scholarly journals Artritis Psoriatika

2021 ◽  
Vol 1 (12) ◽  
pp. 868-883
Author(s):  
Faris Rizki Ardhan ◽  
Muhammad Akbar Hanardi ◽  
Dhila Thasliyah ◽  
Visakha Vidyadevi Wiguna ◽  
Ni Putu Yunandari
Keyword(s):  
Risk Factors ◽  
Psoriatic Arthritis ◽  
Pharmacological Treatment ◽  
Structural Damage ◽  
Ideal Body Weight ◽  
Pharmacological Therapy ◽  
The Body ◽  
Physical Trauma ◽  
Treatment And Prevention

To know the risk factors, pharmacological treatment and prevention of psoriatic arthritis. Psoriatic arthritis is a chronic musculoskeletal disease associated with psoriasis. at least 5% of psoriasis patients develop psoriatic arthritis. Globally, the incidence of PsA reaches 133 per 100,000 patient subjects. The annual incidence of PsA is about 2.7 cases per 100 people diagnosed with psoriasis. In Asia, PsA cases increased from 2000 to 2013 with a prevalence (per 100,000 population) of 11.12 to 37.75. Based on a study at Sanglah Hospital Bali found PsA patients as much as 6.3% of psoriasis patients. PsA patients may have clinical features such as peripheral arthritis, enthesitis, dactylitis, skin, nail, and axial involvement. Risk factors for psoriatic arthritis include obesity, physical trauma, smoking, location of psoriasis in the body, education level and genetic factors. Pharmacological treatment of PsA based on the latest guidelines from EULAR 2019 and ACR recommendations. These two guidelines discuss pharmacological treatment based on the patient's clinical picture. The goal of pharmacological therapy is to improve the patient's quality of life by improving symptomatic complaints and preventing structural damage. As a prevention, PsA maintains an ideal body weight, reduces cigarette consumption, and performs detection as an early detection.

scholarly journals Detection of subclinical skin manifestation in patients with psoriasis and psoriatic arthritis by fluorescence optical imaging

2020 ◽  
Author(s):  
Angelique Schmidt ◽  
Anne-Marie Glimm ◽  
Ida Kristin Haugen ◽  
Paula Hoff ◽  
Gabriela Schmittat ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Weight ◽  
Psoriatic Arthritis ◽  
Optical Imaging ◽  
Correct Diagnosis ◽  
Skin Inflammation ◽  
The Body ◽  
Healthy Controls ◽  
Healthy Individuals ◽  
Fluorescence Optical Imaging

Abstract Objectives: To investigate the frequency of subclinical skin inflammation in both hands by fluorescence optical imaging (FOI) in patients with psoriasis/psoriatic arthritis (Pso/PsA) vs. rheumatoid arthritis (RA) and healthy individuals, and to correlate these findings with cardiovascular (CV) risk factors.Patients and Methods: The FOI scans were analyzed retrospectively to detect clinically invisible skin enhancement (0-3 scale) in both hands without relationship to underlying joints or blood vessels. We further characterized the FOI patterns and sorted the scans into groups based on the assumed diagnosis (Pso/PsA, RA and healthy controls), which was compared with the physician’s diagnosis. Furthermore, the associations between CV risk factors and imaging findings were investigated by regression analyses.Results: We included FOI scans of patients with Pso/PsA (n=80), RA (n=78) and healthy controls (n=25). Subclinical skin enhancement on the back of their hands was more common in Pso/PsA (72.5%) than in RA patients (20.5%) and healthy individuals (28.0%) (p<0.001). Based on the FOI pattern, the majority of patients with Pso/PsA (72.5%), RA (76.9%) and healthy controls (68.0%) were classified correctly using the physician-based diagnosis as reference (overall agreement of 74%, kappa=0.57). No CV risk factors except body weight (kg) was associated with subclinical skin enhancement (OR 1.04, 95% CI 1.02-1.06; p<0.001). Conclusion: Subclinical subdermal skin inflammation was common in Pso/PsA patients using FOI. Based on the FOI pattern, most patients with Pso/PsA and were classified with the correct diagnosis. We demonstrated an important influence of the body weight on our FOI results. FOI may be a helpful novel tool to study microcirculation in rheumatic diseases with skin involvement.

