Laboratory Abnormalities in Patients with COVID-19 in Mazandaran Province, Iran

2020 ◽  
Vol 22 (7) ◽  
Author(s):  
Reza Alizadeh-Navaei ◽  
Majid Saeedi ◽  
Reza Valadan ◽  
Fatemeh Roozbeh ◽  
Omolbanin Amjadi ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Rna Virus ◽  
Laboratory Data ◽  
Age Groups ◽  
Laboratory Diagnosis ◽  
Cross Sectional Study ◽  
Clinical Findings ◽  
Mazandaran Province ◽  
Cross Sectional ◽  
Significance Level

Background: Coronavirus is a single-stranded RNA virus, causing an epidemic of pneumonia and acute respiratory distress syndrome (ARDS) worldwide in late 2019. Objectives: In addition to the clinical symptoms, laboratory diagnosis can greatly help diagnose the diseases; therefore, this study aimed to analyze laboratory parameters in patients with COVID-19. Methods: In this cross-sectional study, the laboratory data of 2563 patients with COVID-19 admitted to hospitals affiliated with Mazandaran University of Medical Sciences were extracted from hospital information systems (HIS). The data were recorded on Excel and analyzed through t-test, chi-squared, and Fisher’s exact tests in SPSS 19 at the significance level of P < 0.05. Results: Out of 2563 patients with a mean age of 55.1 ± 16.7 years, 1409 (55%) were male, and 1154 (45%) were female with a mean age of 55.7 ± 16.8, and 54.3 ± 16.6 years, respectively. As the most frequent clinical findings, ESR, CRP, and LDH were increased by 83.5%, 71%, and 69.3% of the patients, respectively. Other research findings included lymphopenia, disturbed INR, abnormal SGOT, abnormal alkaline phosphatase (ALP), and increased lactate dehydrogenase (LDH), which were significantly higher in men than in women and was different between age groups. Conclusions: Conducting simple, convenient, and inexpensive laboratory tests can be helpful in the diagnosis of COVID-19.

scholarly journals Production of SARS-CoV-2 Antibodies and Emergence of the Clinical Symptoms of COVID-19

2021 ◽  
Author(s):  
Ahmad Hormati ◽  
Hossein Poustchi ◽  
Mohammad Reza Ghadir ◽  
Saeede Jafari ◽  
Narges Jafari ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Clinical Care ◽  
Public Health Problem ◽  
Cross Sectional Study ◽  
Clinical Findings ◽  
Time Duration ◽  
Cross Sectional ◽  
Igm Antibodies ◽  
Gi Symptoms ◽  
Antibody Levels

Coronavirus disease 2019 (COVID-19) is a worldwide public health problem that has attracted much attention due to its clinical findings. Measurement of IgG and IgM antibodies is of great importance for researchers and it will help to develop a new diagnostic and therapeutic method in clinical care. In this cross-sectional study, we aim to measure the IgG and IgM antibody levels in 401 suspected COVID-19 volunteers. We also measure the time duration for the appearance of IgG and IgM antibodies from the onset of symptoms to sampling time. Of 401 participants enrolled in the study, 255 (63.59%) were healthy, 79 (19.70%) were a carrier, 59 (14.71%) were cured and 8 (1.99%) were borderline. Of 142 subjects diagnosed with COVID-19, 41 (28.87%) presented with gastrointestinal (GI) symptoms, 83 (58.45%) had no GI symptoms, and 18 (12.68%) were asymptomatic. According to our findings, the measurement of IgG and IgM antibodies will provide the tool for the diagnosis of COVID-19 and significantly boost research into novel diagnostic and therapeutic approaches.

scholarly journals Parasites found in surgical pathology: the institutional experience

2019 ◽  
Vol 7 (10) ◽  
pp. 3756
Author(s):  
Khushbu P. Shah ◽  
Mandakini M. Patel
Keyword(s):  
Clinical Symptoms ◽  
Age Groups ◽  
Cross Sectional Study ◽  
Surgical Pathology ◽  
Cross Sectional ◽  
Institutional Experience ◽  
Stool Samples ◽  
Immunocompromised State ◽  
Almost All ◽  
Common Parasite

