scholarly journals Lead-induced effects on hematological parameters and red cell indices of Cirrhinus mrigala (Hamilton, 1822) and Ctenopharyngodon idella (Steindachner, 1866)

2020 ◽  
Author(s):  
Chalasani Mamatha ◽  
Rao Lammata Manmadha ◽  
Chakravarty Myla Sarvabhouma
Keyword(s):  
Hematological Parameters ◽  
Ctenopharyngodon Idella ◽  
Red Cell ◽  
Cirrhinus Mrigala ◽  
Red Cell Indices

Impact of Thyroid Dysfunction on Red Cell Indices in a Tertiary Care Hospital

2020 ◽  
Author(s):  
Erum Salim
Keyword(s):  
Thyroid Dysfunction ◽  
Hematological Parameters ◽  
Tertiary Care ◽  
University Hospital ◽  
Categorical Variables ◽  
Care Hospital ◽  
Red Cell ◽  
Hematological Indices ◽  
Significant Difference ◽  
Red Cell Indices

Background: The role of thyroid gland is to regulate the hematopoiesis in the bone marrow, which is carried out by inducing erythropoietin gene expression. The study aimed to compare red cell indices among different thyroid dysfunction disorders patients in our setup. Methods: This retrospective observational study was conducted in Ziauddin University Hospital, Karachi in Clifton campus from January 2017 to September 2017. To maintain confidentiality, patient’s identification was deleted. Total number of recruited patients was 485, out of which 117 were labeled as hyperthyroid, 169 were hypothyroid and 199 were euthyroid. Subjects for all three groups were between 20-60 years old. TSH level of patients were determined by VITROS® ECiQ immunoassay analyzer by Enhanced chemiluminescence technique. Data analysis was done on SPSS 20 while, mean and Standard deviation were calculated for quantitative variables. Percentages and frequencies were calculated for categorical variables and an independent t-test was applied to see significant differences among the groups. Results: Comparison between hyperthyroid and hypothyroid groups revealed a statistically significant difference in the mean hemoglobin (p=0.036) and hematocrit (p=0.022). A statistically significant difference was also found in the RBC count (p=0.043) and hematocrit (p=0.032) while comparing hyperthyroid and euthyroid groups. There was no statistical difference between hypothyroid and euthyroid patients for any of the hematological parameters. Conclusion: There was a proven association between thyroid dysfunction and erythropoiesis, which caused hematological indices to fluctuate, therefore hematological parameters, should be monitored in patients with thyroid diseases.

scholarly journals Haematological and Haemostatic Changes Associated with Major Depressive Disorder among Nigerians.

2021 ◽  
Vol 5 (2) ◽  
pp. 238-245
Author(s):  
Oloruntoba A. Ekun
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Sodium Citrate ◽  
Red Cell ◽  
Major Depressive ◽  
Red Cell Indices ◽  
Healthy Control ◽  
The Mean ◽  
Number Of Individuals ◽  
Apparently Healthy

Background: A link between major depressive disorder (MDD) and haematological as well as co-agulation disorders has been postulated. This study aims to evaluate haematological and haemostatic changes among Nigerians with major depressive disorder Methods: Two hundred volunteers consisting of an equal number of individuals diagnosed with major depressive disorder (MDD) based on DMS-IV criteria and apparently healthy control participated in this study. The blood sample was collected into tri-sodium citrate K2EDTA bottles respectively and was evaluated for some haemostatic parameters , using ELISA, Clauss, Quick’s One Stage, Proctor and Rapaport’s methods. Results: The mean WBC, hemoglobin and differential lymphocyte were significantly higher among MDD total volunteers (p < 0.001). The red cell indices and platelet count were lower among MDD (p <0.001). Also the prothrombin time (PT), fibrinogen, protein-C and erythrocytes sedimentation rate (ESR) were all raised (p <0.001) among volunteers with MDD. Positive associations existed be-tween MCV and RBC (r: 0.364; p<0.001), PT and APTT (r: 0.319 p <0.001), APTT and fibrinogen (r: 0.239, p = 0.017) as well as PT and fibrinogen (r: 0.275 p = 0.006) at 95% confidence interval. Conclusion: Changes in total leucocytes count, lymphocytes values and haemostatic parameters among volunteers with depression may impacts deleterious effects on the immune response as well as haemostatic homeostasis, while decreased red cell indices may suggest occult nutritional anaemia.

