scholarly journals Serum Aspartic Acid ‎as a Marker of Epilepsy

2019 ◽  
Vol 11 (2) ◽  
pp. 142
Author(s):  
Gheyath AlGawwam ◽  
Asaad Adil Mnaather ◽  
Akram Al-Mahdawi ◽  
Hayder A. Fawzi ◽  
Laith G. ‎ Shareef
Keyword(s):  
Serum Level ◽  
Aspartic Acid ◽  
Study Design ◽  
Area Under The Curve ◽  
Partial Epilepsy ◽  
Diagnostic Validity ◽  
Healthy Group ◽  
Epileptic Patients ◽  
Partial Type ◽  
Different Levels

OBJECTIVE: Determine the ‎diagnostic validity of serum aspartic acid as a predictor of epilepsy. STUDY DESIGN & METHODOLOGY: This study enrolled 80 epileptic patients and 80 healthy people, and we measure serum level of ‎aspartic acid by using high liquid performance chromatography. RESULTS: Mean serum aspartic acid ‎was significantly higher in patients (26.2 ± 10.1) mg\dl while in control was (2.8 ± 1.36) mg\dl, ‎the result showed that aspartic acid is an excellent predictor area under the curve [AUC] (95%CI) = ‎‎0.988 (0.97 – 1.0) with 96.3% sensitivity and 97.5% specificity for epileptic patients. Also, the ‎result shows generalized seizure has significantly higher mean serum aspartic acid compared to ‎partial type and GTC show significantly higher mean serum aspartic acid compared to ‎myoclonus. CONCLUSION: Aspartic acid serum level markedly elevated in epileptic patients ‎groups in comparison to the healthy group, also shows a marked difference between generalized ‎and partial epilepsy and show different levels between subtypes of epilepsy.‎

scholarly journals Predicting bacteriophage hosts based on sequences of annotated receptor-binding proteins

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Dimitri Boeckaerts ◽  
Michiel Stock ◽  
Bjorn Criel ◽  
Hans Gerstmans ◽  
Bernard De Baets ◽  
...  
Keyword(s):  
Machine Learning ◽  
Predictive Model ◽  
Receptor Binding ◽  
Bacterial Infections ◽  
Sequence Data ◽  
Sequence Similarity ◽  
Area Under The Curve ◽  
Local Alignment ◽  
Search Tool ◽  
Different Levels

AbstractNowadays, bacteriophages are increasingly considered as an alternative treatment for a variety of bacterial infections in cases where classical antibiotics have become ineffective. However, characterizing the host specificity of phages remains a labor- and time-intensive process. In order to alleviate this burden, we have developed a new machine-learning-based pipeline to predict bacteriophage hosts based on annotated receptor-binding protein (RBP) sequence data. We focus on predicting bacterial hosts from the ESKAPE group, Escherichia coli, Salmonella enterica and Clostridium difficile. We compare the performance of our predictive model with that of the widely used Basic Local Alignment Search Tool (BLAST). Our best-performing predictive model reaches Precision-Recall Area Under the Curve (PR-AUC) scores between 73.6 and 93.8% for different levels of sequence similarity in the collected data. Our model reaches a performance comparable to that of BLASTp when sequence similarity in the data is high and starts outperforming BLASTp when sequence similarity drops below 75%. Therefore, our machine learning methods can be especially useful in settings in which sequence similarity to other known sequences is low. Predicting the hosts of novel metagenomic RBP sequences could extend our toolbox to tune the host spectrum of phages or phage tail-like bacteriocins by swapping RBPs.

scholarly journals Intelligence functions disorders in patients with complex partial epilepsy

2004 ◽  
Vol 62 (4) ◽  
pp. 983-987 ◽  
Author(s):  
Florindo Stella ◽  
Jayme Antunes Maciel
Keyword(s):  
Statistical Analysis ◽  
Cognitive Performance ◽  
Function Method ◽  
Neuropsychiatric Disorders ◽  
Partial Epilepsy ◽  
Intelligence Test ◽  
Complex Partial Epilepsy ◽  
Epileptic Patients ◽  
And Control ◽  
Normal Controls

OBJECTIVES: To compare the performance of patients with complex partial epilepsy with the normal controls in the subtests of an instrument used to assess intelligence function. METHOD: Fifty epileptic patients, whose ages ranged from 19 to 49 years and 20 normal controls without any neuropsychiatric disorders. The Wechsler-Bellevue adult intelligence test was applied in groups, epileptic patients and control subjects. This test is composed of several subtests that assess specific cognitive functions. A statistical analysis was performed using non-parametric tests. RESULTS: All the Wechsler-Bellevue subtests revealed that the intelligence functions of the patients were significantly inferior to that of the controls (p<0.05). This performance was supported by the patient's complaints in relation to their cognitive performance. CONCLUSION: Patients with complex partial epilepsy presented poorer results in the intelligence test when compared with individuals without neuropsychiatric disorders.

