Association between clinical stage of oral cancer and expression of immunohistochemical markers

2017 ◽  
Vol 89 (6) ◽  
pp. 17-22
Author(s):  
Wojciech Świątkowski ◽  
Mansur Rahnama ◽  
Tomasz Tomaszewski ◽  
Mariola Bigas ◽  
Agnieszka Świątkowska ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Detection System ◽  
Tumor Staging ◽  
P53 Protein ◽  
Clinical Stage ◽  
Maxillofacial Surgery ◽  
Response To Treatment ◽  
Control Group ◽  
Oral And Maxillofacial Surgery ◽  
Protein Markers

Aim: The aim of this study is to demonstrate the possible correlation between the expression of examined protein markers - p53, EGFR, PCNA, p44/42 in the mass of the tumor and the clinical stage of disease. Material: 48 patients of the Department and Clinic of Oral and Maxillofacial Surgery, Lublin diagnosed with oral cancer. The control group consisted of 10 patients diagnosed with leukoplakia lesions in the oral cavity. The methods: Immunohistochemical analysis using the detection system DAKO K5007 Cat - Dako REAL ™ Detection System, Peroxidase DAB +, Rabbit / Mouse. Results: Based upon the statistical results, significant correlation between p53 protein and tumor staging; however, a correlation between the level of expression of EGFR, p44/42, PCNA and staging was not likewise revealed. Conclusions: Looking for oral squamous cell carcinoma markers remains an actual issue. Identification of specific markers of oral cancer could be used in screening the population, determining prognosis and response to treatment.

Comparison of Dental Caries Prevalence in Patients with Cleft Lip and/or Palate and Their Sibling Controls

2009 ◽  
Vol 46 (5) ◽  
pp. 529-531 ◽  
Author(s):  
Mahmoud Al-Dajani
Keyword(s):  
Dental Caries ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Maxillofacial Surgery ◽  
Permanent Teeth ◽  
Control Group ◽  
Oral And Maxillofacial Surgery ◽  
Caries Prevalence ◽  
Dmft Index ◽  
And Control

Objective: To evaluate the prevalence of dental caries in patients with cleft lip and/or palate and their cleft-free sibling controls. Methods: The two subject groups (patient and control) comprised 106 participants. The former group consisted of 53 patients with cleft lip and/or palate, aged 12 to 29 years, who visited the Oral and Maxillofacial Surgery Hospital at Damascus University of Syria. The control group consisted of the patients’ siblings who had no clefts, and they were sex matched to the patient group. Dental caries were examined clinically and were reported using the decayed, missing, and filled permanent teeth (DMFT) index. The DMFT scores were compared between the two groups. Results: The author found an overall association of dental caries with the presence of cleft lip and/or palate (odds ratio  =  2.52; 95% confidence interval  =  1.389–4.574; p < .05). The DMFT index scores were proportionally higher in patients with cleft lip and/or palate compared with the control group (p < .001). Conclusion: Subjects with cleft lip and palate are susceptible to dental caries independently of socioeconomic status.

scholarly journals Perioperative mortality of head and neck cancers

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yannan Wang ◽  
Mengxue Wang ◽  
Yan Tang ◽  
Bincan Sun ◽  
Kai Wang ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Cardiopulmonary Arrest ◽  
Clinical Stage ◽  
Maxillofacial Surgery ◽  
Head And Neck Cancers ◽  
Oral And Maxillofacial Surgery ◽  
Perioperative Mortality ◽  
Advanced Clinical Stage

Abstract Background Head and neck cancers are aggressive cancers, most clinical studies focused on the prognosis of patients with head and neck cancer. However, perioperative mortality was rarely mentioned. Methods A retrospective analysis was performed using all head and neck cancer patients admitting in the Department of Oral and Maxillofacial Surgery of the Second Xiangya Hospital, Central South University from January 2010 to December 2019. The analysis of overall survival and progression-free survival were performed using the Kaplan–Meier method, and cross tabulation with chi-squared testing was applied to analyze the difference in parameters between groups. Results From January 2010 to December 2019, a total of 6576 patients with head and neck cancers were admitted to our department and 7 died in the hospital, all of whom were middle-aged and elderly patients including 6 males and 1 female. The perioperative mortality rate (POMR) was about 1‰. The causes of death included acute heart failure, rupture of large blood vessels in the neck, hypoxic ischemic encephalopathy due to asphyxia, respiratory failure and cardiopulmonary arrest. Conclusion Preoperative radiotherapy, previous chemotherapy, hypertension, diabetes, advanced clinical stage and postoperative infection are risk factors for perioperative mortality of head and neck cancer.

scholarly journals Misdiagnosis and Mismanagement of an Infectious Impacted Canine: A Case Presentation