scholarly journals Effects of vitamin D supplementation on red cell indices and cytokines in patients with thalassemia: An open-label randomized clinical trial

2019 ◽  
pp. 170-179
Keyword(s):  
Clinical Trial ◽  
Vitamin D ◽  
Randomized Clinical Trial ◽  
Thalassemia Major ◽  
Vitamin D Supplementation ◽  
Beta Thalassemia ◽  
Red Cell ◽  
Open Label ◽  
Hematological Indices ◽  
Red Cell Indices

Background and aim Deficiency of vitamin D is known as a health problem all over the world and a recognized clinical complication of beta thalassemia patients. Vitamin D acts as a hormone at the nuclear receptor rendering it a beneficial medication for a number of diseases. It is believed that vitamin D is important in the modulation of the inflammation system by regulating the formation of inflammatory cytokines and immune cells. This study aimed to investigate the effect of vitamin D supplementation on the red cell indices and cytokines levels in patients with beta thalassemia major, in an open label randomized clinical trial. Patients and Methods: this study performed an open-label randomized clinical trial in patients with beta thalassemia major. Forty-six patients completed the eight weeks clinical trial and were allocated to administer oral vitamin D3 supplement of 100,000 IU every two weeks as an add-on treatment. During the study, hematological indices, serum iron, ferritin, vitamin D, calcium and inflammatory markers (interleukin-6, interleukin-2 and interleukin-10) were evaluated before (at baseline) and after vitamin D supplementation for 8 weeks. Results: Vitamin D3 supplements significantly decreases interleukin-6 levels and elevates the serum levels of anti-inflammatory cytokines IL-2 and IL-10, it also significantly reduced serum ferritin level, but it did not alter the hematological indices. Conclusion: Our results suggest that administration of vitamin D has a potential anti-inflammatory role in beta thalassemia patients and reduces serum ferritin levels, which may reduce the burdens of iron overload in thalassemia patients.

Red cell indices in normal adults residing at altitudes from sea level to 2670 meters

1980 ◽  
Vol 8 (3) ◽  
pp. 265-271 ◽  
Author(s):  
G. J. Ruíz-Argüelles ◽  
L. Sánchez-Medal ◽  
A. Loría ◽  
J. Piedras ◽  
M. S. Córdova
Keyword(s):  
Sea Level ◽  
Red Cell ◽  
Red Cell Indices ◽  
Normal Adults

Red Cell Indices in Megaloblastosis and Iron Deficiency

Pathology ◽  
1974 ◽  
Vol 6 (2) ◽  
pp. 107-117 ◽  
Author(s):  
R.F. Croft ◽  
A.M. Streeter ◽  
B.J. O'Neill
Keyword(s):  
Iron Deficiency ◽  
Red Cell ◽  
Red Cell Indices

Effects of Thyroid Function on Blood Cell Counts and Red Cell Indices – A Retrospective Study at a Tertiary Care Centre in Mandya, Karnataka

2021 ◽  
Vol 8 (27) ◽  
pp. 2434-2438
Author(s):  
Siddegowda M.S ◽  
Chaithra R ◽  
Shivakumar S ◽  
Maithri C.M
Keyword(s):  
Blood Cell ◽  
Blood Cells ◽  
Thyroid Dysfunction ◽  
Haematological Parameters ◽  
Red Cell ◽  
Corpuscular Haemoglobin ◽  
Significant Difference ◽  
Red Cell Indices ◽  
Mean Corpuscular Haemoglobin ◽  
Rbc Count

