Evaluation of mangosteen (Garcinia mangostana) antioxidant activity in clinical trials and in vivo animal studies: A systematic review

Animal studies and the scarce clinical trials available that have been conducted suggest that bioactive surfaces on dental implants could improve the osseointegration of such implants. The purpose of this systematic review was to compare the effectiveness of osseointegration of titanium (Ti) dental implants using bioactive surfaces with that of Ti implants using conventional surfaces such as sandblasted large-grit acid-etched (SLA) or similar surfaces. Applying the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement, the MEDLINE, PubMed Central and Web of Science databases were searched for scientific articles in April 2020. The keywords used were “dental implants”, “bioactive surfaces”, “biofunctionalized surfaces”, and “osseointegration”, according to the question: “Do bioactive dental implant surfaces have greater osseointegration capacity compared with conventional implant surfaces?” Risk of bias was assessed using the Cochrane Collaboration tool. 128 studies were identified, of which only 30 met the inclusion criteria: 3 clinical trials and 27 animal studies. The average STROBE (STrengthening the Reporting of OBservational studies in Epidemiology) and ARRIVE (Animal Research: Reporting of In Vivo Experiments) scores were 15.13 ± 2.08 and 17.7±1.4, respectively. Implant stability quotient (ISQ) was reported in 3 studies; removal torque test (RTT)—in 1 study; intraoral periapical X-ray and microcomputed tomography radiological evaluation (RE)—in 4 studies; shear force (SF)—in 1 study; bone-to-implant contact (BIC)—in 12 studies; and BIC and bone area (BA) jointly—in 5 studies. All animal studies reported better bone-to-implant contact surface for bioactive surfaces as compared to control implants with a statistical significance of p < 0.05. Regarding the bioactive surfaces investigated, the best results were yielded by the one where mechanical and chemical treatment methods of the Ti surfaces were combined. Hydroxyapatite (HA) and calcium–phosphate (Ca–Ph) were the most frequently used bioactive surfaces. According to the results of this systematic review, certain bioactive surfaces have a positive effect on osseointegration, although certain coating biomolecules seem to influence early peri-implant bone formation. Further and more in-depth research in this field is required to reduce the time needed for osseointegration of dental implants.

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Modulation of Matrix Metalloproteinases by Plant-Derived Products

Current Cancer Drug Targets ◽

10.2174/1568009620666201120144838 ◽

2020 ◽

Vol 20 ◽

Author(s):

Nur Najmi Mohamad Anuar ◽

Nurul Iman Natasya Zulkafali ◽

Azizah Ugusman

Keyword(s):

Clinical Trials ◽

Natural Products ◽

Matrix Metalloproteinases ◽

Animal Studies ◽

Current Knowledge ◽

In Vitro Models ◽

In Vivo Studies ◽

Extracellular Matrix Components

: Matrix metalloproteinases (MMPs) are a group of zinc-dependent metallo-endopeptidase that are responsible towards the degradation, repair and remodelling of extracellular matrix components. MMPs play an important role in maintaining a normal physiological function and preventing diseases such as cancer and cardiovascular diseases. Natural products derived from plants have been used as traditional medicine for centuries. Its active compounds, such as catechin, resveratrol and quercetin, are suggested to play an important role as MMPs inhibitors, thereby opening new insights into their applications in many fields, such as pharmaceutical, cosmetic and food industries. This review summarises the current knowledge on plant-derived natural products with MMP-modulating activities. Most of the reviewed plant-derived products exhibit an inhibitory activity on MMPs. Amongst MMPs, MMP-2 and MMP-9 are the most studied. The expression of MMPs is inhibited through respective signalling pathways, such as MAPK, NF-κB and PI3 kinase pathways, which contribute to the reduction in cancer cell behaviours, such as proliferation and migration. Most studies have employed in vitro models, but a limited number of animal studies and clinical trials have been conducted. Even though plant-derived products show promising results in modulating MMPs, more in vivo studies and clinical trials are needed to support their therapeutic applications in the future.

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A Review on Melatonin’s Effects in Cancer: Potential Mechanisms

Anti-Cancer Agents in Medicinal Chemistry ◽

10.2174/1871520617666171121120223 ◽

2018 ◽

Vol 18 (7) ◽

pp. 985-992 ◽

Cited By ~ 3

Author(s):

Aysegul Hanikoglu ◽

Ertan Kucuksayan ◽

Rana Cagla Akduman ◽

Tomris Ozben

Keyword(s):

Systematic Review ◽

Antioxidant Activity ◽

Membrane Receptors ◽

Cancer Development ◽

Secretory Product ◽

Prevention And Treatment ◽

G Protein Coupled

This systematic review aims to elucidate the role of melatonin (N-acetyl-5-metoxy-tryptamine) (MLT) in the prevention and treatment of cancer. MLT is a pineal gland secretory product, an evolutionarily highly conserved molecule; it is also an antioxidant and an impressive protector of mitochondrial bioenergetic activity. MLT is characterized by an ample range of activities, modulating the physiology and molecular biology of the cell. Its physiological functions relate principally to the interaction of G Protein-Coupled MT1 and MT2 trans-membrane receptors (GPCRs), a family of guanidine triphosphate binding proteins. MLT has been demonstrated to suppress the growth of various tumours both, in vivo and in vitro. In this review, we analyze in depth, the antioxidant activity of melatonin, aiming to illustrate the cancer treatment potential of the molecule, by limiting or reversing the changes occurring during cancer development and growth.

