scholarly journals Sarcomas Epidemiology in Iran: Analysis of Data from Iranian National Cancer Registry between 2009 and 2014

2021 ◽  
Vol 14 (5) ◽  
Author(s):  
Leila Asef-Kabiri ◽  
Afshin Moradi ◽  
Maryam Khayamzadeh ◽  
Farid Moradian ◽  
Mohammad Esmaeil Akbari
Keyword(s):  
Soft Tissue ◽  
Cancer Registry ◽  
Lower Limb ◽  
Distribution Patterns ◽  
Incidence Rates ◽  
World Health ◽  
Long Bone ◽  
Spindle Cell Sarcoma ◽  
National Cancer Registry ◽  
Incidence Trends

Background: Sarcomas are a wide group of tumors with a mesenchymal origin, accounting for 1% of all adult malignancies. Objectives: This study examined the incidence rates and distribution patterns of morphological subtypes and primary sites of soft tissue and bone sarcomas in a 6-years period in the total population of Iran. Methods: The data was retrieved from the Iranian National Cancer Registry (INCR). A total of 14630 patients were identified with either bone or soft tissue sarcoma during 2009 - 2014. The morphological and topographical classifications were based on the ICD-O-3 and World Health Organization (WHO) guidelines. The crude and age-standardized incidence rates (ASIR) were calculated. Results: The combined crude incidence was calculated 3.2/100,000, and for STS and BS was 2.7 and 0.5 per 100,000 individuals, respectively, increasing with the age. Among the patients, 16.47 and 83.53% of cases had BS and STS, respectively with male predilection. The ASIR calculated 2.8 and 2.6 for STS and 0.51 and 0.37 for BS in males and females, respectively. Sarcoma, osteosarcoma, leiomyosarcoma, liposarcoma, and spindle cell sarcoma were the most common morphologies. The connective tissue of the lower limb, long bone of the lower limb, skin, and uterus were the most frequent primary tumor sites. The majority of tumors were of unknown/undifferentiated grade (grade 9), then grade 3, 1, 2, 4, and score 0 had the highest frequencies, respectively. The highest ASIR of sarcoma was detected in Khuzestan, Kohgiloyeh and Boyer-Ahmad, Isfahan, Tehran, Fars, and Khorasan Razavi provinces. Analysis of the incidence trends showed a slight increase over the study period. Conclusions: These findings can help better diagnose and management of sarcoma patients throughout Iran.

scholarly journals Trends in cancer incidence in Uruguay:2002 - 2015

2019 ◽  
Author(s):  
Mariela Garau ◽  
Carina Musetti ◽  
Rafael Alonso ◽  
Enrique Barrios
Keyword(s):  
Lung Cancer ◽  
Cancer Registry ◽  
Cancer Incidence ◽  
Incidence Rates ◽  
Medical Community ◽  
Screening Programs ◽  
National Cancer Registry ◽  
Incidence Trends ◽  
Incidence And Mortality ◽  
Life Style Changes

Background: Uruguay is the southamerican country which has the highest cancer incidence and mortality rates. The National Cancer Registry collects data on cancer cases nationwide since 1989 and has reached high quality standards in the last decades. This is the first report on incidence trends. Methods: Data from the National Cancer Registry of all new cases of invasive cancer from twelve sites diagnosed in 2002-2015 was analyzed. Age-standardized rates were calculated. Trends of incidence rates were analyzed using joinpoint regression models. Results For both, men and women, incidence rates trends for all cancer sites, colo-rectal and bladder cancer remained stable. Esophageal and gastric cancers descend while Thyroid and kidney cancer incidence increased. In men lung cancer decreased; testicular cancer increased, and prostate cancer increased at the beginning of the period and decreased in the final years. In women; lung cancer increased, breast cancer remained stable and cervical cancer presented a significant decline from 2005 to 2010 and reached a plateau since then. Conclusion: Cancer incidence dynamics are complex and affected not only by Public Health policies such as tobacco control, vaccination and screening programs, but also by environmental and life style changes and the attitude of the medical community towards the application of diagnostic and therapeutic tools. The aim of this paper is to analyze cancer incidence time trends in the country and provide possible explanations to them.

scholarly journals Trends in Leading Cancer Incidence among Iranian Women: Annual Cancer Registry Reports, 2003-2015

