Post-Traumatic Arthritis: The Role of Cytokine Levels in Serum and Synovial Fluid

BACKGROUND & OBJECTIVES: Inflammatory processes play an important role in intra-articular fractures. The present study aimed to examine the relationship between chemerin, high-sensitivity C-reactive protein (hs-CRP), and Interleukin 17 (IL-17) serum and synovial fluid levels of osteoarthritis patients and individuals with intra-articular fractures.METHOD: In this case-control study, all osteoarthritis patients and individuals with intra-articular fractures who visited the Imam Khomeini Orthopedic Clinic of Ahvaz were examined. Blood samples (5 cc) were collected prior to surgery to measure chemerin Interleukin 17, and hs-CRP serum levels. Synovial fluid samples (2 cc) were collected during the surgery.RESULTS: Measuring the levels of IL-17, chemerin and hs-CRP indicated a significant statistical difference between the serum and synovial fluids of osteoarthritis patients, individuals with intra-articular fractures, and the control group (p < .001). Post-hoc analyses showed statistically significant differences in all conditions except for hs-CRP levels between osteoarthritis patients and individuals with intra-articular fractures.CONCLUSION: Discovering ways to stop or slow down osteoarthritis is a matter of great concern. The findings on osteoarthritis indicate diverse, complex, and multidimensional processes involving cytokines. Information on cytokines that effect diseases can help develop efficient therapy methods.

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Lower Circulating Levels of Soluble TNF-Like Weak Inducer of Apoptosis and Chromium in Treated Brucella Infection

ACTA MEDICA IRANICA ◽

10.18502/acta.v57i9.2639 ◽

2020 ◽

Author(s):

Mohammad Mohsenpour Azari ◽

Bahram Golestani Eimani ◽

Rasoul Entezarmahdi

Keyword(s):

High Sensitivity ◽

Serum Levels ◽

Control Group ◽

Case Group ◽

Reactive Protein ◽

Serum Chromium ◽

Common Infectious Disease ◽

Hs Crp ◽

Circulating Levels ◽

Control Study

Brucellosis is a common infectious disease around the globe. The aim of the present investigation was to evaluate the effect of brucellosis on the serum levels of chromium (Cr), lead (Pb), soluble TNF–like weak inducer of apoptosis (sTWEAK) as well as high-sensitivity C-reactive protein (hs-CRP) and homocysteine in patients suffering from brucellosis. The present case-control study was executed on 40 treated brucellosis patients (case) and 40 healthy individuals (control). Blood samples were obtained from all the participants for the measurement of the desired indices. The serum levels of chromium in the case group (0.109±0.025 μg/L) was significantly lower compared with that in the control group (0.121±0.027 μg/L, P=0.047). The levels of lead in serum were almost unchanged between the two groups (12.58±1.94 vs. 12.28±2.42 μg/dL, P=0.533). The sTWEAK levels were significantly lower in the case group as compared to the control subjects (235.20±48.45 pg/mL vs. 262.00±67.25 pg/mL, P=0.044). The levels of hs-CRP were significantly higher in the case group (2.23±0.34 mg/L) than that in the control group (2.05±0.32 mg/L, P=0.016); similarly, homocysteine levels were higher in the serum of patients in case group as compared to the control ones (16.18±4.47 µmol/L vs. 14.36±3.06 µmol/L, P=0.038). The current investigation underlined that brucellosis causes alterations in serum chromium and sTWEAK levels, the markers that are considered as the predictors of cardiovascular disease.

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Is Systemic Inflammation Associated With Elevated PSA Serum Levels In Patients Submitted Chronic Hemodialysis?

