Mycotoxin Analysis Using Imprinted Materials Technology: Recent Developments

2016 ◽  
Vol 99 (4) ◽  
pp. 861-864 ◽  
Author(s):  
Michael Appell ◽  
Anja Mueller
Keyword(s):  
Molecular Imprinting ◽  
Molecularly Imprinted Polymers ◽  
Fusaric Acid ◽  
Cost Effective ◽  
Toxic Exposure ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Molecular Imprinting Technology ◽  
Recent Developments ◽  
Mycotoxin Analysis

Abstract Molecular imprinting technology is an attractive, cost-effective, and robust alternative to address the limitations of highly selective natural receptors, such as antibodies and aptamers. The field of molecular imprinting has seen a recent surge in growth, and several commercially available products are of great interest for sample cleanup to improve mycotoxin analysis. Current research trends are in specific applications of imprinting technology for small-molecule sensing and chromatographic cleanup procedures in new commodities. The choice of components and imprinting template are critical factors for mycotoxin recovery or detection optimization. Template mimics offer a means to reduce toxic exposure during polymer synthesis and address issues of leaching template from the imprinted polymer. Recent reports of molecularly imprinted polymers for aflatoxins, ochratoxins, fumonisins, fusaric acid, citrinin, patulin, zearalenone, deoxynivalenol, and T-2 toxin are reviewed.

Application of Response Surface Methodology to Synthesize Appropriate Molecularly Imprinted Polymer for Diazinon

2014 ◽  
Vol 605 ◽  
pp. 67-70 ◽  
Author(s):  
Mohsen Rahiminezhad ◽  
Seyed Jamaleddin Shahtaheri ◽  
Mohammad Reza Ganjali ◽  
Abbas Rahimi Rahimi Forushani
Keyword(s):  
Molecular Imprinting ◽  
Molecularly Imprinted Polymer ◽  
Binding Sites ◽  
Capillary Electrochromatography ◽  
Template Molecule ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Molecular Imprinting Technology ◽  
Cross Linker

Molecular imprinting technology has become an interesting research area to the preparation of specific sorbent material for environmental and occupational sample preparation techniques (1). In the molecular imprinting technology, specific binding sites have been formed in polymeric matrix, which often have an affinity and selectivity similar to antibody-antigen systems (2). In molecular imprinted technology, functional monomers are arranged in a complementary configuration around a template molecule, then, cross-linker and solvent are also added and the mixture is treated to give a porous material containing nono-sized binding sites. After extraction of the template molecule by washing, vacant imprinted sites will be left in polymer, which are available for rebinding of the template or its structural analogue (3). The stability, convention of preparation and low cost of these materials make them particularly attractive (4). These synthetic materials have been used for capillary electrochromatography (5), chromatography columns (6), sensors (7), and catalyze system (8). Depending on the molecular imprinting approach, different experimental variables such as the type and amounts of functional monomers, porogenic solvent, initiator, monomer to cross-linker ratio, temperature, and etc may alter the properties of the final polymeric materials. In this work, chemometric approach based on Central Composite Design (CCD) was used to design the experiments as well as to find the optimum conditions for preparing appropriate diazinon molecularly imprinted polymer.

Recent developments in molecularly imprinted polymer nanofibers and their applications

2015 ◽  
Vol 7 (18) ◽  
pp. 7406-7415 ◽  
Author(s):  
Shabi Abbas Zaidi
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Molecularly Imprinted Polymers ◽  
Imprinted Polymer ◽  
Polymer Nanofibers ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Recent Developments ◽  
Analyte Detection

Molecularly imprinted polymers (MIPs) have been potential and versatile candidates for analyte detection.

scholarly journals Chiral separations of mandelic acid by HPLC using molecularly imprinted polymers

2005 ◽  
Vol 30 (4) ◽  
pp. 67-73 ◽  
Author(s):  
Chin-Yin Hung ◽  
Han-Hung Huang ◽  
Ching-Chiang Hwang
Keyword(s):  
Molecular Imprinting ◽  
Molecularly Imprinted Polymers ◽  
Mandelic Acid ◽  
Occupational Exposures ◽  
Bulk Polymerization ◽  
Chiral Separations ◽  
Phenyl Acetic Acid ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Chromatographic Resolution

