scholarly journals Alisma plantago-aquatica L.: the cytoskeleton of the suspensor development

2014 ◽  
Vol 83 (2) ◽  
pp. 159-166 ◽  
Author(s):  
Joanna Świerczyńska ◽  
Jerzy Bohdanowicz
Keyword(s):  
Basal Cell ◽  
Early Stage ◽  
Cell Development ◽  
Mature Stage ◽  
Rhodamine Phalloidin ◽  
Cytoskeleton Organization ◽  
Stage Of Development ◽  
Embryo Suspensor ◽  
Embryo Cells ◽  
Nucleus Surface

The actin and the tubulin cytoskeleton organization during the differentiation of the embryo-suspensor in <em>Alisma plantago-aquatica</em> was studied in comparison with the development of embryo, using immunofluorescence detection and rhodamine-phalloidin assay. At the early stage of the suspensor basal cell development (from 2- to ~10-celled embryos) microfilaments form an abundant network in the cytoplasm of the basal cell, while the microtubules form a delicate network. At the mature stage of development (from a dozen to several dozen-celled embryos), in the suspensor basal cell, the microfilaments and microtubules were localized from micropylar to chalazal pole of the cell. At the micropylar end of the basal cell a high amount of actin and tubulin material was observed. The microfilaments were mainly arranged parallel whereas numerous bundles of microtubules distributed longitudinally or transversally to the long axis of the cell. At this stage of basal cell functioning, some bundles of microtubules appeared to pass close to the nucleus surface. Microtubules were also observed distributed at the chalazal pole of the basal cell. At the senescence stage of the suspensor basal cell (&gt;100-celled embryos) the actin and tubulin filaments disorganize, some disrupted microfilaments and microtubules were observed in the cytoplasm of the basal cell. At all stages of the suspensor basal cell development in the embryo cells an extensive actin and tubulin network was observed.

scholarly journals Suspensor Development in Gagea Lutea (L.) Ker Gawl., with Emphasis on the Cytoskeleton

2015 ◽  
Vol 56 (2) ◽  
pp. 79-90 ◽  
Author(s):  
Joanna Świerczyńska ◽  
Jerzy Bohdanowicz
Keyword(s):  
Fluorescence Microscopy ◽  
Basal Cell ◽  
Actin Filaments ◽  
Early Phase ◽  
Cortical Network ◽  
Dense Network ◽  
Cell Cytoplasm ◽  
Embryo Suspensor ◽  
Gagea Lutea ◽  
Nucleus Surface

Abstract The study used fluorescence microscopy to examine changes in cytoskeleton configuration during development of the embryo suspensor in Gagea lutea and to describe them in tandem with the development of the embryo proper. During the early phase of embryo suspensor development, tubulin and actin filaments were observed in the cytoplasm of the basal cell from the micropylar to the chalazal ends of the cell. Around the nucleus of the basal cell were clusters of numerous microtubules. These accumulations of tubulin arrays congregated near the nucleus surface; numerous bundles of microtubules radiated from the nucleus envelope. At this time, microfil-aments formed a delicate network in the cytoplasm of the basal cell. In the fully differentiated embryo suspensor, microtubules were observed at the chalazal end of the basal cell. Numerous bundles of microtubules were visualized in the cytoplasm adjacent to the wall separating the basal cell from the embryo proper. Microfilaments formed a dense network which uniformly filled the basal cell cytoplasm. There were some foci of F-actin material in the vicinity of the nucleus surface and at the chalazal end of the basal cell. In all studied phases of embryo suspensor development a prominent cortical network of actin and tubulin skeleton was observed in embryo proper cells.

The Application of UX Research in New Energy Vehicle Innovation

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Menghan TAO ◽  
Ning XIAO ◽  
Xingfu ZHAO ◽  
Wenbin LIU
Keyword(s):  
Early Stage ◽  
Rapid Expansion ◽  
The Other ◽  
Innovative Product ◽  
Stage Of Development ◽  
New Energy ◽  
New Energy Vehicle ◽  
The One ◽  
New Energy Vehicles ◽  
Degree Of Innovation

New energy vehicles(NEV) as a new thing for sustainable development, in China, on the one hand has faced the rapid expansion of the market; the other hand, for the new NEV users, the current NEVs cannot keep up with the degree of innovation. This paper demonstrates the reasons for the existence of this systematic challenge, and puts forward the method of UX research which is different from the traditional petrol vehicles research in the early stage of development, which studies from the user's essence level, to form the innovative product programs which meet the needs of users and being real attractive.

scholarly journals Learning health systems in primary care: a systematic scoping review

