scholarly journals Microenvironment in Vagina as a Key-Player on Cervical Cancer: Interaction of Polymorphic Genetic Variants and Vaginal Microbiome as Co-Factors

2018 ◽  
Author(s):  
Andreia Matos ◽  
Alda Pereira da Silva ◽  
Rui Medeiros ◽  
Manuel Bicho ◽  
Maria Clara Bicho
Keyword(s):  
Cervical Cancer ◽  
Genetic Variants ◽  
Vaginal Microbiome

scholarly journals The impact of genetic variants inIL1R2on cervical cancer risk among Uygur females from China: A case-control study

2018 ◽  
Vol 7 (1) ◽  
pp. e00516 ◽  
Author(s):  
Fanglin Niu ◽  
Tianchang Wang ◽  
Jing Li ◽  
Mengdan Yan ◽  
Dianzhen Li ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Risk ◽  
Genetic Variants ◽  
Case Control Study ◽  
Case Control ◽  
Cervical Cancer Risk ◽  
The Impact ◽  
Control Study

scholarly journals Identification of Genetic Variants of Human Papillomavirus in a Group of Mexican HIV/AIDS Patients and Their Possible Association with Cervical Cancer

2021 ◽  
Vol 70 (4) ◽  
pp. 501-509
Author(s):  
FELIPE ORTIZ-GUTIÉRREZ ◽  
LILIA SÁNCHEZ-MINUTTI ◽  
JOSÉ F. MARTÍNEZ-HERRERA ◽  
INDIANA D. TORRES-ESCOBAR ◽  
ELIAS B. PEZZAT-SAID ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Genetic Variants ◽  
Direct Relationship ◽  
Low Risk ◽  
Hiv Positive ◽  
Hiv Positive Women ◽  
Immunodeficiency Virus ◽  
Regional Population ◽  
Polymerase Chain

Infections caused by the human immunodeficiency virus (HIV) and human papillomavirus (HPV) cause thousands of deaths worldwide each year. So far, there has been no consensus on whether there is a direct relationship between the incidence of neoplasms and the immunosuppression caused by HIV that could help understand if coinfection increases the likelihood of cervical cancer. The objective of the study was to identify the presence of genetic variants of HPV in a group of HIV-positive women and their possible association with cervical cancer. Cervical samples were taken from HIV-positive patients for cytological analysis to identify the HPV genotype by polymerase chain reaction (PCR) and sequencing. The most preva¬lent L1 capsid protein mutations in the HPV genotype were ana¬lyzed in silico. Various types of HPV were identified, both high-risk (HR) and low-risk (LR). The most prevalent genotype was HPV51. Analysis of the L1 gene sequences of HPV51 isolates showed nucleo¬tide variations. Of the samples analyzed in Puebla, Mexico, HPV51 had the highest incidence (17.5%, 7/40). Different mutations, which could be used as population markers, were detected in this area, and they have not been reported in the L1 databases for HPV51 in Mexico. Genotypes 6, 14, 86, 87, 89, and 91, not detected or reported in samples from patients with HPV in Mexico, were also identified. Data from the population analyzed suggest no direct relationship between HIV immunosuppression and cervical cancer, regardless of the high- or low-risk HPV genotype. Furthermore, it is possible to develop regional population markers for the detection of HPV based on the mutations that occur in the sequence of nucleotides analyzed.

scholarly journals Genetic Variants in microRNA Target Sites of 37 Selected Cancer-Related Genes and the Risk of Cervical Cancer

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e86061 ◽  
Author(s):  
Yang Mi ◽  
Lijuan Wang ◽  
Lu Zong ◽  
Meili Pei ◽  
Qingyang Lu ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Genetic Variants ◽  
Microrna Target ◽  
Target Sites

scholarly journals Microbiome and Cervical Cancer

Pathobiology ◽  
2020 ◽  
pp. 1-11
Author(s):  
Cristina Paula Castanheira ◽  
Mayara Luciana Sallas ◽  
Rafaella Almeida Lima Nunes ◽  
Noely Paula Cristina Lorenzi ◽  
Lara Termini
Keyword(s):  
Cervical Cancer ◽  
Genital Tract ◽  
Current Knowledge ◽  
Disease Onset ◽  
Female Genital Tract ◽  
Hpv Infection ◽  
Vaginal Microbiome ◽  
Associated Lesions ◽  
Cervical Disease ◽  
Female Genital

Persistent infection with some types of mucosal human papillomavirus (HPV) is the etiological factor for the development of cervical cancer and its precursor lesions. Besides, several cofactors are known to play a role in cervical disease onset and progression either by favoring or by preventing HPV infection and persistence. The microbiome of a healthy female genital tract is characterized by the presence of 1 or few varieties of lactobacilli. However, high-throughput studies addressing the bacterial diversity and abundance in the female genital tract have shown that several factors, including hormonal levels, hygiene habits, and sexually transmitted diseases may disrupt the natural balance, favoring the outgrowth of some groups of bacteria, which in turn may favor some pathological states. Recently, the vaginal microbiome has emerged as a new variable that could greatly influence the natural history of HPV infections and their clinical impact. In this context, changes in the vaginal microbiome have been detected in women infected with HPV and women with HPV-associated lesions and cancer. However, the role of specific bacteria groups in the development/progression or prevention/regression of HPV-associated pathologies is not well understood. In this review we summarize the current knowledge concerning changes in vaginal microbiome and cervical disease. We discuss the potential functional interplay between specific bacterial groups and HPV infection outcomes.

