scholarly journals The influence of chronic supply of vanadium compounds on organ weights and body mass in animal diabetes model (NZO)

2019 ◽  
Vol 4 (1) ◽  
pp. 63-72 ◽  
Author(s):  
Mirosław Krośniak ◽  
Janusz Szklarzewicz ◽  
Ryszard Gryboś ◽  
Barbara Tatar ◽  
Metin Yildirim ◽  
...  

Vanadium is an element that has an effect on improving glucose levels in animals with diabetes. However, its operation is strongly dependent on the chemical structure of compounds of this element. The influence of newly synthesized vanadium compounds on biochemical processes is also unknown. The paper presents the influence of eight new vanadium compounds on organ weights of animals (mice NZO) in whom diabetes was induced by a high-fat diet during 8 weeks. Tested vanadium complexes were administered by 5 weeks. After this time organs were collected and weighed. Tested complexes had a remarkable different effect on organ weights, despite having similar composition ([VO(L)(phen)] and the same co-ligand (1,10-phenanthroline) . This indicate on separate metabolic pathways of these compounds in the body of tested animals and role of the tridentate L Schiff base ligands. The compounds C2, C3 and C5 shoved biggest influence on organs weight and these results suggest influence on the metabolic pathways and therefore are interesting for further investigations.

2019 ◽  
Vol 25 ◽  
pp. 107602961985942 ◽  
Author(s):  
Beata Sarecka-Hujar ◽  
Izabela Szołtysek-Bołdys ◽  
Ilona Kopyta ◽  
Barbara Dolińska ◽  
Andrzej Sobczak

Epilepsy is a disease arising from morphological and metabolic changes in the brain. Approximately 60% of patients with seizures can be controlled with 1 antiepileptic drug (AED), while in others, polytherapy is required. The AED treatment affects a number of biochemical processes in the body, including increasing the risk of cardiovascular diseases (CVDs). It is indicated that the duration of AED therapy with some AEDs significantly accelerates the process of atherosclerosis. Most of AEDs increase levels of homocysteine (HCys) as well as may affect concentrations of new, nonclassical risk factors for atherosclerosis, that is, asymmetric dimethylarginine (ADMA) and homoarginine (hArg). Because of the role of these parameters in the pathogenesis of CVD, knowledge of HCys, ADMA, and hArg concentrations in patients with epilepsia treated with AED, both pediatric and adult, appears to be of significant importance.


Cancers ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 1588 ◽  
Author(s):  
Teresa Maria Elisa Modica ◽  
Francesco Dituri ◽  
Serena Mancarella ◽  
Claudio Pisano ◽  
Isabel Fabregat ◽  
...  

Calcium is the most abundant element in the human body. Its role is essential in physiological and biochemical processes such as signal transduction from outside to inside the cell between the cells of an organ, as well as the release of neurotransmitters from neurons, muscle contraction, fertilization, bone building, and blood clotting. As a result, intra- and extracellular calcium levels are tightly regulated by the body. The liver is the most specialized organ of the body, as its functions, carried out by hepatocytes, are strongly governed by calcium ions. In this work, we analyze the role of calcium in human hepatoma (HCC) cell lines harboring a wild type form of the Epidermal Growth Factor Receptor (EGFR), particularly its role in proliferation and in EGFR downmodulation. Our results highlight that calcium is involved in the proliferative capability of HCC cells, as its subtraction is responsible for EGFR degradation by proteasome machinery and, as a consequence, for EGFR intracellular signaling downregulation. However, calcium-regulated EGFR signaling is cell line-dependent. In cells responding weakly to the epidermal growth factor (EGF), calcium seems to have an opposite effect on EGFR internalization/degradation mechanisms. These results suggest that besides EGFR, calcium could be a new therapeutic target in HCC.


2009 ◽  
Vol 81 (7) ◽  
pp. iv
Author(s):  
João Costa Pessoa

Knowledge of the chemistry and biochemistry of vanadium has increased enormously since the early 1980s, particularly that of vanadium(III), (IV), and (V). This led to remarkable developments in the understanding and recognition of the properties of vanadium compounds. A consequence of these new insights has been numerous applications of vanadium complexes ranging from therapeutics to catalysis and from new materials to green chemistry. Many of the more recent advances were presented at the 6th International Vanadium Symposium held 17‚Äì19 July 2008 in Lisbon, Portugal.The conference included 56 oral communications and 52 poster presentations. The following 12 papers are a selection from the oral communications presented. This conference attracted over 100 participants from 27 countries and 4 continents. The inorganic chemistry of vanadium, application of vanadium chemistry in catalysis and organic synthesis, and biological aspects of vanadium chemistry were discussed in invited lectures as well as in poster communications.The Vanadium Award, a prize first introduced at the 4th International Vanadium Symposium held in 2004 in Szeged, Hungary to recognize an outstanding contributor to the advancement of vanadium science, was awarded in 2008 to Prof. Toshikazu Hirao of the Osaka University, Japan, and his contribution is the first paper presented herein.The additional contributions that embody this issue are mostly papers covering aspects related to catalytic applications of vanadium compounds, including their use as functional models of vanadiumdependent haloperoxidases. Electron transfer in oxo and non-oxo vanadium complexes, the use of NMR to characterize the complexes, and synthesis of new polyoxovanadates are the subjects of other papers included.We look forward to the 7th International Vanadium Symposium to be held in Japan in 2010, where additional studies on the role of vanadium in life, the vanadium nutritional essentiality, vanadium toxicity, and vanadium therapy, as well as new contributions to the use of vanadium compounds in catalysis, including "green chemical" industrial applications, will certainly be presented.João Costa PessoaConference Chair


