scholarly journals Classification and clinical evaluation of the types of angiokeratoma

2021 ◽  
Vol 12 (2) ◽  
pp. 130-134
Author(s):  
Khalifa Sharquie ◽  
Raed I Jabbar
Keyword(s):  
Fabry Disease ◽  
Male Genitalia ◽  
Age Of Onset ◽  
Early Adulthood ◽  
History Taking ◽  
Reticular Dermis ◽  
Therapeutic Results ◽  
Different Types ◽  
Skin Biopsies ◽  
Superficial Dermis

Background: Angiokeratoma is a group of benign vascular telangiectasias in the superficial dermis associated with hyperkeratosis of the epidermis. There are different types of angiokeratoma and the color of the lesions—pink, red, dusky red, blue-red—depends on their age. Materials and Methods: Twenty-four patients with different varieties of angiokeratoma were collected from April 2013 through March 2020 and classified according to well-defined types. Each patient gave their formal consent after the nature of the disease was explained to them. Full medical history taking and clinical examination were performed on all patients. Skin biopsies were taken from 12 cases and processed for histopathology with H&E stain. As for therapy, diathermy was used for the treatment of selected localized cases, especially those on the scrotum. Results: Twenty-four cases with different types of angiokeratoma were evaluated, 19 (79.16%) males and 5 (20.83%) females, with ages ranging from 13 to 25 years and a mean age of 19 years. The age of onset was most commonly around adolescence and early adulthood. The lesions were classified into the following: 11 (45.83%) cases of Fordyce, 5 (20.83%) cases solitary, 4 (16.66%) cases circumscriptum, 3 (12.5%) cases oral (on the tongue), and one (4.16%) corporis diffusum (Fabry disease). All patients displayed warty red, blue, or black papules, nodules, or plaques, with the exception of isolated angiokeratoma. Their histopathology revealed hyperkeratosis of the epidermis, which could have been mild or marked acanthosis, as seen in the form of pseudoepithelial hyperplasia with marked elongation of rete ridges. As a dermal change, markedly dilated blood vessels occupied the papillary and reticular dermis. Diathermy was an effective mode of therapy in selected patients with satisfactory cosmetic and therapeutic results. Conclusion: All types of angiokeratoma were recognized but the most common were angiokeratoma of Fordyce, mainly affecting male genitalia, followed by solitary angiokeratoma, affecting mainly the limbs, and angiokeratoma circumscriptum linearly along the limbs. Oral angiokeratoma of the tongue appeared in three patients. All these types have a characteristic presentation that is easy to recognize: warty dusky-red lesions.

scholarly journals Social Participation Across Midlife and Later Life: Evidence From the Silent Generation

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 408-408
Author(s):  
Eric Vogelsang
Keyword(s):  
Social Participation ◽  
Early Adulthood ◽  
Later Life ◽  
Silent Generation ◽  
School Activities ◽  
Wisconsin Longitudinal Study ◽  
Different Types ◽  
Exercise Activity ◽  
The Life Course ◽  
Made In

Abstract Despite the well-established benefits of social participation for individuals and communities, little is known about how it varies throughout the life course. Drawing upon data collected between 1957 and 2011 by the Wisconsin Longitudinal Study (22,023 observations from a cohort of 6,627), this study provides four valuable results. One, I find evidence of five distinct social participation trajectories between the ages of 35 and 71; the majority of which demonstrate social disengagement over time. Two, these participation declines are primarily attributable to changes in meeting friends and group exercise activity. Three, the most pronounced activity differences separating those in more favorable and unfavorable participation trajectories are cultural event attendance and voluntary group membership. Lastly, I identify particular high school activities that are associated with social participation decades later. In total, these results highlight heterogeneity among different types of social activities, and underscore the possible consequences of membership decisions made in early adulthood.

Age of onset of mental disorders and use of mental health services: needs, opportunities and obstacles

2011 ◽  
Vol 21 (1) ◽  
pp. 47-57 ◽  
Author(s):  
G. de Girolamo ◽  
J. Dagani ◽  
R. Purcell ◽  
A. Cocchi ◽  
P. D. McGorry
Keyword(s):  
Early Intervention ◽  
Mental Disorders ◽  
Transition To Adulthood ◽  
Psychotic Disorders ◽  
Age Of Onset ◽  
Early Stage ◽  
Early Adulthood ◽  
Special Focus ◽  
Long Term Effects ◽  
Health Services Needs