2021 ◽  
Vol 16 (3) ◽  
Author(s):  
Alireza Navabazam ◽  
Somayyeh Ebrahimi ◽  
Hadi Noori
Keyword(s):  
Nasal Congestion ◽  
Maxillofacial Surgery ◽  
Acute Bronchitis ◽  
Response To Treatment ◽  
Cone Beam ◽  
Oral And Maxillofacial Surgery ◽  
Case Presentation ◽  
Tooth Impaction ◽  
Impacted Canine ◽  
The Face

: Tooth impaction is defined as a partial or complete eruption of a tooth regarding the eruption time. Hereby, we present an infectious canine in a 38-year-old man that primarily presented with chest pain and dyspnea. After two days, he demonstrated a painful swelling and erythema of the face, severe perspiration, nasal congestion, and pleural effusion. The patient was diagnosed with acute bronchitis, mucormycosis, and nasal septum abscess, leading to unnecessary antibiotic therapy and lack of treatment response. After oral and maxillofacial surgery consultation, cone-beam computed tomography (CBCT) revealed an impacted and infectious canine that was surgically extracted. Due to lack of desired response to treatment, he underwent CBCT after oral and maxillofacial surgery consultation. An impacted and infectious canine was detected, which was surgically extracted. Three days later, his symptoms significantly improved, and he was discharged with a stable general condition.

scholarly journals Shortening of bones using novel contraction osteogenesis device: An experimental study

2021 ◽  
Vol 11 (Suppl. 1) ◽  
pp. 26-31
Author(s):  
Hakan Ocak ◽  
Erdem Kılıç ◽  
Alper Alkan
Keyword(s):  
Experimental Study ◽  
Maxillofacial Surgery ◽  
Latency Period ◽  
Test Group ◽  
Study Groups ◽  
Skin Incision ◽  
Alternative Methods ◽  
Control Group ◽  
Oral And Maxillofacial Surgery ◽  
Complication Rates

Aim: Given the high complication rates associated with orthognathic surgery for the correction of maxillomandibular malformations, studies have focused on alternative methods of strengthening the jaw, such as distraction osteogenesis. However, methods of shortening of the jaw are not well-elucidated in oral and maxillofacial surgery practice. This study aims to investigate the efficacy of a new method of shortening osteotomized jaws. Methodology: A 2.5–3 cm skin incision was made on the left tibia of each of 15 New Zealand white rabbits aged 12–18 months, followed by fixation of 15 mm pre-opened distractor devices to the tibia after osteotomy. After a five-day latency period, the distractors were activated to a total of 8 mm, with closure of the device set at a rate of 0.25 mm/day in the test group. After a five-day latency period, the distractors closed at a rate of 0.125 mm/day, achieving a total contraction of 5 mm. The distractors were not activated in the control group. The bone at the contraction range was evaluated, and the resultant shortening was measured. Results: The tibia was shortened by an average of 4.32 mm. Exaggerated bone formation was identified around the osteotomized cortical bone in all rabbits in the control and study groups, and there were minimal complication rates. Conclusion: This study verified that the jaw can be shortened by performing slow, controlled contraction with a bone resorption pattern.   How to cite this article: Ocak H, Kılıç E. Alkan A, Shortening of the bones using a novel contraction osteogenesis device: An experimental study. Int Dent Res 2021;11(Suppl.1):26-31. https://doi.org/10.5577/intdentres.2021.vol11.suppl1.5   Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.

scholarly journals Do Noncoding RNAs Mediate the Efficacy of Energy Psychology?

2019 ◽  
Vol 8 ◽  
pp. 216495611983250 ◽  
Author(s):  
Garret Yount ◽  
Dawson Church ◽  
Kenneth Rachlin ◽  
Katharina Blickheuser ◽  
Ippolito Cardonna
Keyword(s):  
Detection System ◽  
Negative Control ◽  
Response To Treatment ◽  
Control Group ◽  
Intervention Period ◽  
Treatment As Usual ◽  
Expression Levels ◽  
Rna Molecules ◽  
Energy Psychology ◽  
Treatment Analysis