2020 ◽  
Vol 63 (8) ◽  
pp. 110-117
Author(s):  
Galina V. Omelchenko ◽  

The first half of the 20th century is characterized by discoveries in the field of biochemistry. During this period, the active substances necessary for the development of the body and maintaining homeostasis were first studied. After a long study of vitamins, scientists discovered a number of substances that have properties similar to vitamins, later they were called "vitamin-like substances". The mechanisms of regulation of the body's vital activity are always based on the course of special biochemical reactions, including with the participation of vitamin-like substances, which, unlike vitamins, can be synthesized by the body itself endogenously and come from exogenous sources (inside with food or in laboratory/industrial conditions). There is a need to maintain their balance through food intake. The article examines the role of vitamin-like substances of plant origin in the processes of vital activity of the organism, ensuring the implementation of specific tasks in the system of organs, cells and tissues. Due to the low quality of modern products, the concentration of useful components in their composition is reduced. Therefore, many people currently do not receive additional vitamin-like compounds and vitamin supplements are necessary to replenish them. The latter, due to the intense rhythm of life, people may forget to use or take irregularly. Therefore, the urgency of enriching the composition of familiar food products, in particular by means of yeast cultures, which are able to accumulate useful components in themselves, depending on the substrates consumed, has increased. The aim of this work is to study the possibilities of using yeast cultures to enrich the composition of familiar food products with vitamin-like substances from plant sources. Materials and methods. The article analyzes the possibilities of enriching familiar non-alcoholic food products by cultivating yeast cultures on substrates of plant origin. The role of vitamin-like substances in the biochemical processes of the body in comparison with the biologically active fermentative of yeast has been determined. To perform a systemic in-depth analysis, a synergistic principle was used to study the effect of the vitomin-like substances used on biochemical processes, that is, an analysis was carried out by studying the self-organization of the functional systems of the body without taking into account data on specialized pharmaceutical therapy. The research was carried out on the basis of the relevant Russian and English language information sources. Results. To achieve this goal, the reasons for the need and indispensability of vitamin-like substances in the biological processes of the body were initially considered, their classification and dosage were briefly characterized. Further, the methods of enriching food products by means of yeast cultures are studied in detail and the influence of each compound or group found in information sources on the biochemical processes in the body is considered. The possibilities of using yeast as a source of vitamin-like substances and for carrying out the fermentation of plant objects for enriching food products and non-alcoholic beverages with special components are considered separately. The composition and benefits of the active fermentative of yeast have been investigated, it has been established that the composition of the vitamin-like substances of the final product has not been sufficiently studied. It was revealed that successful attempts are being made to use Saccharomyces cerevisiae for the formation of food products enriched with bioflavonoids with antioxidant properties.


2017 ◽  
Vol 2017 ◽  
pp. 1-14 ◽  
Author(s):  
W. A. García-Suástegui ◽  
L. A. Ramos-Chávez ◽  
M. Rubio-Osornio ◽  
M. Calvillo-Velasco ◽  
J. A. Atzin-Méndez ◽  
...  

Organisms have metabolic pathways that are responsible for removing toxic agents. We always associate the liver as the major organ responsible for detoxification of the body; however this process occurs in many tissues. In the same way, as in the liver, the brain expresses metabolic pathways associated with the elimination of xenobiotics. Besides the detoxifying role of CYP2E1 for compounds such as electrophilic agents, reactive oxygen species, free radical products, and the bioactivation of xenobiotics, CYP2E1 is also related in several diseases and pathophysiological conditions. In this review, we describe the presence of phase I monooxygenase CYP2E1 in regions of the brain. We also explore the conditions where protein, mRNA, and the activity of CYP2E1 are induced. Finally, we describe the relation of CYP2E1 in brain disorders, including the behavioral relations for alcohol consumption via CYP2E1 metabolism.


2022 ◽  
Vol 5 (1) ◽  
pp. 01-06
Author(s):  
Gudisa Bereda

The pancreas in a non-diabetic patient invariably produces a lesser quantum of insulin (basal production). Insulin furnishes glucose homeostasis by keeping the plasma glucose worth in an optimum class throughout the day. It assists transport blood glucose into the body cells where the glucose is metabolized to generate energy. Regular insulin is inserted pre-meal to abrupt the postprandial ascend in glucose levels. It figures hexamers after insertion into the subcutaneous space sluggishing its absorption. Ultra-fast acting commences to act 4-7 minutes before regular apidra and lasts for around 3 hours. The absorption rate of lente insulin is downgraded by the extension of zinc to the insulin preparation. Long-acting insulins furnish basal insulin coverage. Atrophy of subcutaneous fat owing to applicability of further greater accumulated insulin preparations of neutral potenz hydrogen.