BACKGROUND Thyroid hormones play an important role in the regulation and production of red blood cells. Thyroid dysfunction induces different effects on blood cells such as anaemia, erythrocytosis, leucopenia, thrombocytopenia and alteration in red cell indices. In this study, we wanted to compare the changes in haematological parameters of thyroid dysfunction patients with those of euthyroid group. METHODS This was a retrospective study done on 310 individuals by collecting data from the medical records. Later the patients were categorized into hypothyroid (33) thyroid stimulating hormone (TSH > 5.5 μIU/mL), hyperthyroid (19) (TSH < 0.3 μIU/mL) and euthyroid (258) (TSH = 0.3 - 5.5 μIU/ml) groups. The haematological parameters of all these patients were obtained by 5-part automated cell count analyser. Finally, the obtained data was analyzed by statistical package for social sciences (SPSS) software. RESULTS The data obtained from the analysis revealed statistically significant (P < 0.05) difference between hypothyroidism, hyperthyroidism and euthyroidism in mean red blood cell (RBC) count, mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), red cell distribution width (RDW), white blood cell (WBC) count and platelet count but the difference was not significant for mean haemoglobin, mean corpuscular haemoglobin concentration (MCHC) (P > 0.05). The mean haemoglobin was lower in hypothyroid patients when compared to euthyroid and hyperthyroid patients. The RBC count (P < 0.007), MCH (P = 0.002) and RDW (P < 0.001) showed statistically significant difference between hypothyroidism and euthyroidism, MCV (P = 0.005) showed statistically significant difference between hyperthyroid and euthyroid groups. CONCLUSIONS In case of patients with abnormal haematological parameters, thyroid hormones evaluation is necessary. KEYWORDS Hypothyroidism, Hyperthyroidism, Haemoglobin, Blood Count, Red Cell Indices

Hematological alteration among visceral leishmaniasis patients attending in Western Tigrai, Ethiopia, 2018/2019: A cross-sectional study

2020 ◽  
Author(s):  
Gebremedhin Gebremichail ◽  
Brhane Tesfanchal ◽  
Getachew Belay ◽  
Gebreslassie Gebremariam ◽  
Gebreyohans Teklehaymanot ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Blood Cell ◽  
Hematological Parameters ◽  
Cross Sectional Study ◽  
P Value ◽  
Sectional Study ◽  
Control Groups ◽  
Cross Sectional ◽  
Red Cell Indices ◽  
Hematological Abnormalities

Abstract Background: Hematological abnormalities are common in visceral leishmaniasis patients, which is one of the main public health problems worldwide. The most common hematological abnormalities are anemia, leucopenia and thrombocytopenia. Therefore, this study aimed to assess the hematological alteration among visceral leishmaniasis patients attending Western Tigrai, Ethiopia, 2019. Method: Hospital based comparative cross sectional study was conducted from November 2018 to March 2019 in Western Tigrai, Ethiopia. A total of 100 Visceral Leishmaniasis patients and 100 control groups were included in this study. Blood was collected and analyzed by mindray BC-5800 hematology analyzer. Data was entered and analyzed using Statistical package for social science version 23. Student independent t-test was used for data analysis. P value <0.05 was considered as statistically significant at 95% confidence level. Result: From the total 100 visceral leishmaniasis patients the following abnormalities were reported: 96(96%) anemia, 95(95%) leucopenia, 92(92%) neutropenia, 73(73%) Lymphopenia, 45(45%) eosinopenia and 97(97%) had thrombocytopenia. Red blood cell, hemoglobin, hematocrit, red cell indices and platelet were significantly lower (p<0.05) in visceral leishmaniasis patients compared with the control groups. Similarly the total White blood cell, neutrophil, lymphocyte, eosinophil and basophil count were significantly lower (p<0.05) in visceral leishmaniasis patients compared with the control groups. Conclusion: The major changes in peripheral blood of patient with visceral leishmaniasis are reduced number of red blood cells, reduction in leukocytes and decreased platelet count. Visceral leishmaniasis patients presented with anemia, leucopenia and thrombocytopenia. So this finding indicates that visceral leishmaniasis causes alterations of hematological parameters. Key words: Amastigote, Anemia, Hematological Parameters, Promastigote, Visceral leishmaniasis, Ethiopia .

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