scholarly journals Validation of the Indonesian Version of Modified Checklist for Autism in Toddlers: a diagnostic study

2020 ◽  
Vol 60 (3) ◽  
pp. 159-65
Author(s):  
Hendra Salim ◽  
Soetjiningsih Soetjiningsih ◽  
I Gusti Ayu Trisna Windiani ◽  
I Gede Raka Widiana ◽  
PITIKA ASPR
Keyword(s):  
Predictive Value ◽  
Characteristic Curve ◽  
Area Under The Curve ◽  
Negative Likelihood Ratio ◽  
Autism Spectrum ◽  
Diagnostic Study ◽  
Diagnostic Validity ◽  
Dsm Iv ◽  
Pediatric Outpatients ◽  
Sensitivity Specificity

Background Autism is a developmental disorder for which early detection in toddlers is recommended because of its increased prevalence. The Modified Checklist for Autism in Toddlers (M-CHAT) is an easy-to-interprete tool that can be filled out by parents. It has been translated into the Indonesian language but needs to be validated. Objective To evaluate the diagnostic validity of the Indonesian version of M-CHAT in detection of autism spectrum disorder in Indonesia. Methods A diagnostic study was conducted at Sanglah Hospital, Denpasar, Bali, from March 2011 to August 2013. Pediatric outpatients aged 18 to 48 months were included. The Indonesian version of the M-CHAT tool was filled by parents. Autism assessment was done according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV-TR). The assessment results were analyzed with the MedCalc program  software, in several steps: (i) reliability of M-CHAT; (ii) description, distribution, and proportion to determine the characteristics of the subjects of research; and (iii) validity of M-CHAT compared to the gold standard DSM-IV-TR by a receiver operating characteristic curve and several area under the curve cut-off points, in order to assess the sensitivity, specificity, positive predictive value, negative predictive value, and positive and negative likelihood ratio, accompanied by the 95% confidence interval of each value. Results The Indonesian version of M-CHAT in toddlers had 82.35% sensitivity and 89.68% specificity, using the cut-off point of more than 6 failed questions. Conclusion The Indonesian version M-CHAT translated by Soetjiningsih has optimal diagnostic validity for detection of autism in toddlers.

Influence of age and comedication on steady-state clonazepam serum level-dose ratios in Japanese epileptic patients

2001 ◽  
Vol 26 (5) ◽  
pp. 375-379 ◽  
Author(s):  
E. Yukawa ◽  
M. Satou ◽  
T. Nonaka ◽  
M. Yukawa ◽  
S. Ohdo ◽  
...  
Keyword(s):  
Steady State ◽  
Serum Level ◽  
Epileptic Patients

scholarly journals Serum Level of Antibody against Benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA Adducts in People Dermally Exposed to PAHs

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Lenka Borska ◽  
Ctirad Andrys ◽  
Jan Krejsek ◽  
Vladimir Palicka ◽  
Marcela Chmelarova ◽  
...  
Keyword(s):  
Serum Level ◽  
Dna Adducts ◽  
Elevated Level ◽  
Total Duration ◽  
Potential Hazard ◽  
Polycyclic Aromatic ◽  
Pasi Score ◽  
General Goal ◽  
Almost All ◽  
Different Levels

Some specific antibodies indicate the presence of antigenic structures on DNA (DNA adducts) that can play an important role in the process of mutagenesis and/or carcinogenesis. They indicate the presence of increased genotoxic potential (hazard) prior to the formation of disease (primary prevention). The present study was focused on the serum level of benzo[a]pyrene 7,8-diol-9,10-epoxide-DNA adducts antibodies (anti-BPDE-DNA) in psoriatic patients(n=55)dermally exposed to different levels of polycyclic aromatic hydrocarbons (PAHs). The general goal of the study was to contribute to better understanding of the value of the assumed biomarker (anti-BPDE-DNA) for evaluation of the organism's answer to genotoxic exposure to PAHs. Elevated level of exposure to PAHs resulted in the increased level of anti-BPDE-DNA. However, almost all levels of anti-BPDE-DNA ranged within the field of low values. Both variants of GT (CCT-3% and CCT-5%) induced higher expression of anti-BPDE-DNA in the group of nonsmokers. Significant relations between the level of anti-BPDE-DNA and PASI score, total duration of the therapy, or time of UVR exposure were not found. Further studies are needed to reduce interpretation uncertainty of this promising bioindicator.