International Archives of Medicine ◽

10.3823/2522 ◽

2017 ◽

Vol 10 ◽

Author(s):

Gilmar Pereira Silva ◽

Vitor Pereira Xavier Grangeiro

Keyword(s):

Systemic Inflammation ◽

Serum Levels ◽

Chronic Hemodialysis ◽

Control Group ◽

Inclusion Criteria ◽

Reactive Protein ◽

Free Psa ◽

Significant Difference ◽

Level Elevation ◽

Hs Crp

Backgroundː whereas that systemic inflammation (SI) affects 40–60% of patients on hemodialysis (HD) is characterized by serum C-reactive protein (CRP) level elevation or proinflammatory interleukin production or both. We evaluated the association between SI and total (tPSA) and free PSA (fPSA) in patients on HD with tPSA <4ng / ml. Methodsː Sixty patients with chronic kidney disease (CKD) undergoing HD and 20 controls were included. Inclusion criteria were patients aged 18-60 years; tPSA < 4 ng/mL without clinically detectable prostate cancer; and patients undergoing HD for >6 months. Patients were excluded if they had local infections or SI. Hs-CRP was measured using turbidimetry, and tPSA and fPSA levels using immunochemoluminescence. Overall, 27 patients had inflammation (hs-CRP >5 mg/L) and 33 had no inflammation (hs-CRP was ≤5 mg/L). In the control group, hs-CRP was ≤ 1 mg/L. Resultsː there was no significant difference in mean levels among groups 3 and 4 for age (p=0,058), tPSA (p=0,74) and fPSA (p=0,30). The SI did not promote differences between groups 1, 2 and 4 for the levels of tPSA (0,71 ± 0,18 vs 0,67 ± 0,15 vs 0,67 ± 0,11; p=0,69) and fPSA (0,34 ± 0,01 vs 0,34 ± 0,01 vs 0,35 ± 0,01, p= 0,59) . As well as maintained no correlation with tPSA and fPSA (p>0,05). Conclusionː The systemic inflammation in hemodialytic patients without clinically detectable cancer (PSA<4ng/ml) is no associated with changes fractions of tPSA and fPSA.

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Evaluation of Inflammatory Markers in Pregnant Women at Risk, for the Prediction of Preeclampsia

Acta Medica Marisiensis ◽

10.2478/amma-2014-0019 ◽

2014 ◽

Vol 60 (3) ◽

pp. 94-98 ◽

Cited By ~ 1

Author(s):

Mihaela Daniela Oancea ◽

N. Costin ◽

Daria Maria Pop ◽

R. Ciortea ◽

Ioana Trif ◽

...

Keyword(s):

Pregnant Women ◽

Inflammatory Markers ◽

High Sensitivity ◽

Serum Levels ◽

Second Trimester ◽

Prospective Longitudinal Study ◽

Reactive Protein ◽

Group I ◽

Hs Crp ◽

Prospective Longitudinal

Abstract Introduction: A low degree of inflammation has been associated with complications in pregnancies, including preeclampsia (PE). The aim of our study was to determine the serum values of high sensitivity C Reactive Protein (hs-CRP) and Interleukin-6 (IL-6) in the first and second trimesters of pregnancy in pregnant women with risk factors for the development of PE, and to evaluate their relevance for the prediction of this disorder. Material and methods: We performed a prospective longitudinal study on 120 pregnant women, who were divided based on the pregnancy evolution, into two groups: group I - 26 pregnant women who developed preeclampsia and group II - 94 pregnant women with physiological evolution of pregnancy. Results: Our study has shown an increase in serum levels of hs-CRP and IL-6 in the first and second trimester of pregnancy in patients from group I, significant values being revealed only in the second trimester of pregnancy. The predictive power of the selected inflammatory markers was significant only for values of hs-CRP in the second trimester of pregnancy, while the association with IL-6 increased the prediction. Conclusions: Increased values of hs-CRP and IL-6 in the second trimester of pregnancy are associated with higher risk for preeclampsia, however the study provided only a modest efficiency of the prediction capacity.