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Mining of high throughput screening database reveals AP-1 and autophagy pathways as potential targets for COVID-19 therapeutics

Scientific Reports ◽

10.1038/s41598-021-86110-8 ◽

2021 ◽

Vol 11 (1) ◽

Cited By ~ 2

Author(s):

Hu Zhu ◽

Catherine Z. Chen ◽

Srilatha Sakamuru ◽

Jinghua Zhao ◽

Deborah K. Ngan ◽

...

Keyword(s):

Clinical Trials ◽

High Throughput Screening ◽

Animal Studies ◽

Cytopathic Effect ◽

Mechanisms Of Action ◽

Activity Profile ◽

Pathway Activity ◽

Global Pandemic ◽

Approved Drugs

AbstractThe recent global pandemic of the Coronavirus disease 2019 (COVID-19) caused by the new coronavirus SARS-CoV-2 presents an urgent need for the development of new therapeutic candidates. Many efforts have been devoted to screening existing drug libraries with the hope to repurpose approved drugs as potential treatments for COVID-19. However, the antiviral mechanisms of action of the drugs found active in these phenotypic screens remain largely unknown. In an effort to deconvolute the viral targets in pursuit of more effective anti-COVID-19 drug development, we mined our in-house database of approved drug screens against 994 assays and compared their activity profiles with the drug activity profile in a cytopathic effect (CPE) assay of SARS-CoV-2. We found that the autophagy and AP-1 signaling pathway activity profiles are significantly correlated with the anti-SARS-CoV-2 activity profile. In addition, a class of neurology/psychiatry drugs was found to be significantly enriched with anti-SARS-CoV-2 activity. Taken together, these results provide new insights into SARS-CoV-2 infection and potential targets for COVID-19 therapeutics, which can be further validated by in vivo animal studies and human clinical trials.

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Is antimicrobial photodynamic therapy an effective treatment modality for aggressive periodontitis? A systematic review of in vivo human randomized controlled clinical trials

Photodiagnosis and Photodynamic Therapy ◽

10.1016/j.pdpdt.2021.102314 ◽

2021 ◽

pp. 102314

Author(s):

Snehal Dalvi ◽

Stefano Benedicenti ◽

Reem Hanna

Keyword(s):

Systematic Review ◽

Clinical Trials ◽

Photodynamic Therapy ◽

Aggressive Periodontitis ◽

Antimicrobial Photodynamic Therapy ◽

Controlled Clinical Trials ◽

Randomized Controlled Clinical Trials ◽

Randomized Controlled ◽

Effective Treatment Modality

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Tissue engineering of urethra: Systematic review of recent literature

Experimental Biology and Medicine ◽

10.1177/1535370217731289 ◽

2017 ◽

Vol 242 (18) ◽

pp. 1772-1785 ◽

Cited By ~ 2

Author(s):

Stanislav Žiaran ◽

Martina Galambošová ◽

L'uboš Danišovič

Keyword(s):

Systematic Review ◽

Tissue Engineering ◽

Clinical Trials ◽

Animal Studies ◽

Recent Literature ◽

Cell Attachment ◽

Experimental Studies ◽

Clinical Results ◽

Bioactive Molecules ◽

Urethral Reconstruction

The purpose of this article was to perform a systematic review of the recent literature on urethral tissue engineering. A total of 31 articles describing the use of tissue engineering for urethra reconstruction were included. The obtained results were discussed in three groups: cells, scaffolds, and clinical results of urethral reconstructions using these components. Stem cells of different origin were used in many experimental studies, but only autologous urothelial cells, fibroblasts, and keratinocytes were applied in clinical trials. Natural and synthetic scaffolds were studied in the context of urethral tissue engineering. The main advantage of synthetic ones is the fact that they can be obtained in unlimited amount and modified by different techniques, but scaffolds of natural origin normally contain chemical groups and bioactive proteins which increase the cell attachment and may promote the cell proliferation and differentiation. The most promising are smart scaffolds delivering different bioactive molecules or those that can be tubularized. In two clinical trials, only onlay-fashioned transplants were used for urethral reconstruction. However, the very promising results were obtained from animal studies where tubularized scaffolds, both non-seeded and cell-seeded, were applied. Impact statement The main goal of this article was to perform a systematic review of the recent literature on urethral tissue engineering. It summarizes the most recent information about cells, seeded or non-seeded scaffolds and clinical application with respect to regeneration of urethra.

