scholarly journals The Lutetian Society1

2005 ◽  
Vol 16 (2) ◽  
pp. 73-101 ◽  
Author(s):  
Denise Merkle
Keyword(s):  
The Novel ◽  
Personal Appreciation ◽  
Insight Into

Abstract This paper will examine the role of the late-Victorian Lutetian Society translators (Alexander Teixeira de Mattos, their leader, Ernest Dowson, Havelock Ellis, Percy Pinkerton, Victor Plarr, Arthur Symons) as translating subjects and cultural agents, united by the “cause” of providing British readers with unexpurgated translations of some of Émile Zola’s maligned, if not banned, masterpieces so that they might be able to form an unbiased opinion of the literary merits of the works. Furthermore, the paper will explore what motivated these translators to join in this clandestine translation project and try to give some insight into the effect of their (re)translation activity on their personal appreciation of Zola and the novel translated. The paper concludes that the act of (re)translation served to expand the cultural horizons of the Lutetian Society translators. Their translations would, in turn, expand the cultural horizons of those who read them.

scholarly journals Investigation of the genetic variation in ACE2 on the structural recognition by the novel coronavirus (SARS-CoV-2)

2020 ◽  
Author(s):  
Xingyi Guo ◽  
Zhishan Chen ◽  
Yumin Xia ◽  
Weiqiang Lin ◽  
Hongzhi Li
Keyword(s):  
Genetic Variation ◽  
The Novel ◽  
S Protein ◽  
Angiotensin Converting Enzyme 2 ◽  
Missense Variants ◽  
Catalytic Metal ◽  
Using Data ◽  
Novel Coronavirus ◽  
Insight Into

Abstract Background: The outbreak of coronavirus disease (COVID-19) was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), through its surface spike glycoprotein (S-protein) recognition on the receptor Angiotensin-converting enzyme 2 (ACE2) in humans. However, it remains unclear how genetic variations in ACE2 may affect its function and structure, and consequently alter the recognition by SARS-CoV-2. Methods: We have systemically characterized missense variants in the gene ACE2 using data from the Genome Aggregation Database (gnomAD; N = 141,456). To investigate the putative deleterious role of missense variants, six existing functional prediction tools were applied to evaluate their impact. We further analyzed the structural flexibility of ACE2 and its protein-protein interface with the S-protein of SARS-CoV-2 using our developed Legion Interfaces Analysis (LiAn) program.Results: Here, we characterized a total of 12 ACE2 putative deleterious missense variants. Of those 12 variants, we further showed that p.His378Arg could directly weaken the binding of catalytic metal atom to decrease ACE2 activity and p.Ser19Pro could distort the most important helix to the S-protein. Another seven missense variants may affect secondary structures (i.e. p.Gly211Arg; p.Asp206Gly; p.Arg219Cys; p.Arg219His, p.Lys341Arg, p.Ile468Val, and p.Ser547Cys), whereas p.Ile468Val with AF = 0.01 is only present in Asian.Conclusions: We provide strong evidence of putative deleterious missense variants in ACE2 that are present in specific populations, which could disrupt the function and structure of ACE2. These findings provide novel insight into the genetic variation in ACE2 which may affect the SARS-CoV-2 recognition and infection, and COVID-19 susceptibility and treatment.

scholarly journals Role of Short-wavelength Blue Light in the Formation of Cataract and Expression of Caspase-1, -11 and Gasdermin D in rat Lens Epithelium Cells: Insight into the Novel Pathogenesis of Cataract.

2019 ◽  
Author(s):  
Yamin Wang ◽  
Min Zhang ◽  
Ying Sun ◽  
Xiaohui Wang ◽  
Zhaowei Song ◽  
...  
Keyword(s):  
Blue Light ◽  
Short Wavelength ◽  
Light Exposure ◽  
The Novel ◽  
Blue Led ◽  
Caspase 1 ◽  
Epithelium Cells ◽  
Experimental Group ◽  
Insight Into