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A STUDY TO EVALUATE THE ROLE OF HIGH SENSITIVITY C-REACTIVE PROTEIN IN CEREBROVASCULAR ACCIDENT IN THE DARBHANGA MEDICAL COLLEGE AND HOSPITAL

10.36106/ijsr/3720009 ◽

2021 ◽

pp. 71-73

Author(s):

Amit Kumar Tiwari ◽

Umesh Chandra Jha ◽

Debarshi Jana

Keyword(s):

Cerebrovascular Accident ◽

High Sensitivity ◽

Serum Levels ◽

Cross Sectional Study ◽

Abrupt Onset ◽

C Reactive Protein ◽

Cross Sectional ◽

Medical College ◽

Reactive Protein ◽

Hs Crp

INTRODUCTION:Cerebrovascular accident (commonly called stroke) is dened as an abrupt onset of a neurologic decit that is attributable to a focal vascular cause. Thus, the diagnosis of stroke is clinical and laboratory studies including brain imaging are used to support the diagnosis AIMS AND OBJECTIVES: To evaluate the serum levels of high sensitivity C-reactive protein (hsCRP) in different types of cerebrovascular accidents on admission. MATERIALS AND METHODS: This study was an institution based cross-sectional study designed to investigate the association of hs-CRP levels with stroke and its types in Indian patients. The study was done in the Department of Medicine, Darbhanga Medical College and Hospital, Laheriasarai, Bihar from march 2019 to March 2020. 50 patients of either sex above 12 years of age admitted in Medicine Department of DMCH, Laheriasarai, Bihar with clinically or radiologically diagnosed stroke. RESULT: The mean level of hsCRP (mean ± s.d.) of the cases in our study was 7.65±7.01 with range 1.4 – 26 and the median was 3.7 and 58% of the cases were having level of hsCRP≥3 (p=0.023).Mean level of hsCRPof cases was signicantly higher than that of control (t98=7.25;p=0.001). CONCLUSION:We concluded that hs-CRPlevel is increased in cases of cerebrovascular accident- ischemic as well as haemorrhagic, suggesting an inammatory response in acute cerebrovascular accident. hs-CRP level is increased in patients with ischemic cerebrovascular accident dramatically but not in haemorrhagic cerebrovascular accident which might be considered as useful adjunct method for determining type of stroke in patients with cerebrovascular problems.

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High-sensitivity C-reactive protein and lipoprotein-associated phospholipase A2 in predicting recurrence and severity of stenosis in symptomatic intracranial atherosclerotic disease

Current Proteomics ◽

10.2174/1570164617666200414123848 ◽

2020 ◽

Vol 17 ◽

Author(s):

Soumya Krishnamoorthy ◽

Deepa Damayanthi ◽

Srinivas Gopala ◽

Rejith Paul ◽

P. N. Sylaja

Keyword(s):

High Sensitivity ◽

Serum Levels ◽

Atherosclerotic Disease ◽

Stroke Recurrence ◽

Pla2 Activity ◽

C Reactive Protein ◽

Reactive Protein ◽

Intracranial Atherosclerotic Disease ◽

Hs Crp

Background: Symptomatic intracranial atherosclerotic disease (sICAD) is associated with risk of recurrence of cerebral ischemic events in 4-19% of stroke patients annually. Previous studies indicate elevated high-sensitivity C-Reactive Protein (hs-CRP) and lipoprotein-associated phospholipase A2 (Lp-PLA2) to be associated with risk of recurrence. Objective: This prospective, observational study investigated serum levels of hs-CRP and the activity of Lp-PLA2 in patients with sICAD in predicting the risk of long-term stroke recurrence. Methods: We enrolled 48 patients with sICAD at 3 months from onset. The demographics, clinical and imaging characteristics were recorded. Serum hs-CRP and Lp-PLA2 activity were assessed using automated high-sensitivity C-reactive protein assay and photometric technique, respectively. Patients were followed up at 6 months and 1 year and presence of new vascular events were recorded. Results: The mean age of our study population was 59.5 ± 10.3 years and 91.7% were men. Four patients developed recurrent strokes during follow-up. The mean Hs-CRP was elevated in patients with events than in patients without events (5.9 ± 10.4 mg/L vs. 1.7 ± 2.4 mg/L, P=0.03). However, there was no significant association of mean Lp-PLA2 activity (118.3±42.9 nmol/min/ml vs. 111.9 ± 34.2 nmol/min/ml, P=0.73) with recurrence. Elevation of hs-CRP (3.02 ± 4.8 mg/L vs. 0.95 ± 0.57mg/L, P=0.02) and Lp-PLA2 activity (120.1±40.3 nmol/min/ml vs. 103.3 ± 23.9 nmol/min/ml, P=0.04) was correlated with high-grade stenosis in these patients. Conclusion: Our study suggests serum levels of hs-CRP may serve as a predictor of long-term stroke recurrence risk in sICAD and elevation of hs-CRP and Lp-PLA2 correlated with the severity of stenosis in symptomatic intracranial atherosclerotic disease.

