scholarly journals Systems Glycobiology: Past, Present, and Future

2020 ◽  
Author(s):  
Songül Yaşar Yıldız
Keyword(s):  
Systems Biology ◽  
Computational Modeling ◽  
Structure Function ◽  
Leading Edge ◽  
Research Area ◽  
Basic Knowledge ◽  
Bioinformatics Tools ◽  
Wet Lab ◽  
Living Organisms ◽  
The Impact

Glycobiology is a glycan-based field of study that focuses on the structure, function, and biology of carbohydrates, and glycomics is a sub-study of the field of glycobiology that aims to define structure/function of glycans in living organisms. With the popularity of the glycobiology and glycomics, application of computational modeling expanded in the scientific area of glycobiology over the last decades. The recent availability of progressive Wet-Lab methods in the field of glycobiology and glycomics is promising for the impact of systems biology on the research area of the glycome, an emerging field that is termed “systems glycobiology.” This chapter will summarize the up-to-date leading edge in the use of bioinformatics tools in the field of glycobiology. The chapter provides basic knowledge both for glycobiologists interested in the application of bioinformatics tools and scientists of computational biology interested in studying the glycome.

scholarly journals Genetic Learning: A New Conceptual Framework for Studying the Impact of the Environment on Changes in Genetic Behavior

2021 ◽  
Author(s):  
Sean Hughes ◽  
Jan De Houwer
Keyword(s):  
Genetic Material ◽  
Research Area ◽  
Behavior Changes ◽  
Genetic Activity ◽  
Genetic Level ◽  
Nature And Nurture ◽  
Living Organisms ◽  
New Research ◽  
Future Work ◽  
The Impact

Research shows that genetic material and environment are engaged in an ongoing conversation, one that dictates both physiology and psychology. In this paper we argue that genetic material and environment are not engaged in a single conversation but rather multiple types of conversations, and offer researchers a set of conceptual tools to better understand what nature and nurture are saying to one another. In Part I we highlight three types of activity that can be studied: behavior, changes in behavior, and learning. We define what it means to say that learning has taken place and highlight different ways in which living organisms do so. In Part II we apply this analysis to the genetic level. We argue that until now, the life and social sciences have primarily focused on two types of genetic activity (genetic behavior and changes in genetic behavior), while a third (genetic learning) is still waiting to be explored systematically. In Part III we consider how our approach better organizes past, present, and future work on genetic activity (heuristic value) and opens up a new research area centered on genetic learning (generative value).

Piezoelectric β-polymorph formation of new textiles by surface modification with coating process based on interfacial interaction on the conformational variation of poly (vinylidene fluoride) (PVDF) chains

2020 ◽  
Vol 91 (3) ◽  
pp. 31301
Author(s):  
Nabil Chakhchaoui ◽  
Rida Farhan ◽  
Meriem Boutaldat ◽  
Marwane Rouway ◽  
Adil Eddiai ◽  
...  
Keyword(s):  
High Efficiency ◽  
Vinylidene Fluoride ◽  
Research Work ◽  
Research Area ◽  
Interfacial Interaction ◽  
Tetraethyl Orthosilicate ◽  
Poly Vinylidene Fluoride ◽  
Carbon Nanofillers ◽  
The Impact ◽  
Advanced Applications

Novel textiles have received a lot of attention from researchers in the last decade due to some of their unique features. The introduction of intelligent materials into textile structures offers an opportunity to develop multifunctional textiles, such as sensing, reacting, conducting electricity and performing energy conversion operations. In this research work nanocomposite-based highly piezoelectric and electroactive β-phase new textile has been developed using the pad-dry-cure method. The deposition of poly (vinylidene fluoride) (PVDF) − carbon nanofillers (CNF) − tetraethyl orthosilicate (TEOS), Si(OCH2CH3)4 was acquired on a treated textile substrate using coating technique followed by evaporation to transform the passive (non-functional) textile into a dynamic textile with an enhanced piezoelectric β-phase. The aim of the study is the investigation of the impact the coating of textile via piezoelectric nanocomposites based PVDF-CNF (by optimizing piezoelectric crystalline phase). The chemical composition of CT/PVDF-CNC-TEOS textile was detected by qualitative elemental analysis (SEM/EDX). The added of 0.5% of CNF during the process provides material textiles with a piezoelectric β-phase of up to 50% has been measured by FTIR experiments. These results indicated that CNF has high efficiency in transforming the phase α introduced in the unloaded PVDF, to the β-phase in the case of nanocomposites. Consequently, this fabricated new textile exhibits glorious piezoelectric β-phase even with relatively low coating content of PVDF-CNF-TEOS. The study demonstrates that the pad-dry-cure method can potentially be used for the development of piezoelectric nanocomposite-coated wearable new textiles for sensors and energy harvesting applications. We believe that our study may inspire the research area for future advanced applications.