Abstract Background Cataracts have been verified to be associated with a number of risk factors. The sun and artificial light sources, including light-emitting diode (LED) and fluorescent light tubes, are the primary sources of short-wavelength blue light. With the increasing popularity of blue-rich LED-backlit display devices, our eyes are now exposed to more short-wavelength blue light than they were in the past. The goal of this study was to evaluate the role of short-wavelength blue light in the formation of cataract. Additionally, the pathogenesis of cataracts after short-wavelength light exposure was investigated.Methods SD rats were randomly divided into 2 main groups: a control group (10 rats each for the 4-, 8-, and 12-week groups) and an experimental group (10 rats each for the 4-, 8-, and 12-week groups). The rats in the experimental group were exposed to a short-wavelength blue LED lamp for 12 hours per day. After exposure to the blue LED lamp, the rats were maintained in total darkness for 12 hours, after which a 12-hour light/dark cycle was resumed. The intensity of the lamp was 3000 lux. At the end of the short-wavelength blue LED lamp exposure (for 4, 8, and 12 weeks), the expression levels of caspase-1, caspase-11 and gasdermin D (GSDMD) in rat epithelium cells (LECs) were examined in rat epithelial cells (LECs) using qRT-PCR and Western blotting analyses. Results After 6 weeks, cataracts had developed in the experimental rats (4/20 eyes). The clarity of the lens then gradually worsened with the duration of exposure. Twelve weeks later, all of the rat eyes had developed cataracts. Then the expression levels of caspase-1, caspase-11 and GSDMD at 4, 8, and 12 weeks were significantly higher in samples from rats exposed to a short-wavelength blue LED lamp than samples from control rat (p˂0.05). Conclusion The data indicate that pyroptosis play a key role of in cataracts induced by short-wavelength blue light exposure, highlighting caspase-1, caspase-11 and GSDMD as possible therapeutic targets for cataract treatment. This study might provide new insight into the novel pathogenesis of cataracts.

scholarly journals miR-539 activates the SAPK/JNK signaling pathway to promote ferropotosis in colorectal cancer by directly targeting TIPE

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yan Yang ◽  
Zeyang Lin ◽  
Zhaopu Han ◽  
Zhengxin Wu ◽  
Jianyu Hua ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
High Recurrence Rate ◽  
The Novel ◽  
Potential Therapeutic Target ◽  
Tnf Α ◽  
Jnk Signaling Pathway ◽  
The Relationship ◽  
Insight Into ◽  
Necrosis Factor

AbstractColorectal cancer (CRC) is a common tumor that harms human health with a high recurrence rate. It has been reported that the expression of microRNA-539 (miR-539) is low in several types of cancer, including CRC. Tumor necrosis factor (TNF)-α-induced protein 8 (TNFAIP8/TIPE) is highly expressed in CRC and promotes the proliferation, migration and angiogenesis of CRC. However, the relationship between miR-539 and TIPE and the mechanisms by which they regulate the proliferation of CRC remain to be explored. We aimed to investigate the functions and mechanisms of miR-539 in CRC proliferation. Functionally, miR-539 can bind to and regulate the expression of TIPE, and miR-539 activates SAPK/JNK to downregulate the expression of glutathione peroxidase 4 (GPX4) and promote ferroptosis. Our data reveal the novel role of miR-539 in regulating ferroptosis in CRC via activation of the SAPK/JNK axis, providing new insight into the mechanism of abnormal proliferation in CRC and a novel potential therapeutic target for advanced CRC.

scholarly journals Molecular Docking Studies of some Antiviral and Antimalarial Drugs Via Bindings to 3CL-Protease and Polymerase Enzymes of the Novel Coronavirus (SARS-CoV-2)

2020 ◽  
Vol 10 (5) ◽  
pp. 6444-6459 ◽  
Keyword(s):  
Molecular Docking ◽  
Docking Studies ◽  
Antimalarial Drugs ◽  
The Novel ◽  
Rapid Spread ◽  
Novel Virus ◽  
Novel Coronavirus ◽  
3Cl Protease ◽  
Insight Into

The rapid spread of the novel coronavirus (SARS-CoV-2) as a serious threat to the world public health is in dire need of finding potential therapeutic agents. Chinese have tested several antiviral and antimalarial drugs as potent inhibitors for the novel virus, such as remdesivir, chloroquine, hydroxychloroquine, umifenovir and favipiravir. In this study, we used the molecular docking models to study the binding interactions between these pharmaceuticals, as well as our proposed remdesivir analogue (AZCV-20) with the 3CLpro and RNA-dependent RNA polymerase (RdRp) of the SARS-CoV-2, using MEO and Autodock4 methods. Our study provides insight into the possible role of structural flexibility and efficacy during interactions between 3CLpro, RdRp and the drugs.

scholarly journals Le Rabelais ressuscité (1611) de Nicolas de Horry et la tradition des mandements joyeux

