sexes. Reduced MTHFR protein in the livers of FASD mothers and male pups resulted in choline/methyl metabolite disruptions in offspring liver (decreased betaine) and brain (decreased glycerophosphocholine and sphingomyelin in male pups, and decreased phosphatidylcholine in both sexes). These results indicate that moderate folate supplementation downregulates MTHFR and alters choline/methyl metabolism, contributing to neurobehavioral alterations. Our findings support the negative impact of high FA on brain development, and may lead to improved guidelines on optimal folate levels during pregnancy.

scholarly journals THE IMPACT OF BODY MASS INDEX ON THE ONE YEAR OUTCOME OF PATIENTS TREATED BY PCI WITH BIOLIMUS- AND SIROLIMUS- ELUTING STENTS FROM THE LEADERS TRIAL.

2010 ◽  
Vol 55 (10) ◽  
pp. A198.E1861
Author(s):  
Giovanna Sarno ◽  
Scot Garg ◽  
Yoshinobu Onuma ◽  
Pawel Buszman ◽  
Axel Linke ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
One Year ◽  
The One ◽  
The Impact

scholarly journals Evaluation of the impact of body mass index on warfarin requirements in hospitalized patients

2018 ◽  
Vol 12 (8) ◽  
pp. 207-216 ◽  
Author(s):  
Katie B. Tellor ◽  
Steffany N. Nguyen ◽  
Amanda C. Bultas ◽  
Anastasia L. Armbruster ◽  
Nicholas A. Greenwald ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
International Normalized Ratio ◽  
Hospitalized Patients ◽  
Morbidly Obese ◽  
Weekly Dose ◽  
Obese Patients ◽  
Significant Difference ◽  
Underweight Patients ◽  
The Impact

Background: Despite well established empiric dose adjustments for drug and disease-state interactions, the impact of body mass index (BM) on warfarin remains unclear. The objective of this study is to evaluate warfarin requirements in hospitalized patients, stratified by BMI. Methods: This retrospective review included two cohorts of patients: cohort A (patients admitted with a therapeutic international normalized ratio (INR)) and cohort B (newly initiated on warfarin during hospitalization). Exclusion criteria included: age under 18 years, pregnancy, INR (goal 2.5–3.5), and warfarin thromboprophylaxis post orthopedic surgery. The primary outcome was mean total weekly dose (TWD) of warfarin based on weight classification: underweight (BMI <18 kg/m2), normal/overweight (BMI 18–29.9 kg/m2), obese (BMI 30–39.9 kg/m2), and morbidly obese (BMI ⩾ 40 kg/m2). Data were extracted from two community hospitals in reverse chronologic order during July 2015–June 2013 until both study institutions evaluated 100 patients per cohort in each BMI classification or until all patients had been evaluated within the prespecified timeframe. Results: A total of 585 patients were included in cohort A (26 underweight, 200 normal/overweight, 200 obese, 159 morbidly obese). There was a statistically significant difference in TWD as determined by one-way analysis of variance ( p < 0.05). A Tukey post hoc test revealed a statistically significantly higher TWD in morbidly obese (41.5 mg) compared with underweight (25.6 mg, p < 0.05), normal/overweight (28.8 mg, p < 0.05) and obese patients (32.4 mg, p < 0.05). In cohort B, 379 patients were evaluated (9 underweight, 166 normal/overweight, 152 obese, 52 morbidly obese). Overall, 191 patients had a therapeutic INR on discharge (88.9% underweight, 52.4% normal/overweight, 44.1% obese, 55.8% morbidly obese, p = 0.035). Of those, there was a statistically significant difference in TWD ( p = 0.021) with a higher TWD in the morbidly obese (41 mg) compared with underweight patients (24.4 mg, p = 0.017). Conclusions: Based on the results of this study, morbidly obese patients may require higher TWD to obtain and maintain a therapeutic INR.

scholarly journals Facebook Powered Measurement and Evaluation for Iron Folic Acid Health Intervention in India

2019 ◽  
Vol 3 ◽  
pp. 1536
Author(s):  
Drew Bernard ◽  
Chris McCullough ◽  
Sarah Francis ◽  
Avery Holton ◽  
Nadia Diamond-Smith
Keyword(s):  
Social Media ◽  
Folic Acid ◽  
Health Sector ◽  
Uttar Pradesh ◽  
Health Intervention ◽  
Change Communication ◽  
Northern India ◽  
Iron Folic Acid ◽  
Measurement And Evaluation ◽  
The Impact

As the media landscape changes and billions of people around the world turn to Facebook, Instagram, WhatsApp, and other social media platforms for information and social interactions, the need to develop effective methods of leveraging social media for social behavior change communication (SBCC) becomes increasingly important. Yet, in order for the public health sector to embrace social media for SBCC, we must have methods for measuring the impact of social media-based SBCC. In this letter, we share a new approach for measurement and evaluation of social media-based SBCC campaigns. The approach was developed as part of an iron-folic acid health intervention targeting young women in two states in northern India; Uttar Pradesh and Maydar Pradesh.