The yield of perennial grass stands on drained organic soils of Steppe

2016 ◽  
Vol 1 (90) ◽  
pp. 92-97
Author(s):  
I.T. Slusar ◽  
V.A. Serbenyuk ◽  
A.N. Gera ◽  
A.P. Solyanik ◽  
A.A. Tarasenko
Keyword(s):  
Zinc Sulphate ◽  
Foliar Application ◽  
Perennial Grass ◽  
Mineral Fertilizer ◽  
Dry Weight ◽  
Research Area ◽  
Organic Soils ◽  
Growth Promoters ◽  
Cobalt Sulfate ◽  
The Impact

Research on the impact of the introduction of micro fertilizers and growth promoters on a background of mineral fertilizer and without N90R45К120 spent on old peat in shallow carbonate floodplain r.Supiy, Yahotyn Kyiv region. Power peat horizon about 60-70 cm, 7,4-7,6 pH of the aqueous extract, stupas schedule 56-60%, density 0,49-0,52 assembly soil, total nitrogen content (%) - 1.9; gross forms of phosphorus - 0,4, potassium 0.2, 20% lime. In experiments studying biological rehoplant, radustym, Biolan, emistim, Jets, humisol, plantafol, radyfarm and micronutrients: copper, boric acid, manganese sulphate, zinc sulphate, potassium humates. Treatment drugs conducted in the spring by spraying mixtures. Space research area of 60 m2, three-time repetition. It is established that the use of growth stimulants and micronutrients in the background N90R45К120 provided the highest yield mixtures of years, against making BIOLan - 9.9 t / ha Radyfarmu - 9.6 t / ha Radostymu 9.3 t / ha dry weight. In areas for making other preparations were intermediate yield growth rates - 0.5 - 2.0 t / ha dry weight. Also good gains herbage yields obtained by making all kinds of micronutrients and growth stimulants in the background without making makrodobryv which was within 5.3 - 6.9 t / ha to control without fertilization - 4.5 t / ha dry weight. In deep peat copper fertilizer (25 kg / ha of copper sulphate or 5 kg / ha pirytnoho cinders) in all zones should be making every 3-4 years, and zinc, cobalt and molybdenum advisable to make time for the growing season, spring, by foliar application in such numbers: ammonium molibdenovokyslyy - 0.3 kg / ha; cobalt sulfate - 3 kg / ha zinc sulphate 0.5 kg / ha or placers these salts should be mixed with major fertilizer.

scholarly journals Prognostic implications of troponin T variations in inherited cardiomyopathies using systems biology

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Rameen Shakur ◽  
Juan Pablo Ochoa ◽  
Alan J. Robinson ◽  
Abhishek Niroula ◽  
Aneesh Chandran ◽  
...  
Keyword(s):  
Heart Failure ◽  
Systems Biology ◽  
Sudden Cardiac Death ◽  
Risk Stratification ◽  
Clinical Data ◽  
Cardiac Death ◽  
Troponin T ◽  
Management Options ◽  
Familial Cardiomyopathy ◽  
The Impact

AbstractThe cardiac troponin T variations have often been used as an example of the application of clinical genotyping for prognostication and risk stratification measures for the management of patients with a family history of sudden cardiac death or familial cardiomyopathy. Given the disparity in patient outcomes and therapy options, we investigated the impact of variations on the intermolecular interactions across the thin filament complex as an example of an unbiased systems biology method to better define clinical prognosis to aid future management options. We present a novel unbiased dynamic model to define and analyse the functional, structural and physico-chemical consequences of genetic variations among the troponins. This was subsequently integrated with clinical data from accessible global multi-centre systematic reviews of familial cardiomyopathy cases from 106 articles of the literature: 136 disease-causing variations pertaining to 981 global clinical cases. Troponin T variations showed distinct pathogenic hotspots for dilated and hypertrophic cardiomyopathies; considering the causes of cardiovascular death separately, there was a worse survival in terms of sudden cardiac death for patients with a variation at regions 90–129 and 130–179 when compared to amino acids 1–89 and 200–288. Our data support variations among 90–130 as being a hotspot for sudden cardiac death and the region 131–179 for heart failure death/transplantation outcomes wherein the most common phenotype was dilated cardiomyopathy. Survival analysis into regions of high risk (regions 90–129 and 130–180) and low risk (regions 1–89 and 200–288) was significant for sudden cardiac death (p = 0.011) and for heart failure death/transplant (p = 0.028). Our integrative genomic, structural, model from genotype to clinical data integration has implications for enhancing clinical genomics methodologies to improve risk stratification.