2020 ◽  
Vol 21 (23) ◽  
pp. 8992
Author(s):  
Akiko Suzuki ◽  
Mina Minamide ◽  
Chihiro Iwaya ◽  
Kenichi Ogata ◽  
Junichi Iwata

Carbohydrates, fats, and proteins are the underlying energy sources for animals and are catabolized through specific biochemical cascades involving numerous enzymes. The catabolites and metabolites in these metabolic pathways are crucial for many cellular functions; therefore, an imbalance and/or dysregulation of these pathways causes cellular dysfunction, resulting in various metabolic diseases. Bone, a highly mineralized organ that serves as a skeleton of the body, undergoes continuous active turnover, which is required for the maintenance of healthy bony components through the deposition and resorption of bone matrix and minerals. This highly coordinated event is regulated throughout life by bone cells such as osteoblasts, osteoclasts, and osteocytes, and requires synchronized activities from different metabolic pathways. Here, we aim to provide a comprehensive review of the cellular metabolism involved in bone development and homeostasis, as revealed by mouse genetic studies.


2021 ◽  
Vol 22 (2) ◽  
pp. 630
Author(s):  
Ewa Maria Kratz ◽  
Katarzyna Sołkiewicz ◽  
Adriana Kubis-Kubiak ◽  
Agnieszka Piwowar

Sirtuins (SIRTs), enzymes from the family of NAD+-dependent histone deacetylases, play an important role in the functioning of the body at the cellular level and participate in many biochemical processes. The multi-directionality of SIRTs encourages scientists to undertake research aimed at understanding the mechanisms of their action and the influence that SIRTs have on the organism. At the same time, new substances are constantly being sought that can modulate the action of SIRTs. Extensive research on the expression of SIRTs in various pathological conditions suggests that regulation of their activity may have positive results in supporting the treatment of certain metabolic, neurodegenerative or cancer diseases or this connected with oxidative stress. Due to such a wide spectrum of activity, SIRTs may also be a prognostic markers of selected pathological conditions and prove helpful in assessing their progression, especially by modulating their activity. The article presents and discusses the activating or inhibiting impact of individual SIRTs modulators. The review also gathered selected currently available information on the expression of SIRTs in individual disease cases as well as the biological role that SIRTs play in the human organism, also in connection with oxidative stress condition, taking into account the progress of knowledge about SIRTs over the years, with particular reference to the latest research results.


Molecules ◽  
2020 ◽  
Vol 25 (13) ◽  
pp. 3073
Author(s):  
Patrizio Campitelli ◽  
Marcello Crucianelli

For a long time the biological role of vanadium was not known, while now the possibility of using its derivatives as potential therapeutic agents has given rise to investigations on their probable side effects. Vanadium compounds may inhibit different biochemical processes and lead to a variety of toxic effects and serious diseases. But, on the other hand, vanadium is an essential element for life. In recent years, increasing evidence has been acquired on the possible roles of vanadium in the higher forms of life. Despite several biochemical and physiological functions that have been suggested for vanadium and notwithstanding the amount of the knowledge so far accumulated, it still does not have a clearly defined role in the higher forms of life. What functions could vanadium or its very stable oxidovanadium(IV) derivatives have had in the prebiotic world and in the origins of life? In this review, we have briefly tried to highlight the most useful aspects that can be taken into consideration to give an answer to this still unresolved question and to show the high versatility of the oxidovanadium(IV) group to act as promoter of several oxidation reactions when coordinated with a variety of ligands, including diketones like acylpyrazolones.


Author(s):  
Zaenah Zuhair Alamri

Liver plays an essential role in metabolism and has an important role in preserving and regulating the levels of lipid, glucose in the body as well as energy metabolism. Among the important functions performed by the liver is maintaining of blood glucose levels under different conditions through group of processes included; glycolysis, glycogenesis, glycogenolysis, gluconeogenesis. The absorbed free fatty acids and those derived from the adipose tissue reach the liver and are utilized for energy, membrane synthesis, or stored as triglyceride. In addition, the liver has a crucial role in keeping homeostasis of body level of cholesterol. Regarding protein metabolism, urea cycle occurs in the liver through the action of urea cycle enzymes to produce urea in order to get rid of the toxic ammonia. In the liver, cholesterol is utilized for bile acids synthesis through a complicated process. These bile acids are considered essential in order to absorb and transport of lipid-soluble vitamins dietary and fat in the diet as well as clearance of drugs, toxic substances and xenobiotics. Adding to these hepatic functions is hepatic detoxification where liver metabolizes a various type of drugs to make soluble execretable compounds. In conclusion, the liver has so important metabolic functions which if impaired will resulted in many liver diseases and might progress to more dangerous conditions such as liver fibrosis or cirrhosis.


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