2021 ◽  
Author(s):  
Razieh Bidhendi-Yarandi ◽  
Mohammad Hossein Panahi
Keyword(s):  
Breast Cancer ◽  
Cancer Registry ◽  
Cancer Incidence ◽  
Breast Cancer Incidence ◽  
Iranian Women ◽  
Annual Percent Change ◽  
National Cancer Registry ◽  
Incidence Trends ◽  
History Of ◽  
Increasing Trends

Background: Cancer is one of the most important causes of death in the world and has an increasing trend globally. We aimed at investigating the five leading cancers in Iranian women based on a 10-year history of cancer registry reports and illustrating the trends in all cancer sites and breast cancer as the top leading one from 2003 to 2015. Methods: Data were obtained from national cancer registry study. Age-Specific Incidence Rate (ASR) data were obtained from Iran’s annual national cancer registry reports between 2003 to 2010 and 2014 to 2015. Using Joinpoint regression, we analyzed incidence trends over time for all cancer sites and the top leading cancer from 2003 to 2015. Results: Breast cancer was ranked first in Iranian women. Its ASR raised from 15.96 in 2003 to 32.63 in 2015. Results of trend analysis based on Annual Percent Change (APC) index showed 5.6 (95%CI: 2.9 to 8.3) and 4.6 (95%CI: 2.0 to 7.2) annual increase in the incidence of all cancer sites and breast cancer from 2003 to 2015, respectively. Conclusion: This study indicates significant increasing trends in all cancer sites and breast cancer incidence in Iran. Despite the national coverage of cancer registry over the past decade, more considerations should be taken into account, especially in Breast cancer.

Validation of a Soft Tissue Sarcoma Nomogram Using a National Cancer Registry

2015 ◽  
Vol 22 (S3) ◽  
pp. 398-403 ◽  
Author(s):  
Sanjay P. Bagaria ◽  
Amy E. Wagie ◽  
Richard J. Gray ◽  
Barbara A. Pockaj ◽  
Steven Attia ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Cancer Registry ◽  
National Cancer Registry

scholarly journals Incidence and clinicopathological features of colorectal cancer among multi-ethnic patients in Kuala Lumpur, Malaysia: a hospital-based retrospective analysis over two decades

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e12425
Author(s):  
Khairul Najmi Muhammad Nawawi ◽  
Norfilza M. Mokhtar ◽  
Zhiqin Wong ◽  
Zairul Azwan Mohd Azman ◽  
Deborah Chia Hsin Chew ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Retrospective Analysis ◽  
Incidence Rate ◽  
Age Groups ◽  
Incidence Rates ◽  
Clinicopathological Features ◽  
World Health ◽  
Kuala Lumpur ◽  
Incidence Trends ◽  
The Mean

Background The incidence rate of colorectal cancer (CRC) in Asian countries is increasing. Furthermore, recent studies have shown a concerning rise in the incidence of CRC among younger patients aged less than 50 years. This study aimed to analyze the incidence trends and clinicopathological features in patients with early-onset CRC (EOCRC) and later-onset CRC (at age ≥ 50 years). Methods A retrospective analysis was performed on 946 patients with CRC diagnosed from 1997 to 2017 at Universiti Kebangsaan Malaysia Medical Centre. The time trend was assessed by dividing the two decades into four 5-year periods. The mean age-standardized and age-specific incidence rates were calculated by using the 5-year cumulative population of Kuala Lumpur and World Health Organization standard population. The mean incidence was expressed per 100,000 person-years. Results After a stable (all age groups) CRC incidence rate during the first decade (3.00 per 100,000 and 3.85 per 100,000), it sharply increased to 6.12 per 100,000 in the 2008–2012 period before decreasing to 4.54 per 100,000 in the 2013–2017 period. The CRC incidence trend in later-onset CRC showed a decrease in the 2013–2017 period. Contrariwise, for age groups of 40–44 and 45–49 years, the trends showed an increase in the latter 15 years of the study period (40–44 years: 1.44 to 1.92 to 2.3 per 100,000; 45–49 years: 2.87 to 2.94 to 4.01 per 100,000). Malays’ EOCRC incidence rate increased from 2008–2012 to 2013–2017 for both the age groups 40–44 years (1.46 to 2.89 per 100,000) and 45–49 years (2.73 to 6.51 per 100,000). Nearly one-fifth of EOCRC cases were diagnosed at an advanced stage (Dukes D: 19.9%), and the majority of them had rectal cancer (72.8%). Conclusion The incidence of EOCRC increased over the period 1997–2017; the patients were predominantly Malays, diagnosed at a later stage, and with cancer commonly localized in the rectal region. All the relevant stakeholders need to work on the management and prevention of CRC in Malaysia.