Styrene is used in a variety of chemical industries. Environmental and occupational exposures to styrene occur predominantly through inhalation. The major metabolite of styrene is present in two enantiomeric forms, chiral R- and S- hydroxy-1-phenyl-acetic acid (R-and S-mandelic acid, MA). Thus, the concentration of MA, particularly of its enantiomers, has been used in urine tests to determine whether workers have been exposed to styrene. This study describes a method of analyzing mandelic acid using molecular imprinting techniques and HPLC detection to perform the separation of diastereoisomers of mandelic acid. The molecularly imprinted polymer (MIP) was prepared by non-covalent molecular imprinting using (+) MA, (-) MA or (+) phenylalanine, (-) phenylalanine as templates. Methacrylic acid (MAA) and ethylene glycol dimethacrylate (EGDMA) were copolymerized in the presence of the template molecules. The bulk polymerization was carried out at 4ºC under UV radiation. The resulting MIP was grounded into 25~44¼m particles, which were slurry packed into analytical columns. After the template molecules were removed, the MIP-packed columns were found to be effective for the chromatographic resolution of (±)-mandelic acid. This method is simpler and more convenient than other chromatographic methods.

scholarly journals Rapid and selective recognition of Vibrio parahaemolyticus assisted by perfluorinated alkoxysilane modified molecularly imprinted polymer film

RSC Advances ◽  
2020 ◽  
Vol 10 (24) ◽  
pp. 14305-14312 ◽  
Author(s):  
Kaiyue Fu ◽  
Huiwen Zhang ◽  
Yuanyuan Guo ◽  
Juan Li ◽  
Heran Nie ◽  
...  
Keyword(s):  
Polymer Film ◽  
Molecular Imprinting ◽  
Molecularly Imprinted Polymer ◽  
Vibrio Parahaemolyticus ◽  
Selective Recognition ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
High Affinity ◽  
Molecular Imprinting Technology

Molecular imprinting technology offers a means of tailor-made materials with high affinity and selectivity for certain analysts.

Molecularly Imprinted Materials: Towards the Next Generation

2002 ◽  
Vol 723 ◽  
Author(s):  
Lei Ye ◽  
Klaus Mosbach ◽  
David A. Spivak ◽  
Martha Sibrian-Vazquez
Keyword(s):  
Molecular Imprinting ◽  
Next Generation ◽  
Polymer Beads ◽  
Molecularly Imprinted ◽  
Molecular Imprinting Technology ◽  
Recent Developments ◽  
Short Presentation

AbstractThis brief overview summarizes some recent developments from our Center for Molecular Imprinting related to the topic of this symposium. After a short presentation of the principle of molecular imprinting and recognition, the use of different materials including hybrids for the formation of the host will be discussed, followed by examples given of different formats used such as small polymer beads. In closing, potential directions for the next generation of molecular imprinting technology will be discussed.

A core–shell CdTe quantum dots molecularly imprinted polymer for recognizing and detecting p-nitrophenol based on computer simulation

RSC Advances ◽  
2015 ◽  
Vol 5 (90) ◽  
pp. 73424-73433 ◽  
Author(s):  
Yingchun Wang ◽  
Ningwei Wang ◽  
Xiaoni Ni ◽  
Qianqian Jiang ◽  
Wenming Yang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Computer Simulation ◽  
Molecular Imprinting ◽  
Molecularly Imprinted Polymer ◽  
Cdte Quantum Dots ◽  
Core Shell ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Molecular Imprinting Technology

A novel molecular imprinting technology, combined with computer simulation and QDs, was used to detect 4-NP.

scholarly journals The Use of Computational Methods for the Development of Molecularly Imprinted Polymers

