A case-control study of autonomic function tests in male cigarette smokers and healthy control subjects

Abstract Background Evidence for periconceptional or prenatal environmental risk factors for the development of congenital diaphragmatic hernia (CDH) is still scarce. Here, in a case-control study we investigated potential environmental risk factors in 199 CDH patients compared to 597 healthy control newborns. Methods The following data was collected: time of conception and birth, maternal BMI, parental risk factors such as smoking, alcohol or drug intake, use of hairspray, contact to animals and parental chronic diseases. CDH patients were born between 2001 and 2019, all healthy control newborns were born in 2011. Patients and control newborns were matched in the ratio of three to one. Results Presence of CDH was significantly associated with maternal periconceptional alcohol intake (odds ratio = 1.639, 95% confidence interval 1.101–2.440, p = 0.015) and maternal periconceptional use of hairspray (odds ratio = 2.072, 95% confidence interval 1.330–3.229, p = 0.001). Conclusion Our study suggests an association between CDH and periconceptional maternal alcohol intake and periconceptional maternal use of hairspray. Besides the identification of novel and confirmation of previously described parental risk factors, our study underlines the multifactorial background of isolated CDH.

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Analysis of glutathione S-transferase genes polymorphisms and the risk of schizophrenia in a sample of Iranian population

Neuron Glia Biology ◽

10.1017/s1740925x12000130 ◽

2011 ◽

Vol 7 (2-4) ◽

pp. 199-203 ◽

Cited By ~ 7

Author(s):

Farah Lotfi Kashani ◽

Dor Mohammad Kordi-Tamandani ◽

Roya Sahranavard ◽

Mohammad Hashemi ◽

Farzaneh Kordi-Tamandani ◽

...

Keyword(s):

Genomic Dna ◽

Case Control Study ◽

Gene Interaction ◽

Case Control ◽

Glutathione S Transferase ◽

Chain Reaction ◽

Healthy Control ◽

Glutathione S Transferases ◽

Polymerase Chain ◽

Control Study

Glutathione S-transferases (GSTs) are major intracellular antioxidants, which, impaired in their function, are involved in the progress of schizophrenia (SCZ). The aim of this case-control study was to investigate the association between the polymorphism of glutathione S-transferases M1 (GSTM1), T1 (GSTT1), the glutathione S-transferase P1 gene (GSTP1) and SCZ. We isolated genomic DNA from peripheral blood of 93 individuals with SCZ and 99 healthy control subjects' genotypes analyzing them for GSTM1, GSTT1 and GSTP1 using polymerase chain reaction. The analysis of the gene–gene interaction between GSTs indicated that the magnitude of the association was greater for the combined AG/GSTT1 & GSTM1 genotypes (OR = 2.51; 95% CI: 1.13–5.63, P = 0.02). The AG and combined AG + GG genotypes of GSTP1 increased the risk of SCZ (OR = 1.83; 95% CI: 0.94–3.75 and OR = 1.71; 95% CI: 0.92–3.19, respectively). The genotypes of GSTT/NULL, NULL/GSTM and NULL/NULL increased the risk of SCZ (OR = 2.05; 95% CI: 0.9–4.74; OR = 2.0; 95% CI: 1.68–2.31; and OR = 1.8; 95% CI: 0.57–2.46, respectively). The present study supports previous data that suggest that impairment in the function of GSTs genes may increase the risk of SCZ.

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Comparison Of Lung Function Tests Between Healthy And Asthmatic Individuals

BioSight ◽

10.46568/bios.v1i2.6 ◽

2020 ◽

Vol 1 (2) ◽

pp. 6-10

Author(s):

Hira Liaquat ◽

Tabinda Najeeb ◽

Rahima Aftab ◽

Tayyaba Kazmi ◽

Padma Rathore ◽

...

Keyword(s):

Healthy Subjects ◽

Case Control Study ◽

Pulmonary Function Tests ◽

Case Control ◽

Asthmatic Patients ◽

Function Tests ◽

Lower Lung ◽

Medical University ◽

Control Study ◽

Asthmatic Case

Background: Comparison of pulmonary function tests (PFTs) were achieved between asthmatic case and Controls. Materials & Methods: Case-control study conducted at Baqai Medical University (50 cases and 50 control). PFTs in both the participants were estimated by spirometry; FEC, FEV1 and their ratios were estimated. Results: According to the findings all spirometric values were lower in asthmatic patients as compared to healthy subjects. Moreover the asthamatic subjects had lower lung values when compared with healthy subjects. Conclusion: The current study evaluated spirometric values in asthmatic patients in Gadap area. This study's findings can be applied to the treatment of asthma in people of all ages.