Biomarkers in Psoriasis and Psoriatic Arthritis: GRAPPA 2008

2010 ◽  
Vol 37 (2) ◽  
pp. 462-467 ◽  
Author(s):  
CHRISTOPHER T. RITCHLIN ◽  
ABRAR A. QURESHI ◽  
KURT de VLAM ◽  
COSTANTINO PITZALIS ◽  
PHILIP S. HELLIWELL ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Psoriatic Arthritis ◽  
Structural Damage ◽  
Joint Damage ◽  
Disease Process ◽  
London School ◽  
University Hospitals ◽  
School Of Medicine ◽  
Translational Approach

Biomarkers can provide valuable insights into disease susceptibility and natural history and may serve as surrogate endpoints for a variety of different outcomes. At the 2008 annual meeting of GRAPPA (Group for Research and Assessment of Psoriasis and Psoriatic Arthritis), members were updated on the development of biomarkers in psoriatic arthritis (PsA). Plenary presentations included a translational approach to biomarker development (Christopher Ritchlin, University of Rochester, NY, USA), biomarkers for psoriasis (Abrar Qureshi, Harvard Medical School, MA, USA), new data on biomarkers for damage in PsA (Kurt de Vlam, University Hospitals Leuven, Belgium), and design considerations for a longitudinal study of joint damage being undertaken under the OMERACT umbrella with colleagues working on rheumatoid arthritis and ankylosing spondylitis (Costantino Pitzalis, Barts and the London School of Medicine, London, UK; Oliver FitzGerald, St. Vincent’s Hospital, Dublin, Ireland). At the conclusion of this session, the meeting attendees discussed specific design issues of the proposed longitudinal study, including study duration, disease process core domains, and the instruments to be used in recording enthesitis, dactylitis, nail involvement, quality of life and structural damage. The appearance of new therapeutic options in PsA raises the need for sensitive biomarkers for both disease activity and outcome.

scholarly journals Detection of Subclinical Skin Manifestation in Patients With Psoriasis and Psoriatic Arthritis by Fluorescence Optical Imaging

2020 ◽  
Author(s):  
Angelique Schmidt ◽  
Anne-Marie Glimm ◽  
Ida Kristin Haugen ◽  
Paula Hoff ◽  
Gabriela Schmittat ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Weight ◽  
Psoriatic Arthritis ◽  
Optical Imaging ◽  
Correct Diagnosis ◽  
Skin Inflammation ◽  
The Body ◽  
Healthy Controls ◽  
Healthy Individuals ◽  
Fluorescence Optical Imaging

Abstract Objectives:To investigate the frequency of subclinical skin inflammation in both hands by fluorescence optical imaging (FOI) in patients with psoriasis/psoriatic arthritis (Pso/PsA) vs. rheumatoid arthritis (RA) and healthy individuals, and to correlate these findings with cardiovascular (CV) risk factors.Patients and Methods:The FOI scans were analyzed retrospectively to detect clinically invisible skin enhancement (0-3 scale) in both hands without relationship to underlying joints or blood vessels. We further characterized the FOI patterns and sorted the scans into groups based on the assumed diagnosis (Pso/PsA, RA and healthy controls), which was compared with the physician’s diagnosis. Furthermore, the associations between CV risk factors and imaging findings were investigated by regression analyses.Results:We included FOI scans of patients with Pso/PsA (n=80), RA (n=78) and healthy controls (n=25). Subclinical skin enhancement on the back of their hands was more common in Pso/PsA (72.5%) than in RA patients (20.5%) and healthy individuals (28.0%) (p<0.001). Based on the FOI pattern, the majority of patients with Pso/PsA (72.5%), RA (76.9%) and healthy controls (68.0%) were classified correctly using the physician-based diagnosis as reference (overall agreement of 74%, kappa=0.57). No CV risk factors except body weight (kg) was associated with subclinical skin enhancement (OR 1.04, 95% CI 1.02-1.06; p<0.001).Conclusion:Subclinical subdermal skin inflammation was common in Pso/PsA patients using FOI. Based on the FOI pattern, most patients with Pso/PsA and were classified with the correct diagnosis. We demonstrated an important influence of the body weight on our FOI results. FOI may be a helpful novel tool to study microcirculation in rheumatic diseases with skin involvement.

scholarly journals The Burden of Pharmacological Treatment on Health-Related Quality of Life in People with a Urea Cycle Disorder – A Qualitative Study

2020 ◽  
Author(s):  
Gillian Yeowell ◽  
Danielle Burns ◽  
Francis Fatoye
Keyword(s):  
Quality Of Life ◽  
Psychological Health ◽  
Pharmacological Treatment ◽  
Urea Cycle ◽  
The Body ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
The Impact