Background: Parasitic infestation has a worldwide prevalence and it affects almost all age groups and both the sexes. The incidence of these infections is slowly rising in today’s era. Parasites are mainly found in stool samples but due to increase in a immunocompromised state now a days, tissue parasitaemia has increased globally necessitating more such type of studies. Parasite found in surgical pathology either incidentally or in clinically suspicious cases not only improves morbidity but also saves clinician’s time and patient’s money.Methods: A retrospective-cross sectional study is done based on histomorphological and cytomorphological evaluation of 25 cases diagnosed at The Department of pathology, New Civil Hospital Surat from January 2015 to January 2017.Results: Most common parasite seen was Echinococcus presenting as hydatid cyst in liver followed by filariasis. Most common age group affected was 0-20 years of age. Most common intestinal parasite found in our study was Entamoeba histolytica. Patients presented with variety of symptoms.Conclusions: Distribution of parasite in tissue section in relation to frequency, age, sex, various system involvements and its correlation with clinical symptoms are analyzed in our study.

scholarly journals Dermoscopy of topical steroid-dependent or damaged face: A cross-sectional study

2021 ◽  
Vol 0 ◽  
pp. 1-7
Author(s):  
Sheenam Sethi ◽  
Payal Chauhan ◽  
Rashmi Jindal ◽  
Yashwant Singh Bisht
Keyword(s):  
Clinical Symptoms ◽  
Low Cost ◽  
Topical Steroid ◽  
Cross Sectional Study ◽  
Clinical Findings ◽  
Cross Sectional ◽  
Female Ratio ◽  
Exact Test ◽  
Steroid Dependent ◽  
Number Of Patients

Background: Topical corticosteroid (TCS) abuse is rampant and results in steroid addiction labeled as topical steroid-dependent or damaged face (TSDF). Indian market is replete with triple combination creams containing TCS sold as over-the-counter products at low cost, luring people to use them without prescription. The resultant damage if detected late is irreversible and difficult to treat. Dermoscopy can help in the early identification of features of TSDF at a preclinical stage resulting in better prognosis. However, the literature on the same is limited. Aims: This study is undertaken to characterize dermoscopic features of TSDF and to correlate them with potency and duration of application of the TCS. Methods: One hundred and thirty-two patients aged 18 years or above, with clinical symptoms and signs suggestive of TSDF and with history of application of TCS on the face for a period of more than one month, were enrolled in the study. Their demographic details, clinical features, and dermoscopy findings were recorded using a predesigned structured format. Comparison of dermoscopic findings with clinical examination, gender, potency of TCS, and duration of TCS use was done using Chi-square test, Fisher’s exact test, and one-tailed Z-test. Results: Mean age of the patients was 31.7 ± 8.1 years. Male to female ratio was 2:9. Sixty-nine (52.3%) patients abused TCS for more than one year. Clinical findings noted in the patients were erythema (81.1%), hyperpigmentation (80.3%), and hypertrichosis (68.2%). The most common dermoscopy findings seen were brown globules (96.2%), red diffuse areas (92.4%), vessels (87.1%), white structureless areas (86.4%), and hypertrichosis (80.3%). Red diffuse areas, vessels, brown globules, white structureless areas, and white hair were observed in a statistically higher proportion of cases dermoscopically. Y-shaped vessels and brown globules were seen in significantly higher number of patients, using TCS for more than three months and in those continuing it beyond six months, polygonal vessels were predominant. Limitations: Lack of histopathological correlation is the limitation of our study. Furthermore, brown globules seen in 96.2% patients of TSDF on dermoscopy may have been over-estimated and not always signify TSDF; instead, it could represent melasma for which patient applied TCS. Conclusion: Dermoscopy in TSDF can help dermatologists in a multitude of ways from confirming the diagnosis to differentiating from other causes of red face and predicting the approximate duration of TCS abuse.

scholarly journals Using a screening tool to identify the auditory behavior of students who are learning to read and write

Revista CEFAC ◽  
2021 ◽  
Vol 23 (4) ◽  
Author(s):  
Giulia Ádni Viana Santos ◽  
Maria Luiza Lopes Timóteo de Lima ◽  
Manoelina Xavier Cavalcante ◽  
Leonardo Gleygson Angelo Venâncio ◽  
Cleide Fernandes Teixeira
Keyword(s):  
School Performance ◽  
Auditory Processing ◽  
Screening Tool ◽  
Age Groups ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Learning To Read ◽  
Significance Level ◽  
Significant Difference ◽  
Auditory Behavior