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Mesenchymal stromal cells: a novel therapy for the treatment of chronic obstructive pulmonary disease?

Thorax ◽

10.1136/thoraxjnl-2017-210672 ◽

2018 ◽

Vol 73 (6) ◽

pp. 565-574 ◽

Cited By ~ 32

Author(s):

Winifred Broekman ◽

Padmini P S J Khedoe ◽

Koen Schepers ◽

Helene Roelofs ◽

Jan Stolk ◽

...

Keyword(s):

Clinical Trials ◽

Mesenchymal Stromal Cells ◽

Stromal Cells ◽

Animal Studies ◽

Chronic Obstructive ◽

Tissue Destruction ◽

Novel Therapy ◽

Model Studies

COPD is characterised by tissue destruction and inflammation. Given the lack of curative treatments and the progressive nature of the disease, new treatments for COPD are highly relevant. In vitro cell culture and animal studies have demonstrated that mesenchymal stromal cells (MSCs) have the capacity to modify immune responses and to enhance tissue repair. These properties of MSCs provided a rationale to investigate their potential for treatment of a variety of diseases, including COPD. Preclinical models support the hypothesis that MSCs may have clinical efficacy in COPD. However, although clinical trials have demonstrated the safety of MSC treatment, thus far they have not provided evidence for MSC efficacy in the treatment of COPD. In this review, we discuss the rationale for MSC-based cell therapy in COPD, the main findings from in vitro and in vivo preclinical COPD model studies, clinical trials in patients with COPD and directions for further research.

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The antioxidant activity of artichoke (Cynara scolymus): A systematic review and meta-analysis of animal studies

Phytotherapy Research ◽

10.1002/ptr.6213 ◽

2018 ◽

Vol 33 (1) ◽

pp. 55-71 ◽

Cited By ~ 12

Author(s):

Shabnam Salekzamani ◽

Mehrangiz Ebrahimi-Mameghani ◽

Khatereh Rezazadeh

Keyword(s):

Systematic Review ◽

Antioxidant Activity ◽

Animal Studies ◽

Meta Analysis ◽

Cynara Scolymus

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Effectiveness of Salvia Officinalis on Mediation of Serum Lipid in Clinical Trials: Systematic Review and Meta-analysis (P12-004-19)

Current Developments in Nutrition ◽

10.1093/cdn/nzz035.p12-004-19 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

Author(s):

Sepideh Alasvand ◽

WIlliam Bridges ◽

Vivian Haley-Zitlin

Keyword(s):

Systematic Review ◽

Clinical Trials ◽

Chronic Disease ◽

Serum Lipid ◽

Animal Studies ◽

Serum Lipids ◽

Meta Analysis ◽

Density Lipoprotein ◽

Salvia Officinalis ◽

Lipoprotein Cholesterol

Abstract Objectives The present systematic review and meta-analysis investigates the effectiveness of S. officinalis leaves in management of dyslipidemia of chronic disease. Dyslipidemia is one of the main indicators of cardiovascular disease (CVD). It is typically characterized by elevated levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL) and triglyceride (TG) along with reduction of high-density lipoprotein cholesterol (HDL) in blood. The handling of dyslipidemia is a crucial factor in the general control of the cardiovascular risk in individuals suffering from diseases such as diabetes, CVD or hypertension. Plant foods have played an important role in chronic disease management. S. officinalis leaves (sage) have been identified as improving glucose homeostasis and serum lipids in animal and human models. Methods PubMed, FSTA, Web of Science, CINAHEL and MEDLINE databases were searched using keywords (“Serum lipids” OR triglyceride* OR cholesterol* OR “LDL” OR “HDL” OR dyslipidemia) AND (sage or "Salvia officinalis") up to January 2019. Review articles, animal studies, non-trial, non-specific related plants, and articles which did not examine lipid profiles were included in the exclusion criteria. Articles that met the inclusion criteria included effects of administration of Salvia officinalis on serum lipid in clinical trials. All statistical calculations were performed using SAS software version 9.2 (SAS, Cary NC, USA). Results From 243 studies, four of the trials met the selection criteria of the meta-analysis. Salvia officinalis significantly improved serum lipids. The estimated value for TC was −52.64 mg/dl, 95% CI: −71.0505 to −34.23, P = 0.0001 and LDL −23.28 mg/dl, 95% CI: −40.07 to −6.48, P = 0.006. Moreover, TG was −74.98 mg/dl, 95% CI: −129.16 to −20.8190, P = 0.006 and HDL-C at 6.3424 mg/dl, 95% CI: 1.58 to 11.1033, P = 0.009) was significantly improved after Salvia officinalis administration Conclusions Although the systematic review and meta-analysis investigation involved few studies it revealed promising efficiency of Salvia officinalis on improving the serum lipids in clinical trials and suggested that Salvia officinalis can be an appropriate plant food to manage dyslipidemia of chronic diseases. Funding Sources N/A.

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