scholarly journals Investigation of metastasis-associated in colon cancer-1 genetic variants in the development and clinicopathologcial characteristics of uterine cervical cancer in Taiwanese women

2020 ◽  
Vol 17 (4) ◽  
pp. 490-497
Author(s):  
Yi-Hung Sun ◽  
Ying-Hsiang Chou ◽  
Chu-Chyn Ou ◽  
Soo-Cheen Ng ◽  
Huang-Pin Shen ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Colon Cancer ◽  
Genetic Variants ◽  
Uterine Cervical Cancer ◽  
Taiwanese Women

Genetic variants in microRNAs are associated with cervical cancer risk

Mutagenesis ◽  
2019 ◽  
Vol 34 (2) ◽  
pp. 127-133 ◽  
Author(s):  
Shizhi Wang ◽  
Haixia Zhu ◽  
Bo Ding ◽  
Xinrui Feng ◽  
Wenxuan Zhao ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Risk ◽  
Genetic Variants ◽  
Cervical Cancer Risk

Genetic Variants of DNA Repair Gene XPC Modulating Susceptibility to Cervical Cancer in North India

2009 ◽  
Vol 18 (7) ◽  
pp. 329-335
Author(s):  
Ruchika Gangwar ◽  
Balraj Mittal ◽  
Shruti Srivastava ◽  
Hariom Singh ◽  
Rama Devi Mittal
Keyword(s):  
Cervical Cancer ◽  
Dna Repair ◽  
Genetic Variants ◽  
North India ◽  
Repair Gene ◽  
Dna Repair Gene

Association of changes in vaginal microbiome with oligoclonal T-cell expansion and early response to chemoradiation for cervical cancer.

2018 ◽  
Vol 36 (5_suppl) ◽  
pp. 8-8
Author(s):  
Lauren Elizabeth Colbert ◽  
Andrea Delgado Medrano ◽  
Rebecca A. Previs ◽  
Patricia J. Eifel ◽  
Anuja Jhingran ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Radiation Therapy ◽  
T Cell ◽  
Clinical Studies ◽  
Cell Expansion ◽  
Bacterial Species ◽  
Early Response ◽  
Vaginal Microbiome ◽  
T Cell Clonality ◽  
Cell Clonality

8 Background: The composition of the vaginal microbiome has been shown to affect clearance of HPV virus and transformation to invasive cancer. Clinical studies correlating the vaginal microbiome with immune activation and response to cancer treatment are lacking. We profiled intratumoral T-cell clonality during radiation therapy and correlated it with the diversity of the vaginal flora. Methods: Thirty patients with newly diagnosed locally advanced cervical cancer were enrolled on a prospective study to characterize changes in the cervical microbiome during chemoradiation. Cervical samples were obtained before radiation therapy and during the 1st, 3rd, and 5th week of radiation therapy. The vaginal microbiome was characterized using 16 sRNA gene sequencing to produce operational taxonomic units (OTU’s) representing individual bacterial species. Disease response was categorized as early response (ER), late response (LR), or nonresponse (NR) on the basis of clinical examination at brachytherapy and 3-month PET/CT. Twenty patients had T-cell receptor β sequencing of DNA performed using the ImmunoSEQ platform. The maximum productive frequency of the top three clones (MP3) was used to assess T-cell clonality. Results: Early response was associated with clonal T-cell expansion with an increase of MP3 of 11.1% during treatment as compared to a decline of 6.1% in patients with LR/NR (p = 0.05). Early response was also associated with lower quantity of observed OTU’s of vaginal microbiota (25.0 [SD 12.68]) vs patients with LR/NR (41.15 [SD = 23.3]) (p = 0·03). Increased MP3 was associated with increased abundance of Corynebacteriales (R = 0.90; p < .0001) , Actinomycetales (R = 0.83; p < .0001) and Bifidobacteriales (R = 0.82; p < .0001) . Decreased MP3 was associated with increased abundance of lactobacillus (R = -0.61; p < .0001). Conclusions: Increased diversity of the vaginal microbiome is negatively associated with outcome, supporting previous clinical studies in non-cancer settings. Specific vaginal bacterial species are associated with increased or decreased T-cell clonality at completion of radiation.

Genetic variants in HLA-DP/DQ contribute to risk of cervical cancer: A two-stage study in Chinese women

2013 ◽  
Vol 129 (2) ◽  
pp. 401-405 ◽  
Author(s):  
Jie Jiang ◽  
Ni Li ◽  
Yan Shen ◽  
Jibin Liu ◽  
Li Liu ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Genetic Variants ◽  
Chinese Women ◽  
Two Stage

Genetic variants of interleukin-1RN and interleukin-1β genes and risk of cervical cancer

2008 ◽  
Vol 115 (5) ◽  
pp. 633-638 ◽  
Author(s):  
H Singh ◽  
R Sachan ◽  
H Goel ◽  
B Mittal
Keyword(s):  
Cervical Cancer ◽  
Genetic Variants ◽  
Interleukin 1Β
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