Catha Edulis (Khat) Chewing Decreases Serum Levels of Iron, Ferritin and Vitamin B12 and Increases Folic Acid

2014 ◽  
Vol 84 (5-6) ◽  
pp. 223-228
Author(s):  
Waled Al-Dubai ◽  
Jameel Al-Ghazaly ◽  
Molham Al-Habori ◽  
Riyadh Saif-Ali ◽  
Ahmed Mohammed
Keyword(s):  
Body Mass Index ◽  
Folic Acid ◽  
Body Mass ◽  
Serum Iron ◽  
Serum Levels ◽  
Control Group ◽  
Vitamin B ◽  
Catha Edulis ◽  
One Year

Abstract. Background: Catha edulis (Khat) is customarily chewed to attain a state of stimulation and reduce physical fatigue. In view of the reported common adverse effects of Khat, the aim of this study was to evaluate the levels of iron, ferritin, folic acid, vitamin B12 and body mass index (BMI) as nutritive indicators in Yemeni Khat chewers. Methods: This study was a prospective cohort study, carried out on 90 male workers aged 19 - 23 years old; 45 were healthy non-Khat chewers serving as control group and 45 were regular Khat chewers. Serum iron, ferritin, folic acid, vitamin B12 and body mass index were measured at baseline and after a year of follow up. Results: Serum iron and BMI were significantly (p < 0.01) lower at baseline in Khat chewers by 9 % and 6 %, respectively; whereas ferritin, folic acid and vitamin B12 were non-significantly different from non-Khat chewers. In the follow-up one year later, serum iron, ferritin, vitamin B12 and BMI were significantly (p < 0.001) lower in Khat chewers by 19.0, 31.4, 20.6 and 10.7 %; whereas folic acid was significantly (p = 0.007) higher by 26.7 %. Comparison within groups showed serum iron, ferritin, and BMI to be significantly (p < 0.01) decreased after one year in the Khat chewers with respect to its baseline; whereas folic acid significantly (p < 0.001) increased. Conclusion: This study shows Khat chewers to be more susceptible to malnutrition, which should be considered by the general population and the public health authorities.

scholarly journals Genes, folate and homocysteine in embryonic development

2001 ◽  
Vol 60 (1) ◽  
pp. 53-61 ◽  
Author(s):  
Thomas H. Rosenquist ◽  
Richard H. Finnell
Keyword(s):  
Folic Acid ◽  
Normal Development ◽  
Folate Receptor ◽  
Population Based ◽  
Normal Function ◽  
Maternal Serum ◽  
Abnormal Development ◽  
Folate Supplementation ◽  
Developmental Defects ◽  
The Impact

Population-based studies of human pregnancies show that periconceptional folate supplementation has a significant protective effect for embryos during early development, resulting in a significant reduction in developmental defects of the face, the neural tube, and the cono-truncal region of the heart. These results have been supported by experiments with animal models. An obvious quality held in common by these three anatomical regions is that the normal development of each region depends on a set of multi-potent cells that originate in the mid-dorsal region of the neural epithelium. However, the reason for the sensitive dependence of these particular cells on folic acid for normal development has not been obvious, and there is no consensus about the biological basis of the dramatic rescue with periconceptional folate supplementation. There are two principal hypotheses for the impact of folate insufficiency on development; each of these hypotheses has a micronutrient component and a genetic component. In the first hypothesis the effect of low folate is direct, limiting the availability of folic acid to cells within the embryo itself; thus compromising normal function and limiting proliferation. The second hypothetical effect is indirect: low folate disrupts methionine metabolism; homocysteine increases in the maternal serum; homocysteine induces abnormal development by inhibiting the function of N-methyl-D-aspartate (NMDA) receptors in the neural epithelium. There are three general families of genes whose level of expression may need to be considered in the context of these two related hypotheses: folate-receptor genes; genes that regulate methionine– homocysteine metabolism; NMDA-receptor genes.

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