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Abstract WMP51: High-sensitivity C-reactive Protein In Asymptomatic Elderly Subjects Is Associated With a Higher Risk For Silent Brain Infarction

Stroke ◽

10.1161/str.44.suppl_1.awmp51 ◽

2013 ◽

Vol 44 (suppl_1) ◽

Author(s):

Chi K Kim ◽

Hyung-Min Kwon ◽

Jong-Won Chung ◽

Mi-Young Oh ◽

Chang-Hun Kim ◽

...

Keyword(s):

Cerebrovascular Disease ◽

Brain Infarction ◽

High Sensitivity ◽

Elderly Subjects ◽

C Reactive Protein ◽

Reactive Protein ◽

Inflammatory Processes ◽

History Of ◽

Silent Brain Infarction ◽

Hs Crp

Objective: Inflammatory processes are involved in the pathogenesis of atherosclerosis, and it has been known that high-sensitivity C-reactive protein (hs-CRP) is associated with coronary heart disease. However, the association of hs-CRP with subclinical cerebrovascular disease is less well established. We investigated the association of hs-CRP with silent brain infarction (SBI) as a marker of subclinical cerebrovascular disease in elderly subjects without history of overt stroke. Methods: Neurologically asymptomatic elderly subjects (n=1,443; age ≥ 65 years) who visited for routine health check-ups were included in this study. The level of hs-CRP was measured and the presence of SBI was determined by brain MRI. Results: A total of 223 subjects (15.5%) had one or more SBIs, and the average hs-CRP level was significantly higher in subjects with SBI (2.2 mg/L) than in those without (1.4 mg/L). Compared with the lowest hs-CRP group (0-0.9mg/L), the proportion of SBI in the highest hs-CRP group (≥ 3 mg/L) was increased (27.1% vs. 13.6%). After adjusting by age, gender and the history of hypertension, diabetes, smoking, hyperlipidemia and coronary heart disease, the risk of SBI was increased significantly two-fold in the highest hs-CRP group compared with the lowest group. Conclusion: Elevated hs-CRP level was found to be associated with the presence of SBI. This result suggests that inflammatory processes may be related to the subclinical cerebrovascular disease.

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The evaluation of serum N-terminal prohormone brain-type natriuretic peptide, troponin-I, and high-sensitivity C-reactive protein levels in children with congenital heart disease

Human & Experimental Toxicology ◽

10.1177/0960327113514097 ◽

2014 ◽

Vol 33 (11) ◽

pp. 1158-1166 ◽

Cited By ~ 5

Author(s):

A Uner ◽

M Doğan ◽

M Ay ◽

Ç Acar

Keyword(s):

