scholarly journals Evaluation of Thyroid Cancer Risk After Laryngeal and Nasopharyngeal Radiotherapy

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Hamid Ghaznavi

Background: Nasopharyngeal carcinoma is an uncommon head and neck cancer, which is commonly seen in young people aged from 15 to 25 years. Laryngeal cancer, on the other hand, is the second most common cancer among head and neck cancers. The primary treatment for patients with these carcinomas is radiotherapy. Objectives: This study aimed at estimation of thyroid cancer risk, as an organ at risk after laryngeal and nasopharyngeal radiotherapy Methods: with permission from the author, data related to thyroid dose of 20 patients who underwent radiotherapy of laryngeal and nasopharynx cancer in Soleimani et al. paper were used, and using the BEIR VII model, we calculated thyroid cancer risk. Results: lifetime attributable risk (LAR) of thyroid increased up to 2.7% in the treatment of nasopharyngeal cancer and up to 1.8% in the treatment of laryngeal cancer. The highest LAR values belonged to the treatment of nasopharyngeal cancer. Conclusions: radiotherapy for nasopharyngeal and laryngeal cancers considerably increased the risk of thyroid cancer in patients undergoing radiotherapy; such that the risk increased by more than 2.5% at younger ages. It is recommended to use an advanced treatment technique to reduce thyroid cancer risk and perform follow-ups annually in terms of the status of the thyroid gland and its changes.

Author(s):  
Selcuk Dagdelen ◽  
Nese Cinar ◽  
Tomris Erbas

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
QingAn Yu ◽  
XiaoYing Lv ◽  
KunPeng Liu ◽  
DaKun Ma ◽  
YaoHua Wu ◽  
...  

Associations have been demonstrated between fertility drugs and a variety of hormone-sensitive carcinomas. The purpose of this study was to determine the relationship between fertility drugs used in the treatment of female infertility and the risk of thyroid cancer. To investigate the clinical significance of fertility drugs used for the treatment of female infertility and the risk associated with thyroid cancer, we performed a literature search using PubMed, MEDLINE, the Cochrane Library, the Web of Science, and EBSCOHOST for comparative studies published any time prior to July 21, 2017. The studies included women who were treated for infertility with fertility drugs, such as clomiphene citrate, gonadotropins, or other unspecified fertility agents, which reported the incidence of thyroid cancer as the main outcome. Eight studies were included in the meta-analyses. Among women with infertility, there was a significant positive association between thyroid cancer risk and the use of fertility drugs (relative risk [RR] = 1.35; 95% confidence interval [CI] 1.12–1.64; P=0.002). Additionally, among women with infertility, the use of clomiphene citrate was associated with an increased risk of thyroid cancer compared to women who did not use fertility drugs (RR = 1.45; 95% CI 1.12–1.88; P=0.005). After pooling results, we found that the parity status of infertile women using fertility drugs was not associated with thyroid cancer risk (RR = 0.99; 95% CI 0.61–1.58, P=0.95). In summary, clomiphene citrate (the most commonly used fertility drug) and other fertility drugs are associated with an increased risk of thyroid cancer.


2018 ◽  
Vol 613-614 ◽  
pp. 679-686 ◽  
Author(s):  
Xufeng Fei ◽  
Zhaohan Lou ◽  
George Christakos ◽  
Qingmin Liu ◽  
Yanjun Ren ◽  
...  

2020 ◽  
Vol 12 (8) ◽  
pp. 492-498
Author(s):  
Navdeep Singh ◽  
Sandeep Singh Lubana ◽  
Saurabh Arora ◽  
Issac Sachmechi

Oncotarget ◽  
2016 ◽  
Vol 7 (30) ◽  
pp. 47750-47759 ◽  
Author(s):  
Na Hu ◽  
Zhan-Ming Li ◽  
Jin-Feng Liu ◽  
Zhen-Zhen Zhang ◽  
Li-Shun Wang

2012 ◽  
Vol 109 (1) ◽  
pp. 118-128 ◽  
Author(s):  
Su Kyoung Jung ◽  
Kirang Kim ◽  
Kyung Tae ◽  
Gu Kong ◽  
Mi Kyung Kim

Thyroid cancer is the most common cancer among Korean women. However, there are few data on dietary factors related to thyroid cancer risk. The objective of the present study was to evaluate the association between raw vegetables and fruits intake and thyroid cancer in a case–control study. We included 111 histologically confirmed malignant thyroid cancer cases and 115 benign cases. Controls who did not have nodules in thyroid ultrasonography were matched to cases by age ( ± 2 years). Food and nutrient intakes were estimated using a quantitative FFQ with 121 items. Conditional logistic regression analysis was used to obtain OR and corresponding 95 % CI. The intake of total vegetables was not associated with malignant thyroid cancer, but inversely associated with benign cases. High raw vegetable intake was inversely associated with thyroid cancer risk both in malignant and benign cases (P for trend = 0·01 in both malignant and benign cases). Among fruits, persimmon intake had an inverse association with thyroid cancer risk in both malignant and benign cases (P for trend = 0·06 in malignant cases; P for trend = 0·01 in benign cases) and tangerine intake had an inverse association in malignant cases (P for trend = 0·03). The frequency of consumption of raw vegetables and persimmon also had a consistent inverse association in both malignant and benign cases. These results suggest that high consumption of raw vegetables, persimmons and tangerines may decrease thyroid cancer risk and help prevent early-stage thyroid cancer.


2018 ◽  
Vol 119 (5) ◽  
pp. 638-645 ◽  
Author(s):  
Ara Cho ◽  
Yoosoo Chang ◽  
Jiin Ahn ◽  
Hocheol Shin ◽  
Seungho Ryu

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