scholarly journals Morphodynamic signatures of MDA-MB-231 single cells and cell doublets undergoing invasion in confined microenvironments

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xingjian Zhang ◽  
Trevor Chan ◽  
Michael Mak
Keyword(s):  
Single Cell ◽  
Single Cells ◽  
Leading Edge ◽  
Cell Group ◽  
Collective State ◽  
Long Term Effects ◽  
Cell Metastasis ◽  
Geometric Confinement ◽  
Short And Long Term ◽  
The Impact

AbstractCancer cell metastasis is a major factor in cancer-related mortality. During the process of metastasis, cancer cells exhibit migratory phenotypes and invade through pores in the dense extracellular matrix. However, the characterization of morphological and subcellular features of cells in similar migratory phenotypes and the effects of geometric confinement on cell morphodynamics are not well understood. Here, we investigate the phenotypes of highly aggressive MDA-MB-231 cells in single cell and cell doublet (an initial and simplified collective state) forms in confined microenvironments. We group phenotypically similar single cells and cell doublets and characterize related morphological and subcellular features. We further detect two distinct migratory phenotypes, fluctuating and non-fluctuating, within the fast migrating single cell group. In addition, we demonstrate an increase in the number of protrusions formed at the leading edge of cells after invasion through geometric confinement. Finally, we track the short and long term effects of varied degrees of confinement on protrusion formation. Overall, our findings elucidate the underlying morphological and subcellular features associated with different single cell and cell doublet phenotypes and the impact of invasion through confined geometry on cell behavior.

Experimental study of heat transfer in the boundary layer of a flat plate with the impact of weak shock waves on the leading edge

2020 ◽  
Author(s):  
V. L. Kocharin ◽  
A. A. Yatskikh ◽  
D. S. Prishchepova ◽  
A. V. Panina ◽  
Yu. G. Yermolaev ◽  
...  
Keyword(s):  
Heat Transfer ◽  
Boundary Layer ◽  
Experimental Study ◽  
Shock Waves ◽  
Flat Plate ◽  
Leading Edge ◽  
Weak Shock ◽  
The Impact

scholarly journals Privileging Electric Vehicles as an Element of Promoting Sustainable Urban Mobility—Effects on the Local Transport System in a Large Metropolis in Poland

Energies ◽  
2021 ◽  
Vol 14 (13) ◽  
pp. 3838
Author(s):  
Marta Borowska-Stefańska ◽  
Michał Kowalski ◽  
Paulina Kurzyk ◽  
Miroslava Mikušová ◽  
Szymon Wiśniewski
Keyword(s):  
Transport System ◽  
Electric Vehicles ◽  
Traffic Management ◽  
Negative Impact ◽  
Software Tool ◽  
Research Area ◽  
Shopping Centre ◽  
Local Transport ◽  
Sustainable Urban Mobility ◽  
The Impact

The main purpose of this article was to determine the impact on the equilibrium of the local transport system from privileging EVs by permitting them to use bus lanes. The study used two sets of data: information on infrastructure and traffic management; and information on the recorded road network loads and traffic volumes generated by a given shopping centre—the E. Leclerc shopping centre (an important traffic generator within the city of Łódź, Poland). These sets were then used to develop a microsimulation traffic model for the shopping centre and the associated effects on the localised transport system. The model was constructed by means of the PTV Vissim software tool. An initial simulation was conducted that formed a basis for subsequent scenarios (in total, 17 simulations were performed). On the basis of the conducted analyses, it was established that—for the researched part of the transport system—privileging the still rather uncommon battery electric vehicles (BEVs) engendered a marginal deterioration of traffic conditions. At the same time, allowing BEVs to use bus lanes within the chosen research area had no negative impact on bus journey times.

