Protective effect of elevated bilirubin levels on cardiovascular disease in patients with Gilbert syndrome

The way of plant sterols transformation and their benefits for humans is still a question under the massive continuing revision. In fact, there are no receptors for binding with sterols in mammalians. However, possible biotransformation to steroids that can be catalyzed by gastro-intestinal microflora, microbial cells in prebiotics or cytochromes system were repeatedly reported. Some products of sterols metabolization are capable to imitate resident human steroids and compete with them for the binding with corresponding receptors, thus affecting endocrine balance and entire physiology condition. There are also tremendous reports about the natural origination of mammalian steroid hormones in plants and corresponding receptors for their binding. Some investigations and reports warn about anabolic effect of sterols, however, there are many researchers who are reluctant to believe in and have strong opposing arguments. We encounter plant sterols everywhere: in food, in pharmacy, in cosmetics, but still know little about their diverse properties and, hence, their exact impact on our life. Most of our knowledge is limited to their cholesterol-lowering influence and protective effect against cardiovascular disease. However, the world of plant sterols is significantly wider if we consider the thousands of publications released over the past 10 years.

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Qualification for physical activity in young adults with arrhythmias

In a good rythm ◽

10.5604/01.3001.0013.0500 ◽

2019 ◽

Vol 4 (49) ◽

pp. 12-17

Author(s):

Agnieszka Katarzyńska-Szymańska ◽

Lidia Chmielewska-Michalak ◽

Przemysław Mitkowski

Keyword(s):

Quality Of Life ◽

Physical Activity ◽

Cardiovascular Disease ◽

Young Adults ◽

Sudden Death ◽

Protective Effect ◽

Leisure Time ◽

Sudden Onset ◽

Recreational Sport

Physical activity has a protective effect against cardiovascular disease. Population awareness has enhanced and more and more people practice not only competitive but also recreational sport. Cardiovascular causes of sudden death in athletes are rare, but still present. Sudden onset of participation in intensive leisure-time sport can lead to SCD during or directly after physical activity. Thus the ultimate goal is prevention of SCD and simultaneously not unnecessarily remove from sport which can deteriorates quality of life.

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Abstract WP217: Light Alcohol Increment May Have Protective Effect on Cardiovascular Disease Occurrence Among Nondrinkers

Stroke ◽

10.1161/str.50.suppl_1.wp217 ◽

2019 ◽

Vol 50 (Suppl_1) ◽

Author(s):

Jun-Young Chang ◽

seulggie Choi ◽

Se Young Jang ◽

Sang Min Park

Keyword(s):

Cardiovascular Disease ◽

Protective Effect ◽

Disease Occurrence

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Homocysteine, Folate, and Cardiovascular Disease

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831.71.3.173 ◽

2001 ◽

Vol 71 (3) ◽

pp. 173-178 ◽

Cited By ~ 28

Author(s):

Mary Ward

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Protective Effect ◽

Plasma Concentrations ◽

Fruit And Vegetables ◽

European Countries ◽

Folate Intake ◽

Western World ◽

The Past ◽

Southern European Countries

Cardiovascular disease (CVD) continues to be one of the main causes of mortality in the western world, however approximately only two-thirds of all episodes can be attributed to traditional environmental and genetic risk factors. Over the past decade it has emerged that a moderate elevation in plasma concentrations of the amino acid homocysteine (tHcy) constitutes a risk factor for atherosclerotic vascular disease in the coronary, cerebral and peripheral vessels. Furthermore, this association is a graded one with no apparent threshold and is independent of, but may enhance the effect of conventional risk factors. Plasma homocysteine is determined by both genetic and nutritional factors. The B-vitamins folate, B-12 and B-6 all play a key role in homocysteine metabolism and in fact it has been proposed that about two-thirds of all cases of hyperhomocysteinemia are due to an inadequate status of one or all of these vitamins. Of the three, folate appears to be the most important determinant and has been shown to significantly lower homocysteine concentration when administered at doses ranging from 0.2 to 10 mg/d in both healthy and hyperhomocysteinemic subjects. There is considerable variation in the rate of CVD mortality between northern and southern European countries. A common dietary element in regions with lower CVD incidence i.e. southern European countries appears to be the higher consumption of fruit and vegetables. In the past this protective effect of fruit and vegetables has been primarily attributed to antioxidants. Fruit and vegetables are however also one of the main sources of folate in the diet, contributing to more than 30% of total dietary folate intake (even in countries where consumption of fruit and vegetables is low). Thus, in light of the evidence that folate may play a role in primary prevention of CVD via homocysteine-lowering the protective effect of fruit and vegetables may be partly explained by folate.