Purpose of review.In this review, we provide an update of recent studies on the age of onset (AOO) of the major mental disorders, with a special focus on the availability and use of services providing prevention and early intervention.Recent findings.The studies reviewed here confirm previous reports on the AOO of the major mental disorders. Although the behaviour disorders and specific anxiety disorders emerge during childhood, most of the high-prevalence disorders (mood, anxiety and substance use) emerge during adolescence and early adulthood, as do the psychotic disorders. Early AOO has been shown to be associated with a longer duration of untreated illness, and poorer clinical and functional outcomes.Summary.Although the onset of most mental disorders usually occurs during the first three decades of life, effective treatment is typically not initiated until a number of years later. There is increasing evidence that intervention during the early stages of disorder may help reduce the severity and/or the persistence of the initial or primary disorder, and prevent secondary disorders. However, additional research is needed on effective interventions in early-stage cases, as well as on the long-term effects of early intervention, and for an appropriate service design for those with emerging mental disorders. This will mean not only the strengthening and re-engineering of existing systems, but is also crucial the construction of new streams of care for young people in transition to adulthood.

scholarly journals “Which mouse kissed the frog?” Effects of age of onset, length of exposure, and knowledge of case marking on the comprehension of wh-questions in German-speaking simultaneous and early sequential bilingual children

2016 ◽  
Vol 43 (3) ◽  
pp. 635-661 ◽  
Author(s):  
ANNE DOROTHEE ROESCH ◽  
VASILIKI CHONDROGIANNI
Keyword(s):  
Age Of Onset ◽  
Bilingual Children ◽  
Language Abilities ◽  
Error Patterns ◽  
Case Marking ◽  
Different Types ◽  
Wh Questions ◽  
German Speaking

AbstractStudies examining age of onset (AoO) effects in childhood bilingualism have provided mixed results as to whether early sequential bilingual children (eL2) differ from simultaneous bilingual children (2L1) and L2 children on the acquisition of morphosyntax. Differences between the three groups have been attributed to other factors such as length of exposure (LoE), language abilities, and the phenomenon to be acquired. The present study investigates whether four- to five-year-old German-speaking eL2 children differ from 2L1 children on the acquisition of wh-questions, and whether these differences can be explained by AoO, LoE, and/or knowledge of case marking. The 2L1 children outperformed the eL2 children in terms of accuracy; however, both bilingual groups exhibited similar error patterns. This suggests that 2L1 and eL2 bilingual children are sensitive to the same morphosyntactic cues, when comprehending wh-questions. Finally, children's performance on the different types of wh-questions was explained by a combination of knowledge of case marking, LoE, and AoO.

scholarly journals “Trividh Pariksha-Ayurvedic and Modern Perspective.”

2020 ◽  
Vol 4 (05) ◽  
Author(s):  
Dubey Shivanikumari Rajesh
Keyword(s):  
Physical Examination ◽  
Modern Medicine ◽  
History Taking ◽  
Important Place ◽  
Different Types ◽  
Factual Data ◽  
Radiological Examinations ◽  
Or History ◽  
Modern Perspective

The term Pariksha is used for the Examinations done on patient for appropriate diagnosis. The prime duty of any Physician is to diagnose the ailment of the patient. The diagnosis cannot be done just on basis of one type of examination. In Ayurveda different types of examinations have been mentioned which were and still are useful in diagnosing the various diseases in patients. Two basic processes. 1) Interrogation or history taking or anamnesis , 2)Physical examination [1]and at present time pathological and radiological examinations are the basic requirements  by which factual data of the diseases are collected. Ayurveda has mentioned in detail about the various Parikshas which have been categorized in Trividh , Panchvidh, Shadvidh , Ashtavidha Pariksha have been mentioned. Here Trividh Pariksha –Darshan, Sparshan and Prashna and its all aspects will be discussed in perspective of both Ayurveda and Modern medicine. These basic methods which are practiced today, with modern terminologies have one of the important place in Ayurvedic Nidan (diagnosis).

Meningococcal Meningitis in Familial Deficiency of the Fifth Component of Complement

PEDIATRICS ◽  
1981 ◽  
Vol 67 (6) ◽  
pp. 882-886
Author(s):  
Georges Peter ◽  
Mary Beth Weigert ◽  
Arthur A. Bissel ◽  
Ronald Gold ◽  
Donald Kreutzer ◽  
...  
Keyword(s):  
Age Of Onset ◽  
Early Adulthood ◽  
Meningococcal Meningitis ◽  
Host Susceptibility ◽  
Meningococcal Infection ◽  
First Year ◽  
Hemolytic Assay ◽  
The Family ◽  
Hemolytic Complement Activity ◽  
First Year Of Life