Background There are over 100 published studies of a therapy called Emotional Freedom Techniques (EFT). This popular form of energy psychology combines elements of established methods like cognitive therapy with acupressure. Our group reported the first evidence of its mechanisms of action at the molecular level, showing that it can influence levels of the stress hormone cortisol. Objectives Given recent advances in molecular genomics that have identified noncoding ribonucleic acid (RNA) molecules as important regulators of gene expression, the aim of this study is to explore the possibility that microRNAs play a role in mediating the effects of EFT. Methods We measured microRNA levels in stored blood samples from our previous study in which veterans were randomized into an EFT group receiving EFT and treatment as usual throughout a 10-week intervention period, and a control group receiving only treatment as usual during the intervention period and then receiving EFT. A broad panel of 800 microRNAs was probed using a multiplexed, direct hybridization, and detection system. Results All of the microRNA targets were expressed at low levels and most were below thresholds established by negative control probes. Baseline variability was determined using samples collected from the control group at the start and end of the intervention period, and used to filter out targets that were too noisy under control conditions to be able to distinguish a response to treatment. Analysis of the remaining viable targets found a general trend of reduced expression following EFT, compared to expression levels in samples from the control group during the intervention period. The most notable decreases in expression levels were found for 2 microRNAs: let-7b and let-7c, although no significance was found after adjusting for multiple comparisons. Conclusions These preliminary data support the feasibility of measuring microRNA expression level changes that correlate with effective EFT therapy.

COMPARISON OF POST EXTRACTION SOCKET HEALING WITH AND WITHOUT USING PLATELET RICH FIBRIN (PRF) – A CLINICAL AND RADIOGRAPHIC STUDY

2021 ◽  
pp. 62-65
Author(s):  
S.P. Indra Kumar ◽  
Kavin T ◽  
Narendar R ◽  
E. Gayathri Priyadharshini ◽  
Akshaya murugan ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Maxillofacial Surgery ◽  
Test Group ◽  
Control Group ◽  
Oral And Maxillofacial Surgery ◽  
Soft Tissue Healing ◽  
Extraction Socket ◽  
Platelet Rich Fibrin ◽  
Tissue Healing ◽  
Socket Healing

AIM: The aim of this study is to comparatively evaluate the post extraction socket healing clinically and radiographically with and without using Platelet Rich Fibrin (PRF). MATERIALS AND METHODS: Fifty, otherwise healthy individuals undergoing dental treatment in the department of Oral and Maxillofacial surgery, Vivekananda Dental College for women, Thiruchengode, were randomly selected and the participants were divided into two groups – test group(PRF, n=25) and control group (Blood clot, n=25). Blood was freshly obtained from the participants of the test group and PRF was prepared. PRF was placed in the sockets of the test group and followed by the pressure application and suturing. Control group were allowed to heal naturally. Clinically, soft tissue healing and socket closure were assessed. Radiographic analysis of socket healing done by comparison of pre- and post-operative radiographs. The clinical follow-up assessments were done at an interval of 3 days, 1 week and 4 weeks and the data obtained were assessed. The patients were aged above 18 years, i RESULT: ncluding 33 females and 17 males. The soft tissue and socket healing were higher in the test group when compared with the control group clinically and the mean proportion of radiographic bone ll was signicantly higher in the test group in all the time intervals of 3 days, 1 week and 4 weeks, respectively. Outcome of the study CONCLUSION: demonstrate that the PRF placement in the extraction socket accelerates soft tissue healing and socket healing and increases the bone ll and reduces the bone resorption using clinical and radiographic methods.

scholarly journals The use of bipolar coagulation forceps prevented salivary fistula in patients with parotidectomy: a retrospective study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Kun Wu ◽  
Keke Zhu ◽  
Yingxi Ye ◽  
Sainan Li ◽  
Hanjiang Wu ◽  
...  
Keyword(s):  
Logistic Regression Model ◽  
Maxillofacial Surgery ◽  
Control Group ◽  
Oral And Maxillofacial Surgery ◽  
Controlled Trials ◽  
Common Complication ◽  
Bipolar Coagulation ◽  
Salivary Fistula ◽  
Central South ◽  
Experimental Group

Abstract Background Salivary fistula is a relatively common complication in patients who have undergone a parotidectomy. The purpose of this study was to investigate the effects of bipolar coagulation forceps use on salivary fistulas. Methods From March 2015 to June 2020, 177 patients who underwent a parotidectomy in the Department of Oral and Maxillofacial Surgery at the Second Xiangya Hospital of Central South University were recruited. The patients were divided into an experimental group and a control group based on whether bipolar coagulation forceps or sutures were used, respectively. Results The drainage output of the experimental group was significantly lower than that of the control group (p = 0.04). The duration of dressing pressure applied in the experimental group was significantly shorter than that in the control group (p = 0.0003). Moreover, the incidence of salivary fistula in the experimental group (9.8%, 8/82) was notably lower than that in the control group (34.7%, 33/95) (p < 0.0001). In the logistic regression model for salivary fistula development, both the use of bipolar coagulation forceps (p = 0.0021) and drainage output (p = 0.0237) were associated with the presence of salivary fistulas. Conclusions Our findings indicate that the use of bipolar coagulation forceps decreases the incidence of salivary fistula in patients who have undergone a parotidectomy. The use of bipolar coagulation forceps is a safe, effective, and convenient method to prevent salivary fistulas in patients who undergo a parotidectomy. Trial registration: Current Controlled Trials ChiCTR2100044722, Date: 26/03/2021, Retrospectively registered.

