scholarly journals Application of Immunohistochemistry in the Diagnosis of Pulmonary and Pleural Neoplasms

2017 ◽  
Vol 141 (9) ◽  
pp. 1195-1213 ◽  
Author(s):  
Jennifer S. Woo ◽  
Opal L. Reddy ◽  
Matthew Koo ◽  
Yan Xiong ◽  
Faqian Li ◽  
...  
Keyword(s):  
Literature Review ◽  
Diagnostic Tool ◽  
Personal Experience ◽  
Review Article ◽  
Data Sources ◽  
Practical Approach ◽  
Valuable Diagnostic Tool ◽  
Histologic Evaluation ◽  
Selection Of ◽  
Pleural Neoplasms

Context.— A vast majority of neoplasms arising from lung or pleura are initially diagnosed based on the histologic evaluation of small transbronchial, endobronchial, or needle core biopsies. Although most diagnoses can be determined by morphology alone, immunohistochemistry can be a valuable diagnostic tool in the workup of problematic cases. Objective.— To provide a practical approach in the interpretation and immunohistochemical selection of lung/pleura–based neoplasms obtained from small biopsy samples. Data Sources.— A literature review of previously published articles and the personal experience of the authors were used in this review article. Conclusion.— Immunohistochemistry is a useful diagnostic tool in the workup of small biopsies from the lung and pleura sampled by small biopsy techniques.

Standardization of Diagnostic Immunohistochemistry: Literature Review and Geisinger Experience

2014 ◽  
Vol 138 (12) ◽  
pp. 1564-1577 ◽  
Author(s):  
Fan Lin ◽  
Zongming Chen
Keyword(s):  
Quality Management ◽  
Literature Review ◽  
Best Practices ◽  
Critical Points ◽  
Medical Center ◽  
Management Program ◽  
Review Article ◽  
Data Sources ◽  
Test Results ◽  
Antibody Validation

Context Immunohistochemistry has become an indispensable ancillary technique in anatomic pathology laboratories. Standardization of every step in preanalytic, analytic, and postanalytic phases is crucial to achieve reproducible and reliable immunohistochemistry test results. Objective To standardize immunohistochemistry tests from preanalytic, analytic, to postanalytic phases. Data Sources Literature review and Geisinger (Geisinger Medical Center, Danville, Pennsylvania) experience. Conclusions This review article delineates some critical points in preanalytic, analytic, and postanalytic phases; reiterates some important questions, which may or may not have a consensus at this time; and updates the newly proposed guidelines on antibody validation from the College of American Pathologists Pathology and Laboratory Quality Center. Additionally, the article intends to share Geisinger's experience with (1) testing/optimizing a new antibody and troubleshooting; (2) interpreting and reporting immunohistochemistry assay results; (3) improving and implementing a total immunohistochemistry quality management program; and (4) developing best practices in immunohistochemistry.

Application of Immunohistochemistry to Liver and Gastrointestinal Neoplasms: Liver, Stomach, Colon, and Pancreas

2008 ◽  
Vol 132 (3) ◽  
pp. 490-499 ◽  
Author(s):  
Stephen A. Geller ◽  
Deepti Dhall ◽  
Randa Alsabeh
Keyword(s):  
Gastrointestinal Tract ◽  
Personal Experience ◽  
Recent Literature ◽  
Malignant Tumors ◽  
Chemotherapeutic Agents ◽  
Gastrointestinal System ◽  
Data Sources ◽  
Gastrointestinal Neoplasms ◽  
Metastatic Neoplasm ◽  
Selection Of

Abstract Context.—Immunohistochemistry has become an integral component of the practice of pathology. Newer antibodies allow for increasingly precise diagnoses for tumors that previously could not be easily identified. Recently, immunohistochemical evaluations have begun to allow pathologists to actively assist in determining prognosis and even in selecting therapies. Objective.—To summarize the usefulness of currently available immunostains for the study of liver and gastrointestinal system neoplasms and to make recommendations for panels of immunostains that can be particularly helpful. Data Sources.—Information has been collected from recent literature as well as from personal experience and practice. Conclusions.—Many immunostains are now available for the practicing pathologist that allow for increasing accuracy in diagnosis of liver and gastrointestinal tract neoplasms. Panels of immunostains can be used to differentiate between various tumors and also to identify site of origin in the case of a metastatic neoplasm. Immunostains that allow for prognostic determinations and for guidance in the selection of chemotherapeutic agents can also be used by pathologists to assist in the management of patients with malignant tumors affecting the liver and gastrointestinal tract.

scholarly journals Morphologic Spectrum of Neuroendocrine Tumors of the Prostate: An Updated Review

