A Cross-sectional Study on Hepatoprotective agents and Antimicrobials in Treatment of Liver Diseases

Serum cytokine levels were explored in a combined group of patients with autoimmune liver diseases (AILDs) and separately in patients with autoimmune hepatitis (AIH) and overlap syndrome. Overall, 60 patients with AILD, among them 32 patients with AIH and 28 patients with overlap syndrome, were included in the cross-sectional study. Serum cytokine levels were measured at baseline and compared to those of 21 healthy controls. Patients with AILD had significantly higher levels of IL-6 (0.70 (range 0.17–99.86) in patients with AILD compared to 0.40 (range 0.14–2.65) in controls,p<0.01), IL-8 (1.66 (0.45–34.58) versus 0.53 (0.35–2.38), resp.,p<0.01), and TNF-α(2.61 (0.23–120.88) versus 1.65 (0.21–7.54), resp.,p<0.01). Adjusted logistic regression analysis revealed a pronounced relation of IL-8 and AILD, 48.36 (3.63–643.60), as well as AIH, 18.54 (1.08–318.54), and overlap syndrome, 23.85 (2.37–240.23), while the associations between the level of other cytokines and AILD were assessed as nonsignificant. In the language of absolute numbers, the increase of IL-8 serum level by 1 pg/mL had increased the chance for a patient to find himself in a group of AILD by 48.36 times. Also, high IL-8 serum levels were strongly related to clinical parameters.

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Change in hepatitis C virus positivity among needle-stick injury source patients: a 10-year experience in a Japanese tertiary hospital

BMC Infectious Diseases ◽

10.1186/s12879-021-06117-4 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Kazuya Okushin ◽

Rie Suzuki ◽

Takeya Tsutsumi ◽

Koh Okamoto ◽

Kazuhiko Ikeuchi ◽

...

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Liver Diseases ◽

Tertiary Care ◽

Cross Sectional Study ◽

Hcv Rna ◽

Care Hospital ◽

Sectional Study ◽

Cross Sectional ◽

Needle Stick

Abstract Background As a blood-borne pathogen, hepatitis C virus (HCV) has long been a major threat associated with needle-stick injuries (NSIs) mainly because no vaccine is available for HCV. Following an NSI, we usually test the source patient for HCV antibody (HCV-Ab). Since HCV-Ab positivity does not necessarily indicate current infection, HCV RNA is further examined in patients positive for HCV-Ab. Direct-acting antivirals (DAAs) have enabled us to treat most HCV-infected patients; therefore, we speculate that the rate of HCV RNA positivity among HCV-Ab-positive patients decreased after the emergence of DAAs. This cross-sectional study was performed to investigate the change in the actual HCV RNA positivity rate in source patients before and after the interferon (IFN)-free DAA era. Methods This was a cross-sectional study of NSI source patients at a tertiary academic hospital in Japan from 2009 to 2019. IFN-free DAA regimens were first introduced in Japan in 2014. Accordingly, we compared HCV status of NSI source patients that occurred between 2009 and 2014 (the era before IFN-free DAAs) with those that occurred between 2015 and 2019 (the era of IFN-free DAAs) in a tertiary care hospital in Japan. Results In total, 1435 NSIs occurred, and 150 HCV-Ab-positive patients were analyzed. The proportion of HCV RNA-positive patients significantly changed from 2009 through 2019 (p = 0.005, Cochran–Armitage test). Between 2009 and 2014, 102 source patients were HCV-Ab-positive, 78 of whom were also positive for HCV RNA (76.5%; 95%CI, 67.4–83.6%). Between 2015 and 2019, 48 patients were HCV-Ab-positive, 23 of whom were also positive for HCV RNA (47.9%; 95%CI, 34.5–61.7%; p = 0.0007 compared with 2009–2014). In the era of IFN-free DAAs, 9 of 23 HCV RNA-negative patients (39.1%) and 2 of 22 HCV RNA-positive patients (9.1%) were treated with an IFN-free combination of DAAs (p = 0.0351). Regarding the departments where NSIs occurred, HCV RNA-negative patients were predominant in departments not related to liver diseases in the era of IFN-free DAAs (p = 0.0078, compared with 2009–2014). Conclusions Actual HCV RNA positivity in source patients of NSIs decreased after the emergence of IFN-free DAAs. IFN-free DAAs might have contributed to this reduction, and HCV RNA-negative patients were predominant in departments not related to liver diseases in the era of IFN-free DAAs.