scholarly journals Pattern of Oral and Maxillofacial New Referrals During COVID-19 Lockdown

2021 ◽  
Vol 16 (2) ◽  
pp. 199-208
Author(s):  
Syed Nabil ◽  
Muhammad Aiman Mohd Nizar ◽  
Muhd Fazlynizam Rashdi ◽  
Szu Ching Khoo ◽  
Muhammad Kamil Hassan ◽  
...  
Keyword(s):  
Emergency Departments ◽  
Maxillofacial Surgery ◽  
Demographic Factors ◽  
Control Group ◽  
Oral And Maxillofacial Surgery ◽  
Bivariate Statistics ◽  
Home Address ◽  
Significant Difference ◽  
Level Of Significance ◽  
The Impact

The study aimed to quantify the impact of lockdown during the COVID-19 pandemic on new case referrals to the Oral and Maxillofacial Surgery (OMS) service. The researchers retrospectively reviewed all new referrals received during a government-imposed 47-day lockdown period and a similar period pre-lockdown as a control group. The main outcome was the differences in the number of new case referrals between the two periods. The contributing clinical and demographic factors were also explored. Appropriate bivariate statistics were computed and the level of significance was set at 0.05 for all tests. A total of 309 referrals were received during the study period. There was a reduction of new referrals due to the lockdown from five to two cases per day. There was a statistically significant reduction of cases referred from outpatient and emergency departments. There was also a statistically significant difference with regard to home address distance to the centre. Medically compromised and orofacial infection referrals were not affected by lockdown. The lockdown imposed due to the pandemic has significantly impacted the pattern of new OMS referrals. Referrals for orofacial infections, the medically compromised and inpatients were minimally affected by lockdown.

scholarly journals Perception and Attitude of Maxillofacial Surgeons towards in-Clinic Counselling on Tobacco Cessation in Tertiary Hospitals in Nigeria

2021 ◽  
Vol 11 (10) ◽  
pp. 177-185
Author(s):  
Olasunkanmi Funmilola Kuye ◽  
Olufemi Olagundoye ◽  
Adeola Mofoluwake Ladeji
Keyword(s):  
Oral Cancer ◽  
Tobacco Cessation ◽  
Maxillofacial Surgery ◽  
Age Groups ◽  
Oral And Maxillofacial Surgery ◽  
Female Ratio ◽  
Perceptions And Attitudes ◽  
Tertiary Hospitals ◽  
Associated Risk Factors ◽  
Study Participants

Cigarettes and other forms of tobacco are known to be highly addictive, the use and production of which are on the rise. Tobacco use is a risk factor in the development of diseases especially oral cancer, affects negatively wound healing in maxillofacial surgical procedure, and periodontal therapies. Therefore, the need for tobacco cessation programs on patients among Maxillofacial surgeons and the trainees is necessary. Objectives- This is to assess the perception, attitude, and the influence of age, gender, duration of practice, and environment/religion on the cessation counseling carried out by Oral & Maxillofacial surgeons Methods- A prospective questionnaire-based study. A survey was carried out by sending validated, structured self-administered pretested questionnaires to Oral and Maxillofacial Surgery trainees and specialists in tertiary hospitals in different parts (North, South, and West) of Nigeria. The questionnaire assessed perceptions and attitudes- of the respondent, as well as the influence of age, gender, duration of practice, and environment/religion on in-clinic tobacco cessation. Results- A total of 44 individuals participated in the study. More respondents from senior registrars 19(43%), and with the majority from the Teaching Hospital 33(75%) out of the three cadres of institutions where the survey was done. Male to female ratio of respondents was 1:2.1, with the mean age of the participants 36.7. All agreed to the need for tobacco cessation counseling among Oral & Maxillofacial surgeons, only 37(84.1%) believe that in-clinic counseling will significantly reduce the prevalence of oral cancer. Age groups, sex, religion, designation, and the years in practice have a significant relationship with the participant perception-related question p=0.001, as well the like use of religious and professional techniques in counseling smokers (p<0.05). The gender of study participants had a significant influence on their perception of the need for in-clinic tobacco cessation counseling. Conclusion- Tobacco cessation program within the health institutions is tested and an affirmed avenue to stop or reduce the associated risk factors with substance use. Therefore, need for policymakers in health sectors to organize training programs for Maxillofacial surgeons. Key words: Oral & Maxillofacial surgeons, Tobacco cessation, attitude, and perceptions, in-clinic counseling.

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