scholarly journals Near-term climate change impacts on sub-national malaria transmission

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jailos Lubinda ◽  
Ubydul Haque ◽  
Yaxin Bi ◽  
Busiku Hamainza ◽  
Adrian J. Moore
Keyword(s):  
Climate Change ◽  
Negative Binomial ◽  
Malaria Incidence ◽  
Incidence Rates ◽  
World Health ◽  
Environmental Predictors ◽  
Incidence Trends ◽  
Spatio Temporal ◽  
Near Term ◽  
The Impact

AbstractThe role of climate change on global malaria is often highlighted in World Health Organisation reports. We modelled a Zambian socio-environmental dataset from 2000 to 2016, against malaria trends and investigated the relationship of near-term environmental change with malaria incidence using Bayesian spatio-temporal, and negative binomial mixed regression models. We introduced the diurnal temperature range (DTR) as an alternative environmental measure to the widely used mean temperature. We found substantial sub-national near-term variations and significant associations with malaria incidence-trends. Significant spatio-temporal shifts in DTR/environmental predictors influenced malaria incidence-rates, even in areas with declining trends. We highlight the impact of seasonally sensitive DTR, especially in the first two quarters of the year and demonstrate how substantial investment in intervention programmes is negatively impacted by near-term climate change, most notably since 2010. We argue for targeted seasonally-sensitive malaria chemoprevention programmes.

scholarly journals Record linkage augments cancer ascertainment in HIV cohorts in South Africa

2017 ◽  
Vol 1 (1) ◽  
Author(s):  
Mazvita Sengayi ◽  
Adrian Spörri ◽  
Eliane Rohner ◽  
Michael Vinikoor ◽  
Hans Prozesky ◽  
...  
Keyword(s):  
South Africa ◽  
South African ◽  
Cancer Registry ◽  
Record Linkage ◽  
Invasive Cervical Cancer ◽  
Cancer Registries ◽  
Incidence Rates ◽  
Attributable Fraction ◽  
Cancer Case ◽  
National Cancer Registry

ABSTRACT BackgroundSub-Saharan Africa is the region most heavily affected by the HIV/AIDS epidemic. HIV increases the risk of developing cancer but the ascertainment of cancers in patients attending antiretroviral therapy (ART) treatment programs might be incomplete. To estimate the under-ascertainment of cancer we compared incidence rates of AIDS-defining cancers in South African HIV cohorts with and without cancer case ascertainment through record linkage with the National Cancer Registry. MethodsWe used the data of adult (≥16 years) HIV-positive persons receiving care between 2004 and 2011 at one of four ART programs in South Africa. These programs collaborate with the International Epidemiologic Databases to Evaluate AIDS Southern Africa (www.iedea-sa.org) and collected data for AIDS-defining cancers but not for other cancers. To improve cancer ascertainment we probabilistically linked patient records (using first name, surname, age, and gender) from two HIV cohorts with the cancer records of the South African National Cancer Registry. We calculated incidence rates per 100,000 person-years after starting ART for the AIDS-defining cancers, i.e. Kaposi sarcoma (KS), invasive cervical cancer (ICC) and non-Hodgkin lymphoma (NHL). We compared incidence rates before and after inclusion of record linkage identified cancer cases using the attributable fraction of cancers identified with 95% confidence intervals (CI). ResultsA total of 49,207 adults starting ART in South Africa were included. 65% of patients were female, median age at starting ART was 35 years (interquartile range 30-41 years). We identified a total of 471 incident cancer cases. With record linkage the incidence increased from 81 to 292 for KS, from 1 to 119 for NHL and 12 to 497 for ICC per 100,000 person-years. The attributable fraction of cancers identified was 72% (95% CI 63-79%) for KS, 98% (95% CI 94-99%) for NHL and 98% (95% CI 95-99%) for ICC. ConclusionAscertainment of cancer in HIV program data in African settings is incomplete. This case study has shown that probabilistic record linkage to cancer registries is both feasible and essential for cancer ascertainment in HIV cohorts in South Africa.

scholarly journals SUN-302 Incidence Trends in Lung and Gastroenteropancreatic Neuroendocrine Neoplasms