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A cross-sectional study on occurrence of type 2 diabetes among patients admitted with chronic liver diseases in a medical college in Kolkata

International Journal of Medicine and Public Health ◽

10.4103/2230-8598.109321 ◽

2013 ◽

Vol 3 (1) ◽

pp. 44 ◽

Cited By ~ 2

Author(s):

Shuvankar Mukherjee ◽

BiswanathSharma Sarkar ◽

KaushikKumar Das ◽

Arka Banerjee

Keyword(s):

Type 2 Diabetes ◽

Liver Diseases ◽

Cross Sectional Study ◽

Chronic Liver ◽

Sectional Study ◽

Chronic Liver Diseases ◽

Cross Sectional ◽

Medical College

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Evaluation of Mortality Risk in Liver Cirrhosis with Albumin- Bilirubin (Albi), Platelet-Albumin-Bilirubin (Palbi), and Fibrosis-4 (Fib-4) Scores

Biomedical & Pharmacology Journal ◽

10.13005/bpj/2200 ◽

2021 ◽

Vol 14 (02) ◽

pp. 985-991

Author(s):

D.A. Sindhughosa ◽

I.K. Mariadi ◽

I.D.N. Wibawa ◽

I.G.A. Suryadarma ◽

N. Purwadi ◽

...

Keyword(s):

Liver Cirrhosis ◽

Liver Disease ◽

Mortality Risk ◽

Liver Diseases ◽

Cross Sectional Study ◽

Meld Score ◽

Sectional Study ◽

Cross Sectional ◽

End Stage Liver Disease ◽

End Stage

Background:The model for end stage liver disease (MELD) score considered as a reliable predictor of survival for advanced liver diseases patients. Among several chemistry laboratorium examinations, albumin, bilirubin and platelet reflect the function of the liver. Objectives: To investigate the correlation of albumin-bilirubin (ALBI), platelet-albumin-bilirubin (PALBI), and fibrosis-4 (FIB-4) scores with mortality risk based on MELD score and evaluate their role in predictingcirrhosis mortality risk. Methods: The analytic cross-sectional study designrecruited adults with liver cirrhosis of any etiology during the period of November 2018 through January 2019. Descriptive and correlative analyses were done before proceeding to diagnostic abilityanalysis. Results: Sixty-two patients with mean age of 52.95 ± 12.05 were included in the analysis. The ALBI, PALBI, and FIB-4 scores were significantly correlated with higher mortality risk based on MELD score. The three scoressignificantly predicted higher mortality risk with varying sensitivity and specificity. Conclusion: Positivecorrelation between ALBI, PALBI, and FIB-4 scores with MELD score was found. ALBI (≥-1.26), PALBI (≥-2.05), and FIB-4 (≥5.84) values higher than the thresholdcould predict mortality risk in cirrhosis.

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Cross sectional study of effects of drinking green tea on cardiovascular and liver diseases

BMJ ◽

10.1136/bmj.310.6981.693 ◽

1995 ◽

Vol 310 (6981) ◽

pp. 693-696 ◽

Cited By ~ 264

Author(s):

K Imai ◽

K Nakachi

Keyword(s):

Green Tea ◽

Liver Diseases ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional

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The relationship between 25-hydroxyvitamin D concentration and liver enzymes in healthy adults: A Cross-sectional Study

10.21203/rs.2.21858/v1 ◽

2020 ◽

Author(s):

Ji-nian Wang ◽

Li Li ◽

Liang-yun Li ◽

Qi Yan ◽

Pan-pan Lian ◽

...

