scholarly journals Low levels of serum vitamin D3 are associated with fibromyalgia syndrome in pre-menopausal women: A pilot study

2020 ◽  
Vol 66 (1) ◽  
pp. 67-72
Author(s):  
Nezihe Akar
Keyword(s):  
Pilot Study ◽  
Vitamin D3 ◽  
Fibromyalgia Syndrome ◽  
Serum Vitamin ◽  
Menopausal Women ◽  
Low Levels

scholarly journals Low Levels of Serum Vitamin D3 Are Associated with Autoimmune Thyroid Disease in Pre-Menopausal Women

Thyroid ◽  
2014 ◽  
Vol 24 (4) ◽  
pp. 655-661 ◽  
Author(s):  
Yun Mi Choi ◽  
Won Gu Kim ◽  
Tae Yong Kim ◽  
Sung Jin Bae ◽  
Hong-Kyu Kim ◽  
...  
Keyword(s):  
Vitamin D3 ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Serum Vitamin ◽  
Autoimmune Thyroid ◽  
Menopausal Women ◽  
Low Levels

scholarly journals Low Levels of Vitamin D Promote Memory B Cells in Lupus

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 291 ◽  
Author(s):  
Erin A. Yamamoto ◽  
Jane K. Nguyen ◽  
Jessica Liu ◽  
Emma Keller ◽  
Nicole Campbell ◽  
...  
Keyword(s):  
Vitamin D ◽  
B Cells ◽  
B Cell ◽  
Vitamin D3 ◽  
Lupus Erythematosus ◽  
Th17 Cells ◽  
Serum Vitamin ◽  
Memory B Cells ◽  
Serum Vitamin D ◽  
Low Levels

Background: Vitamin D deficiency is a known risk factor for Systemic Lupus Erythematosus (SLE), yet clinical trials have not demonstrated efficacy and few studies have utilized lupus models to understand the mechanism underlying this relationship. The Act1-/- mouse is a spontaneous model of lupus and Sjögren’s syndrome, characterized by increased Th17 cells and peripheral B cell expansion. Vitamin D3 has anti-inflammatory properties, reduces Th17 cells and impairs B cell differentiation/activation. Therefore, we assessed how varying amounts of vitamin D3 affected lupus-like disease in the Act1-/- mouse. Methods: Act1-/- mice were fed either low/restricted (0 IU/kg), normal (2 IU/kg), or high/supplemented (10 IU/kg) vitamin D3 chow for 9 weeks, after which lupus-like features were analyzed. Results: While we found no differences in Th17 cells between vitamin D3 groups, vitamin D3 restriction specifically promoted memory B cell development, accompanied by elevated levels of serum IgM, IgG1, IgG3, and anti-dsDNA IgG. A similar significant negative association between serum vitamin D and memory B cells was confirmed in a cohort of SLE patients. Conclusion: Low levels of vitamin D3 are associated with elevated levels of memory B cells in an animal model of lupus and well-controlled SLE patients.

Low levels of serum vitamin D3 in chronic spontaneous urticaria patients

2016 ◽  
Vol 13 (2) ◽  
pp. 92-98 ◽  
Author(s):  
Ashraf M. Hamza ◽  
Carmen I. Farid ◽  
Doreen N. Younan ◽  
Dina S. Abd El-Wahed
Keyword(s):  
Vitamin D3 ◽  
Serum Vitamin ◽  
Chronic Spontaneous Urticaria ◽  
Low Levels

scholarly journals Vitamin D in human serum and adipose tissue after supplementation

2020 ◽  
Vol 113 (1) ◽  
pp. 83-91
Author(s):  
Cora M Best ◽  
Devon V Riley ◽  
Thomas J Laha ◽  
Hannah Pflaum ◽  
Leila R Zelnick ◽  
...  
Keyword(s):  
Vitamin D ◽  
Adipose Tissue ◽  
Pilot Study ◽  
Vitamin D3 ◽  
Serum Vitamin ◽  
Absolute Difference ◽  
Hydroxyvitamin D ◽  
Liquid Chromatography Tandem Mass ◽  
Vitamin D3 Supplementation ◽  
Tissue Vitamin