Neophilologus ◽  
2019 ◽  
Vol 104 (1) ◽  
pp. 33-47
Author(s):  
Rozanne Versendaal
Keyword(s):  
Early Modern ◽  
Narrative Structure ◽  
The Novel ◽  
Institutional Approach ◽  
Modern Novel ◽  
Critical Content ◽  
French Author ◽  
Insight Into

AbstractThis article discusses the role of mandements joyeux or joyful writs in the novel Rabelais ressuscité (1611) by the little-known French author Nicolas de Horry. The article first provides insight into the tradition and parodic nature of joyful writs. In a next step, the joyful writs in Horry’s text are identified, and the functions of these parodic passages in the narrative structure of the novel are analysed. Finally, the article demonstrates how an institutional approach to this Early Modern novel, concentrating on the identification of possible readers of the text, can contribute to a better understanding of the critical content of the joyful writs.

scholarly journals Cholesterol-dependent transcriptome remodeling reveals new insight into the contribution of cholesterol to Mycobacterium tuberculosis pathogenesis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jakub Pawełczyk ◽  
Anna Brzostek ◽  
Alina Minias ◽  
Przemysław Płociński ◽  
Anna Rumijowska-Galewicz ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Sole Carbon Source ◽  
Transcriptome Profiling ◽  
Vitamin B ◽  
The Novel ◽  
Human Pathogen ◽  
Global Effect ◽  
Probable Role ◽  
Insight Into

AbstractMycobacterium tuberculosis (Mtb) is an obligate human pathogen that can adapt to the various nutrients available during its life cycle. However, in the nutritionally stringent environment of the macrophage phagolysosome, Mtb relies mainly on cholesterol. In previous studies, we demonstrated that Mtb can accumulate and utilize cholesterol as the sole carbon source. However, a growing body of evidence suggests that a lipid-rich environment may have a much broader impact on the pathogenesis of Mtb infection than previously thought. Therefore, we applied high-resolution transcriptome profiling and the construction of various mutants to explore in detail the global effect of cholesterol on the tubercle bacillus metabolism. The results allow re-establishing the complete list of genes potentially involved in cholesterol breakdown. Moreover, we identified the modulatory effect of vitamin B12 on Mtb transcriptome and the novel function of cobalamin in cholesterol metabolite dissipation which explains the probable role of B12 in Mtb virulence. Finally, we demonstrate that a key role of cholesterol in mycobacterial metabolism is not only providing carbon and energy but involves also a transcriptome remodeling program that helps in developing tolerance to the unfavorable host cell environment far before specific stress-inducing phagosomal signals occur.

scholarly journals Death in the Line of Duty: Caregivers in the Plague narratives

2020 ◽  
Vol 12 (5) ◽  
Author(s):  
Seema Sinha ◽  
Keyword(s):  
Professional Ethics ◽  
The Other ◽  
Close Reading ◽  
The Novel ◽  
History Record ◽  
The Face ◽  
Novel Coronavirus ◽  
Insight Into

The dystopian tropes in the plague narratives shift our gaze from the presence of professional ethics to the Gothic horror that unfolds subsequently. Yet whether it is the Great Plague of London in the year 1665, or the Novel Coronavirus in Mumbai in the year 2020, the rampant spread of the contagion and the associated dread bring into focus the selflessness of the caregivers, namely, the medical and the para-medic staff. Comparing the occurrences, one historical, the other still unfolding, this study examines the eery similarities that delineate contagion as metaphor, and the role of doctors in the pandemics. The aim is to find out what happens when the doctors stumble – to succumb to fear, to fall prey to diseases that flesh is subject to, or to violate the oath of Hippocrates. We intend to scrutinize if like soldiers on the battle-front, these frontline warriors also keep their tryst with death in the line of duty, or does History record otherwise. Whether the pestilence be classical or modern, the response of the caregivers is the cornerstone on which any society is grounded. The purpose of this study is to evaluate if courage in the face of disaster is still relevant in this age of anxiety, or does self-preservation win against ethics and morality. A close reading of Daniel Defoe’s A Journal of the Plague Year gives us an insight into the timelessness of such issues, especially in a world that is plagued with maladies of its own making.

scholarly journals Investigation of the genetic variation in ACE2 on the structural recognition by the novel coronavirus (SARS-CoV-2)