Septal Defect ◽

Troponin I ◽

High Sensitivity ◽

Control Group ◽

Asymptomatic Group ◽

Reactive Protein ◽

Significant Difference ◽

Healthy Control ◽

Hs Crp ◽

And Control

Although advanced diagnostic and treatment methods are available, congenital heart disease (CHD) holds an important place among the causes of death within the first year of age. Therefore, several prognostic factors are needed for diagnosis and monitoring of these patients. In this study, which includes 66 CHD patients and 38 healthy control children, serum cardiac troponin-I (cTnI), high-sensitivity C-reactive protein (Hs-CRP), and N-terminal prohormone brain-type natriuretic peptide (NT-proBNP) levels were analyzed for their prognostics values. The patient groups were categorized and then evaluated as cyanotic ( n = 16), acyanotic ( n = 50), symptomatic ( n = 23), asymptomatic ( n = 43), and isolated ventricular septal defect (VSD)-isolated atrial septal defect (ASD) groups. Cyanotic group was statistically compared with acyanotic group, symptomatic group with asymptomatic group, and VSD group with ASD group. Between the cyanotic, acyanotic, and control groups; between symptomatic and asymptomatic groups; and between the VSD and ASD groups, significant difference was not showed for age ( p > 0.05). NT-proBNP was found to be significantly higher in the cyanotic group than acyanotic and control group, in the symptomatic group than asymptomatic group; and in the patient group than healthy control group ( p < 0.05). Between the groups of VSD and ASD, significant difference was not showed ( p > 0.05). The same comparison results for TnI and Hs-CRP were not significant ( p > 0.05). TnI and Hs-CRP were only found significantly higher in the patient group than healthy control group ( p < 0.05). Eventually, we think that NT-proBNP, Hs-CRP, and TnI might be used for clinical management and estimation of outcome of these disorders in the future and these also might be able to modify existing strategies, but much more studies are needed.

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Association between unstable angina and CXCL17: a new potential biomarker

Open Medicine ◽

10.1515/med-2019-0080 ◽

2019 ◽

Vol 14 (1) ◽

pp. 939-944

Author(s):

Fu-han Gong ◽

Xiao-qiang Xiao ◽

Xue-ping Zhang ◽

Li Long ◽

Sheng Huang ◽

...

Keyword(s):

Unstable Angina ◽

Stable Angina ◽

High Sensitivity ◽

Control Group ◽

Gensini Score ◽

Reactive Protein ◽

Potential Biomarker ◽

Biochemical Analyzer ◽

Hs Crp ◽

Artery Disease

AbstractAtherosclerosis and chemokines are strongly related, but the role of the chemokine CXCL17 in atherogenesis is still poorly understood. We aim to investigate the serum CXCL17 levels in different stages of patients with coronary heart disease and explore whether these differences contribute to atherosclerosis. In the current prospective study, we enrolled 48 patients with unstable angina (UA), 51 patients with stable angina (SA) and 41 patients for the control group (CG). All subjects were diagnosed by coronary angiography and Gensini score was used to evaluate the severity of coronary artery disease. The CXCL17 levels were determined using ELISA, while lipid metabolism indicators and high sensitivity C-reactive protein (hs-CRP) were detected by automatic biochemical analyzer. We observed that the unstable angina group had higher CXCL17 levels compared with the stable angina and the control group. The logistic regression analysis showed that CXCL17 was an independent risk factor for unstable angina. Our results showed that CXCL17 was also statistically correlated with hs-CRP, while it was irrelevant with Gensini score. CXCL17 levels were associated with activity of inflammatory response and the instability of atherosclerotic plaques. These results suggest that CXCL17 elevation may be a potential new biomarker of unstable angina.

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Association of Mitral Annulus Calcification with High-Sensitivity C-Reactive Protein, Which Is a Marker of Inflammation

Mediators of Inflammation ◽

10.1155/2012/606207 ◽

2012 ◽

Vol 2012 ◽

pp. 1-6 ◽

Cited By ~ 10

Author(s):

Ertuğrul Kurtoğlu ◽

Hasan Korkmaz ◽

Erdal Aktürk ◽

Mücahid Yılmaz ◽

Yakup Altaş ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Systemic Inflammation ◽