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Danielle M. Nash ◽  
Zohra Bhimani ◽  
Jennifer Rayner ◽  
Merrick Zwarenstein
Keyword(s):  
Primary Care ◽  
Quality Improvement ◽  
Health Systems ◽  
Scoping Review ◽  
Early Stage ◽  
Point Of Care ◽  
The United States ◽  
Stage Of Development ◽  
Integrated Health ◽  
Google Search

Abstract Background Learning health systems have been gaining traction over the past decade. The purpose of this study was to understand the spread of learning health systems in primary care, including where they have been implemented, how they are operating, and potential challenges and solutions. Methods We completed a scoping review by systematically searching OVID Medline®, Embase®, IEEE Xplore®, and reviewing specific journals from 2007 to 2020. We also completed a Google search to identify gray literature. Results We reviewed 1924 articles through our database search and 51 articles from other sources, from which we identified 21 unique learning health systems based on 62 data sources. Only one of these learning health systems was implemented exclusively in a primary care setting, where all others were integrated health systems or networks that also included other care settings. Eighteen of the 21 were in the United States. Examples of how these learning health systems were being used included real-time clinical surveillance, quality improvement initiatives, pragmatic trials at the point of care, and decision support. Many challenges and potential solutions were identified regarding data, sustainability, promoting a learning culture, prioritization processes, involvement of community, and balancing quality improvement versus research. Conclusions We identified 21 learning health systems, which all appear at an early stage of development, and only one was primary care only. We summarized and provided examples of integrated health systems and data networks that can be considered early models in the growing global movement to advance learning health systems in primary care.

scholarly journals Open Research Data and Open Peer Review: Perceptions of a Medical and Health Sciences Community in Greece

Publications ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 14
Author(s):  
Eirini Delikoura ◽  
Dimitrios Kouis
Keyword(s):  
Peer Review ◽  
Evaluation System ◽  
Early Stage ◽  
Open Science ◽  
Health Sciences ◽  
Research Data ◽  
Stage Of Development ◽  
Open Research ◽  
Proper Training ◽  
To Receive

Recently significant initiatives have been launched for the dissemination of Open Access as part of the Open Science movement. Nevertheless, two other major pillars of Open Science such as Open Research Data (ORD) and Open Peer Review (OPR) are still in an early stage of development among the communities of researchers and stakeholders. The present study sought to unveil the perceptions of a medical and health sciences community about these issues. Through the investigation of researchers` attitudes, valuable conclusions can be drawn, especially in the field of medicine and health sciences, where an explosive growth of scientific publishing exists. A quantitative survey was conducted based on a structured questionnaire, with 179 valid responses. The participants in the survey agreed with the Open Peer Review principles. However, they ignored basic terms like FAIR (Findable, Accessible, Interoperable, and Reusable) and appeared incentivized to permit the exploitation of their data. Regarding Open Peer Review (OPR), participants expressed their agreement, implying their support for a trustworthy evaluation system. Conclusively, researchers need to receive proper training for both Open Research Data principles and Open Peer Review processes which combined with a reformed evaluation system will enable them to take full advantage of the opportunities that arise from the new scholarly publishing and communication landscape.

scholarly journals Primary Care Networks and Starfield’s 4Cs: A Case for Enhanced Chronic Disease Management

2021 ◽  
Vol 18 (6) ◽  
pp. 2926
Author(s):  
Chuan De Foo ◽  
Shilpa Surendran ◽  
Geronimo Jimenez ◽  
John Pastor Ansah ◽  
David Bruce Matchar ◽  
...  
Keyword(s):  
Primary Care ◽  
Chronic Disease ◽  
Disease Management ◽  
Chronic Disease Management ◽  
Early Stage ◽  
Healthcare Delivery ◽  
Stage Of Development ◽  
Facilitators And Barriers ◽  
Design Options ◽  
First Contact

The primary care network (PCN) was implemented as a healthcare delivery model which organises private general practitioners (GPs) into groups and furnished with a certain level of resources for chronic disease management. A secondary qualitative analysis was conducted with data from an earlier study exploring facilitators and barriers GPs enrolled in PCN’s face in chronic disease management. The objective of this study is to map features of PCN to Starfield’s “4Cs” framework. The “4Cs” of primary care—comprehensiveness, first contact access, coordination and continuity—offer high-quality design options for chronic disease management. Interview transcripts of GPs (n = 30) from the original study were purposefully selected. Provision of ancillary services, manpower, a chronic disease registry and extended operating hours of GP practices demonstrated PCN’s empowering features that fulfil the “4Cs”. On the contrary, operational challenges such as the lack of an integrated electronic medical record and disproportionate GP payment structures limit PCNs from maximising the “4Cs”. However, the enabling features mentioned above outweighs the shortfalls in all important aspects of delivering optimal chronic disease care. Therefore, even though PCN is in its early stage of development, it has shown to be well poised to steer GPs towards enhanced chronic disease management.