Abstract Background Urea cycle disorders (UCD) are a group of conditions of inborn errors of metabolism, typically presenting neonatally. Excess ammonia builds rapidly within the body, risking hyperammonemic episodes and potentially death. Long-term management of the condition includes restrictive protein consumption, pharmacological interventions and, in extreme cases, liver transplantation. Pharmacological treatments such as sodium benzoate and sodium phenylbuturate have proven effective but not without a multitude of negative attributes including poor taste, elevated volume and associated gastrointestinal discomfort that impacts on health-related quality of life. Glycerol phenylbutyrate (GPB) has recently become a widely available pharmacological treatment with early reports of improved qualities. The following study aims to explore the burden of pharmacological treatment on health-related quality of life in people with a UCD. Results 9 carers of people living with a UCD were interviewed regarding their experiences of pharmacological treatment in relation to their, and their dependent’s health-related quality of life after transitioning to GPB. Three main themes were identified following data analysis: psychological health, physical health and social participation. Carers struggled with anxiety surrounding their dependent’s condition and the relentless battle of administering medication. Medication administration was perceived to have improved since the transition to GPB, alleviating distress for both carer and dependent. Issues involving schooling were commonly described, ranging from difficulties integrating their dependent into mainstream schooling and the impact of treatment on participation in school and extracurricular activities. Based upon participant’s experiences, it could be suggested that some burden had been relieved by the transition to GPB. However, it appeared that the burden would persist despite treatment, owing to the continuing nature of the condition. Conclusions Adhering to a strict pharmacological regime caused immense stress for both carers and dependents, severely impacting on typical social activities such as eating at a restaurant or going on holiday. GPB was perceived to have alleviated some burden in terms of administration. Practitioners should consider these findings when making clinical decisions for UCD patients and the effect of pharmacological treatment on health-related quality of life. Emotional support resources should be made readily available to families to assist with daily living.

Risk factors for occurrence and development of ulcerative keratitis in dogs

2020 ◽  
pp. 34-35
Author(s):  
Anastasia V. Chechneva ◽  
Keyword(s):  
Risk Factors ◽  
Corneal Ulcer ◽  
Pathological Process ◽  
The Body ◽  
Adequate Treatment ◽  
Root Cause ◽  
Corneal Vascularization ◽  
Ulcerative Lesions ◽  
Ulcerative Keratitis

Ulcerative keratitis (corneal ulcer) is an inflammatory infected condition of the cornea with a violation of its epithelial layer, affecting the stroma. Due to the fact that the cornea is a tightly innervated tissue of the body, its damage is associated with the appearance of symptoms of varying intensity: hyperemia of the conjunctiva, blepharospasm, the corneal vascularization, a decrease or increase in tear production, the formation of superficial or deep sections of corneal epithelialization, depending on the severity and the duration of the pathological process. The causes of ulcerative keratitis are also diverse: corneal injuries, chronic conjunctivitis, dry keratoconjunctivitis, anomalies of the eyelids, brachiocephalic syndrome. The danger of ulcerative lesions of the cornea is due to their necrotic effect on eye tissue, possible perforation of the eyeball, the development of secondary glaucoma or uveitis, as well as panophthalmitis. It is necessary to establish risk factors for the occurrence and development of ulcerative keratitis in dogs to prevent this pathology in the future, since in the absence of timely diagnosis and treatment, the disease can progress and lead to impaired vision of the animal, thereby lowering the level of their quality of life. Determining the root cause of corneal ulcerative lesions is necessary to understand the possible outcome and relapse of the pathology, as well as the appointment of adequate treatment. Prevention and relief of the etiological factor of the disease and timely prescribed therapy lead to a decrease in the risk of development and complications of ulcerative keratitis.

scholarly journals Long-term consequences of surgical treatment of ovarian apoplexy

2021 ◽  
Vol 4 ◽  
pp. 93-98
Author(s):  
O.M. Ishak
Keyword(s):  
Risk Factors ◽  
Surgical Treatment ◽  
Postoperative Period ◽  
Reproductive System ◽  
Reproductive Function ◽  
Natural Resistance ◽  
Treatment And Prevention ◽  
Long Term Consequences