A Month-by-Month Long-Term Study on Carbamazepine: Clinical, EEG and Pharmacological Evaluation

1979 ◽  
Vol 7 (2) ◽  
pp. 152-157 ◽  
Author(s):  
F Monaco ◽  
A Riccio ◽  
M Fantini ◽  
A Baruzzi ◽  
P L Morselli
Keyword(s):  
Side Effects ◽  
Plasma Levels ◽  
Partial Epilepsy ◽  
Term Study ◽  
Breakdown Rate ◽  
Long Term Study ◽  
First Choice ◽  
Epileptic Patients ◽  
Clinical Eeg

Carbamazepine plasma levels were monitored for a twelve-month period in twenty epileptic patients. Seizure frequency decreased remarkably on inclusion of the drug in the therapy and attainment of plasma levels of 7–9 μg/ml. A faster breakdown rate in children was confirmed, while carbamazepine-10, 11-epoxide was present for carbamazepine levels above 4–5 μg/ml. EEG tracings did not show substantial modifications; this variable was thus considered to be of little value in assessing the clinical picture. Side-effects were minimal. Carbamazepine is increasingly becoming the drug of first choice in the management of both generalized and partial epilepsy, while better and more rapid results are obtained in monotherapy.

Frequency of Hypocalcemia with Exchange Transfusion in Neonatal Jaundice

2021 ◽  
Vol 15 (8) ◽  
pp. 1849-1851
Author(s):  
Ambreen Ali ◽  
Ashfaq Ahmad Shah Bukhari ◽  
Shameela Majeed ◽  
Saira Gul ◽  
Nomana Khalil ◽  
...  
Keyword(s):  
Serum Level ◽  
Study Design ◽  
Selection Criteria ◽  
Exchange Transfusion ◽  
Neonatal Jaundice ◽  
Serum Bilirubin ◽  
Cross Sectional Study ◽  
Total Serum ◽  
Sectional Study ◽  
Cross Sectional

Aim: To determine the frequency of hypocalcemia with exchange transfusion in neonatal jaundice. Study design: Descriptive cross-sectional study Place and duration of study: Departments of Pediatrics and Pathology, Naseer Teaching Hospital Peshawar from 1stJanuary 2018 to 31st December 2018. Methodology: One hundred and sixty twopatients of jaundiced neonates having total serum bilirubin >20mg/dl, both gender and patients having age up to 14 days were included. Patients fulfilling the selection criteria had undergone exchange transfusion. Hypocalcaemia was evaluated and considered positive if calcium serum level is <8 mg/dl or <2 mmol/L. Results: 50% of neonates were between 1-5 days, 45% of neonates were between 5-10 days, and 3% of neonates were in age 10-14 days. One hundred and ten (68%) of neonates were males and 52 (32%) of neonates were females. 30% neonates had hypocalcemia while 70% were without hypocalcemia. Conclusion: The incidence of hypocalcemia was found to be 30% with exchange transfusion in neonatal jaundice. Keywords: Hypocalcemia, Exchange transfusion, Neonatal jaundice

Utility of PET/CT in the diagnosis of recurrent ovarian cancer depending on CA 125 serum level

2015 ◽  
Vol 54 (04) ◽  
pp. 158-162 ◽  
Author(s):  
M. Fularz ◽  
P. Adamiak ◽  
R. Czepczynski ◽  
G. Jarzabek-Bielecka ◽  
A. Rewers ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Serum Level ◽  
Area Under The Curve ◽  
Recurrent Ovarian Cancer ◽  
Diagnostic Value ◽  
Ca 125 ◽  
Ct Examination ◽  
Level Measurement ◽  
Pet Ct ◽  
Sensitivity Specificity

SummaryThe aim of this study was to estimate the diagnostic value of common application of CA 125 level measurement and 18F-FDG PET/CT examination in patients with a suspicion of recurrent ovarian cancer. Patients, methods: A retrospective analysis was performed on a group of 68 patients aged 31–77 (average 57.7) with a suspicion of relapsing ovarian cancer who had CA 125 serum level measurement and PET/CT examination done with a maximum interval of 60 days. Results: PET/CT examination result was positive in 33 patients (48.5%) and negative in 35 (51.5%). Level of CA 125 was significantly higher in women with a positive PET/ CT result than in patients with a negative one (average 199.9 U/ml and 15.7 U/ml, respectively, p < 0.001). Nevertheless, comparison of CA 125 level in groups defined according to the localization of the relapse showed no significant differences. Moreover, the ROC analysis revealed that the optimal cut-off point of CA 125 concentration to predict positive PET/CT result was 17.6 U/ml. Area under the curve was 0.91. Sensitivity, specificity and accuracy in prognosticating positive PET/CT result for the selected cut-off point of 17.6 U/ml were 90.9%, 80.0% and 85.3%, respectively. Conclusion: CA 125 level does not depend on the localization of the recurrence. PET/CT is particularly useful in patients with a suspicion of relapsing ovarian cancer with CA 125 value of at least 17.6 U/ml.

Sign in / Sign up

Export Citation Format

Share Document