2019 ◽  
Vol 144 (3) ◽  
pp. 320-325 ◽  
Author(s):  
Jing Hu ◽  
Bo Han ◽  
Jiaoti Huang
Keyword(s):  
Prostate Cancer ◽  
Literature Review ◽  
Risk Stratification ◽  
Neuroendocrine Tumors ◽  
Broad Spectrum ◽  
Personal Experience ◽  
Daily Practice ◽  
Data Sources ◽  
Laboratory Research ◽  
Pathologic Diagnosis

Context.— The incidence of neuroendocrine tumors of the prostate increases after hormonal therapy. Neuroendocrine tumors possess a broad spectrum of morphologic features and pose challenges in the pathologic diagnosis and clinical management of patients. Objective.— To present a brief updated summary of neuroendocrine tumors of the prostate with an overview of their histopathologic and immunohistochemical profiles and differential diagnoses. Data Sources.— Literature review, personal experience in the daily practice of pathologic diagnosis, and laboratory research. Conclusions.— Our understanding of neuroendocrine tumors of the prostate classification and diagnosis continues to evolve. These advances benefit the risk stratification and management of prostate cancer.

scholarly journals The Differential Diagnosis of Colitis in Endoscopic Biopsy Specimens: A Review Article

2012 ◽  
Vol 136 (8) ◽  
pp. 854-864 ◽  
Author(s):  
Lisa A. Cerilli ◽  
Joel K. Greenson
Keyword(s):  
Differential Diagnosis ◽  
Personal Experience ◽  
Chronic Conditions ◽  
Recent Literature ◽  
Endoscopic Biopsy ◽  
Review Article ◽  
Data Sources ◽  
Biopsy Specimens ◽  
Gastrointestinal Pathology ◽  
Histologic Changes

Context.—A variety of inflammatory disorders may affect the colon, with widely differing clinical outcomes and management. These conditions encompass a spectrum of acute and chronic conditions. Objective.—Review the pathology of the major colitides and highlight the most diagnostically useful features. Data Sources.—Review of recent literature supplemented with personal experience in the field of gastrointestinal pathology. Conclusions.—The etiologies associated with the various types of colitis are diverse and the range of histologic changes is somewhat limited. Nevertheless, the combination of clinical and endoscopic data coupled with histopathology allows for accurate classification in the majority of cases.

Primary Pleural Neoplasia: Entities Other Than Diffuse Malignant Mesothelioma

2008 ◽  
Vol 132 (7) ◽  
pp. 1149-1170 ◽  
Author(s):  
Donald G. Guinee ◽  
Timothy Craig Allen
Keyword(s):  
Differential Diagnosis ◽  
Literature Review ◽  
Malignant Mesothelioma ◽  
Correct Diagnosis ◽  
Metastatic Carcinoma ◽  
Data Sources ◽  
Pleural Tumor ◽  
Neoplasm Primary ◽  
Diffuse Malignant Mesothelioma ◽  
Pleural Neoplasms

Abstract Context.—Overwhelmingly, the most common neoplasm involving the pleura is metastatic carcinoma. In contrast, diffuse malignant mesothelioma occurs relatively rarely; however, it is nonetheless the most common neoplasm primary to the pleura. Metastatic carcinoma and diffuse malignant mesothelioma each have their own prognostic and therapeutic characteristics. Other primary pleural neoplasms occur uncommonly or rarely, with their own prognostic and therapeutic characteristics. Objective.—To review primary pleural neoplasms other than diffuse malignant mesothelioma, to better ensure correct diagnosis and optimal assessment of prognosis and treatment. Data Sources.—Literature review and primary material from the authors' institutions. Conclusions.—A nonexhaustive group of uncommon to rare benign and malignant primary pleural neoplasms— other than diffuse malignant mesothelioma—are presented, of which one must be aware in order to maintain an appropriate index of suspicion to include them in the differential diagnosis of a pleural tumor.

scholarly journals Cholesterol Granuloma of the Maxillary Sinus—A Case Report and Literature Review

2021 ◽  
Vol 12 ◽  
pp. 215265672098478
Author(s):  
Abdulrahman Alghulikah ◽  
Norah Musallam ◽  
Ibrahim Sumaily ◽  
Amany Fathaddin ◽  
Surayie Aldossary
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Maxillary Sinus ◽  
Review Article ◽  
Unusual Presentation ◽  
Differential Diagnoses ◽  
Anatomical Site ◽  
Cholesterol Granuloma ◽  
Comprehensive Literature Review

Cholesterol Granulomas of the Maxillary Sinus, considered an unusual presentation at this anatomical site. Over last 2 decades, only few cases are reported in the literature (English) and no available comprehensive reviews or studies on this entity. Herein in this article we present a comprehensive literature review of the available reports of 16 cases along with reporting a new case which we managed, aided with its histopathological pictures. This review article can be a reference for practitioners in the field of otorhinolaryngology who may encounter these cases. Also, it attracts the attention to consider this pathology among the differential diagnoses of nasal masses. Moreover, including a described pathological imaging may help young pathologist to identify this pathology.