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Heba Alwan ◽  
Stefano La Rosa ◽  
Peter Kopp ◽  
Simon Germann ◽  
Manuela Maspoli-Conconi ◽  
...  
Keyword(s):  
Cancer Registries ◽  
Population Based ◽  
Incidence Rates ◽  
World Health ◽  
International Agency ◽  
Neuroendocrine Neoplasms ◽  
Incidence Trends ◽  
Time Period ◽  
Well Differentiated ◽  
Health Organization

Abstract Abstract Introduction The incidence of neuroendocrine neoplasms (NENs) seems to increase worldwide. However, long-term, population-based data that consider differentiation levels are sparse. Objective To evaluate the incidence trend of lung and gastroenteropancreatic (GEP) NENs according to the latest International Agency for Research on Cancer/World Health Organization classification over a 41-year time period in two Swiss regions. Methods All cases of lung and GEP NENs recorded in the Vaud and Neuchâtel Cancer Registries from 1976–2016 were included. NENs were stratified into well-differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs). Changes in annual age-standardized incidence rates were calculated for lung and GEP NETs and NECs by sex. Results There were 4141 patients diagnosed with NENs, of which 65% were men. The incidence of lung NETs did not reveal any statistically significant trend in men, but increased in women by 4.9%/year between 1976–2016. The incidence of lung NECs in men decreased significantly by 2.6%/year from 1985–2016 whereas the incidence of lung NECs in women increased significantly between 1976–1998 by 6%/year. For GEP NETs, a steady annual increase in incidence occurred between 1976–2016 with a magnitude of 1.7% in men and 1.3% in women. No trend in incidence of GEP NECs was found for both sexes. Conclusions The incidence trends of lung NECs in men and women parallel changes in smoking prevalence in the population whereas causes of the increase in incidence of GEP NETs are not fully understood. Our study supports the importance of evaluating the epidemiology of NENs by their differentiation level.

scholarly journals Opposite Incidence Trends for Differentiated and Medullary Thyroid Cancer in Young Dutch Patients over a 30-Year Time Span

Cancers ◽  
2021 ◽  
Vol 13 (20) ◽  
pp. 5104
Author(s):  
Chantal A. Lebbink ◽  
Medard F. M. van den Broek ◽  
Annemiek B. G. Kwast ◽  
Joep P. M. Derikx ◽  
Miranda P. Dierselhuis ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Registry ◽  
Medullary Thyroid Cancer ◽  
Treatment Options ◽  
Lymph Node Involvement ◽  
Incidence Rates ◽  
Medullary Thyroid ◽  
Incidence Trends ◽  
Netherlands Cancer Registry ◽  
Rising Incidence

Thyroid cancer is the most common endocrine malignancy in children. A rising incidence has been reported worldwide. Possible explanations include the increased use of enhanced imaging (leading to incidentalomas) and an increased prevalence of risk factors. We aimed to evaluate the incidence and survival trends of thyroid cancer in Dutch children, adolescents, and young adults (0–24 years) between 1990 and 2019. The age-standardized incidence rates of differentiated thyroid cancer (DTC, including papillary and follicular thyroid cancer (PTC and FTC, respectively)) and medullary thyroid cancer (MTC), the average annual percentage changes (AAPC) in incidence rates, and 10-year overall survival (OS) were calculated based on data obtained from the nationwide cancer registry (Netherlands Cancer Registry). A total of 839 patients aged 0–24 years had been diagnosed with thyroid carcinoma (PTC: 594 (71%), FTC: 128 (15%), MTC: 114 (14%)) between 1990 and 2019. The incidence of PTC increased significantly over time (AAPC +3.6%; 95%CI +2.3 to +4.8), the incidence rate of FTC showed a stable trend ((AAPC −1.1%; 95%CI −3.4 to +1.1), while the incidence of MTC decreased significantly (AAPC: −4.4% (95%CI −7.3 to −1.5). The 10-year OS was 99.5% (1990–1999) and 98.6% (2000–2009) in patients with DTC and 92.4% (1990–1999) and 96.0% (2000–2009) in patients with MTC. In this nationwide study, a rising incidence of PTC and decreasing incidence of MTC were observed. For both groups, in spite of the high proportion of patients with lymph node involvement at diagnosis for DTC and the limited treatment options for MTC, 10-year OS was high.

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