Self-Acceleration in the Parameterization of Orographic Gravity Wave Drag

2010 ◽  
Vol 67 (8) ◽  
pp. 2537-2546 ◽  
Author(s):  
John F. Scinocca ◽  
Bruce R. Sutherland
Keyword(s):  
Gravity Wave ◽  
Middle Atmosphere ◽  
Wave Train ◽  
Leading Edge ◽  
Wave Theory ◽  
Wave Drag ◽  
Tuning Parameter ◽  
Mean Flow ◽  
Propagating Waves ◽  
The Impact

Abstract A new effect related to the evaluation of momentum deposition in conventional parameterizations of orographic gravity wave drag (GWD) is considered. The effect takes the form of an adjustment to the basic-state wind about which steady-state wave solutions are constructed. The adjustment is conservative and follows from wave–mean flow theory associated with wave transience at the leading edge of the wave train, which sets up the steady solution assumed in such parameterizations. This has been referred to as “self-acceleration” and it is shown to induce a systematic lowering of the elevation of momentum deposition, which depends quadratically on the amplitude of the wave. An expression for the leading-order impact of self-acceleration is derived in terms of a reduction of the critical inverse Froude number Fc, which determines the onset of wave breaking for upwardly propagating waves in orographic GWD schemes. In such schemes Fc is a central tuning parameter and typical values are generally smaller than anticipated from conventional wave theory. Here it is suggested that self-acceleration may provide some of the explanation for why such small values of Fc are required. The impact of Fc on present-day climate is illustrated by simulations of the Canadian Middle Atmosphere Model.

scholarly journals Changes Caused by Low Doses of Bisphenol A (BPA) in the Neuro-Chemistry of Nerves Located in the Porcine Heart

Animals ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 780
Author(s):  
Krystyna Makowska ◽  
Slawomir Gonkowski
Keyword(s):  
Bisphenol A ◽  
Endocrine Disruptor ◽  
Sympathetic Innervation ◽  
Daily Intake ◽  
Everyday Objects ◽  
Living Organisms ◽  
The Impact ◽  
Heart Wall ◽  
Cholinergic Structures

Bisphenol A (BPA) contained in plastics used in the production of various everyday objects may leach from these items and contaminate food, water and air. As an endocrine disruptor, BPA negatively affects many internal organs and systems. Exposure to BPA also contributes to heart and cardiovascular system dysfunction, but many aspects connected with this activity remain unknown. Therefore, this study aimed to investigate the impact of BPA in a dose of 0.05 mg/kg body weight/day (in many countries such a dose is regarded as a tolerable daily intake–TDI dose of BPA–completely safe for living organisms) on the neurochemical characterization of nerves located in the heart wall using the immunofluorescence technique. The obtained results indicate that BPA (even in such a relatively low dose) increases the number of nerves immunoreactive to neuropeptide Y, substance P and tyrosine hydroxylase (used here as a marker of sympathetic innervation). However, BPA did not change the number of nerves immunoreactive to vesicular acetylcholine transporter (used here as a marker of cholinergic structures). These observations suggest that changes in the heart innervation may be at the root of BPA-induced circulatory disturbances, as well as arrhythmogenic and/or proinflammatory effects of this endocrine disruptor. Moreover, changes in the neurochemical characterization of nerves in the heart wall may be the first sign of exposure to BPA.

scholarly journals Beyond analogy: A model of bioinspiration for creative design

2016 ◽  
Vol 30 (2) ◽  
pp. 159-170 ◽  
Author(s):  
Camila Freitas Salgueiredo ◽  
Armand Hatchuel
Keyword(s):  
Design Process ◽  
Design Theory ◽  
Leading Edge ◽  
Knowledge Bases ◽  
Biologically Inspired ◽  
Concept Knowledge ◽  
Bioinspired Design ◽  
Aerodynamic Properties ◽  
Biologically Inspired Design ◽  
The Impact

AbstractIs biologically inspired design only an analogical transfer from biology to engineering? Actually, nature does not always bring “hands-on” solutions that can be analogically applied in classic engineering. Then, what are the different operations that are involved in the bioinspiration process and what are the conditions allowing this process to produce a bioinspired design? In this paper, we model the whole design process in which bioinspiration is only one element. To build this model, we use a general design theory, concept–knowledge theory, because it allows one to capture analogy as well as all other knowledge changes that lead to the design of a bioinspired solution. We ground this model on well-described examples of biologically inspired designs available in the scientific literature. These examples include Flectofin®, a hingeless flapping mechanism conceived for façade shading, and WhalePower technology, the introduction of bumps on the leading edge of airfoils to improve aerodynamic properties. Our modeling disentangles the analogical aspects of the biologically inspired design process, and highlights the expansions occurring in both knowledge bases, scientific (nonbiological) and biological, as well as the impact of these expansions in the generation of new concepts (concept partitioning). This model also shows that bioinspired design requires a special form of collaboration between engineers and biologists. Contrasting with the classic one-way transfer between biology and engineering that is assumed in the literature, the concept–knowledge framework shows that these collaborations must be “mutually inspirational” because both biological and engineering knowledge expansions are needed to reach a novel solution.

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