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Case-control study of 24 hour ambulatory blood pressure in patients with obstructive sleep apnoea and normal matched control subjects

Thorax ◽

10.1136/thorax.55.9.736 ◽

2000 ◽

Vol 55 (9) ◽

pp. 736-740 ◽

Cited By ~ 139

Author(s):

C. W H Davies

Keyword(s):

Blood Pressure ◽

Obstructive Sleep Apnoea ◽

Ambulatory Blood Pressure ◽

Case Control Study ◽

Matched Control ◽

Case Control ◽

Sleep Apnoea ◽

Control Subjects ◽

Obstructive Sleep ◽

Control Study

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Carotid ultrasound findings in rheumatoid arthritis and control subjects: A case-control study

International Journal of Rheumatic Diseases ◽

10.1111/1756-185x.13377 ◽

2018 ◽

Vol 22 (1) ◽

pp. 25-31 ◽

Cited By ~ 6

Author(s):

Martin I. Wah-Suarez ◽

Dionicio A. Galarza-Delgado ◽

Jose R. Azpiri-Lopez ◽

Iris J. Colunga-Pedraza ◽

Estefania E. Abundis-Marquez ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Case Control Study ◽

Case Control ◽

Carotid Ultrasound ◽

Control Subjects ◽

Ultrasound Findings ◽

And Control ◽

Control Study

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Case Control Study of Cerebrovascular Damage Defined by Magnetic Resonance Imaging in Patients with OSA and Normal Matched Control Subjects

SLEEP ◽

10.1093/sleep/24.6.715 ◽

2001 ◽

Vol 24 (6) ◽

pp. 715-720 ◽

Cited By ~ 46

Author(s):

Christopher W.H. Davies ◽

Joy H. Crosby ◽

Rebecca L. Mullins ◽

Zoë C. Traill ◽

Philip Anslow ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Case Control Study ◽

Matched Control ◽

Case Control ◽

Resonance Imaging ◽

Control Subjects ◽

Control Study

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Pronounced risk of nontraumatic osteonecrosis of the femoral head among cigarette smokers who have never used oral corticosteroids: a multicenter case–control study in Japan

Journal of Orthopaedic Science ◽

10.1007/s00776-012-0293-x ◽

2012 ◽

Vol 17 (6) ◽

pp. 730-736 ◽

Cited By ~ 16

Author(s):

Shinji Takahashi ◽

Wakaba Fukushima ◽

Yoshio Hirota ◽

Hiroaki Nakamura ◽

Toshikazu Kubo ◽

...

Keyword(s):

Femoral Head ◽

Case Control Study ◽

Case Control ◽

Cigarette Smokers ◽

Oral Corticosteroids ◽

Control Study

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IKZF1 genetic variants rs4132601 and rs11978267 and acute lymphoblastic leukemia risk in Tunisian children: a case-control study

BMC Medical Genetics ◽

10.1186/s12881-019-0900-1 ◽

2019 ◽

Vol 20 (1) ◽

Cited By ~ 1

Author(s):

Sana Mahjoub ◽

Vera Chayeb ◽

Hedia Zitouni ◽

Rabeb M. Ghali ◽

Haifa Regaieg ◽

...

Keyword(s):

Acute Lymphoblastic Leukemia ◽

Case Control Study ◽

Lymphoblastic Leukemia ◽

Case Control ◽

Snp Genotyping ◽

Control Subjects ◽

False Discovery ◽

Increased Risk ◽

The Common ◽

Control Study

Abstract Background Associations between IKZF1 gene variants and Acute Lymphoblastic Leukemia (ALL) was recently reported. We examined whether the common IKZF1 polymorphisms rs4132601 T/G and rs111978267 A/G are associated with ALL among a Tunisian pediatric cohort. Methods This case-control study involved 170 patients with ALL and 150 control subjects. SNP genotyping was performed by TaqMan® SNP Genotyping Assay. Results The minor allele G of IKZF1 gene polymorphism rs4132601 T/G was significantly higher in ALL cases than in control subjects (P = 0.029), with 1.54-fold increased risk of ALL. The association of rs4132601 with ALL was seen under co-dominant (P = 0.009), recessive (P = 0.006), and additive (P = 0.027) genetic models, of which the co-dominant (P = 0.027) and recessive (P = 0.027) association remained significant after adjusting for covariates, and False Discovery Rate correction. In contrast, no association was noted for rs111978267 variant. Two-locus (rs4132601-rs11978267) IKZF1 haplotype analysis demonstrated association of GA (P = 0.053), with increased ALL risk [OR (95% CI) = 1.58 (1.00–2.51)], which remained significant after controlling for key covariates [aP = 0.046; aOR (95% CI) = 1.61 (1.01–2.57)]. Conclusion We demonstrated the association of IKZF1 polymorphism rs4132601 T/G with increased risk of ALL among Tunisian pediatric cohort, with altered phenotypic changes among ALL patients.

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