Keyword(s):

Vitamin D ◽

Liver Diseases ◽

Liver Enzymes ◽

Linear Regression Analysis ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

The Relationship

Abstract Background: Studies have shown that serum 25-hydroxyvitamin D (25(OH)D), a product of exogenous vitamin D, plays an influential role in calcium and phosphorus balance, anti-inflammation, and cardiovascular protection. There were long-standing interests in the potential benefits of vitamin D for preventing liver diseases. Investigations showed that 25(OH)D was increased in adolescents with abnormal liver function. Yet data about the relationship of 25(OH)D concentration and liver enzymes from prospective cross-sectional study was limited. The present study is undertaken to examine whether serum 25-hydroxyvitamin D and alanine aminotransferase (ALT) ，glutamyl transferase (GGT) and alkaline phosphatase (ALP) were closely related. Methods: The cross-sectional study of 368 healthy volunteers with no history of liver diseases was used to examine risk factors. The associations between ALT, G and ALP and 25(OH)D were assessed by Pearson correlation and Spearman correlation, respectively. Linear regression analysis was carried out in different models with ALT, GGT and ALP as dependent variables. Results: The results found no significant difference between ALT and ALP in different vitamin D groups (25(OH)D < 25 nmol/L、25-50 nmol/L and > 50 nmol/L) ( Kruskal-Wallis test, all p > 0.05 ). Multiple linear regression analysis revealed that there were no significant association between ALT, GGT and ALP levels and 25(OH)D concentration, respectively, after adjusting covariates including age, BMI, sex, BuN, Cr, UA, AST, Ghb, ALB, WBC, cholesterol, HDL, LDL, cholesterol, and total protein. (All p > 0.1). Conclusion: This study suggested that there was no association between the 25(OH)D concentration and the levels of ALT, GGT or ALP in normal population.

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Pregnancy outcomes in women with liver disease: Is pregnancy safe? A cross-sectional study

International Journal of Reproductive BioMedicine ◽

10.18502/ijrm.v13i10.7774 ◽

2020 ◽

Author(s):

Reza Shekarriz-Foumani ◽

Fakhrolmolouk Yassaee ◽

Sara Tarokh ◽

Mahbobeh Taheri

Keyword(s):

Liver Transplantation ◽

Liver Disease ◽

Pregnant Women ◽

Premature Birth ◽

Liver Diseases ◽

Antenatal Clinic ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

In Pregnancy

Background: There is evidence suggesting that the pregnancy outcome may be affected by some medical conditions, such as liver diseases. Objective: The present study aimed to investigate the prevalence of liver disease and its outcomes in pregnant women referred to antenatal clinic in the hospital. Materials and Methods: In this cross-sectional study, all pregnant women with abnormal liver function test attending antenatal clinic affiliated to Shahid Beheshti University of Medical Sciences were recruited from August 2017 to July 2018. All participants were followed-up until delivery with respect to the maternal and neonatal outcome. Results: Of a total of 7,121 pregnant women recruited in the study, 110 (1.58%) women were detected with a liver disease; of these, 105 women were diagnosed with pregnancy-specific liver diseases, including HELLP syndrome (10.9%), preeclampsia (50.98%), partial HELLP (0.9%), eclampsia (0.9%), acute fatty liver (9.1%), intra-hepatic cholestasis 25 (22.7%), and 5 women the non-pregnancy-specific liver disease, including Liver transplantation (2.7%), and Autoimmune hepatitis (1.8%). Prevalence of the premature birth was 64.5% in pregnancy-specific liver disease, but no premature birth was detected in cases with liver transplantation. We found that neonatal mortality was significantly associated with neonatal prematurity (p = 0.013), IUGR (p < 0.001), placental pathology (p = 0.04), we had no maternal mortality. Conclusion: Liver disease is not uncommon in pregnancy. This study demonstrated that pregnancy is safe in women with liver disease. Key words: Liver diseases, Maternal, Outcome, Neonatal, Pregnancy.

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