ABSTRACT Purpose: to analyze the use of a screening tool, by teachers, to identify the auditory behavior of students who are learning to read and write. Methods: a cross-sectional study including 22 students who answered the Fisher’s Auditory Problems Checklist (QFISHER). The analysis of this questionnaire approached the categories of hearing, attention, memory, language, and school performance. The chi-square statistical test and Mann-Whitney test were used to compare the scores between the age groups, considering the 5% significance level. Results: school performance had the worst frequency in QFISHER (87.72%), followed by attention (62.10%), language (60.53%), and hearing (59.65%). The median revealed worse assessment in school performance (100.0%) followed by attention (60.0%). The QFISHER overall score was 66.7%. The comparison between age groups did not reveal any significant difference for the domains assessed. Conclusion: the QFISHER, used by teachers, as a screening tool for children who are learning to read and write, can identify behavioral changes suggestive of auditory processing disorder, broadening the possibility of early interventions.

scholarly journals Aptidão cardiorrespiratória em crianças e adolescentes

2019 ◽  
Vol 20 (6) ◽  
pp. 535-543
Author(s):  
Kenia Rejane de Oliveira Batista ◽  
Mona Gizelle Dreger de Oliveira ◽  
Carla Fabiane dos Santos Lemos ◽  
Josiene De Oliveira Couto ◽  
Nara Michelle Moura Soares ◽  
...  
Keyword(s):  
Cardiorespiratory Fitness ◽  
Age Groups ◽  
Peak Height ◽  
Cross Sectional Study ◽  
Height Velocity ◽  
Age Group ◽  
Peak Height Velocity ◽  
Cross Sectional ◽  
Significance Level ◽  
And Gender

Cardiorespiratory fitness is an important health status indicator. The purpose of this study was to verify the cardiorespiratory fitness according to age group and gender in children and adolescents from Sergipe, Brazil. It is a cross-sectional study with sample consisting of 195 adolescents of both genders with mean age of 11.75 ± 3.0 years. For the characterization of participants, a questionnaire with age and gender identification designed by researchers was used. Subsequently, participants were submitted to anthropometric evaluation in order to estimate the maturational stage by means of the peak height velocity (PHV). The 20-meter back-and-forth test was used to estimate cardiorespiratory fitness. Two-way ANOVA was applied with sample divided into two groups (“up to 13 years” and “above 13 years”). Polynomial contrast was used to identify the type of tendency for cardiorespiratory fitness, and simple contrast for multiple comparisons. All procedures were performed using SPSS version 22.0 software, considering 5% significance level. In the “over 13 years” group, there was a significant effect on the cardiorespiratory capacity behavior according to “gender” [F(1, 45) = 5.54, p = 0.02, r = 0.33] and “age” [F(4.45) = 3.37, p = 0.02, r = 0.48]. The simple contrast identified increased cardiorespiratory fitness behavior in relation to age groups of 15 and 16 year when compared to the age group of 14 years. It was concluded that gender and age positively influence cardiorespiratory fitness from the maturational reference age in the study group.

Alexithymia and anxiety symptoms in Pakistani adolescents: a study of compounded directions

2021 ◽  
pp. 1-13
Author(s):  
Sadia jafer ◽  
Farzana Ashraf ◽  
Amna Arif ◽  
Admin
Keyword(s):  
Psychological Health ◽  
Clinical Symptoms ◽  
Interactive Effect ◽  
Age Groups ◽  
Cross Sectional Study ◽  
Anxiety Symptoms ◽  
Cross Sectional ◽  
Physical And Psychological Health ◽  
And Gender ◽  
Effect Of Age

Abstract     Objectives: There is an empirical evidence that symptoms of internalizing disorders such as alexithymia and anxiety increase in adolescence and these symptoms varies across gender and age groups. The purpose of this study was to explore these differences in adolescents. Method: In this cross-sectional study conducted since November 2018 to March 2019, the sample of 185 adolescents selected through random sampling method from different schools. They were assessed on alexithymia and anxiety symptoms by administering Toronto Alexithymia Scale and Hamilton Anxiety Scale respectively. Multiple Analysis of Variance (MANOVA) was applied to determine the direct and interactive effect of age groups and gender on alexithymia and anxiety symptoms. Results: The results demonstrate that boys reported significantly (p<0.05) higher level of alexithymia symptoms partially (externally oriented) as compared to their counterparts. Further significant (p<0.05) interactive effect of age group and gender was also seen. Conclusion: The present study concluded that the presence of clinical symptoms in school going adolescents may hinder in the physical and psychological health of adolescents, which should be managed through suitable interventions. Keywords: Alexithymia symptoms, Anxiety symptoms, Continuous...

scholarly journals Clinical and Paraclinical Findings in Children With Congenital Hepatic Fibrosis: A Single Center 10-Year Study