High Sensitivity ◽

Control Group ◽

C Reactive Protein ◽

Reactive Protein ◽

Hs Crp ◽

Artery Disease ◽

The Relationship

Objectives. There are limited clinical data revealing the relationship between mitral annular calcification (MAC) and systemic inflammation. The goal of the present study was to compare high-sensitivity C-reactive protein (hs-CRP) levels in patients with and without MAC and investigate the relationship between MAC and hs-CRP.Methods. One hundred patients with MAC who underwent transthoracic echocardiography (TTE) and 100 age-matched controls without MAC who underwent TTE were included in our study. Hs-CRP levels were compared between groups.Results. Prevalence of female gender, hypertension, and coronary artery disease were significantly higher in the MAC group than in the control group (64% versus 45%,P=0.007, 42% versus 28%,P=0.03and 37% versus 18%,P=0.003, resp.). On multivariate analysis, age, gender, and coronary artery disease were the only independent predictors of MAC. The levels of hs-CRP were higher in the MAC group than in the control group (2.02±0.35versus1.43±0.47 mg/dl,P<0.001). This increase in hs-CRP levels in the MAC group persisted in patients without hypertension, coronary artery disease, and in male patients when compared to the control group.Conclusions. Our study demonstrated that hs-CRP, which is a sensitive marker of systemic inflammation, increased in patients with MAC.

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Serum Leukocyte Cell-derived Chemotaxin 2 (LECT2) Level is Associated with Osteoporosis

10.21203/rs.3.rs-985343/v1 ◽

2021 ◽

Author(s):

Qiang Wang ◽

Feng Xu ◽

Wen-Ming M. He ◽

Jiong Chen ◽

Yan-Qing Xie ◽

...

Keyword(s):

Total Cholesterol ◽

Negative Correlation ◽

Roc Curve ◽

High Sensitivity ◽

Serum Levels ◽

Mineral Density ◽

Alcoholic Fatty Liver ◽

Reactive Protein ◽

Potential Biomarker ◽

Hs Crp

Abstract BackgroundPrevious studies have shown that leukocyte cell-derived chemotaxin 2 (LECT2), a hepatokine, is associated with obesity and non-alcoholic fatty liver disease (NAFLD). It is well known that hepatokines play important roles in mediating interactions among bone, adipose tissue, and liver. We sought to examine serum LECT2 levels in subjects with osteoporosis (OP) to confirm its association with OP.MethodsFrom March 2019 to March 2020, a total of 96 adult subjects (52 OP patients and 44 controls) visiting the 2nd Spine Department of the Affiliated Hospital of School of Medicine of Ningbo University were recruited. The bone mineral density (BMD) of all subjects were assessed by dual-energy X-ray (DXA). Blood samples were collected for measurements of high-sensitivity C-reactive protein (hs-CRP), plasma glucose (PG), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (TC), triglycerides (TG), creatinine and uric acid. Serum LECT2 levels of total 96 participants were measured by enzyme linked immunesorbent assay (ELISA). The relationships between serum LECT2 levels and biomedical parameters were analyzed using the Spearman correlation coefficient.ResultsSerum LECT2 levels in OP patients were significantly higher than that of healthy controls (29.57 ng/mL VS 19.82 ng/mL, P < 0.01). To confirm the role LECT2 played in OP, we found a significantly negative correlation in all subjects between serum levels of LECT2 and lumbar BMD, as well as femoralneck BMD. A significantly positive correlation in all was observed between serum levels of LECT2 and TC, whereas there was a significantly negative correlation between serum levels of LECT2 and creatinine. Meanwhile, serum LECT2 levels were measured to diagnose OP patient by plotting receiver-operating characteristic (ROC) curve, the area under the ROC curve was 0.729(P < 0.01). The optimal cutoff point for LECT2 concentration to diagnose OP patient was 16.44 ng/mL.ConclusionsWe showed that serum LECT2 levels were significantly up-regulated in OP patients, and LECT2 levels were significant positively associated with total cholesterol and negatively associated with creatinine. It could be a potential biomarker for OP diagnosis.

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