The objective: to determine the long-term consequences of surgical treatment of ovarian apoplexy, taking into account the risk factors of this urgent pathology.Materials and methods. The study included 112 women (main group, n=112), who underwent surgery for ovarian apoplexy, and 40 patients in the control group (n=40), who had no history of this pathology. All patients underwent a comprehensive examination using clinical, instrumental and laboratory research methods. The groups were homogeneous in age (mean age was 23,6±4,2) and statistically comparable.Results. Based on the analysis of clinical and anamnestic data of patients who underwent surgical treatment of ovarian apoplexy, we identified the main risk factors for this pathology: chronic diseases of the urinary, respiratory and digestive systems, genital infantilism, ovarian retention cysts, chronic salpingo-oophoritis, , menstrual disorders by type of hyperpolymenorrhea and/or algodysmenorrhea, family thrombophilic history, bleeding of various localizations in the anamnesis, artificial abortions, weight loss, smoking.Our proposed comprehensive two-stage rehabilitation system included treatment and prevention measures from the acute period of ovarian apoplexy to the time of reproductive function. The first stage of the treatment complex (early postoperative period) helped to eliminate the effects of ovarian injury, pain relief and hypercoagulable changes in the blood coagulation system, improving the quality of life during inpatient treatment. The second stage (2 months after surgery) provided the restoration of ovarian function and balance of the hemostasis system, thus preparing a woman’s reproductive system for future pregnancy and childbirth. In the remote postoperative period, the complex stage of rehabilitation in 23 treated patients resulted in the birth of healthy children and the absence of obstetric complications in 22 of them.Conclusion. Identification and structuring of risk factors for ovarian apoplexy is an important step for comprehensive treatment and prevention of recurrence of this disease. Eliminating or reducing the impact of these factors will help restore the reproductive system and improve quality of life.A comprehensive assessment of the state of the whole organism in the remote postoperative period indicates the need for rehabilitation measures aimed at increasing the natural resistance of the macroorganism and the effective restoration of reproductive function.

scholarly journals COMPLICATIONS OF CERVICAL SPINE SURGERY. RISK FACTORS AND PREVENTIVE STRATEGIES

2017 ◽  
Vol 8 (2) ◽  
pp. 56-60
Author(s):  
A A Grin ◽  
D S Kasatkin
Keyword(s):  
Risk Factors ◽  
Cervical Spine ◽  
Postoperative Mortality ◽  
Preventive Strategies ◽  
Unified Approach ◽  
Cervical Spine Surgery ◽  
Treatment And Prevention ◽  
Number Of Patients ◽  
Causes Of Errors

According to numerous studies, the percentage of complications after operations on the cervical spine is up to 27.0%, the number of patients requiring re-intervention - to 10.7%. Postoperative mortality is 0.26% [1-10]. The identification and study of the effect of the most important risk factors and their combinations on the frequency and severity of postoperative complications, an analysis of the causes of errors made during surgery or at the stage of planning, and the formation of a unified approach to solving the problem of timely diagnosis, treatment and prevention will reduce the number of complications and improve the quality of surgical treatment of patients with diseases and trauma of the cervical spine on subaxial level.

Study on the Automotive Body Collision Damage and the Repair Method

2014 ◽  
Vol 538 ◽  
pp. 146-149
Author(s):  
Hao Tao He ◽  
Shu Zhan Chang
Keyword(s):  
Structural Damage ◽  
Repair Process ◽  
The Body ◽  
Body Structure ◽  
Automotive Body ◽  
Damage Repair ◽  
Safety And Reliability ◽  
3D Measurement System ◽  
Body Damage

In order to improve the repair quality and efficiency of automotive body collision damage, and ensure the safety and reliability of the automobile after repairing, the paper discusses the integral body deformation characteristics based on the analysis of automobile impact force. Aiming at structural damage of integral body, the paper makes body damage repair process, analyzes the main factors which affect the body fixed and measurement, and puts forward a method which uses a multi-point pulling and the computer 3D measurement system to repair the damage. Finally, the validity of the method is verified by the collision case. The results show that the method can effectively control the position deviation of the body structure not more than 3mm, it can also improve the repair quality of automotive collision and reduce reworking rates effectively.

scholarly journals The Immunomodulatory Effects of Mesenchymal Stem Cells in Prevention or Treatment of Excessive Scars

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Bommie Florence Seo ◽  
Sung-No Jung
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cell Therapy ◽  
The Body ◽  
Joint Mobility ◽  
Immunomodulatory Effects ◽  
Treatment And Prevention ◽  
Keloid Formation ◽  
Prevention Methods

Excessive scars, including keloids and hypertrophic scars, result from aberrations in the process of physiologic wound healing. An exaggerated inflammatory process is one of the main pathophysiological contributors. Scars may cause pain, and pruritis, limit joint mobility, and cause a range of cosmetic deformities that affect the patient’s quality of life. Extensive research has been done on hypertrophic scar and keloid formation that has resulted in the plethora of treatment and prevention methods practiced today. Mesenchymal stem cells, among their multifunctional roles, are known regulators of inflammation and have been receiving attention as a major candidate for cell therapy to treat or prevent excessive scars. This paper extensively reviews the body of research examining the mechanism and potential of stem cell therapy in the treatment of excessive scars.

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