ABSTRACT Background Serum 25-hydroxyvitamin D [25(OH)D] concentration is an indicator of vitamin D exposure, but it is also influenced by clinical characteristics that affect 25(OH)D production and clearance. Vitamin D is the precursor to 25(OH)D but is analytically challenging to measure in biological specimens. Objectives We aimed to develop and validate a liquid chromatography–tandem mass spectrometry (LC-MS/MS) method for quantification of vitamins D3 and D2 in serum and to explore the potential of circulating vitamin D as a biomarker of exposure in supplementation trials. Methods The method was validated using guideline C62-A from the Clinical and Laboratory Standards Institute and was applied in 2 pilot clinical trials of oral vitamin D3 supplementation. Pilot study 1 included 22 adults randomly assigned to placebo or 2000 IU/d. Blood was collected at baseline, 1, 3, 6, and 12 mo. Pilot study 2 included 15 adults randomly assigned to 2000 or 4000 IU/d. Blood and subcutaneous (SUBQ) adipose tissue were collected at baseline and 3 mo. Results In study 1, mean change (baseline to 3 mo) in serum vitamin D3 was −0.1 ng/mL in the placebo group and 6.8 ng/mL in the 2000 IU/d group (absolute difference: 6.9; 95% CI: 4.5, 9.3 ng/mL). In study 2, mean change (baseline to 3 mo) in serum vitamin D3 was 10.4 ng/mL in the 2000 IU/d group and 22.2 ng/mL in the 4000 IU/d group (fold difference: 2.15; 95% CI: 1.40, 3.37). Serum and adipose tissue vitamin D3 concentrations were correlated, and the dose-response of vitamin D3 in adipose mirrored that in serum. Conclusions We validated a sensitive, robust, and high-throughput LC-MS/MS method to quantify vitamins D3 and D2 in serum. Serum and SUBQ adipose tissue vitamin D3 concentrations increased proportionally to dose with 3 mo of daily supplementation. These trials were registered at clinicaltrials.gov as NCT00552409 (pilot study 1) and NCT01477034 (pilot study 2).

SUBLINGUAL VITAMIN D3 DRUG THERAPY IN VITAMIN D DEFICIENCY PATIENTS AT PRAVARA RURAL HOSPITAL

2019 ◽  
pp. 18-20
Author(s):  
Sanjeeva Kumar Goud T ◽  
Rahul Kunkulol
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D3 ◽  
Serum Vitamin ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Significant Difference ◽  
Before And After

The present study was aimed to study the effect of Sublingual Vitamin D3 on Serum Vitamin D level in Vitamin D deficiency patients. This was a cross-sectional and interventional study. All the Vitamin D deficiency patients of age 18-60years and either gender, willing to participate in the study were included. Patients who had greater than 20 ng/ml were excluded from the study. The total number of participants in our study was 200, out of these 111 males and 89 females, the mean age in our study was 51.07 ± 7.39Yrs. All volunteers were given sublingual vitamin D3 (60,000IU) in six doses every fifteen days of follow up for 3 months. The subject’s serum 25(OH)D levels were estimated before and after the treatment of sublingual vitamin D3. There was a statistically significant difference in serum vitamin D3 level before 16.61±6.71 ng/ml and after 35.80±7.80 ng/ml after treatment with Sublingual Vitamin D3. Six doses of 60,000IU of Vitamin D3 sublingual route having improved the role of serum 25(OH)D levels in the treatment of Vitamin D3 deficiency patients.Keywords: Vitamin D3; Sublingual route

Effects of Topical O24 Essential Oils on Patients with Fibromyalgia Syndrome: A Randomized, Placebo Controlled Pilot Study

2007 ◽  
Vol 15 (1) ◽  
pp. 11-19 ◽  
Author(s):  
Gordon D. Ko ◽  
Annie Hum ◽  
George Traitses ◽  
David Berbrayer
Keyword(s):  
Pilot Study ◽  
Essential Oils ◽  
Fibromyalgia Syndrome

scholarly journals Evaluation of vitamin D3 in patients of polycystic ovary syndrome and their correlation

2017 ◽  
Vol 6 (5) ◽  
pp. 2010
Author(s):  
Rooplekha Chauhan ◽  
Sonal Sahani ◽  
Ankita Garg
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Vitamin D3 ◽  
Polycystic Ovary ◽  
Serum Vitamin ◽  
Reproductive Age ◽  
Ovary Syndrome ◽  
Chi Square ◽  
Exact Test ◽  
Young Females ◽  
Vitamin D3 Deficiency

Background: Polycystic ovary syndrome (PCOS) is enigma faced by young females since the onset of urbanization. As on day, PCOS is the most common endocrine disorder in the women of reproductive age affecting 4-10%. This study done to measure serum vitamin D3 levels of PCOS patients and to identify its association with factors associated with various symptoms and signs in PCOS.Methods: Institutional based prospective observational study conducted on 70 patients of PCOS, both suspected and already diagnosed, attending gynecology OPD of Department of obstetrics and gynecology of NSCB Medical College Jabalpur from 1 March 2015 to 31 August 2016. Diagnosis of PCOS was made by Rotterdam 2003 criteria. A detailed assessment was done and preformed proforma was filled. Serum Vitamin D3 levels were estimated by standard lab technique ‘Liquid Chromatography Tandem Mass Spectrometry’ and categorized into vitamin D3 sufficient >30ng/dl, insufficient 20-29ng/dl and deficient <20ng/dl. Categorical data was coded numerically before the analysis. For comparison of frequency distribution chi square test or fisher’s exact test were applied as appropriate.Results: Prevalence of Vitamin D3 deficiency in patients of PCOS was found to be 84.3%.Conclusions: The present study concludes that there is correlation between vitamin D3 and PCOS, screening and correction of vitamin D3 deficiency may prevent PCOS and its manifestations. Hence, it is speculated that improvement of vitamin D3 levels at a younger age can contribute to prevention of PCOS.

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