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The protective effect of pneumococcal vaccination on cardiovascular disease in adults: A systematic review and meta-analysis

International Journal of Infectious Diseases ◽

10.1016/j.ijid.2020.07.038 ◽

2020 ◽

Vol 99 ◽

pp. 204-213

Author(s):

Fawziah Marra ◽

Angel Zhang ◽

Emma Gillman ◽

Katherine Bessai ◽

Kamalpreet Parhar ◽

...

Keyword(s):

Systematic Review ◽

Cardiovascular Disease ◽

Protective Effect ◽

Meta Analysis ◽

Pneumococcal Vaccination

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Protective effect of the omega-3 polyunsaturated fatty acids: Eicosapentaenoic acid/Docosahexaenoic acid 1:1 ratio on cardiovascular disease risk markers in rats

Lipids in Health and Disease ◽

10.1186/1476-511x-12-140 ◽

2013 ◽

Vol 12 (1) ◽

pp. 140 ◽

Cited By ~ 40

Author(s):

Laura Lluís ◽

Núria Taltavull ◽

Mònica Muñoz-Cortés ◽

Vanesa Sánchez-Martos ◽

Marta Romeu ◽

...

Keyword(s):

Cardiovascular Disease ◽

Fatty Acids ◽

Docosahexaenoic Acid ◽

Polyunsaturated Fatty Acids ◽

Eicosapentaenoic Acid ◽

Protective Effect ◽

Disease Risk ◽

Cardiovascular Disease Risk ◽

Risk Markers ◽

Omega 3

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Clinical case of combined genetic pathology in a patient

Terapevticheskii arkhiv ◽

10.26442/00403660.2020.12.200435 ◽

2020 ◽

Vol 92 (12) ◽

pp. 180-184

Author(s):

E. A. Losik ◽

I. I. Yakushina ◽

M. R. Skhirtladze ◽

N. P. Balahonova ◽

V. V. Kerchev ◽

...

Keyword(s):

Clinical Case ◽

Blood Lipid ◽

Protective Role ◽

Alcoholic Beverages ◽

Atherosclerosis Progression ◽

Indirect Bilirubin ◽

Gilbert Syndrome ◽

Elevated Bilirubin ◽

Genetic Combination ◽

Wrist Flexors

Family hypercholesterolemia (HSX) is a form of genetically deterministic increase in blood lipid levels associated with a high risk of cardiovascular disease, usually at a young age. HSX is a common genetic disease found in the general population in most countries in 1:500 people. Clinically xantomas are found in achilles tendor and wrist flexors, lipoid arc of the cornea, concentration of total cholesterol and low-density lipoproteins is 4.911.6 mmol/l. Gilberts syndrome is a hereditary benign hyperbilirubinium, associated with a decrease in the functional activity of the liver enzyme uridinfosfat-glucuronosil transferase. Clinically, this syndrome appers in intermittent jaundice, which is provoked by physical activity, consumption of alcoholic beverages, insulation and an increase in the level of indirect bilirubin within 20100 micromol/ml. The article presents a rare clinical case of genetic combination of HSC SSC and Gilbert syndrome a young patient has and discusses the elevated bilirubin levels protective role in the atherosclerosis progression in Gilbert syndrome.

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