Polymers ◽  
2021 ◽  
Vol 13 (17) ◽  
pp. 2841
Author(s):  
Ian A. Nicholls ◽  
Kerstin Golker ◽  
Gustaf D. Olsson ◽  
Subramanian Suriyanarayanan ◽  
Jesper G. Wiklander
Keyword(s):  
Molecular Imprinting ◽  
Molecularly Imprinted Polymers ◽  
Polymerization Process ◽  
Current Status ◽  
Computational Techniques ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Computational Approaches ◽  
Imprinted Polymers ◽  
Polymerization Mixture

Recent years have witnessed a dramatic increase in the use of theoretical and computational approaches in the study and development of molecular imprinting systems. These tools are being used to either improve understanding of the mechanisms underlying the function of molecular imprinting systems or for the design of new systems. Here, we present an overview of the literature describing the application of theoretical and computational techniques to the different stages of the molecular imprinting process (pre-polymerization mixture, polymerization process and ligand–molecularly imprinted polymer rebinding), along with an analysis of trends within and the current status of this aspect of the molecular imprinting field.

Molecularly imprinted polymers’ application in pesticide residue detection

The Analyst ◽  
2018 ◽  
Vol 143 (17) ◽  
pp. 3971-3989 ◽  
Author(s):  
Saqib Farooq ◽  
Jiyun Nie ◽  
Yang Cheng ◽  
Zhen Yan ◽  
Jing Li ◽  
...  
Keyword(s):  
Thermal Stability ◽  
Pesticide Residue ◽  
Molecular Imprinting ◽  
Molecularly Imprinted Polymers ◽  
High Selectivity ◽  
High Sensitivity ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Residue Detection ◽  
Molecular Imprinting Technology

Molecularly imprinted polymers (MIPs) are produced using molecular imprinting technology (MIT) and have specific analyte-binding abilities and unique properties, including chemical and thermal stability, reusability, high selectivity, and high sensitivity.

Molecularly Imprinted Polymer Particles and Beads: A Survey of Modern Synthetic Techniques

2020 ◽  
Vol 16 ◽  
Author(s):  
Nasrullah Shah ◽  
Zubair Ullah Khan ◽  
Manzoor Hussain ◽  
Touseef Rehan ◽  
Abbas Khan ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Stationary Phases ◽  
Special Focus ◽  
Specific Function ◽  
Separation And Purification ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Molecular Imprinting Technology ◽  
Shape And Size

Abstract: Molecular imprinting technology is based on incorporating template molecules in the polymer matrix followed by their extraction to leave specific cavities similar in shape and size to the incorporated template molecules. The resultant molecularly imprinted polymers (MIPs) then show antibody-like and enzyme-like behavior. MIPs are used as selective adsorbents, stationary phases, sensors, drug delivery agents, ultrafiltration systems and as catalysts etc. To achieve a specific function, MIPs are synthesized in various forms like beads, particles, membranes, fibers and composites. MIP beads and particles have prime importance due to their use in multiple applications. In this article, we present a survey of various polymerization techniques used for the synthesis of MIP beads and particles along with special focus on the studies presenting their use in separation and purification

scholarly journals Ferric Iron-Containing Molecularly Imprinted Polymer as an Adsorbent for Cholesterol

2003 ◽  
Vol 21 (3) ◽  
pp. 261-268 ◽  
Author(s):  
K. Sreenivasan ◽  
R. Sivakumar
Keyword(s):  
Adsorption Capacity ◽  
Molecular Imprinting ◽  
Molecularly Imprinted Polymer ◽  
Molecularly Imprinted Polymers ◽  
Ferric Iron ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Imprinted Polymers ◽  
Chemically Modified

Molecular imprinting is an elegant approach to the synthesis of polymers with predetermined recognition properties, the technique of molecular imprinting involving arranging the functional monomers around the print molecules prior to polymerisation. Molecularly imprinted polymers (MIPs) show a remarkable ability to bind print molecule from a mixture of entities which are close in structure. One of the serious drawbacks of MIPs is their low adsorption capacity and one approach to improving this relies on the use of chemically modified monomers in the synthesis of the MIPs. This report discusses the synthesis and evaluation of an MIP based on ferric acrylate as an adsorbent for cholesterol.

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