Absence of the fifth component of complement (C5) by immunochemical assay and marked deficiency by hemolytic assay (<0.1%) was found in a family in which the oldest male child had suffered severe and recurrent meningococcemia at age 15 years, two brothers developed meningococcal meningitis four years later (at ages 18 and 14 years), and a sister had the gonococcal arthritis-dermatitis syndrome. Although group-specific meningococcal antibody was present in the sera from all four siblings, serum bactericidal activity against Neisseria meningitidis could be demonstrated only in the presence of exogeous rabbit complement. Serum total hemolytic complement activity was undetectable in all four, but was restored to normal by the addition of purified C5. Subsequently, a second episode of group Y meningococcal meningitis was experienced by one brother and presumed gonococcal arthritis-dermatitis syndrome recurred in the sister. The family is the largest C5-deficient kindred to be reported and emphasizes the importance of C5 in host susceptibility to invasive Neisseria infections. In contrast to the peak incidence of N meningitidis disease in the general population in the first year of life, age of onset of meningococcal infection in these patients and in the 13 previously reported patients with terminal complement component deficiency has usually been in adolescence and early adulthood.

Fabry disease: Ultrastructural findings in skin biopsies of five sibs

1983 ◽  
Vol 12 (1-2) ◽  
pp. 152
Author(s):  
M. Valente ◽  
A. Parenti ◽  
M. Piazza
Keyword(s):  
Fabry Disease ◽  
Skin Biopsies ◽  
Ultrastructural Findings

scholarly journals Clinico-histopathological correlation of skin biopsies in leprosy

2013 ◽  
Vol 3 (6) ◽  
pp. 452-458 ◽  
Author(s):  
U Manandhar ◽  
RC Adhikari ◽  
G Sayami
Keyword(s):  
Clinical Information ◽  
Lepromatous Leprosy ◽  
Cross Sectional ◽  
Histopathological Correlation ◽  
Granulomatous Lesions ◽  
Tuberculoid Leprosy ◽  
Special Stain ◽  
Different Types ◽  
Skin Biopsies

Background: In leprosy, there is a range of varied clinicopathologic manifestations and the diagnosis is made from adequate clinical information combined with bacilloscopy and histopathology which helps in diagnosing different types of leprosy and separating it from other granulomatous lesions. Aim of the study was to classify leprosy according to Ridley Jopling classification and perform the clinicopathological correlation. Materials and Methods: A cross sectional comparative study of skin biopsies of newly diagnosed leprosy recieved over a period of 18 months from January 2009 to June 2010 and clinicopathologic correlation was done along with special stain. Results: This study included 75 patients diagnosed clinically as leprosy. Skin biopsy revealed evidence of leprosy in 72 cases. Maximum number of patient clinically belonged to tuberculoid leprosy which constituted 25 (33%) cases followed by borderline tuberculoid 19 (25.33%). On the contrary, histologically borderline tuberculoid was the most common type (40%, n=30) cases and tuberculoid leprosy constituted (13.33%, n=10) cases. Three cases of clinically diagnosed tuberculoid leprosy showed no features of leprosy histologically. Clinical and histopathological correlation was seen in 34 cases (45.33%). The correlation was highest in borderline tuberculoid (63.15%) followed by borderline lepromatous and lepromatous leprosy. Slit skin smear was positive in 31 cases (43.05%). Fite Farraco stain was positive in 18 cases (25%). Conclusion: The classification of leprosy requires attention to the histopathological criteria and correlation with clinicalinformationand bacteriological examination so as to facilitate accurate therapy to prevent undesirable complication. DOI: http://dx.doi.org/10.3126/jpn.v3i6.8992   Journal of Pathology of Nepal (2013) Vol. 3, 452-458

scholarly journals Monitoring the 3-Year Efficacy of Enzyme Replacement Therapy in Fabry Disease by Repeated Skin Biopsies

2004 ◽  
Vol 122 (4) ◽  
pp. 900-908 ◽  
Author(s):  
Beth L. Thurberg ◽  
H. Randolph Byers ◽  
Scott R. Granter ◽  
Robert G. Phelps ◽  
Ronald E. Gordon ◽  
...  
Keyword(s):  
Enzyme Replacement Therapy ◽  
Fabry Disease ◽  
Replacement Therapy ◽  
Enzyme Replacement ◽  
Skin Biopsies

Breast reconstruction

2021 ◽  
pp. 1053-1062
Author(s):  
Nicola R. Dean
Keyword(s):  
Risk Assessment ◽  
Breast Reconstruction ◽  
Consent Form ◽  
Final Part ◽  
History Taking ◽  
Major Focus ◽  
Good Outcome ◽  
Different Types

In post-mastectomy breast reconstruction, appropriate assessment of the patient’s requirements and evaluation of their suitability for any particular procedure is essential to ensuring a good outcome. The clinic environment, history taking, and examination are covered in this chapter. How to explain different types of procedures to patients and how to present them with evidence around different methods of breast reconstruction is a major focus of this chapter. Risk assessment and important elements of consent form the final part of the chapter.

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