2020 ◽  
Vol 5 (2) ◽  
pp. 42-46
Author(s):  
Seyed Mohsen Dehghani ◽  
Amir Saeidi ◽  
Farzaneh Nejati ◽  
Iraj Shahramian ◽  
Ali Bazi ◽  
...  
Keyword(s):  
Gastrointestinal Bleeding ◽  
Hepatic Fibrosis ◽  
Esophageal Varices ◽  
Laboratory Data ◽  
Cross Sectional Study ◽  
Clinical Findings ◽  
Decompensated Cirrhosis ◽  
Congenital Hepatic Fibrosis ◽  
Cross Sectional ◽  
Period 2

Background: Congenital hepatic fibrosis (CHF) is an autosomal hereditary disorder affecting the porto-biliary system. It is a rare hereditary disorder often presenting in childhood or adolescence with hepatomegaly, splenomegaly, and gastrointestinal bleeding. A timely diagnosis of organomegalies by sonography can prevent esophageal varices. Liver transplantation is now the only cure for CHF. Objectives: The current study aimed to determine clinical and paraclinical findings in patients diagnosed with CHF from 2008 to 2017. Methods: This was a descriptive cross-sectional study of all children <18 years of age who were diagnosed with CHF from 2008 until 2017 in the pediatric hepatology ward at Nemazee hospital, Shiraz, Iran. Results: Overall, 32 CHF patients were included during the study period. Of these, 12 (37.5%) and 20 (62.5%) were female and male, respectively. The most frequent clinical presentations at diagnosis were hepatomegaly (81%), splenomegaly (68%), gastrointestinal bleeding (43%), abdominal protrusion (40%), ascites (21%), and epistaxis (6%). Severely enlarged livers were observed in 2 patients. Only 5 patients showed a normal-sized spleen, and kidney sonographic findings were normal in 30 patients. Liver enzymes were not severely deviated from the normal range. There was a significant association between spleen size and esophageal varices (P=0.01). Overall, 8 patients were liver transplanted due to decompensated cirrhosis. One patient developed bone marrow suppression secondary to the Epstein bar virus and ultimately succumbed to post-transplant lymphoproliferative disorder. In the study period, 2 girls and 2 boys died of disease complications. Conclusion: The results of the present study indicated that the most common clinical findings of CHF in pediatric patients are splenomegaly and hepatomegaly presenting as abdominal distention and gastrointestinal bleeding. Laboratory data can be normal in most cases, but ultrasonographic findings (in liver, spleen, and even kidneys) can be helpful. The present study also showed that patients with splenomegaly are at higher risk of esophageal varices.

scholarly journals Characteristics of Children with Coronavirus Disease-2019 From The Pediatric Emergency Room

2020 ◽  
Author(s):  
emel berksoy ◽  
Ali Kanik ◽  
Alper Çiçek ◽  
Şefika Bardak ◽  
Gülşah Demir ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Clinical Status ◽  
Age Groups ◽  
Pediatric Emergency ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Operating Characteristics ◽  
Cross Sectional ◽  
Viral Pathogens ◽  
Syncytial Virus

We describe the demographic, clinical, and laboratory characteristics of children with COVID 19 in comparison with those of not-laboratory-confirmed cases. We conducted a cross-sectional study on the epidemiological, clinical, radiological, and laboratory characteristics, and outcome of 422 children (aged 0–18 years) with suspected and confirmed COVID 19 admitted to the pediatric emergency department from March 23rd to July 23rd, 2020. Of the 422 children with suspected COVID-19 included in this study, COVID-19 was PCR-confirmed in 78 (18.4%). Fever (51.2%) and cough (43.5%) were the most prominent symptoms in children with confirmed cases. The clinical status of the patients with confirmed COVID-19 was significantly milder than that of those with suspected COVID-19. The proportion of COVID-19 pneumonia cases was 44.4%, 5.5%, 18.7%, and 8.5% for the age groups of ≤ 1, 2–6, 7–12, and ≥ 12 years, respectively. Of the 422 children, 128 (30.3%) underwent nasopharyngeal PCR testing for other respiratory viral pathogens; 21 (16.4%) were infected with viral pathogens other than severe acute respiratory syndrome-related coronavirus-2. Only one patient (4.7%) with confirmed COVID-19 had coinfection with respiratory syncytial virus and rhinovirus. The areas under the receiver-operating characteristics curves were 0.812 for WBCs, 0.752 for neutrophils, 0.717 for lactate dehydrogenase, and 0.708 for lymphocyte for predicting COVID-19 (p ≤ 0.001). Fever and cough or other clinical symptoms or signs should not be considered hallmarks of COVID 19. In this study, the WBC, neutrophil, and lymphocyte counts were predictive of COVID-19 positivity.