2020 ◽  
Author(s):  
Xingyi Guo ◽  
Zhishan Chen ◽  
Yumin Xia ◽  
Weiqiang Lin ◽  
Hongzhi Li
Keyword(s):  
Genetic Variation ◽  
The Novel ◽  
S Protein ◽  
Angiotensin Converting Enzyme 2 ◽  
Missense Variants ◽  
Catalytic Metal ◽  
Using Data ◽  
Novel Coronavirus ◽  
Insight Into

Abstract Background: The outbreak of coronavirus disease (COVID-19) was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), through its surface spike glycoprotein (S protein) recognition on the receptor Angiotensin-converting enzyme 2 (ACE2) in humans. However, it remains unclear how genetic variations in ACE2 may affect its function and structure, and consequently alter the recognition by SARS-CoV-2. Methods: We have systemically characterized missense variants in the gene ACE2 using data from the Genome Aggregation Database (gnomAD; N = 141,456). To investigate the putative deleterious role of missense variants, six existing functional prediction tools were applied to evaluate their impact. We further analyzed structural flexibility of ACE2 and the protein-protein interface with the S protein of SARS-CoV-2 using our developed Legion Interfaces Analysis (LiAn) program. Results: Here, we characterized a total of 12 ACE2 putative deleterious missense variants. Of those 12 variants, we further showed that p.His378Arg could directly weaken the binding of catalytic metal atom to decrease ACE2 activity and p.Ser19Pro could distort the most important helix to the S-protein. Another seven missense variants may affect secondary structures (i.e. p.Gly211Arg; p.Asp206Gly; p.Arg219Cys; p.Arg219His, p.Lys341Arg, p.Ile468Val, and p.Ser547Cys), whereas p.Ile468Val with AF = 0.01 is only present in Asian. Conclusions: We provide strong evidence of putative deleterious missense variants in ACE2 that are present in specific populations, which could disrupt the function and structure of ACE2. These findings provide novel insight into the genetic variation in ACE2 which may affect the SARS-CoV-2 recognition and infection, and COVID-19 susceptibility and treatment.

scholarly journals Promethean Rebellion in Ray Bradbury's "Fahrenheit 451": The Protagonist's Quest

2012 ◽  
Vol 4 ◽  
pp. 1-20
Author(s):  
Fernanda Luísa Feneja
Keyword(s):  
Science Fiction ◽  
Personal Development ◽  
Symbolic Power ◽  
The Novel ◽  
Main Character ◽  
Dystopian Fiction ◽  
Ray Bradbury ◽  
Fahrenheit 451 ◽  
Insight Into

The article aims to reflect on the role of the myth in science fiction narrative, namely on the specific forms it may take in utopian/dystopian fiction, such as Fahrenheit 451 (1953) by Ray Bradbury. The personal development of the main character, Guy Montag, constitutes the focus of this analysis, by which we aim to shed some light on the relation between the meaning of the novel and the Promethean features he evinces in the context of a dystropian novel. The symbolic power of fire and of books is also of core relevance to this study, not only because the highlight the hero's inheritance of the Promethean myth, but also because the provide a deeper insight into exegetic possibilities of dystopsian fiction

Unauthorized Storytelling: Reevaluating Racial Politics in Julia Alvarez’s In the Time of the Butterflies

MELUS ◽  
2020 ◽  
Vol 45 (1) ◽  
pp. 95-116
Author(s):  
Tegan Zimmerman
Keyword(s):  
Dominican Republic ◽  
Essential Role ◽  
Historical Novel ◽  
Racial Politics ◽  
Slave Narratives ◽  
The Novel ◽  
Historiographic Metafiction ◽  
Postcolonial Feminist ◽  
Insight Into

Abstract This article revisits Julia Alvarez’s critically acclaimed historical novel In the Time of the Butterflies (1994). While much scholarship has paid attention to the novel as historiographic metafiction, its depiction of Rafael Leónidas Trujillo’s regime (1930-61), and its feminist perspective on the Dominican Republic, its racial politics are under-studied. In particular, scholars have overlooked Fela, the Afra-Dominican servant, spirit medium, and storyteller. I argue that studying Fela’s presence in the text as an unauthorized and unauthored voice not only adds complexity to the production of historiography and storytelling but also provides new insight into postcolonial feminist critiques of voice/lessness, narrative, and marginalized identities in the novel and criticism on it. Closely analyzing Fela’s voice—as it intersects with storytelling, historical slave narratives, Vodou, the maternal, and Haiti’s contribution to the Dominican Republic’s history—makes visible the unacknowledged yet essential role of the Afra-Dominican not only in this novel specifically but also to the Dominican Republic more generally.

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