The magic bullet for rural development? Exploring the impacts of community telecenters in Bangladesh

2021 ◽  
pp. 026666692199750
Author(s):  
Noore Alam Siddiquee ◽  
Md Gofran Faroqi
Keyword(s):  
Service Delivery ◽  
Rural Areas ◽  
Early Stage ◽  
Rural Livelihoods ◽  
Value Added ◽  
Magic Bullet ◽  
Government Information ◽  
Individual Interviews ◽  
Stage Of Development ◽  
Marginalized Groups

This paper explores the impacts of Bangladesh’s Union Digital Centers (UDCs) as government information and service delivery hubs in rural areas. Drawing on user-surveys and semi-structured individual interviews it demonstrates that the UDCs have produced generally positive yet modest impacts on governance of service delivery. It shows that the UDCs are at an early stage of development, and that they offer only a limited set of services. While they helped extend ICT-enabled services to sections of population that would otherwise have missed them, the UDCs do not have much to do with rural livelihoods and empowerment of the poor and marginalized groups. These findings point to current inadequacies and pitfalls of the UDC approach to development. We argue that enhanced viability and effectiveness of the UDC experiment would warrant embedding more value-added governmental services and further strengthening of their capacity, mandate, and connectivity with government agencies at various levels, among others.

Targets, triggers, and directionality in non-local and local place assimilation in child and adult language

2014 ◽  
Vol 50 (3) ◽  
pp. 273-307
Author(s):  
Mi-Hui Cho ◽  
Shinsook Lee
Keyword(s):  
Longitudinal Study ◽  
Early Development ◽  
Early Stage ◽  
Decisive Role ◽  
Diary Study ◽  
Consonant Harmony ◽  
Stage Of Development ◽  
Place Assimilation ◽  
Korean Child ◽  
Non Local

Abstract Data collected from one Korean child in a longitudinal diary study present novel patterns of consonant harmony in that labials, coronals, and velars can be triggers and targets of both progressive and regressive non-local place assimilation in an early stage of development. The same child also shows some cases of local regressive place assimilation. In another study where 4 children's data were gathered from a naturalistic longitudinal study, local regressive place assimilation as well as conso-nant harmony is witnessed regardless of place features. In adult Korean, however, only coronal to labial/velar and labial to velar local regressive assimilation occurs. This paper argues that the non-local and local place assimilation is connected and shows that the connection can be accounted for in terms of different constraint rankings within the Optimality-theoretic framework. More specifically, it is shown that the Ident-Onset(place) constraint plays a decisive role even in the early stage of acquisition, unlike child English, accounting for the predominant regressive assimilation. Also, the Agree-Place constraint is exploded into two sub-constraints in Stage 3, capturing the asymmetrical behavior of assimilation. Further, the unranking of place features in early development gradually evolves to the fixed ranking which reflects the universal markedness hierarchy in adult Korean.

Genera coelomycetarum. I. Urohendersonia

1971 ◽  
Vol 49 (11) ◽  
pp. 1853-1862 ◽  
Author(s):  
T. R. Nag Raj ◽  
Bryce Kendrick
Keyword(s):  
Early Stage ◽  
Type Material ◽  
Stage Of Development

Study of type material of Urohendersonia platensis, U. indica, and U. stipae reveals that structures described by their original authors as ‘basidia’ or ‘pedicels’ (in contemporary parlance, conidiophores) are, in fact, apical conidium appendages. The true conidiophores and the processes of conidiogenesis are described and illustrated. Urohendersonia has unilocular, ostiolate pycnidia producing three-septate, colored conidia that are enclosed from an early stage of development in a sheath which extends apically as a hyaline, filiform process. Urohendersonia and Hendersonia are delineated. Revised descriptions are given for Urohendersonia and its four species. A fifth species, U. mysorensis, is described as new. A key to the five species is given.

Down-Regulation of IL-6 in Mouse Blastocysts From the Embryos Vitrified at Early Stage of Development

2005 ◽  
Vol 84 ◽  
pp. S380 ◽  
Author(s):  
S. Lee ◽  
J. Lee ◽  
K. Choi ◽  
Y. Lee ◽  
S. Lee ◽  
...  
Keyword(s):  
Early Stage ◽  
Down Regulation ◽  
Stage Of Development
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