Prevalence of Scabies and Impetigo in Patients of Different Age Groups in a Tertiary Level Hospital

2021 ◽  
Vol 11 (Number 1) ◽  
pp. 53-59
Author(s):  
Parveen Afroz Chowdhury ◽  
Tahur Abdullah Choudhury
Keyword(s):  
Skin Diseases ◽  
Clinical Symptoms ◽  
Age Groups ◽  
Lower Extremities ◽  
Cross Sectional Study ◽  
Upper Extremities ◽  
Tertiary Level ◽  
Cross Sectional ◽  
The Individual ◽  
Level Hospital

Background:Scabies and impetigo are found as two common skin diseases in developing countries. Scabies affects the whole family and has more impact on children and elderly people. The present study aims to provide an update on the prevalence and severity of scabies and impetigo in individual of different ages visited a tertiary level hospital. Methods: This observational cross sectional study includes a total of 3680 subjects complaining the clinical symptoms of scabies and impetigo. The patients were selected randomly and examined in outpatient department of Sylhet Women’s Medical Hospital during the period January, 2019 to October, 2020. Results:Scabies and impetigo were observed in 65.76% (n=2420) and 34.23% (n=1260) patients, respectively. However, the majority of scabies patients (65.74%, n=1591) were associated with impetigo. Both diseases were prevalent in males (57.02% in scabies and 57.14% in impetigo) compared to females (42.98% in scabies and 42.86% in impetigo). The highest prevalence of scabies (33.63%, n=814) and impetigo (40.88%, n=515) was observed among the individual aged 1-10 years. However, prevalence of the both diseases decreased gradually with the increase of age from 11-20 years to 51-60 years and above. Scabies lesions were more prevalent in upper extremities in patients aged 10-30 years and above. However, lower extremities in patients aged 10 years were found as the more prevalent sites for scabies lesions. On the other hand, impetigo lesions were the most prevalent in lower extremities followed by upper extremities in patients of all age groups. Although scabies and impetigo lesions were mostly mild (>50%) to moderate (~20-35%), lesions were severe in 15.58% of scabies patients aged 10-30 years and 22.89% of impetigo patients aged 10 years. Conclusions: Results reported herein supports the notion that scabies and impetigo are prevalent in school going children.

The Connection between Urinary Equol Levels and the Prevalence of Atopic Dermatitis

2020 ◽  
Vol 182 (1) ◽  
pp. 32-38
Author(s):  
Takahito Chiba ◽  
Takuya Nagai ◽  
Futoshi Kohda ◽  
Takeshi Nakahara ◽  
Michihiro Kono
Keyword(s):  
Atopic Dermatitis ◽  
High Performance ◽  
Clinical Symptoms ◽  
Laboratory Data ◽  
Normal Subjects ◽  
Cross Sectional Study ◽  
Soy Isoflavones ◽  
University Hospital ◽  
Healthy Controls ◽  
Cross Sectional

<b><i>Background:</i></b> Soy isoflavones and their metabolites such as equol have been associated with a reduced risk of hormone-sensitive tumors and metabolic syndromes. However, individual soy isoflavones and equol levels in atopic dermatitis remain uninvestigated. <b><i>Objective:</i></b> The aim of this study is to compare the levels of urinary daidzein, genistein, and equol between atopic dermatitis patients and normal subjects and to examine the correlation between equol concentration and the severity of clinical symptoms. <b><i>Methods:</i></b> A cross-sectional study was conducted at Akita University Hospital and Aso Iizuka Hospital in Japan. Fifty patients with confirmed atopic dermatitis diagnosis and 67 healthy controls were recruited. Daidzein, genistein, and equol in urine were measured by using a high-performance liquid chromatography-mass spectrometry system. <b><i>Results:</i></b> Urinary equol levels were significantly lower in the atopic dermatitis patients than in the healthy controls (<i>p</i> = 0.002). The difference was particularly noticeable in young people (6–19 years, <i>p</i> &#x3c; 0.001). No correlations were found between urinary equol levels and the severity of clinical symptoms and laboratory data in the atopic dermatitis patients. <b><i>Conclusion:</i></b> Equol levels in childhood might be involved in the development of atopic dermatitis.

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