scholarly journals Advances in Fabricating the Electrospun Biopolymer-Based Biomaterials

2021 ◽  
Vol 12 (2) ◽  
pp. 26
Author(s):  
Sebastian Wilk ◽  
Aleksandra Benko
Keyword(s):  
Mechanical Properties ◽  
Whey Protein ◽  
Antimicrobial Properties ◽  
Protein Isolate ◽  
Review Article ◽  
Animal Tissues ◽  
Green Material ◽  
Good Potential ◽  
Fibrous Morphology ◽  
Selection Of

Biopolymers formed into a fibrous morphology through electrospinning are of increasing interest in the field of biomedicine due to their intrinsic biocompatibility and biodegradability and their ability to be biomimetic to various fibrous structures present in animal tissues. However, their mechanical properties are often unsatisfactory and their processing may be troublesome. Thus, extensive research interest is focused on improving these qualities. This review article presents the selection of the recent advances in techniques aimed to improve the electrospinnability of various biopolymers (polysaccharides, polynucleotides, peptides, and phospholipids). The electrospinning of single materials, and the variety of co-polymers, with and without additives, is covered. Additionally, various crosslinking strategies are presented. Examples of cytocompatibility, biocompatibility, and antimicrobial properties are analyzed. Special attention is given to whey protein isolate as an example of a novel, promising, green material with good potential in the field of biomedicine. This review ends with a brief summary and outlook for the biomedical applicability of electrospinnable biopolymers.

scholarly journals A Systematic Literature Review of Multi-Criteria Decision-Making Methods for Sustainable Selection of Insulation Materials in Buildings

2021 ◽  
Vol 13 (2) ◽  
pp. 737
Author(s):  
Indre Siksnelyte-Butkiene ◽  
Dalia Streimikiene ◽  
Tomas Balezentis ◽  
Virgilijus Skulskis
Keyword(s):  
Decision Making ◽  
Literature Review ◽  
Systematic Literature Review ◽  
Energy Demand ◽  
Energy Performance ◽  
Future Research ◽  
Multi Criteria Decision Making ◽  
Insulation Materials ◽  
Advantages And Disadvantages ◽  
Selection Of

The European Commission has recently adopted the Renovation Wave Strategy, aiming at the improvement of the energy performance of buildings. The strategy aims to at least double renovation rates in the next ten years and make sure that renovations lead to higher energy and resource efficiency. The choice of appropriate thermal insulation materials is one of the simplest and, at the same time, the most popular strategies that effectively reduce the energy demand of buildings. Today, the spectrum of insulation materials is quite wide, and each material has its own specific characteristics. It is recognized that the selection of materials is one of the most challenging and difficult steps of a building project. This paper aims to give an in-depth view of existing multi-criteria decision-making (MCDM) applications for the selection of insulation materials and to provide major insights in order to simplify the process of methods and criteria selection for future research. A systematic literature review is performed based on the Search, Appraisal, Synthesis and Analysis (SALSA) framework and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. In order to determine which MCDM method is the most appropriate for different questions, the main advantages and disadvantages of different methods are provided.

scholarly journals Examining and Fine-tuning the Selection of Glycan Compositions with GlyConnect Compozitor

2020 ◽  
Vol 19 (10) ◽  
pp. 1602-1618 ◽  
Author(s):  
Thibault Robin ◽  
Julien Mariethoz ◽  
Frédérique Lisacek
Keyword(s):  
Search Engine ◽  
Posttranslational Modifications ◽  
Search Engines ◽  
Web Application ◽  
Contextual Information ◽  
Fine Tuning ◽  
Data Sources ◽  
Web Interface ◽  
Definition Of ◽  
Selection Of

A key point in achieving accurate intact glycopeptide identification is the definition of the glycan composition file that is used to match experimental with theoretical masses by a glycoproteomics search engine. At present, these files are mainly built from searching the literature and/or querying data sources focused on posttranslational modifications. Most glycoproteomics search engines include a default composition file that is readily used when processing MS data. We introduce here a glycan composition visualizing and comparative tool associated with the GlyConnect database and called GlyConnect Compozitor. It offers a web interface through which the database can be queried to bring out contextual information relative to a set of glycan compositions. The tool takes advantage of compositions being related to one another through shared monosaccharide counts and outputs interactive graphs summarizing information searched in the database. These results provide a guide for selecting or deselecting compositions in a file in order to reflect the context of a study as closely as possible. They also confirm the consistency of a set of compositions based on the content of the GlyConnect database. As part of the tool collection of the Glycomics@ExPASy initiative, Compozitor is hosted at https://glyconnect.expasy.org/compozitor/ where it can be run as a web application. It is also directly accessible from the GlyConnect database.

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